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How does melanin or a lack of it link to tinnitus and PD/AD?

Discussion in 'Educating Doctors' started by Jack Kruse, Sep 13, 2020.

  1. Jack Kruse

    Jack Kruse Administrator

    Melanin is an evolutionary design marvel as this blog eloquently shows. It is a faraday cage, it provides for animal photosynthesis, and it is a molecule that allows animals to extend their brains outside of their CNS to conserve energy. Many people do not know that hearing is the most sensitive sense to hypoxia and it uses more ATP than any other sense humans have. When someone dies of strangulation, at autopsy we see hemorrhage in Ammon's horn of the temporal lobe that is involved in hearing and cognition. Sclerosis of the cornu Ammonis or Ammon's horn sclerosis (AHS) is an "often-described, yet hitherto enigmatic phenomena" as Spielmyer put it in 1927. It has been found in cases with ischemia, anoxia, or hypoglycemia/hypoxia in more than half of the epileptic brains examined at autopsy. The melanin web throughout the human skin is actually a nanoscopic photoelectric computer, as it were. Melanin processes electromagnetic information and simplifies it for the brain to conserve energy use. From this view, the neuroectodermal webs in our skin and brains evolved over time like an extension of the speaking primate’s body and sensory system — not so much its mind. This is another evolutionary trick to conserved energy to build a larger brain.https://www.patreon.com/posts/41558277
     
    Alex97232 likes this.
  2. Melanin is a hybrid ionic-electronic conductor which raises the intriguing possibility of using these materials as a bioelectronic interface. https://espace.library.uq.edu.au/da...XIRvBj89t8ubm9cJCg5DOlr~yuWbK288SheJFszMFJQ__
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  3. Neuromelanin (NM) in the storage and release of dopamine - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399705/
     
  4. Melanin has unique electron spin resonance characteristics. It binds to heavy metals, protects microbes from host defenses, and is effective in antimicrobial therapy. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1635213/
     
  5. Jack Kruse

    Jack Kruse Administrator

    Why does man-made blue light alter melanin function and lead to dopamine and melatonin issues? Melanin is made from the non-essential aromatic amino acid tyrosine. Melatonin is made from the essential aromatic amino acid tryptophan. Melanin can be made from the essential aromatic amino acid phenylalanine too. Both melanin and melatonin are photoreceptors in humans and melanopsin damage ruins both of them via freed retinol (Vitamin A) Blue light and nnEMF cause melanopsin damage and destroys melanin and melatonin. Melatonin controls autophagy and apoptosis in your colony of mitochondria so when melatonin is destroyed it means poor sleep and poor metabolism due to limited ability to burn fat and protein via the TCA cycle. Histamine is an essential aromatic amino acid that is quickly transformed into urocholic acid in the skin with sunlight with UV components. When it is not it creates itchiness in the skin. Blue light toxicity is associated with pale itch skin with melanotic patches. With photoreceptor damage in the skin and eye, the cell has to default to older evolutionary pathways of glucose metabolism or glutamine metabolism to survive. Sleep is always altered in this case because melatonin levels are destroyed. As a consequence uric acid rises compared to urea to protect tissues with higher mitochondrial density to promote cell survival until the environmental stressors go away.
     
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  6. The chemiexcitation path to diseases is now quantized

    The Molecular Basis of Toxins’ Interactions with Intracellular Signaling via Discrete Portals -> 13 such portals have been identified https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371862/ toxins represent one of the most promising natural molecules for developing novel therapeutics that selectively target the major cellular portals involved in human physiology and diseases. Degradation when enzymes of lipid metabolism such as phospholipases A2 (PLA2) or phospholipase C (PLC) act upon it. Several major portals consist of ion channels, pumps, transporters and ligand gated ionotropic receptors which many toxins act on, disturbing the intracellular ion homeostasis.

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  7. Primary treatment of choroidal amelanotic melanoma with photodynamic therapy - https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1442-9071.2005.01083.x
    This course of treatment resulted in complete resolution of the lesion, leaving a flat, atrophic chorioretinal scar, with no subretinalfluid, and a best-corrected visual acuity of 6/6 (Fig. 1e). Thirteen months after her last treatment, she remains asymptomatic with no signs of recurrence.

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  8. "Histamine is an essential aromatic amino acid that is quickly transformed into urocholic acid in the skin with sunlight with UV components."

    Since histamine is primarily located in the myelin sheath, and acts as a neurotransmitter for the brain, spinal cord, don’t you just get itchy reading this?

    Where's my ursodeoxycholic acid for that skin rash?
     

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