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Matty's Journal

Discussion in 'My Optimal Journal' started by Matt Fowler, Dec 21, 2020.

  1. Blog notes (How to Find Your Inner Masterpiece):

    Paragraph 1:

    PPAR Gamma = master regulator of adipocyte and lipid metabolism in the cell.
    PPAR Gamma is under the direct control of Leptin and its receptors and is heavily influenced by light.
    Fat cells receive light as they are directly below the skin surface (in humans).


    Leptin and it's receptors controls Peroxisome Proliferator-Activated Receptor Gamma
    = PPAR Gamma joins with Retinoid X Receptors to make Heterodimers
    = Heterodimers control the transcription of the PON1 Gene
    = The PON1 Gene controls the synthesis and release of Paraoxonase 1 from the liver
    = Paraoxonase 1 acts as a plasma antioxidant which limits the oxidation of LDL (bad Cholesterol) in the blood
    = Decreased risk of atherosclerosis and cardiovascular disease.

    Atherosclerosis and cardiovascular disease is also tied to artificial light exposure, low k2 and low d3 levels.
    High Paraoxonase levels go hand in hand with high glutathione levels. Low glutathione levels are tied to atherosclerosis and cardiovascular disease.


    Low Paraoxonase 1 tied to Vit K2 depletion in arterial walls

    PON1 Gene transcription occurs in the Hepatocyte = It's coded protein is synthesised in the liver and is transported along with HDL in the blood plasma.

    Low levels of HDL are tied to Vit K2 depletion in arterial walls.

    High K2 intake drastically reduces the risk of dying from vascular disease as well as the risk of aortic/coronary artery calcification (Dutch Study).



    Low HDL (usually) = Low Paraoxonase, Low UV exposure + Low Vit K2 Levels, indicative of an indoor existence.

    HDL can be used as a measure of how leaky your gut is to plasma LDL oxidising endotoxins.

    High LDL = little clinical significance
    High levels of oxidised LDL = of great significance
    Low HDL, High hs-CRP, High Ferritin = Potential for highly inflammatory serum plasma (& disease)
    Low HDL, High hs-CRP, High Ferritin = reduces ez water in the blood plasma lowering its ability to carry energy around the body. Also related to lower haemoglobin and hepatocrite levels.

    Haemoglobin is loaded with porphyrins (UV light receptors)

    -This linkage is tied to higher HDL and lower LDL. People who eat Keto, but have high LDL levels, do so because they live indoor lives.


    Inflammatory changes (Low HDL, high hs-CRP, high ferritin)
    + Serum oxidised LDL levels
    = directly influence Paraoxonase 1 serum concentration.

    PPAR Gamma has a coactivator called PGC1 Alpha.

    PGC1 Alpha (belongs to a family of transcription co-activators) plays a central role in the regulation of all cellular energy metabolism.

    PGC1 Alpha Protein may also
    = be involved in controlling blood pressure
    + regulating cellular cholesterol
    + The development of obesity and type two diabetes.

    PGC1 Alpha = helps control mitochondrial number and density within a cell.

    Mitochondrial Biogenesis:

    PPAR Gamma's co-activator PGC1 Alpha regulates mitochondrial numbers (via mitochondrial biogenesis) depending on the energy needs of the cell, as well as cell damage.

    Mitofusin 2:

    PGC1 Alpha is relavent to mitochondrial dynamics because it is a transcriptional co-activator of "fusion mediator" Mitofusin 2.

    Mitofusin 2 connects endoplasmic reticulum to mitochondria + controls cellular calcium homeo stasis.

    Mitocondria/endoplasmic reticulum connectivity is regulated by Mitofusin 2 and can create micro domains that facilitate fission.

    PGC1 Alpha --------> (Co-activates transcription of) Mitofusin 2 (which is a fusion mediator).
    Mitofusin 2 ---------> connects endoplasmic reticulum to mitochondria + controls cellular calcium homeostasis
    Last edited: Jan 7, 2021
    John Schumacher likes this.
  2. Hope you had a good New Year Jan.

    That sounds like a clever pre-emption. Will this bio-hack just lower the severity of the symptoms or eliminate the virus altogether?

    I have been very cynical about C19 - until, today, I heard that a childhood friend of mine is in hospital hooked up to a ventilator. If only he had been privy to this medical study (VIT D and Acute Respiratory Distress Syndrome/lung sepsis) from the University of Birmingham:

  3. Sue-UK

    Sue-UK Gold

    I've not been cynical about C19, but its the politicians' response to it, (both government and the opposition). They are accepting dodgy statistics, test figures and "modelling" and words like "estimated." The worst is counting deaths "within 28 days of a positive test." That implies someone could have been asymptomatic and been knocked down by a bus, or died as expected from terminal cancer, etc etc .. without ever taking up a bed in a Covid ward ICU.

    If the money had been spent on giving everyone at risk a regular vitamin D test, instead of the shielding strategy and lockdowns keeping people out of the sun making things worse ....:mad:

    This is another dirt cheap intervention...... ;)

    Inositol and pulmonary function. Could myo-inositol treatment downregulate inflammation and cytokine release syndrome in SARS-CoV-2?
    Penny and Matt Fowler like this.
  4. Yes, definitely - the whole thing is politicised in my opinion. I bet they could have given everyone a years supply of vit d for less money than the country has lost due to lock downs.

    War on terror = lies
    Mass migration epidemic = lies
    C02 driven climate change = lies
    Brexit = lies
    Greta thunberg = lies
    Covid - 19 = lies

    I wonder what the next mammoth sized yarn theyre gonna spin next :eek:
  5. Penny

    Penny New Member

  6. Sue-UK

    Sue-UK Gold

    Matt Fowler likes this.

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