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Low Cortisol Levels

Discussion in 'Optimal Labs' started by Eddie Garza, Apr 29, 2015.

  1. JanSz

    JanSz Gold

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    ============
    upload_2019-10-12_14-10-17.png


    I was able to get an mp3 file from this podcast. Not able to attach mp3 to post.
    I will e-mail it if interested.
    Below are my notes.
    But to make it short, I have five lines that are main, for me, at this time.
    1. synthesis of H + O to water, is the combustion process
    2. drink only when thirsty
    3. most people he tested have ADH below 1, with some caveats, population as a whole have diabetes insipidus. To much water is consumed.
    4. there is also a description of how he calculated 7200liters/day water production
    5. Medical doctors recommend drinking water, but that is unnecessary.


    https://www.labcorp.com/test-menu/20071/antidiuretic-hormone-adh-profile
    • ADH: 0.0−4.7 pg/mL

    https://www.facebook.com/permalink.php?story_fbid=921183121587713&id=100010881004678
    upload_2019-10-14_11-53-20.png
    time 8:30
    we make water in mitochondria by synthesizing hydrogen and oxygen

    photosynthesis is breaking groundwater into hydrogen and oxygen
    plants are producing oxygen not from CO2 but groundwater (9:15)
    hydrogen is used to capture CO2
    and this is how glucose, fatty acids, and amino acids are produced in plants

    animals eating grass are turning hydrogen into fat

    humans eating meat and fat are producing energy by burning food (9:50) hydrogen and restoring water. (combustion reaction)(as in car engine or human cells)(end at 10:14)

    deuterium level in the body determines the body's level of energy production (13:10)

    (16:30) how we create water, any cell that uses oxygen produce water from hydrogen
    (18:00) to figure how much water is produced, calculate how many nanomotors, 320 thousand nanomotors in each mitochondrion, max velocity 9000 rotations/minute, taking at 3000 rotations, number of mitochondria in our bodies, it comes to 7200 liters/day.
    That corresponds to liters of blood circulated daily.
    Oxygen carried in the blood links these two processes together.
    It seems that these two processes deal with the same volumes.(ends at 20:00)

    (20:50)on drinking, eat natural fat low in deuterium (natural),
    The longest Boros was without water was 4 four days, but he did not challenge himself, not exercising but eating enough fat and breathing.
    Water consumption depends on your thirst.
    Medical doctors recommend drinking water, but that is unnecessary. (22:25)
    The body has its own ability.........
    When exercising you need to drink water, if thirsty you need to drink water, but it is better if it is DDW
    1kg fat produces 1.1kg of water(23:45)(by the end of the day see how much water ate that way)
    carbohydrates and proteins produce about half kg of water

    (24:50) Humans or humanoids started developing brains when they started eating fat, which is bone marrow, by learning to break bones left by bigger animals.

    (26:00) 110ppm rate, less than 125ppm is the desired consumption of deuterium
    the body has a deuterium removal process.
    To be healthy one should have less than 110ppm in the body(end at 27:34)

    D-Terminator (breath, saliva)

    (29:45) personal experience

    (31:30) deuterium depletion is a natural process, not medicine using chemicals

    (35:10) he eats raw meat most of the time,

    (36:00) pregnant women, her body will modify deuterium treatment, no need to modify food

    (39:50) he drinks pharmaceutical water 125ppm or 105ppm, good for general consumption

    (42:20) drink according to thirst, do not drink because it is available
    (43:20) drinking to much water may promote slip to diabetes insipidus
    most people that he measured ADH level is below 1 (43:27)
    so practically current population all have diabetes insipidus


    (43:50) let physiological processes tell you how much to drink, and best guide is thirst
    allow ADH to be less depressed
    melatonin level important


    ------------------------------
    https://www.labcorp.com/test-menu/20071/antidiuretic-hormone-adh-profile
    • ADH: 0.0−4.7 pg/mL

    • Osmolality:
    − Neonates: May be as low as 266 mOsmol/kg
    − 0 to 60 years: 275−295 mOsmol/kg
    − >60 years: 280−301 mOsmol/kg
    --------------------------------
    https://www.mayoclinic.org/diseases-conditions/diabetes-insipidus/symptoms-causes/syc-20351269
    --------------------------------
     
    Last edited: Oct 14, 2019
  2. JanSz

    JanSz Gold

    upload_2019-10-20_12-1-39.png

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    Last edited: Oct 21, 2019
  3. JanSz

    JanSz Gold

  4. JanSz

    JanSz Gold

  5. JanSz

    JanSz Gold

  6. drezy

    drezy Gold

    The number of pre-packaged processed for products at any store is astoundingly high and keeps growing.

    It makes sense economically for the seller. Think about cereal. It must cost 0.10 coproduce and sells for $5-7. It'spretty much a money printing press.
     
    JanSz likes this.
  7. JanSz

    JanSz Gold

    Sodium and Potassium Metabolism (Renin, Angiotensin, Aldosterone, and ADH)

    upload_2019-10-24_8-14-35.png
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    Last edited: Oct 24, 2019
  8. JanSz

    JanSz Gold

  9. JanSz

    JanSz Gold

  10. JanSz

    JanSz Gold

  11. JanSz

    JanSz Gold

  12. JanSz

    JanSz Gold

  13. JanSz

    JanSz Gold

    Last edited: Nov 8, 2019
  14. JanSz

    JanSz Gold

  15. JanSz

    JanSz Gold

    https://forum.jackkruse.com/index.php?threads/ingers-journal.6472/page-96#post-282101

    @DrEttinger
    My bag of salt is getting low. Soon will have to reorder.
    1/2 teaspoon/day chased with little water. Is that good?

    ------------------------
    One more about potassium.
    Other than helping with cramps, Potassium regulates and stabilizes the heartbeat.
    My resting heartbeat now is higher than I like it to be.
    It drops from say 80 to 70bpm a few minutes after taking 1/2 tsp of sodium bicarbonate
    I am taking half teaspoons of potassium bicarbonate twice daily (so I guess 1200mg/day).
    Would it be wise to increase the dose? Aiming at 50-60bpm?

    ....
    Potassium Bicarbonate (KHCO3)
    [​IMG]
     
  16. JanSz

    JanSz Gold

    https://forum.jackkruse.com/index.php?threads/ingers-journal.6472/page-96#post-282105

    https://howirecovered.com/understanding-potassium/

    Understanding potassium
    October 3, 2013 Eric methylation, supplements

    Anyone following Freddd’s methylation protocol or any other high dose methylation support should know there’s a risk of creating a potassium deficiency which is potentially lethal. It’s called hypokalemia. Muscle cramping is one of the warning signs and I’ve experienced some of those cramps. I’m currently supplementing with 2.2 g of elemental potassium a day and suspect I still need more, so I’m trying to understand the potassium issue in more depth before taking more potassium.

    It’s a complicated subject because both too little and too much potassium is dangerous. For this reason, Andy Cutler recommends you not exceed 1 g of supplemental potassium without “doctor supervision”. While I appreciate the warning and take it seriously, I’m saving this precious oxymoron ‘doctor supervision’ as the title for a new post about my pathetic experience with doctors.

    The more I learn, the more I think potassium may be one of those cornerstone supplements for me and for many others. Most of the information on this page comes from Stephanie’s posts on FDC who just happens to be studying and experimenting at the same time as I am:

    These observations are all from the book “Potassium Nutrition” ($4 kindle book on Amazon) unless otherwise noted – the author explores all the research relating to dietary potassium deficiency leading to a functional deficiency, and how it applies to many chronic disease processes (he essentially includes chronic fatigue and fibromyalgia as well). In some cases these correlations have not been examined before, in part because conventional medicine overlooks the role of potassium, and the labs that are typically used to assess potassium and electrolyte levels don’t give the entire picture.

    There really isn’t a good way to assess the overall level of our potassium status (it is possible but the tests to determine this aren’t really available – it requires special equipment which is very expensive). Even measuring RBC potassium and sodium doesn’t give the complete picture – for one thing, our bodies will lose potassium from muscle cells at a far greater rate than blood cells- and this is why muscle cramps and weakness are common symptoms.

    Potassium gluconate (one of the most available supplement forms) goes into solution easily to give potassium ions (which is the electrolyte), and the gluconate part is metabolized in the liver to create bicarbonates. Bicarbonates are also electrolytes. So this is similar to supplementing potassium bicarbonate.

    Potassium bicarbonate is alkalizing and it helps to prevent calcium loss that can be caused by a functional potassium deficiency…. which are both desirable for most people – particularly given modern diets. Potassium bicarbonate is also the form most similar to what you get from eating vegetables. However potassium bicarbonate will tend to lower blood pressure.

    My sense is that salt cravings are a way to help raise blood pressure – it’s actually the chloride in salt that tastes salty and raises blood pressure. My blood pressure was definitely getting lower after cutting back hugely on salt and supplementing with potassium bicarbonate over the course of a few days. Note that one teaspoon of potassium bicarbonate contains roughly 2000 mg of potassium.

    If you have low blood pressure, it’s preferable to supplement primarily with potassium chloride – and use potassium bicarbonate (or potassium gluconate) to help balance pH (if urine pH becomes acidic). Too much bicarb will be too alkalizing and will lower blood pressure so it needs to be balanced with the chloride – which does the opposite.

    Chloride is another important electrolyte – it gives the salty taste to salt and tends to raise blood pressure (loss of chloride usually accompanies a potassium deficiency because chloride is secreted to maintain serum pH). So naturally, potassium chloride tends to raise blood pressure, and tends to be acid forming. Potassium chloride will also help to raise the cell levels of potassium faster than potassium bicarbonate. This seems to make sense given their relative effects on electrolyte balance and blood pressure and pH.

    An ideal ratio of total daily intake (diet and supplements) of potassium to sodium is said to be something like 5:1. But, a low potassium to sodium ratio is the norm these days – especially if you compare that to the ratio that researchers believe humans evolved on… potassium sources were plentiful and the mainstay of diet, whereas sodium was very scarce. Paleo man probably had at least a 10:1 potassium to sodium ratio in his diet, and many put that estimate much higher. So even people who eat a relatively healthy diet these days aren’t necessarily immune to the effects of a lower ratio – given the availability of sodium, and the relative scarcity of high potassium foods from plant sources…, together with all the other influences that affect our acid-alkaline balance and electrolyte balance in modern life (i.e. toxicities).

    Now, even getting to a ratio of 2:1 or 3:1 is better than the average human who eats a lot of processed foods. Of course, there are many other factors besides this ratio to consider – including the source of potassium in food and whether it forms bicarbonates and is therefore alkalizing (this would be the potassium from plant sources, especially leafy greens) – or whether it makes chloride and is therefore acidifying (from protein sources of potassium), so this relates to our pH balance.

    If a person is very deficient (at the cell level), then it can take a long time for general healing to occur… maybe 6 months to a year or more. However, if you’re supplementing – say 1 gram with each meal (~3 grams/day) – then you should be able to correct the deficiency state in a matter of weeks, assuming you lower sodium appreciably and otherwise eat a decent diet and you’re getting enough magnesium, taurine etc (according to Wikipedia, “In cells, taurine keeps potassium and magnesium inside the cell, while keeping excessive sodium out” so, supplementing with taurine – up to 3 grams per day – may be helpful).

    Medications, and other things that might cause potassium loss or create acidity (like toxicity from metals and chelating) have to be taken into account as to how much potassium is right for you, and whether you need extra bicarbonate to neutralize acidity. It’s ideal to get our potassium from food of course, but it seems that can be kind of hard to do, especially for someone dealing with toxicities.

    Hence, supplementing with potassium chloride and potassium bicarbonate as indicated can help improve our K to Na ratio, and overcome the effects of “poor” dietary influences, medications, toxins etc. It’s worth considering that the author of this book suggests that, “our bodies don’t store potassium”…but we need to continually take in a lot of it for healthy metabolism, nerve function etc.

    What becomes pertinent is our ability to regulate the level of potassium in serum and in cells… Which leads to the topic of aldosterone – which is essential for regulating serum potassium… The question being, is it possible one might be low in aldosterone at least in part because we are functionally deficient in potassium? And will slowly improving this ratio of K to Na allow our aldosterone levels to rise along with potassium intake?

    The info in this book suggests this is generally this case (short of permanent atrophy of the part of the adrenal gland that produces aldosterone – or I suppose secondary adrenal insufficiency will prevent the appropriate signaling for the release of adrenal hormones, no matter how much potassium is available). Regardless, one shouldn’t drastically increase potassium intake without keeping an eye on our serum potassium to ensure that our body is handling it properly – as Andy has told us.

    If we don’t have adequate aldosterone, we can go high on serum potassium… And there are other factors too, certain medications and kidney function factor in. By the way, the same could apply to cortisol – that is, secretion may rise as potassium is increased.

    Increasing methylation may have the effect of pulling more potassium into cells that are deficient… at the expense of serum potassium – causing low serum potassium (this is Rich Van K’s theory). According to this theory, people with chronic fatigue caused by methylation block have fewer cells than normal. Ramping up their methylation cycle supplies the missing folate needed to make new DNA and suddenly the body can make new cells. This is what we call ‘healing’:

    All of a sudden, the cells now have enough DNA to overcome the arrest of the cell cycle, and their rate of cell division goes up, making new cells more rapidly. These new cells require potassium, and their membrane pumps start pumping it in from the blood plasma. Unfortunately, since the existing cells, which contain 95% of the body’s potassium inventory, are already low in potassium, there is no cushion or buffer for the blood plasma potassium level, and if it is not augmented by increased potassium intake from the diet or supplements, the PWC’s blood plasma potassium level drops, resulting in hypokalemia.

    While both the cell and serum levels of potassium are important, it’s the serum level of that can be very dangerous if it goes out of the so-called “normal” range. So, if you are ramping up your methylation cycle, keep a bottle of potassium around and know the symptoms of hypokalemia (weakness, lack of energy, muscle cramps, stomach disturbances, an irregular heartbeat, and an abnormal EKG) and hyperkalemia (muscle weakness, slowed heart rate, and abnormal heart rhythm).

    A few words from the author himself, Charles Weber, MS. We asked the author of Potassium Nutrition, to review the summary above for accuracy and this is his response:

    I did not see anything in the URL you sent that was obviously invalid. The body is a complicated soup, though, and it is easy to get things wrong. If a person’s kidneys have not been damaged, by poison for instance, that person can do some great nutritional blunders with respect to potassium and still stagger through. Healthy kidneys can handle some bizarre ratios since they have much more capacity than they need. The only circumstance that I know of that is desperately dangerous is the interaction between potassium and thiamin (vitamin B-1). If potassium is supplemented it is essential that vitamin B-1 be adequate (see http://charles_w.tripod.com/kandthiamin.html ). And of course, if the kidneys have been damaged in such a way as to be unable to excrete potassium there is some danger from supplements. This can easily determined by blood analysis.
    ===================================================================================
    ======================

    [​IMG]
     
  17. JanSz

    JanSz Gold

    https://drmalcolmkendrick.org/2013/03/04/potassium-your-invisible-friend/

    Potassium:
    • lowers blood pressure
    • lowers the risk of arrhythmias
    • lowers the risk of cardiovascular disease
    • lowers the risk of stroke
    • lowers the risk of heart attacks
    • lowers the risk of cancer, and
    • lowers the risk of death
    ..
    Potassium, your invisible friend
    157 Replies

    I recognise that I spent a lot of time telling people what does not cause heart disease, and what does not protect against heart disease. My sister told me… ‘well, what advice would you give people, then?’ I usually shrug my shoulders and reply ‘there is no shortage of advice around, I don’t think I need to add to the daily bombardment.

    However, I shall break the habit of a lifetime and, with slight trepidation, announce that I strongly believe that Potassium is good for you. If you consume more of it you will, most likely, live both longer and in better health.

    How much should you consume? A couple of extra grams a day should do the trick. Having said this, I do recognise that most people will not have the faintest idea how much potassium they consume and, frankly, neither do I. But you are probably not consuming enough, and your kidneys will easily get rid of any excess.

    For those who are not keen on bananas, spinach and broccoli, and other foods high in potassium, you could take it as a tablet. Potassium bicarbonate or potassium citrate appears to be the best formulation. Depending on which brand you decide to buy, it should cost about £15 – 20/year.

    Why this sudden potassiumophilia? Well, there is a growing body of research which points to the fact that potassium is very good for you. The first time I became aware that it might be good for you was when I first looked at the Scottish Heart Health study. The researchers looked at twenty seven different ‘factors’ they thought might cause, or protect against, heart disease – and overall mortality. The authors noted that:

    “[There was] an unexpectedly powerful protective relation of dietary potassium to all-cause mortality,” the study concluded.

    The paper showed that:

    • Men consuming an average of 5400 mg of potassium per day vs 1840 mg were 55% less likely to die during 7.6 year study (the highest one-fifth of men vs the lowest one-fifth of men)
    • Men consuming an average of 5400 mg of potassium per day vs 3350 mg were 22% less likely to die during 7.6 year study (the highest one-fifth of men vs the second highest one-fifth of men)
    • Women consuming an average of 4500 mg of potassium per day vs 1560 mg were 59% less likely to die during 7.6 year study (the highest one-fifth of women vs the lowest one-fifth of women)
    • Women consuming an average of 4500 mg of potassium per day vs 2700 mg were 15% less likely to die during 7.6 year study (the highest one-fifth of women vs the second highest one-fifth of women
    The study can most easily be found here http://www.ncbi.nlm.nih.gov/pubmed/9314758

    I immediately liked this finding. Mainly because it was almost completely unexpected, and unexpected findings are always far more likely to be correct than expected findings. Also, this was a very large effect indeed. It turned out that increased potassium consumption was very nearly as protective as smoking was damaging.

    Of course, this was an observational study, so I filed it under – most interesting – but did nothing much more about it. As the authors said themselves: ‘ Potassium excretion was very significantly related to risk of death from all causes, having a protective role, whereas its role in coronary events was weaker and that of sodium excretion weak and even paradoxical. These results are unifactorial, without correction other than for age and sex. Our findings need corroboration from elsewhere and more detailed analysis with more events from longer follow-up.’

    Since then, a large number of other studies have followed up, and appear to have confirmed that potassium has considerable health benefits. Some of these studies were not just observational, they were interventional. Here is summary of the potential beneficial effects. Potassium:

    • lowers blood pressure
    • lowers the risk of arrhythmias
    • lowers the risk of cardiovascular disease
    • lowers the risk of stroke
    • lowers the risk of heart attacks
    • lowers the risk of cancer, and
    • lowers the risk of death
    These benefits have been confirmed in a number of different studies. However, as this is a blog, I am not going to turn it into a medical paper and provide references for every statement, so I will stick to a couple of referenced studies. (If enough people are interested I can point you at additional papers).

    With regard to blood pressure, a study published in 1997 found that adding roughly 2 grams (2000 mg) of potassium per day lowered blood pressure in older people by 15/8 mm Hg. As good, if not better, than any antihypertensive drug1. And with no side-effects at all.

    When it comes to stroke, it has been found that having a low potassium level is a very potent risk factor for both bleeding (haemorrhagic) and clotting (ischaemic strokes). In an American study it was found that in those with low potassium levels the relative risk of ischaemic stroke increased by 206%. The relative risk increased by 329% for haemorrhagic stroke2.

    Admittedly, these two studies were done in people with high blood pressure to start with, but these effects are also found in healthy people. However, to my mind, the most important thing about potassium is that I cannot find any study, anywhere, which suggests that increasing potassium consumption may be harmful. In short, it seems to be something that does only good.

    I do recognise that a lot of doctors will shudder at the thought of adding potassium to the diet, as they have all been taught that a high potassium level is something terribly dangerous. A condition that needs immediate treatment, or else it will cause arrhythmias and death.

    It is true that you need to be careful of adding potassium to the diet of patients taking medications that can raise potassium levels. These are mainly drugs used to lower blood pressure. However, even in this group the risk of overdosing on potassium is exceedingly small. For everyone else the risk seems to be zero. This is why I now recommend potassium supplementation as a good way to live a longer, healthier life.

    My goodness, I think this is the first time I have ever recommended a dietary supplement. Must go and lie down.
     
  18. DrEttinger

    DrEttinger Choice, the only thing we control

    Yes, that's good. Heartbeats/min is more than just electrolytes! Prepare to get coached.

    Heartbeats - (180 minus your age). I'm 55 so I keep it at 115-125 for 1 hour 2 days/wk on a treadmill.


    The Many Benefits of Zone 2 Training

    In this training zone we stimulate Type 1 muscle fibers, therefore we stimulate mitochondrial growth and function which will improve the ability to utilize fat. This is key in athletic performance as by improving fat utilization we preserve glycogen utilization throughout the entire competition. Athletes can then use that glycogen at the end of the race when many competitions require a very high exercise intensity and therefore a lot of glucose utilization.

    Besides fat utilization, type I muscle fibers are also responsible for lactate clearance. Lactate is the byproduct of glucose utilization which is utilized in large amounts by fast-twitch muscle fibers. Therefore, lactate is mainly produced in fast-twitch muscle fibers which then, through a specific transporter called MCT-4, export lactate away from these fibers. However, lactate needs to be cleared or else it will accumulate. This is when Type I muscle fibers play the key role of lactate clearance. Type I muscle fibers contain a transporter called MCT-1 which is in charge of taking up lactate and transporting it to the mitochondria where it is reused as energy. Zone 2 training increases mitochondrial density as well as MCT-1 transporters. By training Zone 2 we will not only improve fat utilization and preserve glycogen but we will also increase lactate clearance capacity which is key for athletic performance.

    An endurance athlete should never stop training in zone 2. The ideal training plan should include 3-4 days a week of zone 2 training in the first 2-3 months of pre-season training, followed by 2-3 days a week as the season gets closer and 2 days of maintenance once the season is in full-blown.
     
    JanSz likes this.
  19. JanSz

    JanSz Gold

    @DrEttinger

    Yes Sir, I mean yes coach.
    My age 79.5, say 80, 180-80=100
    I have a 1.5-mile loop within my village. That is where I do most days my walking or running. Hopefully better than a treadmill.

    . Image-104.jpg

    Lately hunted by 20 y my junior, Witch.

    upload_2019-11-12_7-56-5.png

    Time flies, not long ago she was likely riding a (turbocharged) broom.

    upload_2019-11-12_8-45-4.png
     
    Last edited: Nov 12, 2019
    Christina Gagnon and DrEttinger like this.
  20. Jack Kruse

    Jack Kruse Administrator

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