1. Registering for the Forum

    We require a human profile pic upon registration on this forum.

    After registration is submitted, you will receive a confirmation email, which should contain a link to confirm your intent to register for the forum. At this point, you will not yet be registered on the forum.

    Our Support staff will manually approve your account within 24 hours, and you will get a notification. This is to prevent the many spam account signups which we receive on a daily basis.

    If you have any problems completing this registration, please email support@jackkruse.com and we will assist you.

MELANOPSIN is in skin and sub cutaneous fat - How is it supposed to work?

Discussion in 'Ask Jack' started by gcnorbury@gmail.com, Apr 23, 2019.

  1. Hi Jack,

    You have taught us an awful lot about what can go wrong with Melanopsin funtion in the modern world. I understand the story of Melanopsin dysfunction, but I feel I need to learn more about how Melanopsin is designed to work in an ideal world (pre nnEMFs) especially in the skin and sub q fat.

    Please could you give me a quick run-through of the process.

    My thinking is that it is there as a light receptor for blue light from the sun to act as circadian timing mechanism for the peripheral clocks and also to link with Leptin using light.
    Does the blue in sunlight also break the weak covalent bond to release free Retinal?
    If so, is this ok because the process is quantised and/or because red light is also present in the sun.
    Is it supposed to be a cyclic process?
    Is it ok because sunlight is unpolarised?

    I have searched all your blogs and talks and haven't find anything related to just how Melanopsin in the skin is supposed to work.

    Thank you.
     
    Linz, Alex97232 and JanSz like this.
  2. Jack Kruse

    Jack Kruse Administrator

    Melanopsin is the blue light detector 435-465nm light that links to leptin hormone in SQ fat. It is the main photoreceptor in the skin and SQ fat. The interaction between melanopsin and leptin allow the hypothalamus to know the correct energy balance in the body and this light information is programmed into the benzene rings of leptin that act as photon traps. This process also controls the levels of melatonin in the body which control the efficiency of apoptosis and autophagy and optimizes tissue level energy and information transfer to and from the brain's hypothalamus to work to operate a tight control over the molecular clock functions in the body. This is why melatonin works with BDNF and cortisol to optimize neural networks, connections, and brain neurite sprouting and growth.
     
  3. Jack Kruse

    Jack Kruse Administrator

    Alex97232 likes this.
  4. Jack Kruse

    Jack Kruse Administrator

    Lymphatic Vessels: A Potential Approach to the Treatment of Atherosclerosis? When the intima is damaged by circadian disruption of the melanopsin mechanism nothing in the circulatory system works as it should. In 2014 we found melanopsin in these vessels. https://www.liebertpub.com/doi/full/10.1089/lrb.2018.0015
     
    Alex97232 and drezy like this.
  5. Jack Kruse

    Jack Kruse Administrator

    Molly and Dylan said,
    Mitochondria provide the energy for your body to work [​IMG]
    If mitochondria don't work, you end tired 24/7 [​IMG]
    Blue light damages their DNA [​IMG]
    Be good to your mitochondria and they'll be good to you [​IMG] #melanopsinwisdom #bluelight hazard #chronicfatigue

    [​IMG]
     
  6. Thanks for the response.

    I'm particularly interested in the difference between how Melanopsin and Vitamin A behave when the skin/SQ fat is exposed to natural circadian sunlight versus fake light/nnEMF exposure.

    Do we still see the breaking of the covalent bond?
    If so, then presumably the retinal floats freely until dusk, when there is a reconnection, maybe.

    Or maybe the blue in natural sunlight with the ever present red doesn't lead to totally free retinal and subsequent photoreceptor damage?

    That's the part I'm missing.

    Thanks
     
  7. Jack Kruse

    Jack Kruse Administrator

    Light waves have many ways to transfer energy and information to and fro in cells and tissues. It turns out how they do it is way more complex then we can imagine. Color is one way they communicate complex information. In physical molecules like melanopsin and leptin, the information can be carried directly in an energy message. It also can be carried solely as an information message in the quantum spin state of electrons, protons, or in photon spin.

    In cells, the chemical coupling is not a linear phenomenon. This is why you are confused about it. Many times in chemical coupling information transfer is associated with a massive loss of energy because the second law of thermodynamics requires this action to allow the cells to remain far from equilibrium. Energy loss in living systems always seems to be in heat or red light wavelengths. This is well understood in the classic thermodynamic theory of the second law with respect to entropy. But we are more complex than this simple linear equation from Boltzmann because we can store energy and information because cells are dissipative structures that use many queer novelties within quantum thermodynamic theory.

    When massive energy is lost in chemical coupling the small amount of residual energy left in the chemical bond is capable of limiting information quanta that are used as a stimulus or signal in the cell build data networks or intelligence. In this way, you begin to see the organization of the system is far more important than the energy quanta that Wallace focuses on. That is the story of the QT series I am laying out on Patreon. It underpins how leptin and melanopsin really are doing their dance with the hypothalamus to get the proper energy balance signal from the fat mass and gut to the brain.

    Blue and red light energy and information quanta are critical in this photonic signaling pathway. Retinol carries a complementary color to blue so it limits the information and energy in the blue light. This is why vitamin coupling to the melanopsin is so critical and so misunderstood in obesity research.

    If you remember in Mae Wan Ho's books she talked about McClare and how it ties to his work on bioenergetics. You might have missed how it ties to this thread. He found that color is critical in how electromagnetic waves to transfer information compared to physical systems like that of the hormone system, drugs, or neurotransmitters, or the second messenger system of cAMP. This is why fundamentally the paradigm of functional medicine is an abject joke from a teleologic perspective to the Black Swan and none of them realize it. They do not know who Ho or McClare is or what their work found. If they did they would never push pills or supplements. Uncle Jack read their work years ago and realized the implications of frequencies color and power. The electromagnetic force, of which the photon is the force carrier, tells us that light has unlimited range and power from an energy and information standpoint. Therefore, it is the DOMINANT perspective to follow with regards to energy and information. The physics of organisms is way more foundational than its biology. He found color was hundreds of time more efficient and powerful in information transfer in human cells.

    Light ability to diffuse in a cells matrix occurs at astronomical speeds because of Fermat's law. The physical couplers that biology and functional medicine are spellbound by only operate at diffusable speeds of a centimeter per second. This speed limit cannot explain what life can do........in the living or experimental state. That alone should tell the wise that focus in on the physical couplers of biochemicals is a waste of time. This is why few understand how melanopsin and leptin are doing what they are with the arcuate nucleus in the brain stem. Uncle Jack sees life way differently. A cell is not a vacuum, so it does not travel at 186, 000 mph. Its speed barrier is limited and controlled by the chromophores that are coded for by mtDNA and the nuclear genome to control the speed of light in cells. This is what controls information and energy transfer. This is the mechanism of how leptin and melanopsin operate way below your ability to sense or see it.......much less understand it.
     
    recoen and Alex97232 like this.
  8. Sun Disciple

    Sun Disciple AKA Paul...That Call Drop'n Canadian

    The blue part of the spectrum is balanced by red/infrared which is always present from from sundown to sun up.
     
  9. Thanks Jack.

    Need to mull that over.
     
  10. JanSz

    JanSz Gold

    Is that the same as addressed on this slide:

    upload_2019-4-24_12-9-8.png
    Also
    there is no vacuum.



    Wallace Thornhill: The Long Path to Understanding Gravity | EU2015
    ====================================


    upload_2019-4-24_12-8-48.png
     
    Last edited: Apr 24, 2019
  11. Any recommendations of which of Mae Wan Ho's books to read first?
     
  12. I read The Rainbow and the Worm then Living Rainbow H2O.

    Both excellent.
     
    recoen, Sean Waters and Marko Pollo like this.
  13. recoen

    recoen Gold

    Note “DOMINANT perspective”, not only...
     
  14. JanSz

    JanSz Gold

    And the next one or two are...?

    .
     
  15. Jack Kruse

    Jack Kruse Administrator

    BLUE LIGHT HAZARD = melanopsin dissociates from retinal and free retinal destroys photoreceptors = destroys optical signaling. The lower your redox is the more retinal is released. Certain stimuli are more apt to release retinal in this way. Blue light is the one that is now best identified. Now that they we know the human bond between melanopsin is a weak covalent bond we know that 1G-5G wave forms can also separate them. We’ve believed that melanopsin was only present in the eye since its discovery in humans since 1998. We then discovered it in human blood vessels in 2014. Then, in December 2017 we got the shock data it was also in our skin and subcutaneous fat helping explain why nature put leptin, another photoreceptor molecule, in our subcutaneous fat. Leptin is designed to take optical data from the skin and skin arteriole surface about day and night and couple that with energy balance information and deliver it to the hypothalamus under the cover of darkness. Free retinol from surface light at the wrong time of the day is what ruins this hormones behavior optically. Once leptin signaling is disrupted by circadian mechanisms, the hypothalamus loses control of all growth and metabolism inputs. This leads to many chronic human maladies such as obesity, diabetes, and metabolic syndrome. They are all defects in optical signaling caused by Vitamin A’s ability to destroy photoreceptors. This is they the authors in the article make this statement, about blue light, ”It's toxic. If you shine blue light on retinal, the retinal kills photoreceptor cells as the signaling molecule on the membrane dissolves.” That is a definitive unequivocal statement. https://phys.org/news/2018-08-chemists-blue.html
     
  16. Jack Kruse

    Jack Kruse Administrator

    It’s not just in the Eyes, it is the skin too!
    Until 2017 we thought that melanopsin only existed in the eyes of humans. A study published in Nature showed that subcutaneous white adipocytes express a light sensitive signalling pathway mediated via a melanopsin/TRPC channel axis. It is now evident that melanopsin was present in the skin and fat cells and can translate light signals even if we block blue light from entering our eyes.
    When TRPC receptors are exposed to blue light after dark it is very common that inflammation occurs. This is probably one of the reasons why night shift workers are the highest users of prescription pain relief medication and why we have a major dependence on pain medication in the developed world. Personally, if I have my skin exposed to blue light after dark I get very twitchy and itchy and this is sure fire proof that blue light is irritating my skin via the TRPC channels via melanopsin activation.
    In humans the bond between melanopsin to retinol is a very weak covalent bond. The bond is easily broken by short wavelength blue light. What do human’s live and work under 24/7? You guessed it, BLUE LIGHT. When you look at rodent models you still find melanopsin in the skin, but how they differ from human’s is they have fur covering the skin, which weakens the influence of blue light on melanopsin. That is why ancestrally speaking when we were covered in hair the main receptors for blue light would be found in the eye. However, we have evolved not to need our body hair and as such have exposed our melanopsin to the outside world. This is now a much larger surface area for melanopsin to be affected by artificial blue and green light after dark.
    WHAT IS THE BLUE LIGHT HAZARD = melanopsin dissociates from retinal and free retinal destroys photoreceptors = destroys optical signaling. The lower your redox is the more retinal is released. Certain stimuli are more apt to release retinal in this way. Blue light is the one that is now best identified. Now that we know the human bond between melanopsin is a weak covalent bond we know that 1G-5G waveforms can also separate them. We’ve believed that melanopsin was only present in the eye since its discovery in humans since 1998. We then discovered it in human blood vessels in 2014. Then, in December 2017 we got the shock data it was also in our skin and subcutaneous fat helping explain why nature put leptin, another photoreceptor molecule, in our subcutaneous fat. Leptin is designed to take optical data from the skin and skin arteriole surface about day and night and couple that with energy balance information and deliver it to the hypothalamus under the cover of darkness. Free retinol from surface light at the wrong time of the day is what ruins this hormones behavior optically. Once leptin signaling is disrupted by circadian mechanisms, the hypothalamus loses control of all growth and metabolism inputs. This leads to many chronic human maladies such as obesity, diabetes, and metabolic syndrome. They are all defects in optical signaling caused by Vitamin A’s ability to destroy photoreceptors. This is why the the authors in the article make this statement, about blue light, ”It's toxic. If you shine blue light on retina, the retinal kills photoreceptor cells as the signaling molecule on the membrane dissolves.”
    That is a definitive unequivocal statement.https://www.ncbi.nlm.nih.gov/m/pubmed/31418890/
     
    Francis Devine and Brent Patrick like this.
  17. Jack Kruse

    Jack Kruse Administrator

  18. Jack Kruse

    Jack Kruse Administrator

    BLUE LIGHT IS A STIMULANT THAT CREATES ROS/RNS NORMALLY

    And stimulants are great. Most Americans drink a few cups of stimulants each morning ☕️ to get themselves up to face the daily grind.

    But you know what's not great? Being stimulated 24 hours of every day by blue light. This ruins the dose response curve of the ROS/RNS. That is exactly what is occuring to modern humans because they live indoors and use tech screens to an excess. What else is different about this version of blue light? The blue light that wakes us up in the sun is NEVER present without 42% IR-A light which is red light. AM sunlight has 42% red light in it and only 1600K of blue light. This small stimulus of blue light is about to improve executive function of the prefrontal cortex. This blue light needs red light to control the oxidation ROS/RNS that blue light makes when it is present without red light in our light environment.

    ALL CELLS contain ion channels in their outer (plasma) and inner (organelle) membranes. Ion channels, similar to other proteins, are targets of oxidative impact, which modulates ion fluxes across membranes. Subsequently, these ion currents affect electrical excitability, such as action potential discharge (in neurons, muscle, and receptor cells), alteration of the membrane resting potential, synaptic transmission, hormone secretion, muscle contraction or coordination of the cell cycle.

    An important class of ion channels is the family of potassium (K+) channels, they are not only in charge of the membrane resting potential or the repolarization of the action potentials, but also control cell proliferation or transmitter/hormone release, to name a few. A subgroup of K+ channels are the so called calcium (Ca2+) activated K+ channels which need either an increase of Ca2+ at their intracellular face to open or a combination of Ca2+ and voltage to function properly. Maxi Ca2+ activated K+ channels, also named BK channels which constitute a subgroup of Ca2+ activated K+ channels.

    DO you know where these ion channels exist in humans? They are found on the inner mitochondrial membrane. EXCESSIVE BLUE LIGHT exposure destroys these potassium ion channels to ruin signaling of cells that control the circadian mechanism and are associated with leptin and melanopsin. LET THAT SINK IN.

    Mitochondria are a major source of ROS generation targeting BK channels. Blue light creates that stimulus when RED LIGHT IS ABSENT.

    The inner membrane of mitochondria contains BK channels (mtBK) which appear essential in the production of ROS. mtBK channels appear to be inserted into the mitochondrial membrane with the toxin binding sites for charybdotoxin and iberiotoxin exposed to the mitochondrial intermembrane space. This can be accessed by using outside-out patch configuration of the inner mitochondrial membrane. Consequently the C-terminal tail domain including the Ca2+ binding site is localized to the mitochondrial matrix where the proton gradient exists. RED LIGHT MOVES PROTONS BEST. Blue light creates the most ROS. Do you understand why subtracting red light from blue creates mitochondrial diseases?

    When you look at your computer screen or phone screen, your brain wakes up. It's alert. Because it hears "It's day time! Time to be focused and do human things!"

    But guess when it's bad to hear that signal?

    The other 14 hours of the day that the Sun wouldn't normally be sending such a signal to the brain.

    We need a break from the stimulus. Otherwise we fry our circuits and get fatigued.

    So take a break from the blue. Stop the intravenous coffee to your SCN and allow yourself to relax.

    This is why I Chillax, with Ra Optics blue blockers when I face when red light is removed from the blue light stimulus. The discount code is OPTIMAL.

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379900/
     
    PaulG and Brent Patrick like this.

Share This Page