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KREBS BICYCLE.........What is it?

Discussion in 'Mitochondrial Rx' started by Jack Kruse, Oct 13, 2018.

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  1. Jack Kruse

    Jack Kruse Administrator

    What is Kreb's bicycle?

    It is where the TCA and urea cycle meet in your mitochondria. "Krebs bicycle," composed of the urea cycle below, which meshes with the aspartate-argininosuccinate shunt of the citric acid cycle on the left. They meet at the enzyme fumerase which adds water to both cycles. The water it adds is also quite special because the water added comes from the mitochondrial matrix and not from the extracellular fluid compartment. Fumarate produced in the cytosol by argininosuccinate lyase of the urea cycle can enter the citric acid cycle in the matrix of the mitochondrion and is converted in several steps to oxaloacetate. This is how these two cycles operate in unison.

    When the two wheels of this bicycle do not rotate freely we get collateral effects in other cycles. One of those areas of collateral damage is in the methionine cycle which controls the flux of homocysteine and the sulfur laced amino acids that make up the major anions of our blood that interact with sunlight. One oxaloacetate accepts an amino group from glutamate by transamination, and the aspartate thus formed leaves the mitochondrion and donates its amino group (nitrogen cycle) to the urea cycle in the argininosuccinate synthetase reaction. Intermediates in the citric acid cycle are boxed in the picture below. When this process is broken reactive nitrogen signal is awry in a cell and it leads to more mitochondrial damage. What breaks it? Anything that is capable of slowing the spin rate of the cycle or its substrates. Deuterium's kinetic isotope effect is the number one offender in illness states. https://www.patreon.com/posts/18925873

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