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Melatonin controls the 2 change programs in mitochondria........

Discussion in 'Mitochondrial Rx' started by Jack Kruse, Jul 13, 2019.

  1. Jack Kruse

    Jack Kruse Administrator

    autophagy and apoptosis.........


    Implications:

    Melatonin is "well‐known as an 'immunological buffer 'and an anti-tumor compound."
    Did you know that ⤵️
    It's 5x more efficient than glutathione?
    More Bad science news for Mr. Asprey's sales..........
    ✔️ Can access ALL parts of the cell?
    Women have more melatonin sensitivity?
    https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.29036
     
    CjHedberg, Mayuri, Jim Laird and 4 others like this.
  2. JanSz

    JanSz Gold

  3. JanSz

    JanSz Gold

    @Jack Kruse
    I rarely dream.
    What may be the reason?

    /
     
  4. Mayuri

    Mayuri Silver

    I used to supplement with it, I’ve always wondered if that is what kept my cancer from spreading?
     
    CjHedberg likes this.
  5. Jack Kruse

    Jack Kruse Administrator

    Blue light lowers melatonin via melanopsin dysfunction.

    BLUE LIGHT IS A STIMULANT THAT CREATES ROS/RNS NORMALLY

    And stimulants are great. Most Americans drink a few cups of stimulants each morning ☕️ to get themselves up to face the daily grind.

    But you know what's not great? Being stimulated 24 hours of every day by blue light. This ruins the dose response curve of the ROS/RNS. That is exactly what is occuring to modern humans because they live indoors and use tech screens to an excess. What else is different about this version of blue light? The blue light that wakes us up in the sun is NEVER present without 42% IR-A light which is red light. AM sunlight has 42% red light in it and only 1600K of blue light. This small stimulus of blue light is about to improve executive function of the prefrontal cortex. This blue light needs red light to control the oxidation ROS/RNS that blue light makes when it is present without red light in our light environment.

    ALL CELLS contain ion channels in their outer (plasma) and inner (organelle) membranes. Ion channels, similar to other proteins, are targets of oxidative impact, which modulates ion fluxes across membranes. Subsequently, these ion currents affect electrical excitability, such as action potential discharge (in neurons, muscle, and receptor cells), alteration of the membrane resting potential, synaptic transmission, hormone secretion, muscle contraction or coordination of the cell cycle.

    An important class of ion channels is the family of potassium (K+) channels, they are not only in charge of the membrane resting potential or the repolarization of the action potentials, but also control cell proliferation or transmitter/hormone release, to name a few. A subgroup of K+ channels are the so called calcium (Ca2+) activated K+ channels which need either an increase of Ca2+ at their intracellular face to open or a combination of Ca2+ and voltage to function properly. Maxi Ca2+ activated K+ channels, also named BK channels which constitute a subgroup of Ca2+ activated K+ channels.

    DO you know where these ion channels exist in humans? They are found on the inner mitochondrial membrane. EXCESSIVE BLUE LIGHT exposure destroys these potassium ion channels to ruin signaling of cells that control the circadian mechanism and are associated with leptin and melanopsin. LET THAT SINK IN.

    Mitochondria are a major source of ROS generation targeting BK channels. Blue light creates that stimulus when RED LIGHT IS ABSENT.

    The inner membrane of mitochondria contains BK channels (mtBK) which appear essential in the production of ROS. mtBK channels appear to be inserted into the mitochondrial membrane with the toxin binding sites for charybdotoxin and iberiotoxin exposed to the mitochondrial intermembrane space. This can be accessed by using outside-out patch configuration of the inner mitochondrial membrane. Consequently the C-terminal tail domain including the Ca2+ binding site is localized to the mitochondrial matrix where the proton gradient exists. RED LIGHT MOVES PROTONS BEST. Blue light creates the most ROS. Do you understand why subtracting red light from blue creates mitochondrial diseases?

    When you look at your computer screen or phone screen, your brain wakes up. It's alert. Because it hears "It's day time! Time to be focused and do human things!"

    But guess when it's bad to hear that signal?

    The other 14 hours of the day that the Sun wouldn't normally be sending such a signal to the brain.

    We need a break from the stimulus. Otherwise we fry our circuits and get fatigued.

    So take a break from the blue. Stop the intravenous coffee to your SCN and allow yourself to relax.

    This is why I Chillax, with Ra Optics blue blockers when I face when red light is removed from the blue light stimulus. The discount code is OPTIMAL.

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379900/
     
    Karen & Glen C. likes this.
  6. Jack Kruse

    Jack Kruse Administrator

    Your dermatologist is giving you a disease faster than the pizza you feel guilty about eating yesterday.
    "They neglect the fact that increased sun exposure, based on latitude, has been associated with protection from several different types of cancer, diabetes, multiple sclerosis and other diseases like high blood pressure, schizophrenia, arthritis and IBS"
    But at least you'll have that virgin vampire-like skin.
    Lots of gems in this paper. Read it and share it...maybe even with your dermatologist or eye doctor. https://www.tandfonline.com/doi/full/10.1080/07315724.2015.1039866
     
    Phosphene, Nadya and drezy like this.

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