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Linoleic acids........are tightly related to circadian biology.

Discussion in 'The Epi-Paleo Diet' started by Jack Kruse, Jan 5, 2019.

  1. Jack Kruse

    Jack Kruse Administrator

    Are omega 6's PUFA really the boogey man for disease food gurus tell you?

    Nope. They remain ignorant of the circadian cycle around this story and you Black Swans have to get it right and let them keep going on their wrong path. At this point it is becoming comical how wrong they have been for decades.

    The data is piling up now how light dysruption leads to a broken circadian mechanism and mtDNA destruction.

    How so?

    HNF4A gene product protein represses the operation of CLOCK and BMAL1, which act as key molecular cogs that drive the circadian rhythms in mammals.


    Inside the cell, the cogs of the clock are universal, but the hands of the clock are specific to each organ, so how the clock does its work in each cell is different.

    Jack can you give us an example of how this protein works in humans?


    This protein from the HNF4A gene also plays a pivotal role in the expression and synthesis of SHBG. SHBG is raised when this protein is not controlled by light cycles. It is an important glycoprotein made primarily in the liver, which in addition to lowering insulin-resistance also serves in reducing levels of free Estrogen as-well as prolonging the half-life of Testosterone. It also causes problems in the kidney and intestine. This protein is also associated with MODY1 diabetes. I believe it is one of the key links to melanopsin dysfunction in the guts of many people.

    Jack is this why people with gut diseases like Chrohn's can get colon cancers? Is this why young people now are getting both diseases at record rates? YEP.


    We now know increased amplification of hepatocyte nuclear factor 4 alpha has been observed in colorectal cancer.


    In humans, there are two isoforms of HNF4: they are HNF4α and HNF4γ, encoded by two separate genes HNF4A and HNF4G respectively.

    The food gurus like to blame omega 6's like LA for diseases but too few of them seem to know about the circadian control of this mechanism by HNF4.


    HNF4 was originally classified as an orphan receptor that exhibits constitutive transactivation activity apparently by being continuously bound to a variety of fatty acids like linoleic acid (LA).

    The existence of a cellular ligand for HNF4 has been somewhat controversial, but linoleic acid (LA) has been identified as the endogenous ligand of native HNF4 expressed in mouse liver. It turns out the binding of LA to HNF4 is reversible and it linked to the repression of CLOCK and BMAL1. So LA in foods really has bystandier effect here when the light cycles are dysrupted. Once again, the food gurus turn up WRONG.

    How does your internal organ clocks run? New research identifies a circadian network in the liver which is linked to diabetes and liver cancer. The liver is the key organ in the gut!!! Disruption of the circadian rhythm may be a risk factor for several age-related chronic diseases. No shocker to any clinician here.

    https://www.sciencedaily.com/releases/2018/12/181211161519.htm
     
    Danco3636 and recoen like this.
  2. Jack Kruse

    Jack Kruse Administrator

    About 20 percent of patients with Crohn's disease have the form known as Crohn's colitis. ... Patients with Crohn's colitis—particularly younger patients—are at increased risk for adenocarcinoma, the same type of carcinoma as colon cancer. This risk does not rise until 7 or 8 years after Crohn's colitis is diagnosed.

    What is Crohn’s disease?
    Crohn’s disease is a chronic inflammatory bowel disease (IBD) that affects approximately 700,000 people in the United States. The disease is named after Dr. Burrill B. Crohn, who first described the disease, along with Dr. Leon Ginzburg and Dr. Gordon D. Oppenheimer, in 1932. This was 53 years after the light bulb was invented.

    https://www.everydayhealth.com/croh...rohns-disease-and-your-risk-for-colon-cancer/
     
    Amber Ament likes this.
  3. Jack Kruse

    Jack Kruse Administrator

  4. Jack Kruse

    Jack Kruse Administrator

    Sooner or later you'll comprehend why it is about light and not the food you eat that drives chronic diseases.
     
    Amber Ament and recoen like this.
  5. Jack Kruse

    Jack Kruse Administrator

    Omega-6 rich diet + radiotherapy/nnEMF 1G-5G = A MITOCHONDRIAL PROBLEM tied to LIGHT and not food.

    I wonder when the paradigm will wake up to the fact this MIGHT be the reason why nnEMF and radiotherapy interventions for gliomas sometimes hurt instead of help. How long will it take for them to realize that nnEMF 1G-5G increases AMPk pathways and glucose metabolism which lead to more mitochondrial damage? = increased ROS/RNS via a loss of control of the mitochondrial process that mounts this response in the matrix. As NAD+ drops so do oxygen and the amount of ROS/RNS. IT is a protective mechanism and not one where we should advocate using NAD+ supplementation.


    4-HNE and other oxidation products are often cited as a danger of PUFAs by the food gurus. Is it true? No it is not.

    This idea ignores that oxidants are required for longevity, and 4-HNE produces hormetic effects experimentally. Oxidation is poorly understood. Taking exogenous antioxidants never panned out. because the cell is built to quantize the amount needed based upon the thermodynamics your colony of mitochondria.

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757694/

    I hope you all begin to realize why nnEMF and mitochondria do not mix. It does not have to be ionizing radiation to get this effect in several ways.
    Exogenous linoleic acid and electromagnetic radiation =
    "Exposure of mice to whole body irradiation (WBI) causes cardiolipin (CL) oxidation and accumulation of its hydrolysis products in small intestine" = mitochondrial damage at cytochrome 4 = Black Swan Mitochondriac wisdom on display yet again!

    Look at the variances of the two pictures below in my FB link and now read the paper.

    https://www.facebook.com/drjackkrus...otif_id=1547385083801768&notif_t=feed_comment


    It is blatantly obvious what the paradigm is missing: NATURE'S TRUTH.

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201180/
     
    JanSz and Brent Patrick like this.
  6. JanSz

    JanSz Gold

    Published online 2014 Apr 20

    phosphatidylserine (PS)8, is lacking from mitochondria

    The majority of phospholipids constituting the inner and outer mitochondrial membranes (IMM and OMM) are manufactured outside of the organelle, with a notable exception of mitochondria-specific cardiolipin (CL).

    Here we report that CL is oxidized to highly diversified polyunsaturated molecular species by cyt c thereby, representing a new biosynthetic pathway for lipid mediator production.
    upload_2019-1-14_10-24-48.png
     
    Last edited: Jan 14, 2019
    Beasol likes this.
  7. Jack Kruse

    Jack Kruse Administrator

    4-HNE and other oxidation products are often cited as a danger of PUFAs by the food gurus. Is it true?

    This idea ignores that oxidants are required for longevity, and 4-HNE produces hormetic effects experimentally. Oxidation is poorly understood. Taking exogenous antioxidants never panned out. because the cell is built to quantize the amount needed based upon the thermodynamics your colony of mitochondria.

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757694/
     
    Beasol and Mitchell97 like this.

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