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Low Cortisol Levels

Discussion in 'Optimal Labs' started by Eddie Garza, Apr 29, 2015.

  1. JanSz

    JanSz Gold

    https://www.jackkruse.com/physician-guest-blog-2-the-invisible-sun-and-purple-light/
    ======================================================
    “You don’t need to speak Chinese to like Chinese food.” – it isn’t necessary to understand every detail of:

    electron spin,
    the retinohypothalamic tract and
    RPE,
    melanopsin,
    methylation,
    biological semi-conduction,
    quantum tunneling,
    SIRT1,
    NAD+/NADPH ratios,
    triplet oxygen and the
    EZ water, etc.
    to be able to apply this information.
    --------------------------------------------------------------
    Electron spin
    Electron magnetic moment
    In atomic physics, the electron magnetic moment, or more specifically the electron magnetic dipole moment, is the magnetic moment of an electron caused by its intrinsic properties of spin and electric charge.

    --------------------------------------------------------------
    Retinohypothalamic tract
    The retinohypothalamic tract (RHT) is a photic neural input pathway involved in the circadian rhythms of mammals.[1] The origin of the retinohypothalamic tract is the intrinsically photosensitive retinal ganglion cells (ipRGC), which contain the photopigment melanopsin. The axons of the ipRGCs belonging to the retinohypothalamic tract project directly, monosynaptically, to the suprachiasmatic nuclei (SCN) via the optic nerve and the optic chiasm.[2][3] The suprachiasmatic nuclei receive and interpret information on environmental light, dark and day length, important in the entrainment of the "body clock". They can coordinate peripheral "clocks" and direct the pineal gland to secrete the hormone melatonin.
    [​IMG]
    The retinohypothalamic tract transmits information on light levels from the eyes to the hypothalamus

    ----------------------------------------------------------------
    RPE,
    Retinal pigment epithelium

    The pigmented layer of retina or retinal pigment epithelium (RPE) is the pigmented cell layer just outside the neurosensory retina that nourishes retinal visual cells, and is firmly attached to the underlying choroid and overlying retinal visual cells.

    Function
    The RPE has several functions,[5] namely,
    light absorption,
    epithelial transport,
    spatial ion buffering,
    visual cycle,
    phagocytosis,
    secretion and
    immune modulation.

    ----------------------------------------------------------------
    melanopsin,
    Melanopsin is a type of photopigment belonging to a larger family of light-sensitive retinal proteins called opsins and encoded by the gene Opn4.[1] Two other opsins in the mammalian retina are both involved in the formation of visual images: rhodopsin and photopsin in the rod and cone photoreceptor cells, respectively.

    Melanopsin is found in intrinsically photosensitive retinal ganglion cells (iPRGCs) in mammalian vertebrates. In non-mammalian vertebrates, however, melanopsin is found in the retina as well as in other tissues, including but not limited to the brain, the pineal gland, and the skin. iPRGCs are photoreceptor cells which are particularly sensitive to the absorption of short-wavelength visible light and communicate information directly to the area of the brain called the suprachiasmatic nucleus (SCN), otherwise known as the central "body clock" in mammals.[2] Consequently, melanopsin plays an important non-image-forming role in the setting of circadian rhythms as well as other functions. Mutations in the Opn4 gene can lead to clinical disorders, such as Seasonal Affective Disorder (SAD).[3]

    Function
    Melanopsin-containing ganglion cells, like rods and cones, exhibit both light and dark adaptation; they adjust their sensitivity according to the recent history of light exposure.[14] However, while rods and cones are responsible for the analysis of images, patterns, motion, and color, melanopsin-containing ipRGCs contribute to various reflexive responses of the brain and body to the presence of light.[7]

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    Methylation,
    In the chemical sciences, methylation denotes the addition of a methyl group to a substrate or the substitution of an atom or group by a methyl group. Methylation is a form of alkylation with a methyl group, rather than a larger carbon chain, replacing a hydrogen atom. These terms are commonly used in chemistry, biochemistry, soil science, and the biological sciences.

    In biological systems, methylation is catalyzed by enzymes; such methylation can be involved in modification of heavy metals, regulation of gene expression, regulation of protein function, and RNA processing. Methylation of heavy metals can also occur outside of biological systems. Chemical methylation of tissue samples is also one method for reducing certain histological staining artifacts. The counterpart of methylation is demethylation.

    ----------------------------------------------------------------
    biological semi-conduction,
    https://en.wikipedia.org/w/index.php?search=biological semi-conduction&title=Special:Search&fulltext=1
    The page "Biological semi-conduction" does not exist. You can ask for it to be created, but consider checking the search results below to see whether the topic is already covered.

    ----------------------------------------------------------------
    Quantum tunnelling
    Quantum tunnelling or tunneling (see spelling differences) refers to the quantum mechanical phenomenon where a particle tunnels through a barrier that it classically could not surmount. This plays an essential role in several physical phenomena, such as the nuclear fusion that occurs in main sequence stars like the Sun.[1] It has important applications to modern devices such as the tunnel diode,[2] quantum computing, and the scanning tunnelling microscope. The effect was predicted in the early 20th century and its acceptance as a general physical phenomenon came mid-century.[3]

    Tunnelling is often explained using the Heisenberg uncertainty principle and the wave–particle duality of matter. Pure quantum mechanical concepts are central to the phenomenon, so quantum tunnelling is one of the novel implications of quantum mechanics.
    [​IMG]

    ----------------------------------------------------------------
    Sirtuin 1
    Sirtuin 1, also known as NAD-dependent deacetylase sirtuin-1, is a protein that in humans is encoded by the SIRT1 gene.[1][2][3]

    SIRT1 stands for sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae), referring to the fact that its sirtuin homolog (biological equivalent across species) in yeast (S. cerevisiae) is Sir2. SIRT1 is an enzyme that deacetylates proteins that contribute to cellular regulation (reaction to stressors, longevity).[4]

    Function
    Sirtuin 1 is downregulated in cells that have high insulin resistance and inducing its expression increases insulin sensitivity, suggesting the molecule is associated with improving insulin sensitivity.[5] Furthermore, SIRT1 was shown to de-acetylate and affect the activity of both members of the PGC1-alpha/ERR-alpha complex, which are essential metabolic regulatory transcription factors.[6][7][8][9][10][11]

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    NAD+/NADPH ratios,

    Nicotinamide adenine dinucleotide (NAD)
    Nicotinamide adenine dinucleotide (NAD) is a coenzyme found in all living cells. The compound is a dinucleotide, because it consists of two nucleotides joined through their phosphate groups. One nucleotide contains an adenine base and the other nicotinamide. Nicotinamide adenine dinucleotide exists in two forms, an oxidized and reduced form abbreviated as NAD+ and NADH respectively.

    In metabolism, nicotinamide adenine dinucleotide is involved in redox reactions, carrying electrons from one reaction to another. The coenzyme is, therefore, found in two forms in cells: NAD+ is an oxidizing agent – it accepts electrons from other molecules and becomes reduced. This reaction forms NADH, which can then be used as a reducing agent to donate electrons. These electron transfer reactions are the main function of NAD. However, it is also used in other cellular processes, the most notable one being a substrate of enzymes that add or remove chemical groups from proteins, in posttranslational modifications. Because of the importance of these functions, the enzymes involved in NAD metabolism are targets for drug discovery.

    Concentration and state in cells
    The balance between the oxidized and reduced forms of nicotinamide adenine dinucleotide is called the NAD+/NADH ratio. This ratio is an important component of what is called the redox state of a cell, a measurement that reflects both the metabolic activities and the health of cells.[16] The effects of the NAD+/NADH ratio are complex, controlling the activity of several key enzymes, including glyceraldehyde 3-phosphate dehydrogenase and pyruvate dehydrogenase. In healthy mammalian tissues, estimates of the ratio between free NAD+ and NADH in the cytoplasm typically lie around 700; the ratio is thus favourable for oxidative reactions.[17][18] The ratio of total NAD+/NADH is much lower, with estimates ranging from 3–10 in mammals.[19] In contrast, the NADP+/NADPH ratio is normally about 0.005, so NADPH is the dominant form of this coenzyme.[20] These different ratios are key to the different metabolic roles of NADH and NADPH.

    -----------------------------------------------------------------
    triplet oxygen and the

    This article has multiple issues.
    Triplet oxygen, systematically but less commonly, 1,2-dioxidanediyl, is a term that refers to normal, gaseous oxygen (O2, dioxygen) in its ground state. It is therefore classified as an inorganic chemical, and more specifically as a particular electronic state of one allotrope of the inorganic chemical element, oxygen. In this particular state, according to one type of modern bonding theory, the electron configuration of the oxygen molecule has two electrons occupying two molecular orbitals (MOs) of equal energy (that is, degenerate MOs), therefore remaining unpaired. These orbitals are classified as antibonding and are of higher energy, so the resulting bonding structure between the oxygen atoms is weakened (i.e., is higher in energy)—for instance, it is higher in energy than the bonding in dinitrogen, where bonding MOs are filled instead. The spectroscopic molecular term symbol for triplet (ground state) oxygen is 3Σg−.[2][3]
    ------------------------------------------------------------------

    Spin
    The s=1/2 spins of the two electrons in degenerate orbitals gives rise to 2x2=4 independent spin states in total. Exchange interaction splits these into a singlet state (total spin S=0) and a set of 3 degenerate triplet states (S=1). In agreement with Hund's rules, the triplet states are energetically more favorable, and the ground state of the molecule carries an electron spin of S=1. Excitation to the S=0 state results in much more reactive, metastable singlet oxygen.

    Because the molecule in its ground state has a non-zero spin magnetic moment, oxygen is paramagnetic; i.e., it can be attracted to the poles of a magnet. The Lewis structure O=O does not accurately represent the diradical nature of molecular oxygen; molecular orbital theory must be used to adequately account for the unpaired electrons. Triplet oxygen is better described by a bond order of one and two halves instead of two to better reflect its unpaired bonding electrons. This allows for easier reasoning of the bond length.

    [​IMG]


    -----------------------------------------------------------------
    EZ water, etc.
    The page "EZ water" does not exist. You can ask for it to be created,
    https://en.wikipedia.org/w/index.php?search=EZ water&title=Special:Search&fulltext=1


    The Fourth Phase of Water - What You Don’t Know About Water, and Really Should
    http://articles.mercola.com/sites/articles/archive/2013/08/18/exclusion-zone-water.aspx#!

    The Fourth Phase of Water: Beyond Solid, Liquid, and Vapor,

    inherent differences between regular water and EZ water include its structure. Typical tap water is H2O but this fourth phase is not H2O; it’s actually H3O2. It’s also more viscous, more ordered, and more alkaline than regular water, and its optical properties are different. The refractive index of EZ water is about 10 percent higher than ordinary water. Its density is also about 10 percent higher, and it has a negative charge (negative electrical potential). This may provide the answer as to why human cells are negatively charged.

    What Creates or Builds EZ Water?

    One of the greatest surprises is that the key ingredient to create EZ water is light, i.e. electromagnetic energy, whether in the form of visible light, ultraviolet (UV) wavelengths and infrared wavelengths, which we’re surrounded by all the time. Infrared is the most powerful, particularly at wavelengths of approximately three micrometers, which is all around you. The EZ water can build on any hydrophilic or water-loving surface when infrared energy is available.

    It builds by adding layer upon layer of EZ water, and can build millions of molecular layers. This is how it occurs in nature. For example, ice doesn’t form directly from ordinary H2O. It goes from regular water to EZ water to ice. And when you melt it, it goes from ice to EZ water to regular water. So EZ water is an intermediate state.

    “Glacial melt is a perfect way to get EZ water. And a lot of people have known that this water is really good for your health,” Dr. Pollack says.

    Testing water samples using a UV-visible spectrometer, which measures light absorption at different wavelengths, Dr. Pollack has discovered that in the UV region of 270 nanometers, just shy of the visible range, the EZ actually absorbs light. The more of the 270 nanometer light the water absorbs, the more EZ water the sample contains. EZ water appears to be quite stable. This means it can hold the structure, even if you leave it sitting around for some time. Water samples from the river Ganges and from the Lourdes in France have been measured, showing spikes in the 270 nanometer region, suggesting these “holy waters” contain high amounts of EZ water. According to Dr. Pollack, there’s compelling evidence that EZ water is indeed lifesaving...




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    Last edited: Oct 14, 2015
    lohd2015, freesia, seanb4 and 2 others like this.
  2. PaulG

    PaulG New Member

    Nice one @JanSz ... is this part of some kind of glossary project you are working on?
     
  3. JanSz

    JanSz Gold

    Not really. I just thought that it may be a handy reference point.

    ..
     
    SeaHorse likes this.
  4. Jack Kruse

    Jack Kruse Administrator

    Be open and discerning using your intuition and realize that your intuition grows as you strengthen your mind. The mind is a function of the electrons in your senses. The way to strengthen your mind is giving it things it is made up of DHA and seafood. You have gotten that message a long time. Maybe this is the day that message hits home deeper. Every time you look at your phone or this keyboard with its blue light it destroys your DHA in your brain. This limits your ability to receive messages from anyone during a talk, a meeting, sex, or any connection................disconnect to reconnect via your senses."

    Senses are the fastest way into the mitochondria to affect it via size and shape changes..........and mitochondria is where your life's reality begins. Senses alter the Angstroms between cytochromes and this changes vibrations, oscillations and the speed of electron tunneling. It also alters the ability to make ROS in a singlet or triplet state...........fundamentally.


    Electrons and light enter cytochromes...........from foods and from things we collect from the environment. UV light is purple. It is furthest from the red part of the spectrum. The directional flow is determined by water pathways on which light travels. How light goes determines the life you get.........If light flows badly, it leads to metabolic dys-regulation and an AMPK deficit which is tied to leakage of infrared light in the cytoplasm to the environment causing outward migration of mitochondria from nucleus to cell membrane cause cell to increase in size and this change in size triggers insulin resistance and nrf2 and nf kappa beta activation. This cause physical and chemical mito nuclear coapatation affect leading to redox shifted mitochondria that make singlet free radicals and tissues are destroyed and replaced by fibroblasts leading scarring and organ failure.

    Your nucleus and its proteins store UV light while you go further out to the cell membrane there is more red light. Purple and red light therefore are topologically organized in a cell making the cell a playground for photons. This causes them to be retained too. How? That light set up an electric and magnetic field that dictates where the mitochondria are in relation to the nucleus. Think ubi 5 blog. The distance is a redox function

    The charge of the nucleus and mitochondria act like the sun and planets in the solar system. Cathodes and anodes.

    Their distance remain fixed unless charge changes. Charge main variable in physics is its atomic mass. This is why size and shape alter thermodynamics so rapidly in a cell or any system. The electric and magnetic field act instant roundly at speed of light

    Atomic mass is linked to gravitational pull in any system, whether it be in the solar system or inside a cell.

    The more atomic mass the nucleus contains the more purple light bends via gravitational lensing to come toward nucleus where DNA/RNA histones and chromatin all work to store UV light. Remember that DNA/RNA is kept very folded and compact by histones and chromatin........maybe now you know why. This is how the nucleus takes advantage of gravitational lensing.

    All nucleic acids fluoresce at 340-350nm. That means their incident light has to be below this emission spectra. That is hard core UVB below 340nm........probably 260nm-300nm.

    I think we can store 260 nm and above because base pairs have unique abilities in a stacked helix. They become an exciton like a Birkland current. This delays photon emission and stores light naturally just like a star does. Macrocosm meets microcosm...........in physics and biologic organization

    The more UV light you store the more compact your DNA and RNA become limiting epigenetic activity. The more you retain UV light the more epigenetic control over genes to limit ubiquitin rates. This all leads to stable redox conditions in a cell across all dimensions..........because light, specifically the UV part of light has more DC electric current in it because it has the smallest most powerful wavelength.

    All DNA/RNA is hydrated and it is well established that the water battery in our cells (EZ) absorbs best at 1500-3000 nm and 270nm. Photons and electrons increase the EZ allowing more UV assimilation.................Everything fits nicely together.
     
    Last edited: May 12, 2016
    freesia, seanb4, Joe Gavin and 3 others like this.
  5. Jack Kruse

    Jack Kruse Administrator

    ^^^^ that is the practical application of what JanSz posted.
     
    Joe Gavin, Brother John and endless like this.
  6. cinnamon

    cinnamon Gold

    @Jack Kruse , could we absorb light in the UVA range and then use some kind of "anti-Stokes Shift" to turn that into the 270 nm frequency that water battery needs?

    I've been thinking about the Stokes Shift and how it is kind of like a step-down transformer ever since you mentioned it in the Psoriasis webinar. I believe you said there that it was also possible for the absorption frequency to be lower than the fluorescence frequency? Do I have that right?
     
    Lahelada likes this.
  7. Jack Kruse

    Jack Kruse Administrator

    Its possible...........
     
  8. Joseph Thia

    Joseph Thia Aspiring Mitochondriac

    Many apologies for the repost! I would like to seek advice regarding UVA lights as I am only able to find blacklight blue tubes in Singapore. The one that I have is an 8W from sankyo-denki and I am using it at my office desk. I am wondering what wattage should I get (i.e. is 8W enough?) and if there is any safety distance that I should keep it away from me (would it have x-ray emissions? it is about 35 inches away from me). Many thanks!

    Information extracted from http://www.sankyo-denki.co.jp/e2_06.html

    [​IMG][​IMG]
    These lamps effciently emit near ultraviolet rays at 315nm- 400nm which have strong photochemical and fluorescent effects.
    They are special deep blue filter glass which absorbs visible rays and transmits near ultraviolet rays and two types of phosphor are used with radiation peak at 352nm and 368nm, respectively.
    They are used for tests, inspections, examinations, and investigations in various fields, as well as for stage illumination in theaters and nightclubs, advertisements and sign boards.
     
  9. Jack Kruse

    Jack Kruse Administrator

    I'd put it in the corner of the room at ceiling level if you use it
     
  10. Joseph Thia

    Joseph Thia Aspiring Mitochondriac

    Many thanks for your advice, Jack! Will continue my search for suitable lights (in addition to the Exo Terra Reptile lights).
     
  11. JanSz

    JanSz Gold

    on this thread, page 18 there are this two lines giving information on natural UVB density reaching earth.
    I assume that one does not want to go over 250 uW/cm2
    ------
    On strong sunny day in middle of USA one may get 150 μW/cm^2 UVB

    50-250 uW/cm2 mimics the natural environment

    ---------------------------------------------------------
    For simplicity, it is easier to think of lamp similar to Solar Glo 160W (or similar build)
    Assume that your proposed lamp is a point,
    sitting within round reflector of 45 degree angle
    shining at the wall,
    all power lits area that have diameter of 2 meters and area π*2^2/4=3.14 m^2

    To get at the wall average power density 1 μW/cm^2 UVB, point must emit
    1μW/cm^2 * 3.14 m^2=3.14 W

    1 μW =1 microwatt = 0.001 milliwatt
    1 μW = 0.001 mW
    1μW=0.000001 W

    (0.000001 W/cm^2) * 3.14 * (1000000 cm^2)=3.14 W

    To get 50 μW/cm^2 UVB at 1 meter distance from lamp, lamp must emit 3.14*50=~150 watts UVB
    To get 150 μW/cm^2 UVB at 1 meter distance from lamp, lamp must emit 3.14*150=~450 watts UVB
    To get 250 μW/cm^2 UVB at 1 meter distance from lamp, lamp must emit 3.14*250=~750 watts UVB


    Your biggest lamp that you propose uses 40W and emits 8.1W of light 320-400nm
    so it is UVA light only

    =====================================================

    Ultraviolet C or (UVC) range, which spans a range of 100 to 280 nm.
    Ultraviolet B or (UVB) range spans 280 to 315 nm
    Ultraviolet A or (UVA) spans 315 to 400 nm
    Visible range of light spans 380 to 780 nm
    =====================

    Note that one reptile lamps I posted on this thread, Reptile UVB200 emits 225
     
    Last edited: Oct 15, 2015
  12. Jack Kruse

    Jack Kruse Administrator

    I got 44 K of D3 yesterday with 4.35 hours of sun exposure.......
     
    Paul T. likes this.
  13. Jack Kruse

    Jack Kruse Administrator

    100% nude.
     
  14. Jack Kruse

    Jack Kruse Administrator

    subtropics rock
     
    Brother John likes this.
  15. JanSz

    JanSz Gold

    44000/4.35=~10115iu/hr=~168.5iu/min

    Going by chart on Solar Glo 160W
    Distance 8", 460μW/cm^2 UVB, 180 iu/min vit D
    Distance 12", 265μW/cm^2 UVB, 75 iu/min vit D
    that would correspond to
    439μW/cm^2 UVB=(168.5-75)*(460-265)/(180-75)+265

    --------------------------------
    Compare that to
    ------
    On strong sunny day in middle of USA one may get 150 μW/cm^2 UVB

    50-250 uW/cm2 mimics the natural environment

    ---------------------------------------------------------

    Comments??

    ..
     
  16. Jack Kruse

    Jack Kruse Administrator

    use www.dminder.info and your info in. It yokes to the environmental conditions that day to give you the accurate assessment of what you get from the sun
     
    Curves likes this.
  17. Jack Kruse

    Jack Kruse Administrator

    You need to add in skin type and % body exposed........the charts you are going off are very inaccurate.
     
  18. JanSz

    JanSz Gold

    Definitely.
     
  19. nicld

    nicld Gold

    Nice app. Love the "start sun session".
     
  20. I'm excited to try that app and see how much I get. Some days the sun is still pretty intense in So Cal even though fall is here.
     

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