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Low Cortisol Levels

Discussion in 'Optimal Labs' started by Eddie Garza, Apr 29, 2015.

  1. JanSz

    JanSz Silver

  2. JanSz

    JanSz Silver

    The potential of light therapy in Parkinson’s disease
    Article (PDF Available) · February 2014 with 1,401 Reads

    Proposed Mechanisms of Photobiomodulation or Low Level Light Therapy

    Jack Kruse shared a link.
    April 6 at 12:12pm

    What power density and wavelengths should you be looking at when examining LLLT? Low level light therapy refers to the use of light in the redor near-infrared (NIR) region, with wavelengths usually in therange of 600 to 700 nm and 780 to 1100 nm, and the laser orLEDs typically having an irradiance or power density between 5mWcm−2to 5 W cm^−2. This type of irradiation can be a continuous wave or a pulsed light consisting of a relatively low-density beam (0.04 to 50 J cm^−2), but the output power can vary widely from 1 mW up to 500 mW in order not to allow thermal effects. The wavelength range between 700 and 780 nm has been found to be rather ineffective as it coincides with a trough in the absorption spectrum of cytochrome c oxidase. Moreover, red/NIR light is chosen because its penetration through tissue is maximal in this wavelength range, due to lower scattering and absorption by tissue chromophores and water's optimal optical window. For many years it was thought that the monochromatic nature and coherence of laser light provided some sort of added benefit over non-coherent LED light. This is no longer thought to be accurate. This is why the Quantlet now uses LED technology. Continuous or pulsed light sources have both been used. Recent studies have found that pulsed sources increase light assimilation with hemoglobin.

    Proposed Mechanisms of Photobiomodulation or Low Level Light Therapy
    Photobiomodulation also known as low-level laser (or light) therapy (LLLT), has been known for almost 50 years but still has not gained widespread acceptance,…
  3. JanSz

    JanSz Silver

    AMP activated protein kinase
    The Cellular Enzyme That Promotes Longevity And Reduces Fat Storage


    In youth, AMPK is more activated and helps protect against obesity and diabetes.
    As we grow older, cellular AMPK activation decreases, weight gain often follows, and we are more likely to succumb to the destructive factors of aging.
    AMPK is found inside every cell and serves as your body’s “master regulating switch.”
    It determines body fat composition and how long you’ll live.
  4. JanSz

    JanSz Silver

  5. JanSz

    JanSz Silver

  6. JanSz

    JanSz Silver

    @Joe Gavin posted this on a facebook

    Jack writes: "I check Leptin sensitivity by asking a few questions, or by ordering a reverse T3 level."

    currently I have FT3/RT3=15.6
    A healthy FT3/RT3 ratio is 20 or greater. Says Jack and people at

    Jack is using RT3 in evaluation, but how?
    How RT3 is used?
    How to improve on it and or on the ratio.

    I am aiming at body temperature 98.6F=37C under tongue at about noon time.
    That was my temperature at youth (16yo)
    Now (77yo) all I am getting is 97.7F=36.44C to 98F=36.7C

    Last checked (on three grains of NTH)


    Total T4=1.13(0.82-1.77)ng/dL
    Total T3 =112 (71-180)ng/dL

    So I assumed slightly high RT3, means that there is too much T4 and replaced one grain NTH with (equivalent) 25mcg of T3.
    It worked but only for one day. Then came back to my new "normal".

    What gives?

    To understand your result, go back to here to learn why it’s happening and what to do about it.

    I do not think I match this reasons:
    Last edited: Apr 21, 2017
  7. I'm placing my bets on #4. It's a much bigger problem for people than we presume. And it has everything to do with population density and the changes that is having, electromagnetically, on our PAMP and DAMP sensing. I just wrote about this here.
  8. JanSz

    JanSz Silver

    Can you pick something that I could test?
    Or better, to try.
    I am assuming no lyme, no mold.


  9. JanSz

    JanSz Silver


    Using the DUTCH Test for Vaginal Atrophy
    April 3, 2017 by Mark Newman
    by Elise Schroeder, ND

    Vaginal atrophy is one of the top complaints among menopausal women and women experiencing estrogen deprivation therapy post breast cancer. Symptoms commonly include: dryness, general pain, pain with intercourse, vaginal burning, and discharge.

    This condition is often paired with results that show lower estrogen and/or testosterone levels. DHEA and DHEA-metabolite levels may be within range and depend a lot on adrenal health, stress and inflammation.

    Non-Hormonal Treatment Options

    Sea buckthorne oil, vitamin E and coconut oil might offer some benefit to women suffering from vaginal dryness especially if they are unable to use hormonal options.

    This 2014 study looked at women with vaginal dryness, itching or burning. The participants were given 3 grams of sea buckthorn oil daily. Compared to placebo, participants had improvements in vaginal health including vaginal pH, moisture and symptomatic relief1.

    Women also report symptomatic relief by applying pure vitamin E oil or coconut oil, topically to soothe the dry tissues.

    If the oils are not helping, locally, low-dose hormones can be incredibly helpful for symptom relief and don’t have a systemic affect.

    Estrogen supports the structure and function of the urogenital area by maintaining collagen and elastic fibers. It also promotes secretions, cellular turnover, blood flow and glycogen, which affect vaginal PH. More alkaline PH increases susceptibility to infections and urinary problems.

    Per this 2004 study, systemic estrogen (estradiol) replacement therapy can be used as a treatment for vaginal atrophy, but 40% of women still experience persistent vaginal dryness2. It is also contraindicated if there has been a history of hormone-mediated cancers and should be paired with progesterone to protect the uterus.

    Local, or vaginal estriol (E3) treatment, improves vaginal symptoms broadly. It is generally considered safer to use in patients on estrogen deprivation therapies and does not require the use of progesterone to protect the uterine lining. It has been shown to re-vascularize the vaginal epithelium and lower urinary tract which improves lubrication, elasticity and pH and reduces vaginal dryness, irritation, itching and urinary urgency. Local estradiol (E2), like a vaginal ring or vaginal cream can also be used, but they can have systemic effects.

    Testosterone also influences vaginal and urogenital tissue in general. Androgen receptors can be found in vaginal epithelium and are in greater concentration in a premenopausal woman then decline with age. Local, low-dose testosterone use improves vaginal atrophy, reduces PH, and improves symptoms including dryness and dyspareunia without increasing estradiol levels (which is especially important in breast cancer patients) plus it also helps with urinary incontinence and libido3.

    DHEA is a pre-curser hormone for estrone (E1) and testosterone. It has been shown that with local low dose treatment, DHEA increases vaginal secretions, tissue color, reduces pain and increases libido. It also has been shown to stimulate the muscle layer of the vaginal wall, which estradiol has not been shown to do. Another draw to DHEA is that is does not appear to have a systemic effect, making it safe to use in women who have contraindications for estrogen or testosterone replacement4.

    A little goes a long way with local hormone use. Each of the hormones discussed are often used at very low doses to relieve vaginal urogenital symptoms — much lower than one might use to get systemic symptom relief. If the goal is to address hot flashes, night sweats, foggy thinking etc., then vaginal administration of these hormones in a larger dose is a viable option. Remember to use progesterone to protect the uterus if using estradiol in doses big enough to relieve systemic symptoms.

    One might be concerned about contamination with vaginal use.

    Unlike other urine-test companies, Precision Analytical has a special procedure to ensure any contamination is removed in order to ensure accurate results. DUTCH testing looks at free hormone, which is not usually found in urine. Naturally, human urine includes conjugated hormones (testosterone, estriol or estradiol), not free hormone. Levels of conjugated hormones correlate very well with systemic values of the hormone. Any free hormone found in the urine is a “contaminant” or exogenous. All samples tested are considered “contaminated”, and free hormone is always filtered out of results. You can rest assured when testing your patients who are using vaginal hormones that results are reliable and accurate.

    A note from our founding scientist Mark Newman…

    There is a caveat to this. We have found, rather surprisingly, that estriol can have spuriously high results even with the contamination removed. With reasonable doses of estriol, very high urine levels can be found. In these cases, we have not only removed any potentially contaminating free hormone (from the actual supplement leaching into the sample), but we have also tested for the existence of free hormone to make sure all contamination was removed. Even with this, we see some patients with very high estriol results. We have theorized that there may be some local conjugation of estriol (turning estriol into the form found in urine, estriol-glucuronide). In other situations, all estriol-glucuronide in the urine is a reflection of systemic estriol being conjugated for excretion. When estradiol and testosterone are used vaginally, the testing is very helpful. We find the testing of limited use for specifically monitoring vaginal estriol. High levels of urine estriol following vaginal estriol therapy does NOT necessarily mean too much estriol has been given.

    Watch this video for more information on monitoring levels with vaginal hormones.

    [1] Larmo, Yang, Hyssala, Heiko, Erkkola. Effects of sea buckthorn oil intake on vaginal atrophy in postmenopausal women: A randomized, double-blind, placebo-controlled study Maturitas Volume 79, Issue 3, November 2014 pages 316-321 2 Johnston SL, Farrell SA, Bouchard C et al. The detection and management of vaginal atrophy. J. Obstet. Gynaecol. Can. 26, 503–515 (2004). 3 Witherby S, Johnson J, Demers L et al. Topical testosterone for breast cancer patients with vaginal atrophy related to aromatase inhibitors: a phase I/II study. Oncologist 16, 424–431 (2011). 4 Labrie F, Cusan L, Gomez JL et al. Effect of intravaginal DHEA on serum DHEA and eleven of its metabolites in postmenopausal women. J. Steroid. Biochem. Mol. Biol. 111, 178–194 (2008).


    Last edited: Apr 21, 2017
  10. JanSz

    JanSz Silver

  11. JanSz

    JanSz Silver

  12. JanSz

    JanSz Silver

    When one would count our cells, we are mostly gut bacteria.
    When we are sick we go to doctor. Doctor gets paid when we are sick.
    Think of doctor's incentives.
    When farmer take care of his animals, sick animal gets slaughtered first and discarded.
    Vet gets paid to keep most animals healthy, growing fast, (excreting lots of good gut bacteria)
    Vet that can't arrange for that gets fired.
    I am not really talking about vets that care for pet animals.
    Animal food cost $$.
    Farmer wants healthy animal that cost less to feed.
    Major part of Solution:
    Fatty acids content of feed.

    @SatoriHeart please rethink your position about fatty acids (that would include Patricia and Ed Kane's work)
    Do that specially while eating Monolaurin.
    And not only get:
    Fatty Acid Profile, Comprehensive (C8-C26), Serum
    employ your neurons in finding better ways of keeping fatty acids in their sweet ranges.

    30 Near-Infra-Red (NIR) experts
    nutrient developments, Pig Net Energy a proven Net Energy (NE) analysis system
    management of carbohydrates by individual fraction to support gut health, and measurement of swine digestible phosphorus
    Cinergy™ FIT, a unique blend of stabilized essential oils compounds specifically selected for their beneficial effect in swine diets.

    November 12, 2013 – Cargill Animal Nutrition
    Benefit categories and specific products included in the PROMOTE™ line of additives include:
    • Essential-oil and organic acid-based products for monogastrics designed to promote growth and gut health – Biacid™, Provimax™, Cinergy™, Prohacid™.
    • The new exclusive poultry performance-enhancing additive, Aloapur®, in collaboration with Purac Corbion.

    Our Grolux™ product family offers a range of different technical properties, enabling functional product design. Our products are energy-dense sources with a beneficial influence on microbial gut population:
    Caprylic acid (C8:0) and Capric acid (C10:0) have been shown to inhibit the growth of a wide spectrum of gram- bacteria,
    whereas Lauric acid (C12:0) impacts a large range of gram+ bacteria. All our products are feed safe (GMP+, Secure Feed/ FSDS).


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    Last edited: Apr 29, 2017 at 8:43 AM
  13. I've recently switched from using MCT oil to pure, unfiltered coconut oil. Positive results thus far. As for Patricia and Ed Kane's work, it's one hair away from pseudoscience and geared toward wrangling people like you to buy fancy products that ultimately have no clinical effect. Rely on third party, peer-reviewed, double-blind studies instead of self-funded enterprises engineered for maximal profit.

    Kane et. al. did not control for full spectrum sunlight. THAT makes all the difference.
    drezy likes this.
  14. JanSz

    JanSz Silver

    Full spectrum light is important.
    Until we destroy our civilization, we will be spending lots of time indoors.
    We have to provide solutions that fits current civilization.

    looks like IR-a may need more attention.

    Atm I do nor really care about dissecting Patricia and Ed Kane's work.
    My mission is much simpler.
    I want all (C8-C26) in their sweet ranges.
    give me that
    and many problems will disappear.


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