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IS Alzheimer's disease a PHOTOelectric disease too?

Discussion in 'Educating Doctors' started by Jack Kruse, Jan 11, 2019.

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  1. Jack Kruse

    Jack Kruse Administrator

    AD = lack of solar redox.

    Oh so you still think sunglasses, clothing, and sunscreen are good modern human ideas that don't affect the SCN or peripheral clocks in your cells? Consider nature's lessons carefully. What does full spectrum sunlight destroy naturally? UVA and B light naturally lowers adrenalin (the stress hormone of the sympathetic nervous system) while its photons re-zip collagen that cortisol release causes at 4AM that wakes us up by allowing water flows to occur between glial cells and neurons via the aquaporin 4 gates in the brain. AM sunrise light has no UVA or UVB present initially. It has blue, green, and red present. It has more blue than any other part of the spectrum and this is stimulatory to waking us up. Naturally, UVA light shows up later in the AM, depending upon your location in latitude, and this frequency of UVA light acts to begin to re-zip the collagen in our skin and eyes. That initial blue light stimulus from the sun’s rise is used to unwind our collagen to increase water flows to stretch the interspaces in neurons to wake our body and mind up at dawn from sleep. The aquaporin 4 gates are what are destroyed in Multiple sclerosis, which is another autoimmune condition.
    When we are missing UV and/or IR light for any reason, these photoelectric and photochemical are not made. When full spectrum sunlight is absent in someone who is chronically stressed for any reason, sleep cannot be induced by the adenosine chemical signal from the hypocretin neurons because the incident light signal of blue blocks it. What else blocks cellular regeneration by circadian de-coupling? Lack of full spectrum solar exposure is the most common reason and most overlooked issue in all of medicine these days. Proper ocular melatonin cycle requires that these two frequencies (UV/IR) of light be present to stimulate the regeneration processes in the eye during daytime. It also requires ABSENCE of blue 400-465nm at sunset!!!! When these things are off the result always = INFLAMMATION = too many protons and/or not enough electrons at the mitochondrial cellular level. If you think about your childhood, when you spent the day at the park of the beach, you might remember how easy it was to fall asleep and get a sunburn. The reason is simple, sunlight induces sleep because the regeneration pathways that use melanopsin need daylight to regenerate. When you did fall asleep, the redness of your skin did not come from the thermal burn, but it was from the increased blood flow due to the release of nitric oxide that acted to bring the arterioles of the dermis layers to the surface. This is a natural photochemical change induced by sunlight to allow the skin to absorb the UVA and UVB light at the surface. UVA and UVB light does not penetrate deep. To absorb the UV light we need the circulatory system to come from the dermis because UV light does not penetrate skin more than a millimeter. The NO engorges and vasodilates the arterioles containing the RBC’s. The RBC’s are filled with hemoglobin and porphyrins that absorb both UV and IR frequencies. Form meets function photoelectrically. The sunburn is really an absorption of too much thermal IR energy. It is a time phenomena not a sun phenomena based upon your sun callus and skin type. Deep sunburns can result from several factors: excessive sun, or thin skin, thick skin, or a poor adaptation to seasonal light due to chronic use of UV blocking makeup, clothing, or sunblock use in strong light cycles. Today we bury the sun and get diseases caused by inflammation. The sun is not the cause of our problems..........no matter the paradigm's belief or your own. https://jlb.onlinelibrary.wiley.com/doi/full/10.1189/jlb.3RU1015-451R
     
  2. Jack Kruse

    Jack Kruse Administrator

    Photobiomodulation = red light therapy.

    We do this at Kruse Longevity Center. If one 7th of the solar spectrum can help Alzheimer's what might the entire power of the sun do for AD patients and protein misfolding?
    The sun reduces all-cause mortality......paper published by physicians act like there is no way it could be true........why? See my pic below as an illustration
    Now think about what the sun can do. If these little devices talked about in this paper can do this much, how can we harness the power of natural sunlight to go much much further than this?

    [​IMG]
    Black Swan mitochondriacs I will be training will learn how it happens. That is the future of medicine.
    https://www.linkedin.com/pulse/growing-evidence-supporting-photobiomodulation-alzheimer-lew-lim/
     
  3. Jack Kruse

    Jack Kruse Administrator

    Ferroptosis is defined by the iron-dependent accumulation of lipid peroxides and is genetically (DNA/mtDNA) and biochemically distinct from other forms of programmed cell death such as apoptosis, necrosis, and autophagy. It is linked to why many gas anesthetics are linked to neurotoxicity in people neurodegeneration. It causes more mitochondrial damage during anesthesia because these patients colony of mitochondria are already damaged and have low redox states. The ferroptosis worsens the situation.

    GPX4 is a lipid repair enzyme, which reduces lipid hydroperoxides to lipid alcohols and limits the initiation of ferroptosis. Inhibition of GPX4 activity leads to rapid accumulation of lipid peroxides and cell death, and deletion of GPX4 is embryonic lethal (Seiler et al., 2008; Yang et al., 2014), therefore GPX4 expression has been used as a marker for ferroptosis in studies I have read.

    Ferroptosis was first described in Dixon et al. (2012). It is a newly recognized mechanism of programmed cell death characterized by the iron-dependent accumulation of lipid peroxides (Angeli et al., 2017; Stockwell et al., 2017; Zilka et al., 2017). 2% isoflurane for 6 hours in anesthesia of nocturnal mammals induced cell death by ferroptosis.

    It appears the mechanism is driven by downstream inactivation of glutathione peroxidase 4 (GPX4, Yang et al., 2014). Peroxidase enzymes are ALSO ALL HEME containing proteins. I believe the fluoride in the inhalational drugs is ONE of the proximal cause of the iron-dependent accumulation of lipid peroxides because it causes a dielectric collapse in the metabolic water around these proteins in mitochondria. I also think this leads to melanopsin dysfunction in the circulatory system where the most heme iron-containing proteins exist in man. The second critical spot they are found is in the mitochondrial membranes of man. This has not been studied as far as I can tell in 2019. The normal dielectric constant of water is 78 in bulk water but it has been shown to be 160 in metabolic water or EZ. I have been waiting for papers to link melanopsin dysfunction to a falling dielectric constant in the anesthesia literature but no luck on that so far. I strongly believe these mechanisms are linked.

    Mitochondrial cytochromes are all heme-containing lipid proteins. This would cause acute colony failure of the photoreceptors there. I bet it would alter catalase in the cell as well which quenches free radical signal H202 as well. Catalase is another heme-containing protein. All heme-containing proteins seem to be red light chromophores as well. Hemoglobin is the main red light chromophore porphyrin in our blood. Hemoglobin has a strong ability to absorb light between 250-600 nm. UV light spectra go from 250-399nm in man. The word porphyrin is derived from the Greek word which stands for purple. Purple light is UV light color in the solar spectrum. Again here you see the link back to UV and IR light in these disease mechanisms. This is why photobiomodulation seems to help in some of these disorders, in my opinion. Few people are making these links in the literature.

    Emerging evidence suggests ferroptosis contributes to neurodegenerative diseases and brain injury associated with oxidative stress (Skouta et al., 2014), including brain hemorrhage (Li et al., 2017), Alzheimer's disease (Fine et al., 2012; Guo et al., 2013), Huntington's disease (Yang et al., 2005; Niatsetskaya et al., 2010; Speer et al., 2013), stroke (Tuo et al., 2017) and traumatic brain injury.

    CITES:
    https://www.ncbi.nlm.nih.gov/pubmed?Db=pubmed&Cmd=ShowDetailView&TermToSearch=22632970
     
  4. Jack Kruse

    Jack Kruse Administrator

  5. Jack Kruse

    Jack Kruse Administrator

    The parabiosis longevity link = astrocytes loaded with Vitamin C = Belousov effect.

    MANF (mesencephalic astrocyte-derived neurotrophic factor) is one of the factors responsible for rejuvenating the transfused older mice according to new research. Shocking no one who reads biophysics.

    We know that MANF regulates metabolism and immune response in flies, mice, humans. what they forgot is that none of them can make their own Vitamin C either.......hence why the parabiosis effect is an RBC's effect.

    The myopia of researchers amazes me.
     
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  6. Jack Kruse

    Jack Kruse Administrator

    What did Dr. Cunnane miss for the Black Swan in training about AD in this video? He is studying food as the fuel effect to see if this is the mechanism behind it and even his initial results do not show this. He has no idea it is not the FUEL effect, and to his credit, he even says it at the end. The food gurus will misuse this talk because they do not understand the real mechanism is in the cytochrome proteins of the matrix and this becomes critical in how we'll build a full understanding of how altered electromagnetic fields cause AD from light.

    Glucose metabolism drops because cytochrome 1 is destroyed by the electromagnetic environment created by non solar light sources. This is mediated via melanopsin dysfunction. At the same time, the effect of nnEMF increases AMPk and glucose in the blood (Volkow/Frey).

    This causes a drop in NAD+ and oxygen (Sinclair) and it will affect both glucose and the ability to perform beta-oxidation because of changes in the morphology of the mitochondria at the IMJ. Megan McManus and Dr. Doug Wallace did this work. Ketone metabolism in the human brain will still decline over time as heteroplasmy expands for any mechanistic reason over time either in this alien environment or as they age. The mechanism humans are facing now is the electromagnetic pollution in their environment and this is what drives the fuel effects that Dr. Cunnane lays out. I hope people STOP their myopic focus on the fuel and realize AD is a photoelectric disease tied to light signaling which changes the mitochondrial cytochromes that handle carbohydrates in the matrix in very specific ways.

    https://www.youtube.com/watch?time_continue=19&v=OU26epaihmw
     
  7. Jack Kruse

    Jack Kruse Administrator

    Bad science here. When the BBB is leaky and open like it is in AD many things get in that should not. Moreover, the reason AD looks like an infection is that mitochondrial dysfunction is part of AD and mitochondria come from PROKARYOTES so as they break down they simulate a prokaryote disease caused by bacteria who got a free ride into the brain. People forget the basics.......what opens the BBB easiest? nnEMF = Allen Frey research from the 1960s. So is the key the bacteria or what opened the floodgates? The methodology in this paper is atrocious and there was no light controls and many confounders. People should ignore papers like this because all they do is confuse people further and add more bad science to the published literature.

    https://www.sciencealert.com/new-evidence-reveals-an-unexpected-culprit-behind-alzheimer-s-disease
     
  8. Jack Kruse

    Jack Kruse Administrator

  9. Jack Kruse

    Jack Kruse Administrator

    WHY MUST YOU HAVE SKiN IN THE GAME FUNDAMENTALLY?

    Animal photosynthesis requires it.

    Could melanin make photosynthesis likely in animals? Photosynthesis in plants is considered the most important chemical reaction in the world because is the first step in the food chain. The first clues of the process were detected by Lavoisier and others during the XVIII century, but the exact nature of the chemical reactions involved remain poorly understood. Moreover, dissociation of the water molecule constitutes the very first reaction of photosynthesis in plants, and was unsuspected, even unthinkable in human beings, until we found it in human retina in the 1990s. The discovery of the amazing capacity of our body to makes the dissociation of the water molecule breaks the paradigm: Plants and human beings have the same very first reaction as the origin of life. The impact in the field of molecular biology is huge; therefore the role of the water and glucose must be redefined, glucose is just a source of biomass, instead water is the real source of energy of the eukaryotic cell, and neuron cell is not an exception. The main source of energy of the CNS is the CSF and therefore the ventricles and subarachnoid space. Blood vessels are merely source of biomass. By the analogy with the process in plants, our discovery was named human photosynthesis. Human being begin to lose the capacity to split the water molecule at 26 years old, ca. 10 % each decade, and after the fifties goes into free fall. Our research along these 23 years thought us that medical modulation of human photosynthesis has extraordinary therapeutic results in CNS´s diseases.
    Melanin is a human chlorophyll; Melanin is to animal kingdom as chlorophyll is to plant kingdom. Both molecules have the amazing capacity to split the water molecule at room temperature. Both of these chemical makes is possible to burn water to liberate electrons. Photosynthesis is the only known process that is capable of actually burning water. But the process in chlorophyll is irreversible and melanin makes the process work in two way. The first is the dissociation and reforming of water molecule with the consequential release of energy.

    The human body has a photosynthesis system composed by Light/ Melanin/ Water, arranged in order of abundance in nature. Melanin is able to absorb the full electromagnetic spectrum, from radio to gamma rays, in contrast, chlorophyll just absorbs blue and red light (400 to 600 nm). This is why plants are surface quantum machines and animals are full thickness solar machines. Secondly, melanin has the intrinsic property to split and reform the water molecule using hydrogen peroxide, and the reaction happens as follows:

    2H2O ↔ 2H2 + O2 + 4e
    Melanin has the astonishing capacity to split the water molecule at room temperature, for instance, in the laboratory, it is necessary to heat up water at 2000°C in order the reach the separation of hydrogen from the oxygen atoms. Melanin is a biogenic amine like dopamine, melatonin, serotonin, and histamine. Moreover, melanin supports the reunification of water molecule giving off liquid water and four high energy electrons. The reaction is not symmetrical in time or optically because, like any other chemical reaction, depends of the photochemistry of the microenvironment

    Human Photosynthesis and the eukaryotic cell breaks the ground of the cellular metabolism, the energy released symmetrically in all directions by melanin is a real source of photonic energy of the eukaryotic cell, and the neuron cell is not an exception. All melanocytes are from neuroectoderm. There is a misconception in photosynthesis that the creation of glucose as is the main source of energy. This bad idea comes from the observation that in plants glucose is the main product of energy absorption photosynthesis. The traditional diagram of photosynthesis must changes as follows:

    6CO2 + 6H2O → C6H12O6 + 6O2 + Energy
    Thus, instead of energy, the word biomass should be used: In this way, light is turned into matter and mass by slowing down as the electromagnetic field changes to suit the form nature requires in the transmutation of energy from one form to another. Electromagnetic fields are the shape shifters and speed controllers of light waves. Mother Nature has optimized how to use them in life forms.

    6CO2 + 6H2O → C6H12O6 + 6O2 + Biomass
     
  10. Jack Kruse

    Jack Kruse Administrator

  11. Jack Kruse

    Jack Kruse Administrator

    So if you are devoid or defective in melanin biology what happens? What are some effects you should be aware of? Well, the sun makes the blood-brain barrier LESS PERMEABLE and has the same effect on the gut barrier by calcium ionic resonance of the voltage-gated channels in cells.
    What do man-made fields do to the BBB and gut? Aberrant non-solar Electric and magnetic fields open the BBB in case you were unaware (Frey Volkow research).

    It is about time for people to realize if an MRI can do it as the link below shows........What will your 1G- 5G city do its topology over your lifetime? You think this is RISK-free. Nature is going to give you a do-over?
    These are questions nobody thinks to ask after reading click bait marketing nonsense for the paradigm of neurodegeneration we have globally created with blue light and technology.

    For the first time, researchers at Sunnybrook Health Center in Toronto have temporarily opened the blood-brain barrier using MRI-guided focused ultrasound in multiple regions of the brain in a patient with Alzheimer's disease. Areas being targeted in this trial include the hippocampus and parietal lobes, which are critical for cognition, memory, and learning.

    "It is important to establish that opening the blood-brain barrier in these critical brain structures, repeatedly, is safe," says Dr. Nir Lipsman, principal investigator of the trial. "We are also determining what influence this may have on amyloid deposits in patients with Alzheimer's disease."

    If it is safe why did nature build a Faraday cage of protection around the brain of water and myelin?
    Sorry Doc Lipsman, your logic escapes the mitochondriacs basic smell test of steaming bullshit here. They are preying on the ignorant in case you haven't figured it out yet folks.

    https://sunnybrook.ca/media/item.as...6GviD8j6qUbP0uXBLVAtFGzQpb8Tornj5Cx9PgO4fJT-0
     
  12. Jack Kruse

    Jack Kruse Administrator

    Glucose metabolism is altered in AD.

    What do insulin and melanopsin have in common? Insulin normally increases blood flow via vasodilation, something that becomes compromised with insulin resistance.

    Where do they differ?

    Insulin is a solar hormone that is stimulated by purple and red light light balancing the effect of blue light and melanopsin is stimulated by blue light. Sunlight has blue but the dose response curve of blue is always buffered from the toxic effects by red light in sun which makes up 42% of terrestrial sunlight.

    When you subtract the purple and red light out you get a relative toxic dose of the blue light hazard and this leads to insulin resistance and melanopsin dysfunction.

    Just standing behind a pane of glass gives this effect and it raises your APMK signaling and glucose levels as if you just ate a snickers bar and nobody seems to realize it.

    https://www.linkedin.com/pulse/insulin-solar-light-hormone-like-vitamin-d3-jack-kruse/
     
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  13. Jack Kruse

    Jack Kruse Administrator

    Remember how the thread began?

    AD = lack of solar redox........

    Let us dive even deeper in the quantum answer to this disease.

    Just standing behind the glass panes in your house can raise your risk for dementia = increased blue light hazard = higher risk of AD. Wait, what do you mean Jack? Could this study be possibly hinting that Alzheimer's disease is also linked to indoor living in the blue light as Uncle Jack has been saying for 15 years? YEP. Study Offers Hint of Hope for Staving Off Dementia in Some People - if you treat high blood pressure aggressively, it might just help both your heart and your brain. https://www.nytimes.com/2019/01/28/health/dementia-blood-pressure-cognitive-impairment.html
     
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  14. Jack Kruse

    Jack Kruse Administrator

    ^^^^HOW IS THIS POSSIBLE UNCLE JACK?

    Every mitochondriac does the sun, so why can't we all do it?
    [​IMG]

    Over supplemented on medications for your BP comes from your doctors being undereducated about light. Your inability to control your light environment makes your BP even worse. Time to get off your ass and get in the sun people and stop trying to use man-made drugs when nature prescription is free and easy to use.

    [​IMG]

    Researchers have shown that when our skin is exposed to the sun's full spectrum rays, Nitric oxide is released into our microcirculation in our blood vessels that helps lower blood pressure while ALSO slowing electron chain transport to decrease our need for food. The findings suggest that exposure to sunlight improves health overall because the benefits of reducing blood pressure far outweigh the risk of developing skin cancer. Full spectrum sunlight also reduces the need for food so it is the way nature asks us to naturally calorie restrict ourselves.

    UVB and UVA and the VDR receptor augment this "fasting effect" on our colony of mitochondria. Very few people understand how sunlight truly keep us well.

    Do not be a fool and think standing behind a pane of glass on a sunny day is wise. It is not. WHY?

    Glass in windows blocks all UVB and most UVA light. It blocks 30-60% of IR light and HAS no effect on blue light from the sun so on a relative basis standing behind glass inside means no Vitamin D3, markedly reduced nitric oxide production which raises your BP, reduction of red to lower your ATP production, and excessive amounts of blue through. Acutely this can be a short term win, but chronically it is a big problem. You could set yourself up for dementia from AD and diabetes. Excessive blue light ruins many key biochemical programs in the brain contrary to what the "experts" have reported.

    Production of this pressure-reducing compound - called nitric oxide - is separate from the body's manufacture of vitamin D3 from cholesterol in the skin, which rises after exposure to sunshine later in the day. UVA light and NO are made much earlier in the day. But you must have skin in the game to gain the benefit.

    Until now only Vitamin D3 had been thought to solely explain the sun's benefit to human health. In 1992, the Nobel Prize in medicine was given for the discovery of nitric oxide. Researchers studied the blood pressure of 24 volunteers who sat beneath tanning lamps for two sessions of 20 minutes each. In one session, the volunteers were exposed to both the UV rays and the heat (IRA) of the lamps. In the other, the UV rays were blocked so that only the heat of the lamps affected the skin. The results showed that blood pressure dropped significantly for one hour following exposure to UV rays, but not after the heat-only sessions.

    Scientists say that this shows that it is the sun's UVA rays that lead to health benefits. The volunteers' vitamin D levels remained unaffected in both sessions.

    Common sense does not grow in every garden. It is the Black Swan Mitochondriac wisdom that the benefits to heart health of sunlight will outweigh the risk of skin cancer. The work published in the literature shows overwhelming evidence of the longevity benefits of solar redox. It provides a QUANTUM mechanism in humans that account for these mitochondrial effects and also explains why dietary vitamin D supplements alone will not be able to compensate for lack of sunlight. Any dermatologist who tells you this is committing malpractice, in my view. We now need cardiologists to reject the "dermatologist evidence" about the sun to look at the relative risks of heart disease and skin cancer in people who have received different amounts of sun exposure. Black swans already know it will confirm that sunlight reduces the death rate from all causes because many other studies have already shown the effects. Humans, who understand light well need to reject the medical paradigm's version of evidence because it is now crystal clear we ALL need to reconsider "the professional advice" that has been given on sun exposure as a falsehood misunderstood based on things never considered in the original studies done in the 1950s in dermatology.
    — at Kruse Longevity Center.
     
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  15. Jack Kruse

    Jack Kruse Administrator

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  16. Jack Kruse

    Jack Kruse Administrator

    AD begins at the eye and skin when we see an alien spectrum of light and that light alters the circadian biology of iron compounds in RBC's that lead to ferroptosis. The nnEMF from the environment works with the light to open the BBB and let the small molecular weight proteins from this ferroptosis into the brain to begin mitochondrial destruction of the brain in many ways.

    The REDOX state of our brain is linked to RBC's circadian clocks because this organ gets 20% of the cardiac output tied to blood flow........just as my Patreon quantum thermodynamic and reality series has shown.

    Circadian clocks are fundamentally important for coordinated physiology. Current models of the clockwork in eukaryotic cells are based on transcription-translation feedback loops of the PER gene. AM sunlight increases PER one transcription every AM and PER proteins must get destroyed every night. Light is what controls this process.

    The 2017 Nobel prize in medicine was awarded for research on these feedback loops. Non-transcriptional mechanisms in the clockwork have been difficult to study in mammalian systems in research for many reasons. Improper light controls are one MAJOR reason.

    This research group developed novel assays using (RBCs), which have no nucleus (or DNA), and therefore cannot perform transcription.

    The results of the paper showed - transcription is not required for circadian oscillations in humans - and those non-transcriptional events appear sufficient to sustain cellular circadian rhythms.

    Peroxiredoxins in RBCs, undergo ~24-hour redox cycles via light dark changes, which persist for many days under constant conditions. (i.e. in the absence of external cues). Peroxiredoxins are heme/Fe proteins.

    Moreover, these rhythms are entrainable (i.e. tunable by environmental stimuli, light, food), and temperature-compensated, both key features of circadian rhythms. By demonstrating these oscillations with a number of cytoplasmic redox parameters that are common to nucleate and non-nucleated cells. The group has seemed to have uncovered interconnectivity between distinct cytoplasmic (DDW metabolic) and nuclear circadian processes. It is clear they do not have the mechanism link to metabolic water fully dialed in.

    The transcription of clock genes (PER) is sensitive to metabolic changes in water production in mitochondrial reduction and oxidation (redox) reactions; however, circadian cycles in protein oxidation have been reported in anucleate cells, where no transcription occurs. RBC's are such a cell and act as a light ferry to the mitochondria.

    https://www.sciencedaily.com/releases/2019/01/190114130825.htm
     
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  17. Jack Kruse

    Jack Kruse Administrator

    Peroxiredoxins are heme proteins and subject to retinal destruction due to melanopsin dysfunction = ferroptosis risk that cause the circadian disruption of the neocortex via the blood and RBC's. The physiological importance of peroxiredoxins is illustrated by their relative abundance. They likely can affect the formation or PER1, 2, and 3 in the brain because they also use phosphorylation mechanism to change the physiologic function of PER.

    They are one of the most abundant proteins in erythrocytes after hemoglobin is peroxiredoxin. They are a ubiquitous family of antioxidant enzymes that control cytokine-induced peroxide levels and thereby mediate signal transduction in mammalian cells.

    I hope you recall that cytochrome 2, 3, and 4 make hydrogen peroxide free radicals that are critically related to peroxiredoxins. Recall H202 is quenched by catalase. Catalase is another heme related protein subject to retinal destruction.

    Peroxiredoxins can be regulated by phosphorylation, redox status such as sulfonation, acetylation, nitration, truncation and oligomerization states. All of these are affected by the light environment of the animal in question.
     
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  18. Jack Kruse

    Jack Kruse Administrator

    The light signal is defective from the skin to RBC in AD and this changes the BBB. I covered this in my Vermont 2017 via when I showed some slides of how light waves resonate with RBC's to make toroids sound waves in the blood vessels that release NO from the arterial wall to change the microcirculation of the brain and BBB.

    For the timing gear shift in RBC peroxiredoxins, the amino acid cysteine is the key time crystal that is likely defective and leads to an oxidized state which does not work. This will affect phosphorylation of PER protein and it won't operate in the brain and likely leads to eventual apoptosis in the frontal and temporal lobes of man where glucose metabolism is defective where the BBB is permeable from nnEMF around us. Trauma can also induce this in my opinion and I think this mechanism is shared with ALS with head and neck trauma. Once the phosphorylation of PER is altered it leads to collateral destruction in neurons over time by altering the chaos/self-ordering effects found in how entropy is used in cells to self organize.

    These enzymes in RBC share the same basic catalytic mechanism, in which a redox-active cysteine (the peroxidatic cysteine) in the active site is oxidized to a sulfenic acid by the peroxide substrate. Cysteine becomes afunctional when it is oxidized and it turns out this is a big issue in the methionine cycle = ruins PER diurnal function being made in the AM in the cytosol by sunlight and then entering the nucleus to affect its function.

    See my comments in QT #14 about methionine as a TIME CRYSTAL for your blood.

    The recycling of the sulfenic acid back to a thiol is what distinguishes the three enzyme classes. 2-Cys peroxiredoxins are reduced by thiols such as thioredoxins, thioredoxin-like proteins, and glutathione, while the 1-Cys enzymes are reduced by ascorbic acid and/or glutathione in the presence of GST-π. This can be augmented with DDW by clinicians who understand the mechanisms I mentioned in detail the November 2018 webinar.
     
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  19. Jack Kruse

    Jack Kruse Administrator

    Why is understanding methionine important as a time crystal? It is one of the key rare sulfur-containing amino acids that help us tell time by passing phosphorus to the PER one gene product every AM. Sulfur also cools the temperature of these proteins for environmental sensing and adjusting of the PER gene product.

    How?

    Throughout 4.5 billion years of molecular evolution, proteins have evolved in order to maintain the spatial proximity between aromatic residues (Trp, Tyr and Phe) and disulfide bridges (SS) (Petersen et al, 1999).

    We might call this mechanism of how light interacts with certain aromatic amino acids and sulfur-containing amino acids how the fractal geometry of life begins. It is a key molecular quantum connection you must understand because it is BASIC to most photoelectric diseases in humans.

    There is a very special spatial geometric relationship that exists because the process is quantized to light frequencies that our star releases to us on Earth wirelessly. This has not been well appreciated by modern healthcare. This is also why the sun reduces all-cause mortality and why it can never be replaced in healthcare. I also believe this is why solar redox is critical to having a child with great morphogenesis and the normal adult form. It can also take a normal organ like the brain and turn it into mush over a life time spent in blue light and nnEMF.

    HOW?

    To suggest this is lunacy is not wise when you really understand the biophysics of amino acids in our cells well.

    The interaction of the most powerful part of the solar spectrum of light (UVA/B/C) measures the collisions in the aromatic amino acids and in the disulfide bridges. THIS IS why the 2017 Nobel Prize in medicine is important to understand and fully understand to understand what UNCLE Jack is teaching you. PER is a protein made every AM by SUNLIGHT stimulus as the picture below shows.

    [​IMG]

    Why is this picture a big deal in understanding AD photoelectric origins? When PER1 cycle is off because of aberrant light or nnEMF so is NAD+ at cytochrome 1 in the mitochondrial matrix and this causes advanced aging in man = David Sinclair's paper in Dec 2013.

    NAD+ is one of the more immediate players in cytochrome 1 that is a huge driver of circadian biology in humans. I told you NAD+ is made from the other time crystal in biology called Tryptophan. Tryptophan also makes melatonin and melatonin is what controls autophagy and apoptosis in humans cells.

    NAD+ is the coenzyme called nicotinamide adenine dinucleotide (NAD+). It participates in a variety of redox reactions in the matrix that help generate DDW. Solar exposure and fasting work with light frequencies to slow ECT flow and this can increase the intracellular NAD/NADH ratio if the light environment is dominated by sunlight. It won't do this with artificial light. It lowers NAD+. This is what sets off a cascade of circadian events that can destroy tissues because they involve epigenetics and the regulation of growth and metabolism of man. LIGHT DOES THIS. NOT FOOD OR FUELS.

    SUN + fasting induced by sun exposure (NO from UVA and IR from sun) ---> increased PER1 creation and cycling is controlled by AM sunlight ---> raised NAD+ -> SIRT1 -> BMAL1/CLOCK -> NAMPT -> NAD+ is increased at cytochrome 1.

    NAD+ major effect is to activate the sirtuins and keep PER on the schedule being made in the cytosol to penetrate the nucleus at night as the reaction above shows in the picture. SIRT 1 is another gear in the light lattice clock that keeps PER on time and SIRT is a family of deacetylase enzymes. When you understand what UV and IR light are doing to a matrix and cytosol at the same time, you can see why fasting and AM light exposure is potentially the best circadian hack one could do for a reset. It won't work in fake light (nnEMF =BBB leaky) when ALAN is present. Eating protein stimulates the thermogenic gears of the clock = why the Leptin Rx uses it.

    BACK TO THE AMINO ACIDS


    The aromatic amino acids location becomes the first step in determining where the position and geometry of residues to act as nanosized antennas in the protein world that can capture UV light (from ~250-298nm). This could be another "yes or no binary code" that cells use to build tissues. You can see why the idea of a time crystal is paramount now when you are building a life form. Think about what I said in my Vermont 2017 and 2018 video now in this light!!!


    The first two protein bends are always determined by nuclear DNA coding and this would save us a lot of time in morphogenesis. The last two bends are tied to the redox state which is linked to this quantum photoelectric process I am describing here now. This is what is defective in AD patients. If the timing of PER is off for any reason at all the binary code of " yes and no's" buried in light frequencies in RBCs (peroxiredoxins) ferried to neurons are off and as a result the protein folding is off, and you'll make glitches in the folding of proteins and organelles in cells and tissues.

    The amount of misfolding affects the ELF-UV light signal the cell can make. Bad folding = more ELF-UV release = more neural tissue destruction.


    Once excited by the incident ELF-UV light these amino acids can enter photochemical pathways likely to have harmful or beneficial effects on protein structures (yes and no binary code plays a role here again) by affecting specific bonds like disulfide bonds in cysteine/cystine on the PER protein made every AM via RBC peroxiredoxins.

    In the circadian mechanism, their effect on the PER protein that is made every AM by sunlight exposure on our body is critical in the right amount of phosphorylation in our cells to tell proper quantum time in neurons and glial cells.

    These two sulfur amino acids are the rarest amino acids in our proteins, and as such can acts as the ideal photo-optical switch or gate for signaling of phosphorylation of PER because of they a relatively rare in humans.

    It turns out cysteine/cystine disulfide bridges in proteins are known to be excellent quenchers of the excited state of aromatic residues by UV light in the literature. I don't believe any AD researchers realize this today.
    This means these disulfide residues naturally decrease the power present in UV light created in the nearby excited aromatic amino acids of the cells in a developing life form.

    Could this study be possibly hinting that Alzheimer's disease is also linked to indoor living in the blue light as Uncle Jack has been saying for 15 years? YEP. The study offers a hint of hope for staving off dementia in some people - if you treat high blood pressure aggressively, it might just help both your heart and your brain. the reason is simple. Staying indoors block most UV and 3--60% of red light allowing the blue light easy passage to and fro because it is not affected by the glass in the window and this causes a relative BLUE LIGHT HAZARD for humans over time. Indoor living is the big link to the photoelectric defect in my opinion. https://www.nytimes.com/2019/01/28/health/dementia-blood-pressure-cognitive-impairment.html

    In this way, the cysteine/cystine disulfide bridges contribute to protein stability of PER and their circadian activity in tissues, thereby, stabilizing ubiquitin rates and helping drive proper morphogenesis via the blueprint in DNA/RNA. I believe the fidelity of this copying mechanism is tied to the OAM number of light that interacts with DNA and I assume that ELF-UV is critical in that dance. When it is off this fosters protein misfolding and I think it is linked to many brain diseases associated with misfolding like ALS, prions, and GBM. I assume each species has its own molecular resonance OAM they operate with = many diseases can happen that share many features = AD/PD/ALS.

    Why do I think the amount of ELF-UV light is the key in this dance of disease?

    Sick neurons make too much ELF-UV light and we know UVA light affects CCO.
    Chronic inhibition of cytochrome c oxidase leads to chronic neurodegenerative disease and that link is found in many papers.

    UV light excitation of the aromatic residues is known to trigger electron ejection from their side chains (Bent & Hayon, 1975a; Bent & Hayon, 1975b; Bent & Hayon, 1975c; Creed, 1984a; Creed, 1984b; Kerwin & Rammele, 2007, Neves-Petersen et al., 2009a).

    These electrons can be captured by disulfide bridges in simple proteins with tons of disulfide bridges like glutathione, leading to the formation of a transient disulfide electron adduct radicals, which will dissociate photoelectrically, leading to the formation of free thiol groups in the protein. What you did not know until my Patreon blogs last year is that DDW water created by the matrix can increase endogenous glutathione for matter creation and organ building and proper maintenance in organs like the brain. In AD this process is broken by RBC changes in the eye and skin to blue light and nnEMF.

    This photochemical change then leads to non-optical signaling at deeper levels in the embryo as development continues using the butterfly effect = non-linear effect that goes back to Turing's 1952 paper on how morphogenesis proceeds.

    The irony in all these details is that UV frequencies foster the creation of matter naturally, and do not cause cancer, by these quantum mechanisms.

    Why do I say this?

    More irony for healthcare myopic paradigm that the sun and UV light is bad: This quantum mechanism using UV light is now being used big pharma to develop drugs using nanotechnology and the ability of cells to make ELF-UV light in a process called LUMI.
     
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  20. Jack Kruse

    Jack Kruse Administrator

    What is the heart of the circadian mechanism in humans?

    How time is told inside of you: the clock mechanism emerged. Over several hours, starting in the early hours of the morning, the PER protein is synthesized and begins to accumulate in the cytoplasm. As its concentration increases, it starts to be transported into the nucleus, peaking in the middle of the night. In the nucleus it binds and deactivates its own transcriptional factors, stopping production of its own mRNA, and turning off further production. Over the next few hours, the PER protein in the nucleus is degraded and removed, until the mRNA starts to be exported again to ramp up PER production for another day.

    This negative feedback loop is at the heart of a circadian control system. It is interconnected with PER transcription and the redox feedback loops of peroxiredoxins of the RBCs that govern rhythmic production of 10–20% of all proteins in cells throughout organisms from mammals to plants and insects.

    These mechanisms are now known to control normal morphogenesis and I believe they are all controlled by information transfer from light to the sun all the way to the PER protein every AM. That is why you cannot miss any AM sunlight if you have AD.
     
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