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Melanin enhancers and inhibitors

Discussion in 'The Cave' started by chocolate, Apr 13, 2012.

  1. chocolate

    chocolate Silver


    4.9. Flavonoid-like Agents

    Flavonoids are natural plant polyphenols found in leaves, bark and flowers. Some 4,000 members

    have been identified to date, all benzo-γ-pyran derivates comprised of phenolic and pyran rings. These

    polyphenolic compounds are known to have anti-inflammatory, antiviral, antioxidant and

    anticarcinogenic properties [20,50,63]. The flavonoids may also have ROS scavenging properties and

    the ability to chelate metals at the active site of metalloenzymes. Flavonoids may have

    hypopigmenting capabilities by directly inhibiting tyrosinase activity at distal portions of the

    melanogenic pathway [20]. Structure-function analysis of flavonoids suggests that flavonoids with an

    α-keto group show potent tyrosinase inhibition due to the similarity between the dihydroxyphenyl

    group of DOPA and the α-keto containing flavonoids [63]. Similar analysis completed by Kubo et al.

    suggests that flavonoids have the capability to chelate copper in tyrosinase’s active site as long as the

    3-hydroxygroup is free [64,68]. A comprehensive review on the properties of plant polyphenols has

    been published by Kim et al. [63] Flavonoids that will be reviewed here include aloesin,

    hydroxystilbene derivates and licorice extracts.

    4.9.1. Aloesin
  2. shilohman

    shilohman New Member

    So how do I fit flavonoids into my paleo diet? I don't want to supplement, I already take way too many supplements. Are there any paleo friendly foods that provide a large enough quantity of flavonoids to bu useful?
  3. MJ*

    MJ* New Member


    That's a great list, for Paleo you would avoid fruit juices for the sugar content and beans for their high carbs
  4. shilohman

    shilohman New Member

    Thanks MJ*, looks like for me dark chocolate is the only one that will keep me paleo.

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