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INSULIN's TRANSGENERATIONAL LINKS TO MOM & DAD's GERMLINE

Discussion in 'Educating Doctors' started by Jack Kruse, Jan 25, 2019.

  1. Jack Kruse

    Jack Kruse Administrator

    Writing this really got me thinking about how important the first few months of life (weeks in a mouse) are for setting beta-cell mass, via beta-cell stress levels, which surely impacts later development of diabetes (probably obesity too).

    I wonder if this is why human also have the same transgenerational effects when Mom has gestational diabetes and the kid grows up to be a T2D with a higher risk of AD and PD?

    https://elifesciences.org/articles/43475
     
    Richelle Jones likes this.
  2. Jack Kruse

    Jack Kruse Administrator

  3. Jack Kruse

    Jack Kruse Administrator

    What do insulin and melanopsin have in common? Insulin normally increases blood flow via vasodilation, something that becomes compromised with insulin resistance.

    Where do they differ?

    Insulin is a solar hormone that is stimulated by purple and red light light balancing the effect of blue light and melanopsin is stimulated by blue light. Sunlight has blue but the dose response curve of blue is always buffered from the toxic effects by red light in sun which makes up 42% of terrestrial sunlight.

    When you subtract the purple and red light out you get a relative toxic dose of the blue light hazard and this leads to insulin resistance and melanopsin dysfunction.

    Just standing behind a pane of glass gives this effect and it raises your APMK signaling and glucose levels as if you just ate a snickers bar and nobody seems to realize it.
     
    Richelle Jones likes this.
  4. Jack Kruse

    Jack Kruse Administrator

    Richelle Jones likes this.
  5. Jack Kruse

    Jack Kruse Administrator

    Vitamin D reduces diabetes risk AND pancreatic cancer risks are linked!

    The knee jerk reaction is to think that you just need to take 2,000 IU of D3 and you should be good.

    BUT, consider this...

    We make Vitamin D from sunlight exposure. God/evolution would not have linked its production to Sun exposure if we were supposed to avoid the sun and wear sunscreen when we were outside.

    What if it’s more than just Vitamin D that is responsible for this disease control? What if it was the actual sunlight that changed the biophysics and allowed our bodies to be healthy and avoid disease?

    In fact, this is the case. Exposure to full-spectrum sunlight and avoiding overexposure to blue light is critical to staying healthy. Clearly, overexposure to the Sun and getting burned is not a good thing.

    https://www.ncbi.nlm.nih.gov/m/pubmed/27030935/
     
    John Schumacher, Inger and drezy like this.
  6. What we know is that pancreatic tumors are wired for high-glucose metabolism. We also know that Infrared photobiomodulation (PBM) therapy improves glucose metabolism. The question is will glucose rich pancreatic tumors respond to IR therapy? This has a high probability; IR light not only penetrates deep into tissue, but hemoglobin stores up light for redistribution.

    From a clinical standpoint, following procedure should prove interesting: inject the tumors with an UV attractant compound in a glucose solution using ultrasound guidance. Once the tumors have uptaken the compound, use UV laser fiberoptics to inject light into the tumors. If the light intensity great enough, the tumors will explode. Depending on the size of the tumors, asperation maybe required to remove the material.

    During the late 1970's, the Soviet Union employed intravenous laser therapy (IVL) by introducing UV light directly in the blood system. It seemed to activate vitamin D3 production greater than sunlight; however, we need to take into account the latitude of the Russian scientists. The therapy was used mostly with CVD patients. The question is - If a strong source of full-spectrum sunlight is not a available, can IVL therapy be considered as part of the treatment?
     
    Last edited: Oct 27, 2019

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