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Leptin and Sleep Apnea

Discussion in 'The Leptin Rx' started by Jason Coates, Aug 11, 2017.

  1. Jason Coates

    Jason Coates New Member


    Experimental studies using animal models of a low leptin state such as leptin deficiency have shown that leptin regulates sleep architecture, upper airway patency, ventilatory function, and hypercapnic ventilatory response. However, findings from human studies do not consistently support the data from the animal models. The effect of leptin on the pathophysiology of obstructive sleep apnea is being investigated, but the results of studies have been confounded by its diurnal variation and the short-term effects of feeding, adiposity, age, and gender. Improved study design and methods of assessing functional leptin levels, specifically its central versus peripheral effects, will improve our understanding of the role of leptin in sleep apnea.

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