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Melanin enhancers and inhibitors

Discussion in 'The Cave' started by chocolate, Apr 13, 2012.

  1. chocolate

    chocolate Silver

    http://www.google.com/url?sa=t&rct=j&q=&The flaesrc=s&source=web&cd=1&ved=0CCMQFjAA&url=http%3A%2F%2Fwww.mdpi.com%2F1422-0067%2F10%2F9%2F4066%2Fpdf&ei=4l6IT-yRKMSXiQKh2MzOCw&usg=AFQjCNH8oInmoiAJf7lDmtMPF2kWUBcTBA&sig2=rqhYlPwzznYytL5YcrdZzw



    Mechanisms regulating skin pigmentation, the rise and fall of melanin


    4.9. Flavonoid-like Agents

    Flavonoids are natural plant polyphenols found in leaves, bark and flowers. Some 4,000 members

    have been identified to date, all benzo-γ-pyran derivates comprised of phenolic and pyran rings. These

    polyphenolic compounds are known to have anti-inflammatory, antiviral, antioxidant and

    anticarcinogenic properties [20,50,63]. The flavonoids may also have ROS scavenging properties and

    the ability to chelate metals at the active site of metalloenzymes.[
    B] Flavonoids may have

    hypopigmenting capabilities by directly inhibiting tyrosinase activity at distal portions of the

    melanogenic pathway [20]. Structure-function analysis of flavonoids suggests that flavonoi[/B]ds with an

    α-keto group show potent tyrosinase inhibition due to the similarity between the dihydroxyphenyl

    group of DOPA and the α-keto containing flavonoids [63]. Similar analysis completed by Kubo et al.

    suggests that flavonoids have the capability to chelate copper in tyrosinase’s active site as long as the

    3-hydroxygroup is free [64,68]. A comprehensive review on the properties of plant polyphenols has

    been published by Kim et al. [63] Flavonoids that will be reviewed here include aloesin,

    hydroxystilbene derivates and licorice extracts.



    this article breaks things down quite a lot. Things that I was afraid of, like licorice, I may now know how to toy around with.
     

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