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Lynch syndrome

Discussion in 'Feedback/Suggestions' started by primalmofo, Jun 22, 2020.

  1. primalmofo

    primalmofo Student Doctor

    Hi everyone,

    I am posting this because I need your help and guidance. I am a long time mitochondriac, and have just discovered I have a mutated gene for Lynch syndrome MSH6 (despite a weak family history of cancer), which puts females and males at around a 20% lifetime risk of getting colon cancer, and puts females at a 50% risk of getting endometrial cancer. I am 27 years old.

    Can someone help me understand how mitochondria and epigenetics play into this?

    Is the consensus here that these genes will only be expressed if we have high heteroplasmy rates?

    The recommendations for males and females is to do a colonoscopy every two years and additionally for females to undergo total hysterectomy.

    I am so stressed and confused as to what to do for myself and my family. Will being a mitochondriac prevent this gene from expressing itself? Should I do what the doctors say and get routine colonoscopies and have the females in my family undergo hysterectomies?

    PS: there are studies (CAPP2) that show daily aspirin can reduce colorectal cancer incidence by 60% in those with Lynch syndrome

    Thanks for reading.

    @JanSz you've always done a great job enlightening me
    @Jack Kruse I wish I could have an appointment with you, but I can't find a way
    JanSz likes this.
  2. JanSz

    JanSz Gold

  3. primalmofo

    primalmofo Student Doctor

    Thanks Jansz, I will consider adding iodine to the mix.

    I am brainstorming a daily supplement to offset me and my family's risk which now looks like: methylene blue (10-20 mg) + aspirin (320 mg) + red light on the abdomen (+ iodine?)

    also considering ozone rectal insufflation if my budget allows

    Still I am not sure what to do about the hysterectomy procedure. As of now we are taking the advice of our physicians and medical professionals that it is what is recommended. I am also planning on undergoing regular colonoscopies about every two-three years
  4. Inger

    Inger Silver

    Do not fear.
    Just live the good life connected to nature, and you will do well. :)

    I would never do a colonoscopy, or hysterectomy! Please dont!!!

    If you are a mitochondriac, you will learn to trust in nature.

    Tan naked grounded to the earth in nature, it will prevent cancer. Eat seafood, and what grows locally. You know all this. I paint iodine(Lugols) on my belly and breasts too a few times/week to make sure those organs get enough iodine.
    And make sure you love life :) :)
    The psyche is also a very important factor for health. If your thoughts are toxic it will destroy your health too. If you have unresolved trauma, do the healing work.
    primalmofo likes this.
  5. JanSz

    JanSz Gold

    Not sure about aspirin.
    Not sure about your proposed dose of Methylene Blue. Instead 10 drops of MB/day. The kind suggested by @DrEttinger
    3grams=3000mg of NAC from Now Foods (Note, the 600mg kind there comes with Selenium (which is not bad).
    There also is a biggie from @DrEttinger ----->> potassium (+++other)
    As a human species, we have changed our diet drastically after inventing agriculture 10000 years ago.
    That seems long ago, but it is a very recent evolution-vise. Not long enough to accommodate.
    As a result, a long list of problems may hopefully be avoided or somewhat postponed if potassium intake is adjusted.

    Table 2
    Some Physiological Effects Of Potassium Bicarbonate
    And Bicarbonate-Generating Organic Anions That Have
    Positive Health Benefits

    Established Associations
    Stomach antacid#
    Diuretic,* natriuretic,* chloruretic*
    Increases serum potassium concentrations to evolutionary
    Corrects thiazide induced hypokalemia*39
    Antihypertensive: reduces systolic & diastolic blood
    Optimizes endothelial function*45
    Increases aortic compliance*46
    Stroke prevention, independently of bp reduction*47,48,49
    Reverses salt-induced (sodium chloride-induced) increases
    in blood pressure*42,50
    Reverses salt-induced increases in urine calcium
    Increases urinary citrate excretion#52–54
    Reduces kidney stone formation#55
    Reduces urine calcium excretion and improves negative
    calcium balance#56
    Reduces urine phosphorous excretion and improves
    negative phosphorus balance#56
    Reduces urine nitrogen excretion#57
    Inhibits osteoclastic bone resorptive activity#58
    Stimulates osteoblastic bone formative activity#58
    Decreases bone resorption markers in vivo#56
    Reduces production of the reno-toxin, ammonia (NH3)#
    Acts as vasodilator59,60
    Reduces production of the reno-vasoconstrictor,
    Increases production of vasodilators, prostaglandins &
    nitric oxide*62,63
    Reduces free radical formation (therefore antiatherogenic)*
    Increases growth hormone blood levels in older
    Neutralizes the diet-induced endogenous acid load#56
    Corrects the systemic metabolic acidosis caused by
    typical American diets#56
    Increases plasma bicarbonate & reduces blood acidity#56
    Lowers serum chloride concentrations#56
    Increases serum phosphorus concentrations*66
    Improves age-related declines in cognitive function*67
    #predominantly a bicarbonate effect
    *predominantly a potassium effect
    #combined potassium and bicarbonate effect
    Thiazide refers to both a class of sulfur-containing organic molecules

    how much and when are you suggesting (Sodium bicarbonate)?
    When using it, does that affect daily dose of sea salt?


    Last edited: Jun 23, 2020
    primalmofo likes this.
  6. primalmofo

    primalmofo Student Doctor

    Thank you @Inger for your sound and caring words. I am going on a camping trip this upcoming week where I will be grounding and getting sun, trying to eat my best. I will be meditating as well for the psyche. However given my increased risk, I think colonoscopy may be wise as it is screening, prevention and treatment in one. I may try to increase the interval from 2 years to longer though. As far as hysterectomy, it will be up to the ladies in my life if that is how they want to proceed. They are not mitochondriacs like myself, but are healthy. The issue for them is there are not sufficient screening options for gynecological cancers.
  7. primalmofo

    primalmofo Student Doctor

    Thank you @JanSz. Potassium and NAC will be added to the regimen. There is a low amount of NAC in the PQQ supplement I take on occasion, but I will get a separate supplement for it now.

    As for aspirin, I am not so sure of it either. The reason for me including it is this study: https://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(20)30366-4.pdf

    They found that colorectal cancer incidence for people with Lynch dropped 60% after four years of daily 600 mg aspirin, and the effect lasted beyond 10 years after stopping.

    This study evaluates methylene blue + aspirin + red light for breast cancer (posted by Jack) : https://pubmed.ncbi.nlm.nih.gov/28499173/

    And Gerald pollack claims aspirin increased the EZ zone by 3x

    Given this info, why wouldn't I include it in my regimen?
  8. primalmofo

    primalmofo Student Doctor

    Hey @JanSz, what is the reasoning behind your 3g NAC suggestion? I did purchase and took it yesterday but have found conflicting reports. Some say it inhibits cancer while some say it promotes cancer. Not sure if I should be taking it since I have a genetic mutation to begin with.
  9. JanSz

    JanSz Gold

    Look up an explanation on @DrEttinger web page. Right on the top of it.

  10. DrEttinger

    DrEttinger Choice, the only thing we control

    FYI: I have been taking (2) Now Foods 600mg NAC (also contains selenium and molybdenum) for almost 27 years. I will take it until the day I die. I do not believe it will contribute to cancer nor its progression. I believe it will do just the opposite.
    Marko Pollo likes this.
  11. I got an NADplus iv yesterday. $500 for 500mg. Anyone else try this? Does anyone know of a source of pure nad powder? Is the sublingual form effective? Different in any way from iv form? Thanks
  12. Inger

    Inger Silver

    The effect of aspirin on colon cancer might be from it lowering the iron.

    You do wise in monitoring your iron panel regularly. Limit red meat if you have enough iron. Do seafood mainly. Or.. include red meat and organs and do blood donations several times/year to prevent iron overload... which increases cancer risk.

    If you are not doing all the things that will promote health, like heavy seafood diet, avoiding nnEMF, living on the countryside, being naked in the sun as much as possible - especially in the morning, good sleep hygiene, avoiding artificial light after dark etc. - to do a colonoscopy is insanity to me.

    This site is not about invasive, destructive procedures.
    It is about nature, and how it heals in its own gentle and pretty magic way, when we stop separating ourselves from it.
  13. Ignore my post. Must have seen what I wanted to see, not what was written.
  14. primalmofo

    primalmofo Student Doctor

    Thanks for your take
  15. primalmofo

    primalmofo Student Doctor

    good thoughts on iron, thank you. I still embrace conventional medicine, in this case optimal mitochondrial function may not inhibit genetic susceptibility

    what do you think about dark chocolate considering it has a high amount of iron? I eat a ton
    Last edited: Jul 23, 2020

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