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INSULIN's TRANSGENERATIONAL LINKS TO MOM & DAD's GERMLINE

Discussion in 'Educating Doctors' started by Jack Kruse, Jan 25, 2019.

  1. Jack Kruse

    Jack Kruse Administrator

    Writing this really got me thinking about how important the first few months of life (weeks in a mouse) are for setting beta-cell mass, via beta-cell stress levels, which surely impacts later development of diabetes (probably obesity too).

    I wonder if this is why human also have the same transgenerational effects when Mom has gestational diabetes and the kid grows up to be a T2D with a higher risk of AD and PD?

    https://elifesciences.org/articles/43475
     
    Richelle Jones likes this.
  2. Jack Kruse

    Jack Kruse Administrator

  3. Jack Kruse

    Jack Kruse Administrator

    What do insulin and melanopsin have in common? Insulin normally increases blood flow via vasodilation, something that becomes compromised with insulin resistance.

    Where do they differ?

    Insulin is a solar hormone that is stimulated by purple and red light light balancing the effect of blue light and melanopsin is stimulated by blue light. Sunlight has blue but the dose response curve of blue is always buffered from the toxic effects by red light in sun which makes up 42% of terrestrial sunlight.

    When you subtract the purple and red light out you get a relative toxic dose of the blue light hazard and this leads to insulin resistance and melanopsin dysfunction.

    Just standing behind a pane of glass gives this effect and it raises your APMK signaling and glucose levels as if you just ate a snickers bar and nobody seems to realize it.
     
    Richelle Jones likes this.
  4. Jack Kruse

    Jack Kruse Administrator

    Richelle Jones likes this.

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