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High heteroplasmy = poor H20 recycling in mito = poor sleep

Discussion in 'Mitochondrial Rx' started by Jack Kruse, Oct 10, 2017.

  1. Jack Kruse

    Jack Kruse Administrator

  2. Scompy

    Scompy Gold

    "The dissociation of a deuteron from Asp61 of the c subunit when exposed to the matrix half-channel is likely to be slowed, since it is exposed to the channel for a very short time because of the Brownian motion of the c subunit. This slow dissociation may cause temporary stutter in the rotor. If we were able to observe all ~15000 ATP synthases (Table (Table1)1) in a mitochondrion, we would see a percentage of them stuttering at any given time."

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1808445/
    Paleodocteur and Brent Patrick like this.
  3. Jack Kruse

    Jack Kruse Administrator

    correct. red light drives it only when H+ is in the ATPAse. stoicometry of theTCA protons recycling works with IR-A, IR-B 1538.5 especially.........
    Lahelada, Penny, Scompy and 1 other person like this.

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