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Klotho

Discussion in 'Mitochondrial Rx' started by Sue-UK, Aug 15, 2020.

  1. Sue-UK

    Sue-UK New Member

    @John Schumacher

    In answer to your question on the melanin thread, https://forum.jackkruse.com/index.p...ournal-articles-ever.22932/page-3#post-291515



    I'm still going through the references on this blog, but it is starting to explain a few intuitive choices ....

    https://mybiohack.com/blog/longevity-intelligence-klotho-genetics-fat-vitamin?rq=klotho

    and also found these interesting

    http://www.brjnmims.org/article.asp?issn=2349-3666;year=2019;volume=6;issue=1;spage=1;epage=6;aulast=Pathare
    Klotho: An emerging factor in neurodegenerative diseases

    http://www.bumc.bu.edu/provost/bumcnews/insulin-regulates-the-secretion-of-the-anti-aging-hormone-klotho/
    Insulin Regulates the Secretion of the Anti-Aging Hormone Klotho

    In terms of the link of klotho to melanin in the RPE

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810551/
    Klotho Regulates Retinal Pigment Epithelial Functions and Protects Against Oxidative Stress
    @CarolandNick

    Its a bit of a rabbit hole, but the link to melanin in the eye is interesting because Herrera is an opthamologist, and - apart from avoiding AD - although I would love it if I could regenerate my right eye retina, keeping my left eye healthy is a top priority. :)
     
    Alex97232 and John Schumacher like this.
  2. Thank you for sharing - I really liked the https://mybiohack.com
     
    Sue-UK likes this.
  3. Sue-UK

    Sue-UK New Member

    https://selfhacked.com/blog/do-you-...bout-klotho-and-how-to-increase-it-rs9536314/

    (Klotho) "suppresses the production of biologically active vitamin D (decreases 1alpha-hydroxylase)"

    "Vitamin D (Calcitriol) increases Klotho. However, Vitamin D supplements apparently don’t work in humans to increase Klotho, even when calcitriol goes up. In dialysis patients, vitamin D supplements actually decrease Klotho."

    "In dialysis patients, vitamin D supplements decrease Klotho. "

    From the mybiohack link

    "If you are genetically predisposed to produce low klotho, then supplementing Vitamin D may reduce dopamine in the brain.

    This is because klotho inhibits 1-α hydroxylase, the enzyme responsible for the production of active vitamin D (1,25 dihydroxy vitamin D3)."

    From the ways to increase klotho (diet) section

    Sugar.


    I'm wondering if the sugar (from fruits eaten seasonally in their natural form rather than sucrose) increases klotho, which spares vitamin D, keeping it for a time when klotho is lowered by a seasonal change in diet to high fat (from seasonal winter food or stored body fat)?:confused:

    Fruits would also contain vitamin C and there seems to be a vitamin C/melatonin connection

    https://faseb.onlinelibrary.wiley.com/doi/full/10.1096/fj.201601085R
    Melatonin-mediated upregulation of GLUT1 blocks exit from pluripotency by increasing the uptake of oxidized vitamin C in mouse embryonic stem cells

    (I found figure 7 and the discussion after it most useful at getting the general idea :confused::confused::confused:) Possible red flag to year round ketosis if that downregulates GLUT 1?
     
  4. From the articles you posted, we know Klotho increased with insulin sensitivity, thus it improves during cycles of cell growth not recovery.
    Have you considered loading d-Ribose in a cold herbal tea as a post-workout drink? Mine contains: Cinnamon & Red Zinger.
     
  5. Sue-UK

    Sue-UK New Member

    No, particularly as I'm not testing, its not something I'd do at the moment with my context. :) Adding it in summer whilst I'm eating 3 meals a day (which would include naturally occurring d ribose) and seasonal carbs could be a bad idea.


    https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(17)30393-6/fulltext
    d-Ribose as a Contributor to Glycated Haemoglobin

    Keto in winter might be different ... but although I haven't read the paper linked to see the mechanism/doses etc, its nocturnal animals blah blah, the wiki entry says "Oral D-Ribose intake is linked to memory loss, anxiety, & Aβ-like deposits associated with Alzheimer’s in mice."

    I'd need to understand the risks more than I do now. :)
     
    Last edited: Aug 18, 2020
    John Schumacher likes this.
  6. Sue-UK

    Sue-UK New Member

    John Schumacher likes this.
  7. The article believes that - "As an aging suppressor, Klotho is an important molecule in aging processes and its overexpression results in longevity."
    and "aerobic exercise increases Klotho gene expression in muscle cells and decrease ROD production"
     

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