IS Alzheimer's disease a PHOTOelectric disease too?

Jack Kruse · Apr 21, 2022

https://pubmed.ncbi.nlm.nih.gov/32305654/

Jack Kruse · Sep 14, 2022

The ipRCGs in the eye is the melanopsin blue light detectors that link to SCN & and the habenular nucleus of the brain. The habenula is a complex nucleus in the thalamus of humans composed of lateral and medial subnuclei, which connect between the limbic forebrain and midbrain in the brainstem as shown below. Over the past 5 years, the lateral habenula has finally received considerable attention because of its potential roles in cognition and in the pathogenesis of various psychiatric disorders.

The habenula is an evolutionarily conserved structure in the brain and regulates the central monoaminergic metabolism in humans. Disturbances in monoamine metabolism include depletion of norepinephrine and suppression of central dopamine in the brain. This region is a light relay center for the brain. It is very close to the pineal gland and the collicular plate which links it to all things visual. This is why eye changes tells us about the brain's toxic light effects. Despite a surge of interest in the habenula in neuroscience since 2016, the function of the human habenula remains murky to centralized MDs.

https://medicalxpress.com/news/2022-08-insights-retinal-neurons.html

For example, the medial habenula is the source of one of the major cholinergic pathways in the brain, but relatively few studies have been conducted to understand its roles. When acetylcholine is destroyed in the brain, cognition drops due to a fall in mitochondrial redox power, water inside cells decreases and K+ and Ca2+ shifts in the cells DESTRUCTING cell water (bad battery), and low ACh is associated with Alzheimer's disease. I believe this is how AD begins and develops photoelectrically.

Nicotine addiction operates in this situation as well. This is why I believe people who wear blue-blocking glasses find the use of nicotine to become more difficult over time. People who are blue light toxic almost seem immune to it. This is another clue I use in patients during their workups to know how badly blue light toxic they are.

I believe this nucleus holds the clues to many diseases including depression, bipolar disorder, and Parkinson's disease. I also believe this pathway is acutely disrupted in people who use exogenous steroids when their brains are low in Vitamin C due to light stress. Giving these patients synthetic steroids, while they are blue light toxic, hyperactivates glucocorticoid receptors preferentially in the SCN, PHb, and the hypothalamus simultaneously, which suppresses the secretion of cortisol by the adrenal glands. Few physicians understand these light relationships.

This is why most modern humans have flat-lined cortisol cycles when one checks their cortisol levels. Decentralized MDs know to look for it, and centralized MDs think this is quackery because they are ignorant of the neural wiring diagram above from the retina to the midbrain.

The slide above tells you how the pathophysiology develops. Chronic blue light exposure ruins the regeneration of the ipRRGs in the retina via the destruction of dopamine and melatonin in cells. They rely on optimized dopamine and melatonin levels to keep our timing mechanisms via the SCN intact. When the photoreceptors cannot regenerate mood disorders can also manifest because of the disruption of the tracts from the IpRCGs to the perihabenular nucleus.

The slide above shows when dopamine control is lost in the central retinal pathways, GABA also will be lowered in the brain. Remember what I said about all the musicians who killed themselves in various podcasts I've done? They were also abusing GABA-like drugs (benzodiazepines). Most of them smoked as well. Now you might understand why they were doing it now. What else happens? Acetylcholine receptors will drop and as this happens, acetylcholine levels will rise in neural circuits to also lower GABA.

A deficiency in ACh receptors and lowered dopamine levels can mimic myasthenia gravis (check my MG blog on Patreon out) with poor muscle tone. A deficiency in GABA activity can contribute to certain mental health conditions such as anxiety disorders, schizophrenia, and depression. It's also involved in some physical conditions, including Huntington's disease, dystonia, and muscle spasticity. Low dopamine levels are also associated with mood disorders like depression. These deficits all get worse and eventually are all present at the same time when the human brain begins to contemplate taking its own life.

What raises cortisol best in Nature? Bright AM sunlight via the central retinal pathways at sunrise.

When you are given exogenous steroids and you do not get enough sunlight, it is the perfect storm for getting steroid-induced psychosis. This is a key point why a lack of sunlight or too many exogenous steroids cause the same problem = MENTAL ILLNESS or neurodegeneration