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Low Cortisol Levels

Discussion in 'Optimal Labs' started by Eddie Garza, Apr 29, 2015.

  1. JanSz

    JanSz Gold

    UTSW Presidential Lecture Jun 8, 2018
    Touchstone Diabetes Center
    Philipp Scherer Ph.D. Director of the Touchstone Diabetes Center at UT Southwestern Medical Center

  2. JanSz

    JanSz Gold

    If you give a kid cupcake, he eats it and shortly after he jumps and has sugar high, that is normal.
    If you give a fat (or not fat) kid a cupcake, he eats it and looks for more cookies, but he does not have a sugar high.
    If a kid eats cupcakes and does not have sugar high, he is already sick. Help him.
    Christine_L likes this.
  3. JanSz

    JanSz Gold

  4. drezy

    drezy New Member

    Christine_L likes this.
  5. JanSz

    JanSz Gold

    over here

    Staying alive
    is important
    helps breathing

    Will these help in visceral fat minimization?


    If You Can't Cut the Mustard

    Last edited: Dec 14, 2019
    Christine_L and drezy like this.
  6. How's this to accompany your dinner @drezy?

  7. drezy

    drezy New Member

    With that tempo I might eat too fast!
    Christine_L likes this.
  8. JanSz

    JanSz Gold

  9. Jack Kruse

    Jack Kruse Administrator

    Low cortisol levels alter the metabolic catabolism of tryptophan from the melanopsin induced destruction of melatonin, NAD+, and serotonin.

    What if I told you that 5G, nnEMF, and blue light all cause a relative thiamine deficiency in the matrix.......

    Do you know WHAT THAT IMPLIES?

    The conversion of tryptophan (Trp) → nicotinamide (Nam) is an important pathway for supplying vitamin niacin to make NAD+, serotonin, and melatonin. The key reasons these matters are tied to the following two phenomena: (1) severe calorie restriction led to an increase in the Trp → Nam which can augment NAD+ in aging and in disease generation to extend survival; (2) the conversion of Trp → Nam is also increased by a vitamin B1 deficiency. This begs the question...........does B1 deficiency confer a survival advantage by creating a pseudohypoxic state in mitochondria that are badly damaged? The answers in this new blog and new series might surprise some of you.

    Did you know the production of Nam from Trp is important for maintaining cellular NAD+ concentration? For example, half of the niacin supply is accounted for by Trp intake. Tryptophan is an essential aromatic amino acid. Many environmental effects of light affect various factors on the conversion percentage of Trp → Nam and most people seem oblivious to this fact. It has been well researched and reported that vitamin B1 deficiency increased the conversion percentage of Trp → Nam. Now ask yourself what this implies and what the collateral effects of this might be in a world built around alien lights? https://www.patreon.com/posts/32419906
  10. JanSz

    JanSz Gold

    Thank you @Jack Kruse
    It has been well researched and reported that vitamin B1 deficiency......
    Vit B1 has a problem with getting thru the Blood/Brain Barrier.
    That was discussed on the thread:

    That thread has since been removed.
    Please get it back.
    I think there were nice tidbits, and the discussion was timely for today's topic.

    Allithiamine is a lipid-soluble form of vitamin B₁ which was discovered in garlic in the 1950s along with its homolog prosultiamine.

    Last edited: Dec 17, 2019
  11. Jack Kruse

    Jack Kruse Administrator

    ^^^^^NOT TRUE.

    Thiamine does cross the BBB. No one knows the mechanism but it does cross.
    JanSz likes this.
  12. JanSz

    JanSz Gold

    Last edited: Dec 17, 2019
  13. DrEttinger

    DrEttinger Choice, the only thing we control

    You are correct if everything is perfect - enough B1 from dietary sources, a properly functioning GI tract, no excess alcohol consumption, low A1C, normal blood glucose, normal magnesium level, no genetic anomalies, proper enzymatic conversion to thiamine pyrophosphate (TPP)... If any of these issues cause a deficiency of B1 and supplementation is needed, Thiamin HCl and benfotiamine are not the best sources; sulbutiamine is. You hedge your bets that it will get the job done.

    Thiamine Deficiency and Delirium

    At the blood brain barrier (BBB), its transport occurs through both passive and active mechanisms depending on the concentration of thiamine in the blood. When the concentration of thiamine in the blood is high, transportation of thiamine through the BBB occurs via passive diffusion. However when the concentration of thiamine in the blood is low, thiamine crosses over via active transport.

    Benfotiamine, a synthetic S-acyl thiamine derivative, has different mechanisms of action and a different pharmacological profile than lipid-soluble thiamine disulfide derivatives

    "Free thiamine is not lipophilic and cannot cross the blood-brain barrier by simple diffusion. ... Thus, raising free blood thiamine concentrations does not necessarily lead to an important increase in thiamine transport across the blood-brain barrier."

    Evidence for neuroprotective effect of sulbutiamine against oxygen-glucose deprivation in rat hippocampal CA1 pyramidal neurons.

    sulbutiamine, a synthetic thiamine analogue that can cross the blood-brain barrier easily, on hippocampal neurons under an in vitro model of ischemia, oxygen-glucose deprivation (OGD).

    Pharmacologic and therapeutic features of sulbutiamine.

    Sulbutiamine, a highly lipophilic thiamine derivative, is the only antiasthenic compound known to cross the blood-brain barrier and to be selectively active on specific brain structures directly involved in asthenia.
    JanSz likes this.
  14. JanSz

    JanSz Gold

  15. Jack Kruse

    Jack Kruse Administrator

    CHEW on this: Today's 1G-5G factoid: Vitamin C is the primary circulatory antioxidant used in the blood plasma. It is used and depleted during oxidative stress from nnEMF and blue-lit quickly changing the zeta potential of your blood and this leads to the fingerprint of disease we screen for at Kruse Longevity Center. This is more accurate than any 5G meter I have tested. This is why doing peripheral blood smears matter. Since plasma Vitamin C is used up first in the blood plasma, it acts to sparing other endogenous antioxidants. When those antioxidants are lowered we know for sure what is going on in neurons of the brain, brainstem, and adrenal gland because they contain more endogenous stores of Vitamin C than any tissue in humans. This unique function of vitamin C as a first-line “ROS/RNS sink” has supported by many in vitro studies on plasma vitamin C, in which various kinds of ROS/RNS primarily cause a fast depletion of vitamin C in neuroectodermal derived tissues. What are some of the other endogenous antioxidants that gain this protection? Vitamin E and glutathione are oxidized only after exhaustion of vitamin C. When someone takes Vitamin E or glutathione it also depletes them because it uncouples the natural feedback mechanisms built into cells. This is why in TBI/stroke/ sepsis/cardiac injuries we do not use these antioxidants in treatment and neither should you as a supplement. These are things the supplement makers never tell you because they have no idea what a loss of feedback control means. Instead, I consider the use of IV thiamine to offset the hypoxia of matrix inefficiency.

    WHAT IT MEANS: Hormesis occurs when both positive and negative feedback loops are yoked or connected to some coupler. In cells, it can be the level of hormones or antioxidants and the power of light in the cell codified by the redox potential. The redox potential is the electrical potential between cytochrome 1-oxygen in a cell. When you take exogenous glutathione you alter the redox balance and uncouple the endogenous system. Hormesis effects are lost or extinguished. How? Hormesis is a fine edge between positive and negative feedback loop reactions that ARE ONLY linked by the circadian mechanism in man. This is why people who say chronic fasting or chronic ketosis optimize endogenous systems are DEAD wrong. The same thing is true about taking supplements of things normally made in a cell. Glutathione and Vitamin E being examples here. Hormesis is built by Nature to be a temporary state of being/behavior to help cells cope with stressors. Hormesis only works when the positive feedback loop is properly coupled to the negative feedback control tied to light and dark cycles. When the coupling mechanism is not present, hormesis becomes impossible and extinction for both sides of the feedback loop occur and the labs show flatlining of the substance in question. This is why so many people's glutathiones drop to undetectable when they take exogenous glutathione.
    In the brain and adrenal gland, Vitamin C has to be changed to the oxidized version called dehydroascorbate (DHA) to cross the blood-brain and cervical cord barrier to gain entrance to protect the tissues and maintain the levels of cortisol, norepinephrine, epinephrine, and dopamine. Recall, that cortisol is needed to CONTROL the catabolic pathways of tryptophan. This limits the neurotoxic derivatives and supports the recreation of NAD+ when melanopsin damage has occurred. All of the amines are depleted by oxidative stress especially when thiamine levels are destroyed in the matrix. Taking Vitamin E and glutathione does nothing to protect those stores. Decreased recycling of dehydroascorbate (DHA), the oxidized form of vitamin C) to vitamin C may further contribute to low plasma vitamin C levels (and destroyed thiamine stores) post-EMF or organ damage due to the altered redox state of the colony of mitochondria in that organ.
    Mary B and JanSz like this.
  16. Jack Kruse

    Jack Kruse Administrator

    This all assumes you want the oral route. Black Swans don't when their matrix is screwed. That is why the Farm exists.
    JanSz likes this.
  17. JanSz

    JanSz Gold

    What is wrong with the oral route, when using Sulbutiamine?


    Last edited: Dec 18, 2019
  18. JanSz

    JanSz Gold

    What good that kind of IV does when it cannot cross the blood-brain barrier?


    Last edited: Dec 18, 2019
  19. JanSz

    JanSz Gold

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