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Kruse's Law?

Discussion in 'Educating Doctors' started by NeilBB, Apr 30, 2014.

  1. nonchalant

    nonchalant Silver

    Are you sure it's not because 19 is a Prime number?
     
  2. Jack Kruse

    Jack Kruse Administrator

    December 4, 2013

    Source:
    Karolinska Institutet

    Summary:
    New research shows that omega-3 fatty acids in dietary supplements can cross the blood brain barrier in people with Alzheimer’s disease, affecting known markers for both the disease itself and inflammation. The findings strengthen the evidence that omega-3 may benefit certain forms of this seriously debilitating disease.
    Omega 3 fatty acids are essential for human nutrition. Our bodies cannot produce these fatty acids, so we must consume them through our diet. Integral to the proper functioning of cell membranes, omega-3 fatty acids help to regulate hormone and cell receptor functions. According to the Harvard School of Public Health, these protective and supportive properties of Omega-3 benefit the cardiovascular and nervous systems.Beneficial for:

    • Anti-Aging ( promotes the production of Telomerase)

    • Heart Health

    • High Blood Pressure

    • High Cholesterol

    • Diabetes Management

    • Periodontal Disease

    • Improved Mental Alertness

    • Improved Stamina & Endurance

    • Improved Immune Function

    • Prevention of LDL

    * Fights inflammation

    * Mental Stress


    • A derivative of docosahexaenoic acid (DHA), a main ingredient of fish-oil supplements, can alleviate and prevent neuropathic pain caused by sensory system injuries, researchers from Duke University Medical Center reported in the Annals of Neurology.
      The authors say that the DHA derivative – a compound called neuroprotectin D1=protectin D1 (NPD1=PD1) – may provide doctors and patients who are concerned about pain medication addictions and opioids with a more natural and healthier alternative.
      NPD1=PD1 is a bioactive lipid which cells produce in response to external stimuli. It is present in human white blood cells and plays a role in resolving brain and abdominalinflammation.
      Head researcher, Ru-Rong Ji, professor of anesthesiology and neurobiology at Duke University Medical Center, said:
      “These compounds are derived from omega-3 fatty acids found in fish oil, but are 1,000 times more potent than their precursors in reducing inflammation.”
      In an animal experiment, the scientists used lab mice models of nerve injuries to simulate the pain symptoms commonly linked to nerve trauma caused by surgery. The mice were treated with chemically-synthesized NPD1=PD1, which was administered either locally or by injection, to determine whether the compound might relieve these symptoms.
      Not only did NPD1=PD1 relieve pain symptoms, but it also reduced nerve inflammation following the injuries. The compound reduces pain by inhibiting the productions of chemokines and cytokines, small signaling molecules that attract inflammatory macrophages to the nerve cells.
      NPD1=PD1 protected nerve cells from further damage by preventing the production of chemokines and cytokines. The lipid compound also reduced neuron firing, resulting in less pain for the injured mice.
      Ji said “Chronic pain resulting from major medical procedures such as amputation, chest and breast surgery is a serious problem.”
      Current neuropathic pain medications, including gabapentin and several opioids, can lead to dependency and sensory nerve cell destruction.
      Below is a list of the main advantages of NPD1=PD1:
      • Only low doses are needed to relieve neuropathic pain
      • It does not appear to lead to physical dependence
      • No enhanced tolerance towards the compound was observed in the mice
      • It reduces nerve inflammation following injuries
      • currently dosages given via transdermal patches allow the use of natural DHA for immediate delivery to the bloodstream
      Ji said “We hope to test this compound in clinical trials.” He suggested that in apreliminary trial, DHA could be administered via diet and transdermal patches. “DHA is very inexpensive, and can be converted to NPD1 by an aspirin-triggered pathway.” for those who can take "baby"aspirin.White willow bark as a supplement will also trigger the pathway.
      Health Flex suggest that to achieve rapid pain relief that you double your omega-3/COQ10 patch to twice a week instead of once a week along with a baby aspirin or white willow bark extract. It is safe non toxic and cheaper than drugs!
      The team said their ultimate objective is to develop a safer approach to controlling chronic pain.

      Omega oils protect the heart from mental stress. A study study published in theAmerican Journal of Physiology - Regulatory, Integrative, and Comparative Physiologyrevealed that people who took fish oil supplements for over a month experienced less mental stress in measurements of cardiovascular health than those who did not.
      • Benefits for the fetus - omega-3 consumption boosts fetal cognitive and motor development - scientists from L'Université Laval Laval found that omega-3 consumption by the mother during her last three months of pregnancy improved her baby's sensory, cognitive and motor development.
      • Protecting from vision loss - adequate dietary consumption of DHA protects people from age-related vision loss, Canadian researchers reported in the journal Investigative Ophthalmology & Visual Science.
      • Heart benefits found - a 2011 study, on the other hand, carried out by researchers at Michigan Technological University, found that fish oil consumption can improve blood flow by reducing triglyceride levels, as well as slowing down the growth rate of atherosclerotic plaques.

        Fish oils help patients with stents in their arteries. People with stents in their heart who took two blood-thinning drugs as well as omega-3 fatty acids were found to have a lower risk of heart attacks compared to those not on fish oils.

        Are low Japanese heart disease rates linked to high fish oil consumption?
        Researchers from the University of Pittsburgh Graduate School of Public Health set out to determine why the incidence of heart disease in Japan is much lower than in the USA, Canada, Western Europe and Australasia.

        They reported in the Journal of the American College of Cardiology in April 2008 that omega-3-rich fish consumption in Japan is much higher than in other developed nations. The authors believe that the greater consumption of fish oils in Japan is a main contributor to its relatively lower heart disease rates.

        The scientists explained that the difference cannot be explained by genetic factors. Third and fourth generation Japanese-Americans have either the same or higher rates of hardening of the arteries (atherosclerosis) than the rest of the US population. Atherosclerosis is a major risk factor for heart disease.
      Journal Reference:
      1. Yvonne Freund Levi, Inger Vedin, Tommy Cederholm, Hans Basun, Gerd Faxén Irving, Maria Eriksdotter, Erik Hjorth, Marianne Schultzberg, Bengt Vessby, Lars-Olof Wahlund, Norman Salem, Jan Palmblad. Transfer of omega-3 fatty acids across the blood-brain barrier after dietary supplementation with a docosahexaenoic acid (DHA)-rich omega-3 fatty acid preparation in patients with Alzheimer's disease: the OmegAD study.Journal of Internal Medicine, 2013; DOI: 10.1111/joim.12166
     
  3. Martin

    Martin Gold

    I'm recognizing a lot of big words in the above. Off to review "Cambrian Explosion"!
     
  4. Brother John

    Brother John Silver

    Josh, I agree completely about the eyes being an energy hog. I shut mine for learning movement, music and sensing when the eyes are not so needed. Sometimes esp at night I walk with eyes shut and let my feet tune in the path by feeling the edges of it. Do you have any "data links" for the eyes and ears energy usage? No biggee just wondering.
    Thanks,
    brother john
     
  5. i think these senses are newer in evolutionary history thus need more energy as a rule. you can look up when these senses appear in the evolutionary timeline, it is also outlined in a book by phillip beach called muscles and meridians
     
  6. Jack Kruse

    Jack Kruse Administrator

    Senses are a water phenomena born of the special abilities of hydrogen. You'll see soon enough..........you've learn a lot about electrons..........its time to go positive on you.
     
  7. NeilBB

    NeilBB New Member

    Kruse's Law (Neil version) strikes again! Lol
     
  8. Jack Kruse

    Jack Kruse Administrator


    Peroxidases like H2O2 are electron acceptors.............in redox reactions.

    How do redox reactions in proteins and light link?

    Porphyrin rings in chlorophyll and hemoglobin.

    Photosynthesis froms the basis of the food chains on Earth.

    Did you know plants us both chlorophyll and hemoglobin?

    Both are heme proteins.

    Do you know that cytochrome c the major signaling molecule in mitochondria is also a heme protein?

    Cytochrome c is absolutely essential for life; organisms that lack it cannot live. It has been shown that the human cytochrome c protein works in yeast (a eukaryotic unicellular organism) that has had its own native cytochrome c gene deleted, even though yeast cytochrome c differs from human cytochrome c over 40% of the protein. Cytochrome c is a heme related protein. It is related to porphyrins which absorb UV light. In fact, the cytochrome c genes from tuna (fish), pigeon (bird), horse (mammal), Drosophila fly (insect), and rat (mammal) all function in yeast that lack their own native yeast cytochrome c .Only about a third of the 100 amino acids in cytochrome c are necessary to specify its function. Most of the amino acids in cytochrome c are hypervariable. Importantly, Hubert Yockey has done a careful study in which he calculated that there are a minimum of 2.3 x 1093 possible functional cytochrome c protein sequences, based on these genetic mutational analyses. For perspective, the number 1093 is about one billion times larger than the number of atoms in the visible universe. Thus, functional cytochrome c sequences are virtually unlimited in number, and there is no a priori reason for two different species to have the same, or even mildly similar, cytochrome c protein sequences.
    In terms of a scientific statistical analysis, the "null hypothesis" is that the identity of non-essential amino acids in the cytochrome c proteins from human and chimpanzee should be random with respect to one another. However, from the theory of common descent and our standard phylogenetic tree we know that humans and chimpanzees are quite closely related. We therefore predict, in spite of the odds, that human and chimpanzee cytochrome c sequences should be much more similar than, say, human and yeast cytochrome c - simply due to inheritance. Humans and chimpanzees have the exact same cytochrome c protein sequence. The "null hypothesis" given above is false. In the absence of common descent, the chance of this occurrence is conservatively less than 10-93 (1 out of 1093). Thus, the high degree of similarity in these proteins is a spectacular corroboration of the theory of common descent. Furthermore, human and chimpanzee cytochrome c proteins differ by ~10 amino acids from all other mammals. The chance of this occurring in the absence of a hereditary mechanism is less than 10-29. The yeast Candida krusei is one of the most distantly related eukaryotic organisms from humans. Candida has 51 amino acid differences from the human sequence. A conservative estimate of this probability is less than 10-25. One possible, yet unlikely, objection is that the slight differences in functional performance between the various cytochromes could be responsible for this sequence similarity. This objection is unlikely because of the incredibly high number of nearly equivalent sequences that would be phenotypically indistinguishable for any required level of performance. Additionally, nearly similar sequences do not necessarily give nearly similar levels of performance.

    Nonetheless, for the sake of argument, let us assume that a cytochrome c that transports electrons faster is required in organisms with active metabolisms or with high rates of muscle contraction. If this were true, we might expect to observe a pattern of sequence similarity that correlates with similarity of environment or with physiological requirement. However, this is not observed. For example, bat cytochrome c is much more similar to human cytochrome c than to hummingbird cytochrome c; porpoise cytochrome c is much more similar to human cytochrome c than to shark cytochrome c. As stated earlier in prediction 1.3, the phylogenetic tree constructed from the cytochrome c data exactly recapitulates the relationships of major taxa as determined by the completely independent morphological data (McLaughlin and Dayhoff 1973). These facts only further support the idea that cytochrome c sequences are independent of phenotypic function (other than the obvious requirement for a functional cytochrome c that transports electrons).

    Is there a point to all this? Yep..........
     
    Richelle Jones likes this.
  9. yewwei.tan

    yewwei.tan Gold

    Well, to tie the above back to Ubiquitination, I'd highly suggest that people read Nick Lane's latest book 'The Vital Question'. In it, he describes precisely how it is cytochrome c function that determines the decision of a cell to kill itself.

    Dysfunction or loss of cytochrome c => signal to nucleus for apoptosis => more cell turnover => expensive on the body => disease if kept up chronically.

    In general, to make UV light useful, you are going to need some form of Nitrogen-containing ring (like Porphyrin). One direct example is Phenothiazin, which is pictured below (https://en.wikipedia.org/wiki/Phenothiazine). Heme Porphyrin is pictured below Phenothiazin.

    Here is a direct study of UV irradiation (close tho 380nm band), in which production of Phenothiazine in a more basic environment (pH 7 -8) allowed for stability of the cytochrome c protein, while a lack of Phenothiazine in an acidic pH led to destruction of the protein -- http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0076857

    I am not sure how to apply this clinically. Will be interesting to see where the Quantlet biohack goes ;)


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    Richelle Jones likes this.
  10. Jack Kruse

    Jack Kruse Administrator

    Eukaryotic cells all release ELF UV light, and in Roeland Van Wijk, book Life Sculpting Light, you begin to see how O2 consumption and cellular light release seem linked in a very interesting way. Hemoglobin (made of porphyrins) carries O2 but it appears that free radical release and O2 utilization are the key to light generation in cells. This makes looking at RBC's contents critical (porphyrins). They are loaded with hemoglobin, have no mitochondria, and are loaded with catalase and deal with H2O2. H2O2 breaks down into H2O and O2 in most places but not in arteries or in veins where hemoglobin is present. Many heme-binding proteins have diverse functions. Some known functions include electron-transferring cytochromes, intracellular peroxidases and lignin-degrading extracellular peroxidases. Peroxidases are heme-containing enzymes that use hydrogen peroxide as the electron acceptor to catalyze a number of oxidative reactions. Did you know the thyroid has a peroxidase that is usually altered in Hashimoto's? Most people with Hashimoto's have low Vitamin D, low UV exposures, excessive blue light exposures and low tissue DHA content.
     
  11. Jack Kruse

    Jack Kruse Administrator

    More light is released from cells in pseudohypoxic states. This also explains why fluorescent light has an adverse effect on human tissues exposed to peroxides. RBC’s are loaded with an enzyme catalase. Catalase is present in the peroxisomes of nearly all aerobic cells, serves to protect the cell from the toxic effects of hydrogen peroxide by catalyzing its decomposition into molecular oxygen and water without the production of free radicals.

    Interesting huh?
     
    Alex97232 and Richelle Jones like this.
  12. River

    River Gold

    I have Hashimoto's (diagnosed 2004). Context: VDR mutation, computer programmer since 1985, lived on a farm eating home grown land animals but only a handful of seafood meals per year for 13 years prior.

    All that has turned around now (sun, grounding, no artificial lights in home, limit computer work and use blue blockers, seafood for breakfast and dinner (raw or cooked on very low heat) for about a year.

    I have antibodies less than 40 now, but if I stop my desiccated thyroid medication (120mg) they shoot back up to a very high level.

    I'm hoping with more time to reverse the Hashi's for good. The extreme fatigue from lack of functional thyroid tissue has already lessened by at least 50%. I realize I'm somewhat alone in this thyroid / hashi bio-hack but keeping my eyes and ears open here on the forums.

    Thanks for all the nuggets thus far.
     
    Alex97232 likes this.
  13. Grmoline

    Grmoline Gold

    No, not alone with a Hashi's bio-hack, but Hashi's is all part of the bigger picture I am hacking. Tissue DHA content and cutting down blue light exposures are things I have been working on. UV exposure is a problem due to latitude, and excess nnEMF is something I'm mitigating by moving in a few days. I have stopped the antibodies going up, but haven't seen them come down much yet and probably won't until the environment is changed. I'm not sure if complete thyroid function without exogenous T4/T3 is possible, however. Might depend on the damage done and remains to be seen.
     
    Alex97232 likes this.
  14. Jack Kruse

    Jack Kruse Administrator

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