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Lectures of Michael Crawford (& others) on DHA

Discussion in 'The Epi-Paleo Diet' started by Sean Waters, Aug 20, 2021.

  1. Sean Waters

    Sean Waters New Member

    Would like to start a thread that dives back into the world of DHA through lectures from Crawford.

    I love relearning the importance of the fundamentals - I had life lesson this last two weeks on how essential it is for me (n=1) to be balancing my 06:03 ratio while I heal. To get to 1:1 you really have to omit Pork, Olive oil, Nuts and even Grass Fed Meat unfortunately.

    It really is a Seafood only diet in the tropics, because the levels of Omega 3 here are much lower (Snapper, Yellowfin Tuna, Marlin, Wild Shrimp, Clams/ Mussels) than they are in the High Latitudes (Salmon, Mackerel, Herring).

    The result has been very good for my Brain. Please share any other talks/ podcasts you have - I'll be sharing more I listen to as I go.

    16.03 for Bazan Effect/ Photoreception and DHA's role in the evolution of the Human brain.
  2. ND Hauf

    ND Hauf Pleb

    Here Prof. Crawford briefly touches on need to eat marine life not try to get DHA from a pill/oil. The good shit doesn’t come in a pill….

    Johan Lindstrøm and Sean Waters like this.
  3. Sean Waters

    Sean Waters New Member

    ND Hauf and Johan Lindstrøm like this.
  4. ND Hauf

    ND Hauf Pleb

    Sean Waters likes this.
  5. Adding to the thread -
    @ND Hauf & @Sean Waters
    If you’re interested in reading Dr Crawford’s work->
    The unique molecular structure of DHA allows for quantum transfer and communication of p-electrons, which explains the precise depolarisation of retinal membranes and the cohesive, organised neural signalling. –

    The brain can contains numerous proteins but is absolutely dysfunctional without DHA and AA.
    Crawford postulated that the p-electrons of the double bonds are confined to potential wells by the intervening methyl groups.

    What is being explained is ->
    As a wave, there are probability distributions in which the electron penetrates barriers and can communicate with neighbouring molecules or end up in other regions of the molecule. Removal of an electron in a neighbouring orbit will reduce repulsive forces and invite the electron into a new, higher-energy orbit. An electropositive charge will increase the probability of occupation. The pelectrons have opposite intrinsic angular momentums or spin.

    Bottomline: Know your source of DHA seafood, make sure its of good quality.
    Sean Waters, JanSz and ND Hauf like this.
  6. Sean Waters

    Sean Waters New Member

    awesome John
  7. Sean Waters

    Sean Waters New Member

    This is why finally getting a hold of Wild, Fresh Fish has been a really turning point for me.

    Unfortunatel,y much of the caribe is over fished (tulum) and too many restaurants to feed. So, not much remaining except Farmed Chilean salmon and Farmed shrimp or Farmed tilapia

    huge difference eating wild tuna, snapper and marlin
    Johan Lindstrøm likes this.
  8. You are so right - wild vs farmed - you can taste the difference; then the followup how do you feel -> from poor to great.
    Fresh wild caught is in minimal supply; so I often just go for frozen wild caught.
    Sean Waters likes this.
  9. ND Hauf

    ND Hauf Pleb

    I hear ya….Probably the biggest flaw in my health regime is my geo. location. I spend the majority of my time on the edge of the super volcano in Wyoming and Montana. Winters farther south but still in the mountains.

    Fresh seafood is a bitch when you choose to live in places like that. I make trips to the coasts and islands as often as possible to simply feed on seafood and winter sun.

    I still manage to eat seafood everyday but it really dicks with my BTC stacking. Here’s the sources I’ve been tapping lately.

    Oysters..- https://www.whitestoneoysters.com/

    Salmon…- https://seabear.com/

    Sardines/Salmon…- https://www.vitalchoice.com/?utm_source=google&utm_medium=cpc&utm_campaign=11440468773&utm_term=vital choice seafood&utm_content=474995942137&gclid=EAIaIQobChMI9IairdXU8gIVGGpvBB0aYAWXEAAYASAAEgLEIfD_BwE&utm_referrer=https://www.google.com

    Zinc/Selenium/copper/etc. all in balance in seafood. A few more Crawford nuggets in this one.
    Last edited: Aug 28, 2021
    Sean Waters and John Schumacher like this.
  10. Jack Kruse

    Jack Kruse Administrator

    New blog out today: So you might be wondering if DHA is so critical to humans how did it show up on Earth initially? Before DHA, Molybdenum was the key element for bacteria and archaea who used the sun for energy. https://www.patreon.com/posts/55049793
  11. Sean Waters

    Sean Waters New Member

    I have made a statement about Quintana Roo/ Tulum area not being an A* for health. I think it's more like a C. For this reason, the Seafood is limited due to overfishing, and most of it goes to restaurants first. I often found difficult getting consistent wild fish more than once per week......... always Farmed tilapia and farmed salmon and farmed shrimp.

    I thought they were fine until I came to Costa Rica and started eating Wild and Fresh fish: Snapper, Tuna, Clams/ Mussels, Wild Shrimp (my lord so good) and Pink Marlin - a new favourite of mine.

    I've actually decided to leave here, because I've found an even better Seafood destination in Mexico: Puerto Escondido. They have Oysters there all the time and much more Seafood as the Water is colder! So, I've had to sell my Motorbike and my Red Light panel and go through a lot of shit to leave here - but........ when an A is available......
  12. Sean Waters

    Sean Waters New Member

    Just finished reading....... EPIC.
    DrEttinger likes this.
  13. Sean Waters

    Sean Waters New Member

    I've been hitting a 1:1 Omega 6 to 3 ratio the last 2-3 weeks and I've noticed DRAMATIC changes in my energy and assimmilation of Sunlight - I can feel the Sunlight charging me up, whereas with a higher Omega 6 template - Carnivore/ Meat - I always feel stressed after a short while in Sunlight.

    My sleep, my gut, my mental health - all of them are peaking right now. Making some really good decisions - I just paid for an secured an EMF Canopy Tent, something that I've just never pulled the trigger on - now it seems absolutely clear.

    I feel like I can read Jack's blogs easier too. I've listened to about 12 webinars and QAs in the last month and actually understood it. Including this one, which is important for seafood:
    December 2016 - The Q Cycle

    This Carnivore fad is as dangerous as veganism IMO.
    Last edited: Aug 31, 2021
  14. ND Hauf

    ND Hauf Pleb

    EPIC 2.0......Damn that closed some circles.

    Thankful to be Here

    Sean Waters likes this.
  15. ND Hauf

    ND Hauf Pleb

  16. @JanSz @ND Hauf @Sean Waters @Richard Watson - To understand DHA metabolizing -

    We may want to start with cholesterol efficacy - https://www.nature.com/articles/s41598-018-33116-4

    Why cholesterol may not convert to healthy -> Phosphatidyl -

    Understanding your three cell membrane lipids

    The Role of Fatty Acids in Production of Energy

    Fatty acids provide a major energy source for the myocardium, skeletal muscle, and liver via β-oxidation, which occurs in the mitochondria.1 Short-chain and medium-chain fatty acids can enter the mitochondria directly, but long-chain fatty acids (LCFAs) must be transferred in via a shuttle involving 3 enzymes/transporters and carnitine. Once inside the mitochondrial matrix, β-oxidation progresses in a cycle of 4 steps, which result in the sequential cleavage of 2-carbon acetyl-coenzyme A (CoA) from the fatty acid chain and the transfer of electrons to the respiratory chain for adenosine triphosphate (ATP) production (Figure). Acetyl-CoA can be utilized as a substrate in the tricarboxylic acid (TCA) cycle to create additional reducing equivalents for the electron transport chain, or it can be utilized for ketone synthesis, an alternate form of energy for the brain, myocardium, muscle, kidney, and other tissues. This energy is especially critical during periods of fasting when glucose is unavailable and during periods of physiologic stress. The metabolism of LCFAs to support creation of energy focuses on oxidation of acetyl-CoA in the mitochondrial TCA cycle. For proper TCA cycle function, inflow of substrates (anaplerosis) must be balanced by outflow (cataplerosis). In anaplerosis, intermediates are continuously replenished to sustain TCA cycle function and drive ATP production. With cataplerosis, other intermediates are removed to drive gluconeogenesis and lipogenesis. This balance is critical to maintaining energy homeostasis.​

    So why is butyric acid so important? https://www.nature.com/articles/labinvest201370?proof=t

    Why does the brain recover using DHA-containing-Phosphatidyls? - https://lipidworld.biomedcentral.com/articles/10.1186/s12944-020-01253-3

    Liposome-incorporated DHA increases neuronal survival by enhancing non-amyloidogenic APP processing - https://sci-hub.se/10.1016/j.bbamem.2010.10.014

    In Dr. @Jack Kruse - CPC #56: DHA, information theory, thermodynamics, semiconduction - https://optimalklubs.com/blogs/
    Jack stated - Hydrated DHA is the key to its operation (optical photonic signal processing) Interorganellar communication and ...
    hormone signalling

    I'm thinking -> better sex...

    Jack is thinking -> "connecting the dots of optical signal processing (OAM) in biological semiconductors, to show how the fidelity of signaling is created, maintained, and compressed optically to give rise to a quantum biologic revolution in medicine."
    Last edited: Sep 1, 2021
  17. Sean Waters

    Sean Waters New Member


    Pretty epic site for the Human Evolution of Brain and Seafood.... lots of links/ sources

    Week 4 of the 1:1 Omega 6:3 ratio diet... or Tier 1-3 Epi Paleo diet.

    This morning I nailed 6 oysters caught out the ocean, I saw the guy come out with his flippers and drop them on the table. I ate them moments later. Instant hit of energy... Got 12 more for later.

    Cleaned off some Dorado for Lunch, around 500g. Got a whole Red Snapper for later.
  18. ND Hauf

    ND Hauf Pleb

    Damn that’s awesome. I need to get farther south and closer to the coast. I love the mountains but I'm starting to realize they are a B not an A and that’s a hard shit pill for me to swallow.
    John Schumacher and Sean Waters like this.
  19. ND Hauf

    ND Hauf Pleb

    Hey @Sean Waters don't bust my balls too hard for linking this video to a Crawford thread. I’ve been checking his DHA research out after I heard @Jack Kruse mention him in Vermont 2017 speech. He’s got some interesting stuff out there just a little hard to find and understand the cat….

    He then uncovered that DHA supply to the photoreceptors and synapses is liver-regulated and that in photoreceptor cell renewal, retinal pigment epithelium recycling retains DHA within photoreceptors by a “short loop” (RPE-to-photoreceptors) after the “long loop” (liver-to-retina). He found that Usher’s Syndrome patients from Cajun families from Louisiana have DHA shortage in the blood, implicating the long loop in retinal degenerations. He discovered the enzyme-mediated formation of DHA derivatives in the retina and coined the term docosanoids. He and his colleagues, in collaboration with Dr. Charles N. Serhan (Harvard Medical School), then discovered the synthesis and bioactivity of the first docosanoid, Neuroprotectin D1 (NPD1), which arrests apoptosis in retinal pigment epithelial cells at the pre-mitochondrial level, and is neuroprotective in brain ischemia-reperfusion and in cellular models of Alzheimer’s disease. Then he and his colleagues found a decrease in DHA-derived NPD1 in the CA1 area of Alzheimer’s disease patients, and that NPD1 promotes down-regulation of pro-inflammatory genes and of pro-apoptotic Bcl-2 proteins and neuronal and glial cell survival from Aβ toxicity. He discovered novel mediators that counteract early events in Alzheimer’s, stroke, and other diseases as well a novel painkiller. Currently, he is beginning to apply his discoveries by translating them into intellectual property (patents) in two startup companies that he co-founded: NeuResto Therapeutics, LLC (novel discoveries for Alzheimer’s, Parkinson’s, retinal degenerations, stroke, and other brain and retina diseases) and South Rampart Pharma, LLC (novel non-addictive painkiller).
    John Schumacher and Sean Waters like this.
  20. Sean Waters

    Sean Waters New Member

    Oh my man.... we should rename this thread, ALL THINGS DHA.... absolutely share the shit out of Bazan. Pretty sure Jack did his residency at the same place he worked and at the same time he discovered all of this.......

    Jan 2017 webinar is on this too I believe, phenomenal stuff.
    John Schumacher likes this.

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