What happens when you knock out melatonin receptors via melanopsin dysfunction from the liberation of Vitamin A? You get insulin resistance and set the stage for many mitochondrial diseases like diabetes and cancer.





Do you know what I'm talking about? Light shapes life. How is it shaping yours?
https://onlinelibrary.wiley.com/doi/full/10.1038/oby.2010.24

FYI: "Photoreceptor cells do not regenerate in the eye. When they're dead, they're dead for good. The retinal-generated toxicity by blue light is universal. It can kill any cell type."

Free retinal destroys melatonin by this mechanism below.
https://phys.org/news/2018-08-chemists-blue.html

 

On the Phys.org/news link they say to wear Sunglasses. Doesn’t natural sunlight always have the right mix of colors to protect the eye from blue light damage? Do we ever need sun glasse outside?

“To protect your eyes from blue light, Karunarathne advises to wear sunglasses that can filter both UV and blue light outside and avoid looking at your cell phones or tablets in the dark.”

 

This statement would be contextual ie. on a boat, in the snow (albedo effect), outside of those considerations you should be fine with no sunglasses. I never wear them anymore and my eyes are better than they were 6 years ago.

 

What might the effect of working in a blue-lit 5G environment for over 30 years do to the eye when you chronically wear a headset? Any fast-food workers paying attn? You do not need trauma from a football collision to get a trauma like condition because the biologic disruption is the same metabolically and via melanopsin damage. http://www.nfl.com/news/story/0ap30...itle-vision-vikings-coach-ready-to-fight-back

 

Blue light sans red light causes severe melanopsin dysfunction that destroys melatonin levels and this ruins the two change programs in mtDNA called autophagy and apoptosis.

Implications for the colony of mitochondria below affected by the blue light?

BLUE LIGHT IS A STIMULANT THAT CREATES ROS/RNS NORMALLY

And stimulants are great. Most Americans drink a few cups of stimulants each morning ☕️ to get themselves up to face the daily grind.

But you know what's not great? Being stimulated 24 hours of every day by blue light. This ruins the dose-response curve of the ROS/RNS. That is exactly what is occurring to modern humans because they live indoors and use tech screens to an excess. What else is different about this version of blue light? The blue light that wakes us up in the sun is NEVER present without 42% IR-A light which is red light. AM sunlight has 42% red light in it and only 1600K of blue light. This small stimulus of blue light is about to improve executive function of the prefrontal cortex. This blue light needs red light to control the oxidation ROS/RNS that blue light makes when it is present without red light in our light environment.

ALL CELLS contain ion channels in their outer (plasma) and inner (organelle) membranes. Ion channels, similar to other proteins, are targets of oxidative impact, which modulates ion fluxes across membranes. Subsequently, these ion currents affect electrical excitability, such as action potential discharge (in neurons, muscle, and receptor cells), alteration of the membrane resting potential, synaptic transmission, hormone secretion, muscle contraction or coordination of the cell cycle.

An important class of ion channels is the family of potassium (K+) channels, they are not only in charge of the membrane resting potential or the repolarization of the action potentials, but also control cell proliferation or transmitter/hormone release, to name a few. A subgroup of K+ channels are the so-called calcium (Ca2+) activated K+ channels which need either an increase of Ca2+ at their intracellular face to open or a combination of Ca2+ and voltage to function properly. Maxi Ca2+ activated K+ channels, also named BK channels which constitute a subgroup of Ca2+ activated K+ channels.

DO you know where these ion channels exist in humans? They are found on the inner mitochondrial membrane. EXCESSIVE BLUE LIGHT exposure destroys these potassium ion channels to ruin signaling of cells that control the circadian mechanism and are associated with leptin and melanopsin. LET THAT SINK IN.

Mitochondria are a major source of ROS generation targeting BK channels. Blue light creates that stimulus when RED LIGHT IS ABSENT.

The inner membrane of mitochondria contains BK channels (mtBK) which appear essential in the production of ROS. mtBK channels appear to be inserted into the mitochondrial membrane with the toxin binding sites for charybdotoxin and iberiotoxin exposed to the mitochondrial intermembrane space. This can be accessed by using the outside-out patch configuration of the inner mitochondrial membrane. Consequently, the C-terminal tail domain including the Ca2+ binding site is localized to the mitochondrial matrix where the proton gradient exists. RED LIGHT MOVES PROTONS BEST. Blue light creates the most ROS. Do you understand why subtracting red light from blue creates mitochondrial diseases?

When you look at your computer screen or phone screen, your brain wakes up. It's alert. Because it hears "It's day time! Time to be focused and do human things!"

But guess when it's bad to hear that signal?

The other 14 hours of the day that the Sun wouldn't normally be sending such a signal to the brain.

We need a break from the stimulus. Otherwise, we fry our circuits and get fatigued.

So take a break from the blue. Stop the intravenous coffee to your SCN and allow yourself to relax.

This is why I Chillax, with Ra Optics blue blockers when I face when the red light is removed from the blue light stimulus. The discount code is OPTIMAL.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379900/

 

Just ask Steve Jobs and Paul Allen if staying late is good for your health. https://businesschicks.com/effects-of-working-overtime/

 

the link does not open for me Jack... just a blank page..

 

It looks mostly like this for me:

 

If anyone continues to think Adrenal dysfunction is not a brainstem disease linked to light exposure you are officially out of date with your knowledge.https://www.cell.com/cell-metabolism/fulltext/S1550-4131(05)00269-X

 

If “melatonin counteracts cancer tumor metastases” then probably not a good idea to have your lights on when the sun goes down suppressing your melatonin night after night after night after night. #LAN #ALAN #CancerAwareness #BlueLight
https://onlinelibrary.wiley.com/doi/full/10.1111/jpi.12370