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How does Leptin Sensitivity increase fatty acid metabolizm?

Discussion in 'Ask Jack' started by John Schumacher, Sep 28, 2020.

  1. Fatty Acid Oxidation -
    • Beta Oxidation occurs in our mitochondria
    • Alpha & Beta Oxidation occurs in our peroxisome
    • Omega Oxidation occurs in our endoplasmic reticulum
    Mitochondria uses acetyl CoA
    Peroxisome process molecules in a similar fashion but includes enzymatic steps - glyceronephosphate O-acyltransferase (GNPAT) and alkylglycerone phosphate synthase (AGPS)
    Endoplasmic Reticulum hydroxylates and oxidizes fatty acids to dicarboxylic acids

    We know hypothalamic leptin signaling increases fatty acid oxidation.

    My question is: How does Leptin Sensitivity increase fatty acid metabolizm?
    Last edited: Sep 28, 2020
    JanSz likes this.
  2. Jack Kruse

    Jack Kruse Administrator

  3. For those following, Jack's answer ->
    Leptin stimulates muscle glucose uptake via the hypothalamic–sympathetic nervous system and β-adrenergic mechanism. Both VMN neurons and POMC neurons involve the leptin's action. Leptin stimulates fatty acid oxidation in muscle via AMPK. The activation of muscle AMPK is mediated by two distinct mechanisms: one is a direct effect of leptin and another is mediated by the hypothalamic–sympathetic nervous system and a-adrenergic mechanism. Activation of AMPK by leptin phosphorylates and inhibits ACC, and results in potent stimulation of fatty acid oxidation in muscle.
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