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July 2017 Webinar Questions

Discussion in 'Ask Jack' started by Jamie Ward, Jul 16, 2017 at 11:55 AM.

  1. Jamie Ward

    Jamie Ward Gold

    Listened only once at this point...

    1/ Where does melanin/browning of the skin from tanning coming into this? What effect is that having on the mitochondria? Tighter coupling?

    2/ Myer said increase perspiration from physical labor was leading to earlier mortality... You also said perspiring is a sign of how much water your mito makes and was tied into leptin Rx (i.e. you sweat more when leptin sensitive). How does the latter tie in with the former? Do you think it is a zero sum game for the mitochondria, i.e. the more heat it needs to produce to compensate lack or IR from the sun the shorter the lifespan?

    3/ How do we test our proteins similar to your testing you did with MB and topological Mg?

    4/ What were your hair hacks etc. and effects? What are you still trying to reverse from them?

    5/ Is there a colour test out there for mitochondria?

    Thanks
  2. Jack Kruse

    Jack Kruse Administrator

    Melanin is made from tyrosine and it is the key UV photosynthetic protein in animals. It is also in the RPE granules of the eye to drive the DC electric current.

    Not Mayer....Lavoiser found that. Meaning he was the first person to discover why Calorie restriction works: Because it lowers respiration.....assuming the environment is solar based. Today that assumption is shot and that is why CR is not a part of any long term smart plan for humans but fasting is. Lavosier studied people who were uncoupled who did heavier work. This is unusual state for an uncoupled haplotype. Why? In the Vermont talk I said that equatorial animals are all tightly coupled because they need all energy to run from lions but they need to eat more food to make heat and ATP to stay warm in cold. This is the key why Lavoisier found in uncoupled humans who were over worked. The more they respired the quicker they die. They do not need a ton of exercise because further from the equator there is less predators and more cold and less light frequencies. This means they must conserve where they use their energy wisely.
    All biologic scaling is non linear because the light we use to control metabolism is also non linear. The only part of the visible spectrum that is capable of non linear optics is UV light (purple light) . At high latitudes this light is not present in excess. It turns our all biologic scaling reflects the underlying quantum principles in UV light. My members will find biologic scaling (Kleiber's law) an interesting discussion. Why? Mice have massive metabolic rates and elephants do not. Mice are mammals adapted to non equatorial zones and are nocturnal and are uncoupled. Elephants are adapted to equatorial living. Metabolic rate is tied to the amount of coupling or uncoupled efficiency in mitochondrion which is a function of heteroplasmy rate. Who are the guys who proved this first in biology: Mayer, Lavoisier, and Dr. Doug Wallace = July 2017 webinar. Google my name and Kleiber's law. I've spoken about many times.



    HRV is the easiest way. GDV can be uses. When optical scanners become common place they will be great. I also had the benefit of using pulse oximeter in the OR to test the topical effects of sunscreens with Sperti D lights and bulbs of different colors.

    Still in progress about the hair hacks. They have been buggers.

    As of now, in humans none that I know of.
    Last edited: Jul 16, 2017 at 5:59 PM
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  3. Jack Kruse

    Jack Kruse Administrator

    Telomerase is a specialized reverse transcriptase containing an intrinsic telomerase RNA (TR) which provides the template for telomeric DNA synthesis. This molecule is loaded with aromatic amino acids. All aromatic amino acids have benzene rings that are photon traps. What Blackburn forgot is the basics.......low or high telomerase is not the key. The key for the mitochondriac to get: Are telomerase's electrons exicted or not properly by UV light to work well physiologically? The reason is that electron excitation of the sun is tied to HR, scaling laws, longevity, HRV, and metabolic rates. The higher the metabolic rate the less UV light will be present in the animal system. The lower the metabolic rate the more UV light will be captured within the system and the longer an animal will live. This is why mice live 2-3 years as nocturnal high latitude living mammals. They also have highly uncoupled haplotypes. Mice and elephants however usually have the same amount of cardiac heatbeats in their entire life. They just need more heartbeats in their two years of living while an elephant can live lng with a lower heart rate because UV-A light raised NO to lower cardiac output and lower blood pressure to decrease the HR of the elephant. Mice have no advantage. The only way to help a mouse live longer who is uncoupled is to cool it or to starve it. Elephants are large equatorial mammals that live 50-60 years and spend most of their lives in stable equatorial solar lit environments. That is the key to understanding resistance of the following molecules as well in humans: leptin, amylin, and many other solar chemicals like insulin, melatonin, and dopamine.

    https://blogs.scientificamerican.co...-much-telomerase-can-be-as-bad-as-too-little/
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  4. Jack Kruse

    Jack Kruse Administrator

    All biologic scaling is non linear because the light we use to control metabolism is also non linear. It also turns out coupling rates in mitochondrion are also non linear because of the geometry of the cytochromes. The only part of the visible spectrum that is capable of non linear optics is UV light (purple light) It turns our all biologic scaling reflects the underlying quantum principles in UV light. Not even the physicists seem to realize this link as the podcast linked here shows. My members will find biologic scaling (Kleiber's law) an interesting discussion. Why? Mice have massive metabolic rates and elephants do not. The reason is simple and these very smart guys miss the reason. Metabolic rate is tied to the amount of coupling or uncoupled efficiency in mitochondrion which is a function of heteroplasmy rate. Mice are nocturnal uncoupled animals and elephants are tropical mammals under the powerful influence of UV light. All mammals who are circumpolar/higher latitudes have large uncoupling efficiencies and these guys missed it in their discussion and missed in disscusing the scaling laws with the arterial tree in us as well. The funny part is one guy knew that uncoupled haplotypes can lower their metabolic rates using COLD and UV light. This is the basis of the CT-6 blog at my site. That is caused by dermal pooling in the skin to UVA light from NO release. The same process happens in the eye and gut too. Pooling occurs with sunlight in the RPE and when we eat food. Who are the guys who proved this first in biology that these physicists missed: Mayer, Lavoisier, and Dr. Doug Wallace. I covered this unique connection in the July 2017 webinar. https://www.samharris.org/podcast/item/from-cells-to-cities
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  5. Jack Kruse

    Jack Kruse Administrator

    What is the other part of the equation? Life is designed to be as predictable as a pair of dice when you understand the thermodynamic chaos that exists on Earth. Moreover, July 2017 told you precisely why complex life stole a bacteria and turned it into a mitochondria to create excitons. Excitons are electrons excited by the sun. Excitons have this amazing property of slowing light down while simulataneously not beign able to experience time. They are timeless because they work instantaneously. This is the way life slowed light down to make a living thing. This first happened in chloroplasts and 50 million years later life figured out how to move the reaction center of the chloroplast further away to a mitochondrion to use the exact same mechanism on land based animals. The systems are coupled via their exhaust products to lower entropy. Excitons are the unseen part of nature's fabric you learned about before. Now you have to add them to the equation you got in Vermont, in July 2017 to really understand how a mitochondrion works. These sequential steps were all quantized by UV light frequencies and it allowed cells to make better predictions using solar light to gain stability to create order from chaos. This is life to a mitochondriac.
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  6. Jack Kruse

    Jack Kruse Administrator

    Melanin is a ubiquitous biological pigment with unusual physicochemical properties. It is paramagnetic, like O2 and DHA. This makes its interaction with UV light very interesting.

    One of the most unusual properties of melanin as a bio-macromolecule is its persistent electron spin resonance (ESR) signal, a clear indication of free radical centers present in the material. This tells us that it can make free radicals and excitons. This is why melanin is likely the animal photosynthetic protein that helped link RBC's ferry boats of light to mitochondrion via the skin. Melanin being a natural antioxidant that can protect pigment cells from oxidative stress by sequestration of redox-active metal ions, quenching of electronically excited states of photosensitizing dye molecules and singlet oxygen, and by scavenging of reactive free radicals. Melanin comes from tyrosine and DOPA precursors made from slowing light.
    Aromatic amino acids like tyrosine are relatively nonpolar and act like photon traps for UV light. A trap not only captures light but it slows it. To different degrees, all aromatic amino acids absorb ultraviolet light. Tyrosine and tryptophan absorb more than do phenylalanine; tryptophan is responsible for most of the absorbance of ultraviolet light (ca. 280 nm) by proteins. Tyrosine is the only one of the aromatic amino acids with an ionizable side chain. Tyrosine is one of three hydroxyl containing amino acids.

    G. Prota, M. D'Ischia, A. Napolitano, The chemistry of melanins and related metabolites, in "The Pigmentary System", ed. JJ Nordlund et al., Oxford University Press, 1988.

    Melanin is a very complex absorbing material. Melanins from natural sources fall into two general classes: eumelanin
    A black-to-dark-brown insoluble material found in human black hair and in the retina of the eye. Eumelanin is a very unusual bio-molecule.
    The characteristic emission of eumelanin does not in any way mirror the absorption or excitation line shapes. This means there is not a clear symmetry that exists between the absorption and emission of light from these proteins. This completely violates one of the most basic rules of electronic spectroscopy, the so-called “mirror image rule” of organic chromophores (Lakowics, 1999). Computationally methods failed to predict the properties of melanin despite that works in others macromolecules. I have a sense the reason why this is the case is because eumelanin is a true quantum computer itself capable or infinite interactions with the electromagnetic spectrum that only decides what it will do based upon the environment this interaction occurs in.
    pheomelanin
    A yellow-to-reddish-brown alkali-soluble material found in red hair and red feathers. A variety of low molecular weight pheomelanins are called "trichromes".

    The amount of photons absorbed by a melanosome is pertinent to oxidative reactions catalyzed by melanosomes exposed to blue or ultraviolet light. That should stop you right there.................and make you think what happens when your world goes from normal sunlight to a blue lit microwaved version of it??? Might this be why dark people have so many more heart attacks and CVA's than those without melanin when they are exposed to man made light?
    Is this why darker skin links to tightly coupled mitochondrial haplotypes and lower metabolic rates? So if we put a dark skinned person at an uncoupled latitude would this have a massive uncoupling effect on them according the July 2017 webinar?
    What sits right below the basal skin layer a few mm's down? The arteriole system of the skin where blood lies with the ferry boats (250-600nm).
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  7. Jack Kruse

    Jack Kruse Administrator

    Is the skin a giant solar panel for the brain and heart where our mitochondrial density is buried????

    Hemoglobin’s peak light absorption peaks at 280 mm 420nm 540nm and 580nm and has sharp cutoff at 600 nm since green and yellow wavelengths of krypton ion lasers peak at 531 mm and 568 mm respectively they almost perfectly match the absorption peaks of hemoglobin which is why they coagulate blood so well. Yellow is a complementary color to blue. Blue light can causes clotting of blood too, while red light makes RBC's less sticky to coagulation. Absorption spectra of the skin, aortic wall and cornea show us some interesting connections when we look at them all plotted together. In the visible range of light (sunlight). The absorption spectra of the skin is 20-30 times that of the cornea. The absorption spectra of the aortic wall exhibits VERY SIMILAR absorptionpeaks as hemoglobin. This data has been published for years. No one seems to link it. Parrish and Anderson from 1983, Keijzer et al. in 1989 and Eichler and Seiler in 1991 have all shown this. The peak absorption of human melanin pigment occurs around 335 nm, and absorption is almost completely attenuated for wavelengths longer than 700nm in melanin. This makes sense when you understand the suns spectrum is 250-780 nm on Earth.
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  8. Jack Kruse

    Jack Kruse Administrator

  9. Jack Kruse

    Jack Kruse Administrator

  10. Jack Kruse

    Jack Kruse Administrator

    Mito-Hack one, habit to break: Scroll and bowl. See picture below. The blue light of the phone directly effects the mitochondrial colony in your central retinal pathways that control all growth and metabolism pathways. Blue light increases blood glucose irrespective of the foods you eat and this raises your basal metabolic rate, increases your heart rate and BP, while lowering your heart rate variability, and shortens your lifespan as a result.
    [​IMG]

    Proof: GAME CHANGER: THE EYE's CHOROID WAS THE TRAP DOOR to slow light down and make things with mass and structure. This causes the pituitary to enlarge to make the hormones in the gland. So a lack of all hormone tells you the quantum process is not optimized for some environmental reason.

    I realized physics of light exposure controlled our biology at all levels. I told the world this in Vermont 2017.

    Much of what we believe about diet and exercise is based upon many false assumptions because we ignore the effects of light. If nutrition studies are done from season to season why don't we put animals in environments in labs that mimic those lighting environments to study the effects. Any person who observes mammals knows that mammalian appearanxces changes and reflects biochemistry changes in these animals that are entrained by light only. Many changes are also altered by temperature variations too. So it raises the point how can anyone infer anything about growth and metabolism if your experiments never controlling for variable changes that occur in seasons with respect to light and temperature? What if the light in the lab was not full spectrum sunlight, could that alone make a difference? Most researchers appear to be unaware that mammals normally do this seasonally as their environments change WITH RESPECT TO SUNLIGHT SPECTRUM!!!!

    The reason this science is tough to get is because no one really understands the leptin-melanocortin pathways with respect to a varying light and temperature gradient. UV light and cooling are the two things that are the knobs on our metabolic rate. Circumpolar uncouple mammals have HIGHER metabolic rates and when they do more work they get sick first and die sooner. So what should the Rx be. Do less, eat more fat, and embrace the cold while adding in a ton of UV light to lower heteroplasmy rates. Light is never controlled for in any nutrition studies. Neither are controlled for in biology or the nutrition studies so they are missing in all experiments. We see variations in all studies of plants and animals. Everyone knows you cannot naturally grow roses in Alaska. It hard to understand something when you do not realize its true quantized function of the mitochondria colony in the retina and skin.

    The choroid, also known as the choroidea or choroid coat, is the vascular layer of the eye, containing connective tissue, and lying between the retina and the sclera. When this "coat" changes it affects the Tarkovsky effect of the retina below and above. This affects the Fe-S couples in the mitochondrion to alter spins and free radical signalling (July 2017 webinar). The human choroid is thickest at the far extreme rear of the eye (at 0.2 mm), while in the outlying areas it narrows to 0.1 mm. Choroidal thickness (CT) increases in childhood obesity. The thickeness occurs prior to the fat mass, why? Anything that loses energy gets bigger as a result. Think about you sprain ankle, your heart after heart failure, or a star that is dying. All get bigger as they lose energy. So this means as the eye is blocked from UV/IR light FOR ANY REASON, we should expect CT to happen followed by obesity and myopia, retinal tears and AMD as they person ages. Findings revealed that adiposity causes a significant increase in CT, and it may be related to ocular complications. When we use glasses, sunglasses or contacts we change the spectral density and energy density to the choroid of the eye. Melanopsin happens to be in the outside part of the retina that the choroid happens to bring blood flow too. This means that choroidal thickness is a sign of poor melanopsin regeneration and poor melatonin production in the eye. The choroid of the eye is primarily a vascular structure supplying the outer retina where the non visual photoreceptor, melanopsin resides. Melanopsin contrl all growth metabolism functions in the central retinal pathways that connect the retina to the SCN and to the leptin receptor. This is where obesity starts. You think Gary Taubes or any food guru understands this? The choroid has several unusual features: It contains large membrane-lined lacunae, which, at least in birds (high mito capacity like humans), function as part of the lymphatic drainage of the eye and which can change their volume dramatically, thereby changing the thickness of the choroid as much as four-fold over a few days (much less in primates). It contains non-vascular smooth muscle cells, especially behind the fovea, the contraction of which may thin the choroid, thereby opposing the thickening caused by expansion of the lacunae. It has intrinsic choroidal neurons, also mostly behind the central retina, which may control these muscles and may modulate choroidal blood-flow as well. These neurons receive sympathetic, parasympathetic and nitrergic innervation. This controls tone in the vagus nerve and paraventricular nucleus. This is where adrenal fatigue begins people!

    The choroid has several other functions: Its vasculature is the major supply for the outer retina; impairment of the flow of oxygen from choroid to retina may cause Age-Related Macular Degeneration (AMD). The choroidal blood flow, which is as great as in any other organ in humans, may also cool and warm the retina which is important in how it operates with variable light frequencies from the sun as the diurnal variation in light occurs on a latitude altitude basis. In addition to its vascular functions, the choroid contains secretory cells, probably involved in modulation of vascularization and in growth of the sclera. Finally, the dramatic changes in choroidal thickness move the retina forward and back, bringing the photoreceptors into the plane of focus (eye camera function), a function demonstrated by the thinning of the choroid that occurs when the focal plane is moved back by the wearing of negative lenses, and, conversely, by the thickening that occurs when positive lenses are worn by a person. Think about that when you put glasses and contact on your eyes now.

    In addition to focusing the eye, more slowly than accommodation and more quickly than emmetropization, the data now argue that the choroidal thickness changes also are correlated with changes in the growth of the sclera, and hence of the eye because of the amount of dopamine and melatonin are made by sunlight in the retina. Because transient increases in choroidal thickness are followed by a prolonged decrease in synthesis of extracellular matrix molecules and a slowing of ocular elongation, and attempts to decouple the choroidal and scleral changes have largely failed, it seems that the thickening of the choroid may be mechanistically linked to the scleral synthesis of macromolecules due to the variation in solar frequencies. Thus , the choroid maybe the key player and be the most important role with sunlight to give humans homeostatic control of eye growth, and melanopsin function and, consequently, in the etiology of myopia and hyperopia and circadian diseases that can ruin mitochondrial function in the RPE of the eye. As the picture below show small amounts of UV light getting through the lens into the choroid is critical in the eye. https://www.ncbi.nlm.nih.gov/m/pubmed/28060389/
    [​IMG]
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  11. Jack Kruse

    Jack Kruse Administrator

    Do you feel me now?
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  12. Jamie Ward

    Jamie Ward Gold

    So lowering respiration is a good thing for us... now I can see another angle to cold water swimming holding your breath might be useful...
  13. Jack Kruse

    Jack Kruse Administrator

    For you and Kate.......yes. Kate more than you. She has a pod in her you and I most concerned with and that POD is connected via her retina. You'll understand my brother. We're entangled now.
  14. Jack Kruse

    Jack Kruse Administrator

    they key between my words in Vermont:
    It is hard to see what you don't know is even there--isn't it, (doubly true for a physician). I think Osler, the great MD quoted something very similar, I just read it and was totally in agreement. -->here it is "The eye cannot see what the mind does not know" We don't see UV and IR because the mind is not allowed to ponder what they do much less what they mean as that light slows.
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  15. Jamie Ward

    Jamie Ward Gold

    What were the hair hacks and effects?
  16. Jack Kruse

    Jack Kruse Administrator

    Not talking about them yet because I am not going in another direction with them based upon the failures over 4 years.
  17. Jack Kruse

    Jack Kruse Administrator

    NASA LISTENS IN AS ELECTRONS WHISTLE WHILE THEY WORK.

    Light gets slowed when electrons absorb light photons = excitons

    When this happens is sound made?

    Space is not empty, nor is it silent. While technically a vacuum, space nonetheless contains energetic charged particles, governed by magnetic and electric fields, and it behaves unlike anything we experience on Earth. In regions laced with magnetic fields, such as the space environment surrounding our planet, particles are continually tossed to and fro by the motion of various electromagnetic waves known as plasma waves. These plasma waves, like the roaring ocean surf, create a rhythmic cacophony that — with the right tools — we can hear across space. https://www.nasa.gov/feature/goddard/2017/nasa-listens-in-as-electrons-whistle-while-they-work
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  18. drezy

    drezy Gold

  19. Jamie Ward

    Jamie Ward Gold

    Jack, you said gravity is neglible in space/non-existent so yarkovsky effect works. You say the same is happening in the mitochondria. I thought before we were saying mito's have magnetism and it is shown where there is magnetism there is gravity? Don't the forces adjust at small scales?
  20. Jack Kruse

    Jack Kruse Administrator

    Mitochondria make magnetic fields from the spinning head of the ATPase. Field emant from the mitochondrion. Within the cell gravity is negligible because of the water it makes. This means that all the Fe-S couples in the mouth of cytochromes are in a gravity less field.......making it very likely the Yarkovsky effect is present. Moreover, phyicists know the effect increases as size goes smaller.......this is additive to my argument.

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