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Granpa John's Optimal Journal

Discussion in 'My Optimal Journal' started by John Schumacher, Jul 18, 2019.

  1. Continuing - Dr. @Jack Kruse has magnetism, water & light as the three legs of our biological framework.

    We've looked at the math.
    We've reviewed physics Xiao-Feng Pang's work on proton movement in hydrogen-bonded chains.
    We've reviewed an understanding of water under the influence of magnetism.
    We've reviewed studies using Structured (magnetized) Water on animals.

    But what maybe the mechanism of action?
    Let's look...

    Electron generation in water induced by magnetic effect and its impact on dissolved oxygen concentration

    pH, oxidation-reduction potential (ORP) and dissolved oxygen (DO) concentration are important parameters in water quality surveillance and treatment. The changes of these parameters are associated with electron density in water. Several techniques including electrolysis and catalysis which require redox reactions and electron exchange are employed to improve these parameters.​


    Results of pH, ORP and DO concentration of water after magnetization by using different magnets arrangements

    H2O⇋H++OH−H2O⇋H++OH− (4)

    4OH−⇋2H2O+O2+4e−4OH−⇋2H2O+O2+4e− (5)

    Water molecules ionize to form H+ and OH− ions under equilibrium condition based on Equation (4) above.
    1. Current is induced when magnetic effect is disrupted by the mechanical motion of water flow, which is flowing in the direction perpendicular to the magnetic field.
    2. The induced current will promote flow of electrons.
    3. The generated electrons have the tendency to bind with H+ cation from ionized water molecule through metastable bonding.
    4. Consequently, pH of water increases and the concentration of OH− anion also increases simultaneously.
    5. When there is excess OH− anion due to pH increment, the chemical equilibrium is disturbed. As a result, subsequent oxidation of OH− anion occurs to form O2, H2O and electron (Equation (5) above) in order to restore chemical equilibrium based on Le Chatelier’s principle.
    Magnetic effect increased pH and DO concentration while decreased the ORP of water.

    The combined variables of non-reversed polarity magnets arrangement and the lowest flow rate (0.1–0.5 mL s− 1) led to pH and DO concentration increment by 3.5 and 5.6%, respectively and ORP decrement by 6.9%.

    These indicate that magnetic effect increases electron density and DO concentration in water. The ORP decrement corresponded to 8.0 × 1013 number of electron generation in water.

    Meanwhile, Raman characterization shows that magnetic effect strengthens intermolecular hydrogen bonding of water molecules and promotes smaller water clusters formation.

    Conclusion: The electron generation and DO concentration increment in water may be regarded as potential applications in treatment of infectious diseases induced by free radical species.
  2. Continuing - Dr. @Jack Kruse has magnetism, water & light as the three legs of our biological framework.

    What another ...
    - because Real Physics - is disprovable.

    However - mathematical justification for imaginary theories of relativity, chasing an ever expanding incalculable chaos - is like taking Ayahuasca for emotional trauma - it can be personally therapeutic...

    Water flow patterns induced by bridge oscillation of magnetic fluid between two permanent magnets subjected to alternating magnetic field

    This paper describes the characteristics of water flow induced by the bridge oscillation of magnetic fluid between two permanent magnets subject to an external alternating magnetic field. The magnetic fluid bridge is formed in the space between a pair of identical coaxial cylindrical permanent magnets submerged in water. The direction of alternating magnetic field is parallel /antiparallel to the magnetic field produced by two permanent magnets. The magnetic fluid bridge responds to the external alternating magnetic field with harmonic oscillation. The oscillation of magnetic fluid bridge generates water flow around the bridge.​



    Formation of magnetic fluid bridge and size of permanent magnets​


    The magnetic fluid bridge system is composed of two circular cylindrical permanent magnets and magnetic fluid.

    The bridge system is subjected to the alternating magnetic field. The alternating magnetic field is generated by applying the sinusoidal voltage to the Helmholtz coil. The applied voltage is given as follows:​



    Figure above shows the visualization photographs of water flow induced by the bridge oscillation of magnetic fluid at the constant frequency f0¼50 Hz and time t¼0.3 s.

    Such flows are mainly ruled by complex vortex–vortex and vortex–structure interaction phenomena involving stability problem, bifurcation and three-dimensional patterns.

    The magnitude of the water flow velocity increased with the increase of the Keulegan–Carpenter number at the constant Stokes number.​
    Last edited: Oct 15, 2022
  3. Ok, so we know magnetic fields change the biochemistry of water - see posts above
    But what about pulsed electromagnetic fields on water?
    How may these variables of types of nnEMF change the Potentiality of Hydrogen (PH)?

    Treatment Method of Water based on the Magnetic Devices
    DOI: 10.36348/sijb.2020.v03i07.003


    Experimental model design - Magnetic water treatment technology is a device based on frequency modulation using a coil wound around a pipe section of the water system. This coil is triggered by a constantly changing power supply of polarity, frequency and amplitude. When water goes through the pipe section, which is rolled by this coil, they are inhibited, losing their ability to adhere to the wall of the device, and melting of older deposits, so that the surface of the device is free of scale, increasing heat transfer efficiency, saving energy, and extending the life of the heat transfer.

    We use a tank with filled water; the dimensions of the tank are 850 mm in length, 450 mm for width and 600 mm in height. The TDS concentration in water was measured as 1182 ppm and PH concentration in water was measured as 11.2.​

    Note: The PH concentration of the water they used in this experiment started at 11.2, which is anioma.



    Figure 7 above: PH concentration measurement results at 100Hz, 500Hz, 1KHz, 5KHz, 10KHz and 15KHz
    Let’s look at this graph above; the PH concentrations in the water at time 1 hour begins at 11.2, which is anomia or soapy water. The experiment using pulsations of 5kHz brought down the PH to 9.9, which is just above baking soda and almost the level of milk of magnesia.

    Can we predict from this experiment that these pulsated electromagnetic frequencies could lower normal water’s Potential of Hydrogen (PH) of 7.0 in a similar manner?

    We can see that most of the frequencies tested had made the “most” effect within 2 hours of exposure.
    • 100 Hz lowering by 0.2 at two hours
    • 500 Hz lowering by 0.45 at four hours
    • 1kHz lowering by 0.6 at five hours
    • 15 kHz lowering by 0.7 at seven hours
    • 10 kHz lowering by 1.0 at six hours
    • 5 kHz lowering by 1.3 at six hours
    Here’s a simple chart for PH and their represented products

    If pulsated electromagnetic frequencies of 5kHz were applied to human blood of 7.4 PH, is it possible that this (5kHz treatment) could reduce its value to 6.1 PH? Using the chart above, 6.1 PH is within the range of Urine.

    Dr. @Jack Kruse – What maybe the impact on our cell’s net-negative charge (redox) under the influence of these pulsated electromagnetic frequencies (nnEMF)? Could we predict it to go up? Say from -200 mV to -100mV or -50mV?

    When our mitochondria "sense" a voltage (redox) loss, what will be their "instinctive" response? -> In my option, this is one of the mechanisms for triggering (requesting) the process of Glycogen Synthase Activation

    Activation of Glycogen Synthase Kinase 3β Disrupts the Binding of Hexokinase II to Mitochondria by Phosphorylating Voltage-Dependent Anion Channel


    The mitochondria interaction with the voltage-dependent anion channel (VDAC)...
    ATP-dependent process, HXK II mediates the first and a rate-controlling step of glycolysis, phosphorylating glucose to produce glucose-6-phosphate. HXK I and HXK II are capable of binding to the mitochondria. Inhibition of Akt promotes the activation of glycogen synthase kinase 3β resulting in a disruption of the binding of hexokinase II to the mitochondria.

    Glycogen synthase kinase 3β phosphorylates voltage-dependent anion channel and prevents it from binding to hexokinase II.​

    Mitochondrial Hexokinase II Promotes Neuronal Survival and Acts Downstream of Glycogen Synthase Kinase-3*


    Mitochondrial alterations are detected in most neurodegenerative disorders and may contribute to the dysfunction and demise of neuronal cells. Mitochondrial HKII is essential for chronic GSK-3 inhibition to exert a neuroprotective effect.​

    I do not believe nnEMF has an ionizing effect; specifically, because 5G for example is not within the ionizing frequency.

    However, we know these pulsated electromagnetic frequencies penetrate the human body.

    The "assault" seems to have a leveling curve over time as demonstrated by Figure 7 above, with the Potentiality of Hydrogen (PH) reduction.

    What interests me is the harmonizing effect of these frequencies -> the crystalline effect within our water molecules under these penetrating pulsated electromagnetic frequencies.

    Theory of electrolyte crystallization in magnetic field

    The basis of the theory is a crystal model of a sparingly soluble salt with NaCl structure, where the ions are divalent, and the anion is a base. It is assumed that almost all the anions in the surface layer are protonized, and that an approaching metal ion pushes the proton away to a neighbouring anion, which then becomes doubly protonized. If the two protons are in the same spin state, the Pauli principle requires that one of them enter a state of higher energy, which enhances the activation energy and reduces the rate of the process, but even with opposite spins the incoming proton must enter an excited state due to its momentum. Spin relaxation in magnetic field may remove hindrances to proton transfer.​


    The sodium chloride percentage in the plasma varies between 0.58 and 0.62 per cent.
    The cell volume varied between 37 and 22 per cent.​


    I do not believe we are asking the right questions concerning human biological effect under nnEMF.

    It is not a matter of a direct effect from “pure” nnEMF values – but their harmonics.

    I invite the reader to Dr. @Jack Kruse Threads
    Last edited: Nov 5, 2022
  4. From their work during the 1920's, the authors of "The Encyclopedia of Health and Physical Culture" published in 1931, warned about "air pollution"
    However, not for its danger to the lungs.

    They believed the greatest hazard of "air pollution" was blocking and absorption of the sun's full spectrum. Specifically, those rays in the ultra-violet range.

    pages 2677 & 2678:
    "Soft coal being less expensive than anthracite or hard coal, it is used extensively in manufacturing, in residences, apartment and office building, and upon the railroads, filling the atmosphere of the cities and forming a ray-filtering film over a large section of the surrounding country. In winter, and almost to the same extent in spring and autumn, these communities have a greatly reduced amount of ultra-violet rays, a condition which is responsible for much of the disease prevalent at these seasons. Even in summer the amount of actinic rays is greatly below that which is actually given off by the sun. This is very difficult in our modern communities, especially, where the dearth of sunlight (starvation) is felt most and where sun-baths are most needed."

    "It is now only at considerable elevations above sea-level that practically the entire amount of ultra-violet rays given off by the sun is received. Altitudes of five to eight thousand feet are usually above the smoke clouds in the atmosphere. Example: Dr. Rollier's clinics at Leysin in the Swiss Alps, are at altitudes of 4900, 5300, and 5900 feet. It is the combination of unhindered ultra-violet rays and stimulating cold atmosphere that is responsible for the remarkable results he has secured in the treatments of many diseases including tuberculosis; there being few days throughout the year on which the sun does not shine with extreme clearness."

    Question - Can we "learn" from the doctors who broke away from centralize medical over a hundred years ago? - I hope so.
    Last edited: Oct 28, 2022
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  5. Briefly we now know that the UV light from our sun does more than just "vitamin" D stimulation

    JanSz likes this.
  6. The "red-shift" Doppler effect may not be the rate of an object is moving away from us.

    Let's review some science -

    Inverse Compton Scattering of Mark 421 creating double peaks
    - The photon is absorbed and then re-emitted in a different direction

    Rayleigh scattering is predominantly an elastic scattering of electromagnetic radiation by particles much smaller than the wavelength of the radiation. It results from the electric polarizability of the “particles.” The oscillating electric field of a light wave acts on the charges within a particle, causing them to move at the same frequency.


    The particle, therefore, becomes a small radiating dipole whose radiation we see scattered light. This effect is the reason for the blue colour of the daytime sky as well as the yellowish to reddish hue of a low sunset.

    Sunlight is also subject to Raman scattering, which changes the rotational state of the molecules and gives rise to polarization effects.

    Mie scattering is an elastic scattering of light by a dielectric sphere. This means it does change the frequency of the incoming photon. It often produces resonances in the scattered light.

    In principle, we can therefore say that where the state of the electron before and after the absorption and re-emitting of the photon is unchanged, the incoming photon frequency is the same as the re-emitted one. When this is not the case and the electron is scattered, then we can see that the electron move relative to the observer and therefore we get a Doppler shift and a subsequent change in the frequency relative to the observer.

    Note: Astrophysicists who believe in a "red-shifted" Doppler effect do not study plasma physics, but hold dearly to 100-year old "flat-earth" ideas which state that red-shifted means the object is moving away from Earth.

    Bohr put it this way, "It is wrong to think that the task of physics is to find out how nature is."

    I believe -

    The mystery of physics seems very limited by our ability to understand the data of plasma behavior as energy emerges from light. Perhaps, if we could examine the results with eyes from a different paradigm, we just may see life is not calculable chaos but it is ordered emergence from dielectric inertia. It is in this study we may develop better questions.
    Last edited: Oct 31, 2022
    JanSz likes this.
  7. Dr. @Jack Kruse - for your review:
    So what are the supercapacitors of our brain?​

    Let's look at the next scientific emergence of ultracapacitor development...

    Emergence of melanin-inspired supercapacitors

    In recent years, both natural melanin and their synthetic analogs have attracted increasing attention as an emerging class of bioinspired supercapacitor materials, due to their rich sources, excellent processability, and extraordinary electrochemical performances. Particularly, the inherent heteroatoms and catechol groups within natural melanin and polydopamine (PDA) nanomaterials can promote the total electrochemical activities and surface activation capabilities of the systems. This review strives to summarize the recent advances and highlights of melanin-inspired supercapacitors by focusing on their chemical structures, fabrication methods, working mechanisms as well as various applications ranging from wearable devices, flexible capacitors to supercapacitor separators.

    Supercapacitors, also known as electrochemical capacitors or ultracapacitors, are considered as one of the most promising candidates among energy-storage systems due to their various applications in portable devices, electric vehicles, and stationary energy storage systems. Compared with traditional fuel cells and capacitors, supercapacitors possess both high energy density and highpower density because of their special energy storage mechanisms. Generally, based on the distinct energy storage mechanisms, supercapacitors can be classified into two categories: One is the electrical double layer capacitor (EDLC), where the capacitance comes from the pure electrostatic charges accumulated at the electrode/electrolyte interface, therefore it is strongly dependent on the surface areas and porous structure of the electrode materials that is accessible to the electrolyte ions. The other is the pseudocapacitor, in which fast and reversible faradic processes take place due to the presence of electroactive species. These two mechanisms usually exhibit synergy effects simultaneously depending on the nature of electrode materials. The capacitance and charge storage of the supercapacitor usually depend on the used electrode materials intimately. And the development of the new electrode materials with high capacitance and improved performances has been regarded as one of the most important issues in functional supercapacitors during the past years.


    Hydrogel materials have attracted increasing research interests due to their unique crosslinking network structures surrounded by water molecules. This characteristic gives the material both wet and soft, making it an ideal electrolyte material for scalable energy storage devices such as supercapacitors and rechargeable batteries.

    The redox properties of polydopamine (PDA) could improve the electron and charge transport properties, increase the oxidation in situ, and provide Faraday capacitance at the hydrogel electrolyteelectrode interface. The conjugated structure of polydopamine showed a smaller HOMO-LUMO energy gap (HLG), than that of organic small molecular electrolytes. The polydopamine (PDA) could maintain free catechol groups in the hydrogel. And the π–π stacking of PDA and abundant hydrogen bonds of catechol groups were also crucial for aerogel's stretchability, self-healing and adhesion.
    In review, this sounds like Nature’s construct for Neuromelanin. The perfect battery for the brain, “hiding” in the deep creatives, including: its folds, substantia nigra, midbrain dopaminergic (DA) neurons and in the locus coeruleus noradrenergic neurons.

    The photosynthesis light source is supplied through myelin sheaths.


    Of the top ten proteins enriched in Neuromelanin within the substantia nigra (SN) pars compacta (SNSurr) tissue were found to be characteristic for neuron-surrounding tissue, such as the myelin-associated glycoprotein (MAG) as a part of the neuronal myelin sheath. Proteins exclusively identified in SNSurr. tissue stressed the neuronal character of the tissue, as for example myelin proteolipid protein, dynein light chain 1 and peripherin. https://link.springer.com/article/10.1007/s00702-022-02530-4

    So how does the brain “battery” electrically power up the grid?

    I believe it is the three-dimensional behavior of hydrogen molecules when stimulated by photons that rules, not the covalent bonds; thus, I believe it is the non-covalent "bonds" of melanin or behavior of protons which jump across the melanopsin within the cell member's intracellular matrix from melanosomes to endoplasmic reticulum, peroxisomes and our mitochondria.​

    Over time, Neuromelanin has the capacity to enrich. Diseases like Parkinson’s destroy it. However, the goldilocks effects (too much of a good thing) may also be a problem. Our mitochondria can produce a peroxide to trim away the “excess.”

    Neuromelanin appears in large quantities in the human brain.


    Images of the Substantia nigra – above.​

    The building blocks of Neuromelanin – specific proteins and cholesterol stimulated by full spectrum sunlight. Note the light starved substantia nigra on the right image above.

    Melanin drives the photon energy of lower-energy radiation sources by quenching electrons and initiating an ionic event independently of their relative energy contention.

    Dopa-melanin was synthesized from DOPA (dihydroxyphenylalanine) following the auto oxidizing procedure. There is a general agreement that melanin are macromolecules of 5,6-dihydroxyindole (DHI) and 5,6-dihydroxyindole-2- carboxylic acid (DHICA).

    Melanin can be envisaged as an energy transducer with the properties of an amorphous semiconductor; it can absorb many different types of energy (light) and convert it in another more useful type of energy (electric power). New “melanincompound” made photovoltaic cells, based on Melanin construct report a new photoelectrochemical, conducting, polymer type properties.

    A great part of the photonic energy is transformed by Neuromelanin into chemical electrical energy.


    Neuromelanin is known to be derived from 5-S-cysteinyl-dopamine and dopaminochrome (Figure 8D below). Neuromelanin pigment is a synthetic byproduct of catecholamine synthesis. The golden-brown Neuromelanin pigment granules accumulate with age in catecholaminergic neurons.

    Neuromelanin are the Supercapacitors, Electrochemical capacitors or Ultracapacitors in our brain.

    Last edited: Nov 1, 2022
  8. Dr. @Jack Kruse - for your review

    In the thread “What treatments would a “quantum clinician” employ to improve the function of the choroid plexus?” post https://forum.jackkruse.com/index.php?posts/313278 - I presented the electromagnetic flux movement through a microtubule in choroid plexus.

    Here – I will provide the Cherenkov radiation principle as an explanation for the diagram below

    Cherenkov radiation is electromagnetic radiation emitted when a charged particle passes through a dielectric medium at a speed greater than the phase velocity of the light in that medium. This results in the blue radiation seen in an underwater nuclear reactor. It is similar to a sonic boom.

    In water, light will travel at about ¾ its speed in a vacuum. When a charged particle passes through a medium, the particles of the medium will polarize around it in response. The charged particle excites the molecules in the polarizable medium and then return to their ground state, molecules re-emit the energy given to them to achieve excitation as photons.

    The polarization field is asymmetric along the direction of the motion of the particle, as the particles of the medium do not have enough time to recover their normal states. This results in an overlapping wavefronts and constructive interference leading to an observed cone-like signal at a characteristic angle.


    Thus, as the electric energy moves (propagates in the direction of the arrow), the magnetic force expels radially; “ions” are then pushed out in a cone cavity whose space charge finally pulls the expelled “magnetic flux” back, forming a high-density region on the propagation axis. The oscillations wake into the cavity and then transversely the electric energy longitudinally expels directionally again.

    This Magnetic flux is not hindered by “barriers”. Thus, parallel microtubules firing electric circuit directionally creates a combined cohesive magnetic flux across and over all microtubules, moving in a cone like fashion, “scooping” material across the entire cell membrane. This motion creates what is known as dynamic-magnetic-flow.

    See the magnetic rotation - click on the image reference below:

    From the:
    Dynamic magnetic field alignment and polarized emission of nanoplatelets in a liquid crystal polymer

    Thus, the mechanism of action by which molecules, secreted chemicals, sacs filled with genetic sequencing material are moved across the cell, is not magical quantum motors within machines tethered to the microtubules which move these molecular signals about the cell.

    It is good-old fashion electromagnetic power.
    Last edited: Nov 17, 2022
    ND Hauf and JanSz like this.
  9. Dr. @Jack Kruse - Since you seem to be a big believer in Einstein's theories, I present Dr. Halton Arp's warning:
    "It is only through crucial observational discoveries can we begin to hypothesis ideas which break away from current dogma."​

    Cosmologist now speculate a new idea of replacing the notion of nothing with inflation and/or quantum fluctuations.

    Why are these dystopian concepts being devised? The belief in a singularity has its roots in theoretical mathematics - that is - the “value” of zero measurement.

    As with all mathematical models, these can be made (remodeled) to do whatever we want them to do. So, how does this form of thinking differ from any mythology?

    The James Webb Space Telescope providing data which has “made waves in cosmological", causing an inspired panic in “scientism.”
    Astronomer Dr Allison Kirkpatric wrote, “I find myself lying awake at three in the morning, wondering if everything I’ve done is wrong.”

    Why? Because they now believe galaxy formation is a result of tiny quantum fluctuations in the aftermath of a Big Bang where dark matter, dark energy, dark entropy, dark etc. clustered and took shape over great periods (billions of light-years) of time.

    However, our space telescopes have provided exquisite graphic vistas, presenting a clear and extensive view of an organized volume of star systems the deeper we look into space (billions of light-years into the "beginning" of a believed Big Bang). These discoveries are not dust storms of pregalaxy debris, but fully formed galaxies very similar to our Milky Way. However, Cosmologist continue to chase after a violent explosion, a chaos increasingly expansion moving even faster away from Earth.

    Dr. Halton Arp Phd with associate Margaret Burbidge (on the left in image below) and others published “Catalogue Discordant Redshift Associations”; where they demonstrated highly redshifted quasars which were clearly in front of lower redshifted galaxies in the background.


    For example: Galaxy 4319 with connecting bridge on the left, and NGC7603 with connecting bridge on the right in the image below.


    This evidence was an unequivocal violation of an expanding universe.

    Dr. Halton Arp and colleagues published a compilation ‘Quasars, Redshifts and Controversies’ in 1987. He wrote, “As a general scientific principle, it is undesirable to depend crucially on what is unobservable as an explanation to what is observable.”

    In 1992 he published, ‘Progress in New Cosmologies – Beyond the Big Bang’, Dr. Arp warns – “It is only through crucial observational discoveries can we begin to hypothesis ideas which break away from current dogma. When we investigate the nearest galaxies to us, the ones we can resolve in detail, we immediately encounter irreconcilable contradictions with the expanding universe theory. For example: If the redshifts of major companion galaxies are due to orbital velocity around the central galaxy, there should be as many negative as positive spectral shifts. However, instead, 21 out of 21 of these companions are redshifted positively. This has one chance in a two million of happening accidentally and therefore shows that these companion galaxies have intrinsic excess redshifts.”

    In 1997, he published ‘Seeing Red’.

    What’s crumbling around the gravity-only-dominated theory? We have found “problems” in observational data such as galactic revolution rotation, which have laid the need for fantasy mathematical hypotheses for dark matter, dark energy, dark entropy, anti-momentum, dark volume, anti-charge, dark movement, anti-shape, dark time, anti-size. All for which these lofty expanding mathematical theorems (such as time-space-quantum-fluctuations) are presented dogmatically as “proof”, as “experimental evidence”; however, this "scientific evidence" is limited to the Esoteric Allusions' mythology.


    I see a connected Universe
    Last edited: Nov 17, 2022
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  10. JanSz

    JanSz Gold

    This sentence should be tattooed on every Nobel laureate forehead.
    As with all mathematical models, it will do whatever we want it to do. So, how does this form of thinking differ from any mythology?
    John Schumacher likes this.
  11. @JanSz - Thank you for the edit.

    As with all mathematical models, these can be made (remodeled) to do whatever we want them to do. So, how does this form of thinking differ from any mythology?
    Last edited: Nov 16, 2022
  12. JanSz

    JanSz Gold

    Not correction. More like a wishful thinking.
    Actually, I thank you again for presenting the situation in such a clear way.

    By now I am not really sure if 2+2=4
    or possibly prayers of mathematicians made it so.

    On similar vein.


    Who would have thought that one of the above is hardly related to the other.

    John Schumacher likes this.
  13. Dr. @Jack Kruse - for your review:

    We know sunlight is fundamental & infrared light has a photobiomodulational effect. But how and what maybe the mechanism of action(s) on our most precious mitochondria?

    Let's take a look at optogenetics influence on protonmotive forces within our mitochondria.


    Light-activated proton movement mitochondria-ON (mtON) is expressed in mitochondria.

    Mitochondria generate an electrochemical proton gradient. This is described as the protonmotive force (PMF), which consists of an electrical charge gradient that moves the respiratory complexes of the electron transport chain (ETC) located in the mitochondrial inner membrane (IM).

    The data shows that more photons result in increased polarization of the protonmotive force, which is in line with the biophysical. As expected, mtON activation increased ATP levels light dose dependently. In mitochondria, the amount of ADP converted to ATP is reliant on O2 consumption by the electron transport chain.
    Our mitochondria not only "absorbs" the light, but undergoes a fission and fusion dynamics. Specifically, Blue light impacts mitochondrial functions by altering mitochondrial fusion and fission imbalance or upregulating complexes III, IV and V.

    Mitochondrial fission allows mitochondrial deoxyribonucleic acid (DNA) synthesis and mitochondrial biogenesis and facilitates metabolic adaptation by regulating the mitochondrial number, distribution, and quality, through concerted processes with autophagy, apoptosis, and cell division.

    Mitochondrial fusion allows mitochondrial to repair.


    Figure a above. Representative time-lapse images of lysosomes contacting mitochondria at the site of mitochondrial division (white arrows) during mitochondrial fission in living HeLa cells expressing LAMP–mCherry–CRY2 (i.e., for lysosomes) and TOM20–CIB–GFP (i.e., for mitochondria) under blue light illumination.


    Figures above d Schematic representation of mitochondrial fragmentation induced by MLCs under time-lapse blue light exposure. “L” stands for length; “W” stands for width; “L/W” stands for dividing the length by the width.

    Note: A lysosome moved alongside the fission site during mitochondrial fission until the mitochondrion divided into two sister mitochondria.

    f Schematic representation of the reversibility of mitochondrial fission caused by light-induced MLCs after 24 hours darkness.

    Note: When cells were kept in the dark for 24 hours after blue light illumination, the fragmented mitochondria became more elongated again (Fig. 2f–j and Supplementary Fig. 12), indicating that the change of mitochondria morphology was reversible following optogenetic treatment.
    So light induces a deformation of our mitochondria by distortion of the outer & inner membranes of our mitochondria.


    Figure above. Spatial control of mitochondria membrane deformation in subcellular areas. The COS-7 cell was transfected with CRY2-mCh-Miro1 and KIF5A-GFP-CIBN.

    (A) Before any blue light stimulation, mitochondria stayed in short and chubby shapes, as shown in zoomed-in images of both dashed and solid yellow line-indicated areas.

    (B) Blue light was given to a subcellular region which is indicated by the blue box and contains the solid line indicated area. Tubule formation can only be observed in mitochondria within the illuminated area, as observed in the zoomed-in image of the solid line indicated area.

    (C) Subsequent illumination on the whole cell induced mitochondria deformation across the entire cell, as demonstrated in zoomed-in figures of both dashed and solid yellow line-indicated areas. Scale bars, 10 μm.

    (D) Scheme for optical induction of mitochondria deformation using the mechanical force provided by dynein motors that mobilize toward the minus end of microtubules. In this design, SspB(Micro) is fused to BICDN which is a dynein adapter protein.

    (E) The dynein-driven optogenetic system can induce mitochondria deformation upon blue light stimulation in the COS-7 cell expressing iLID-mCh-Miro1 and GFP-BICDN-SspB(Micro). Scale bars, 5 μm.

    In this report, we demonstrate that mitochondria membrane deformation can be optically and non-invasively induced in live cells via light-induced recruitment of molecular motors onto mitochondria. We show that both the outer and inner membranes of mitochondria can be stretched and deformed using this optical strategy. Different phenomena following the initial deformation of inner and outer membranes are observed, including extension of several tubules from the same mitochondria, the bifurcation of the stretching tubule, retrieval of the stretching tip, and the partition of the stretching fragment. Subcellular spatial control can be achieved by confining the light stimulation area. In addition, we also show that different optical hetero-dimerizers and molecular motors can be incorporated using this strategy to induce mitochondria distortion.
    Note: Because of limiting number of images allowed per post, Figure 2D could not be inserted here. Its description is: "(D) Merged images showing a stretching mitochondrial tubule diverged at the crossover points between two microtubules indicated by the dashed-lined boxes."

    The light stimulated mitochondria extend itself out and attached to the microtubules, which are the photoelectric circuit infrastructure and highway carrying voltage from the melanosomes throughout our cells.

    This reach for life extending power is needed by the mitochondria during this time of transformation so that once the fission process completes, we may have two or more fully functional replicas of the original mitochondria.

    Ok, great - Light stimulates proton movement mitochondria-ON (mtON), fission and fusion dynamics and deformation as it interacts with neighboring microtubules. Nice, but what's a clinical application?

    Blue light therapy to the rescue? -> Illumination with blue light reactivates respiratory activity of mitochondria inhibited by nitric oxide

    This study aimed at clarifying whether low level illumination at specific wavelengths recovers mitochondrial respiration inhibited by NO. NO fully inhibited respiration of liver mitochondria at concentrations occurring under septic shock. The respiration was completely restored by illumination at the wavelength of 430 nm while longer wavelengths were less effective.


    Figure. 1. Above. Effects of NO and light on liver mitochondrial respiratory activity. Liver homogenates were incubated in a temperature-controlled respirometer and illuminated with blue (A), green (B), red (C) light, or not illuminated (D). Oxygen concentration (dotted line) and rate of oxygen consumption (solid line) were recorded simultaneously. Where indicated 25 lM NO in physiologic NaCl solution was added; experiments were carried out at 25 C. Mitochondria were illuminated with light from light emitting diodes (LEDline2 , Philips, Austria) of 629 nm (red), 530 nm (green) and 470 nm (blue). The illumination was started at the time indicated by arrows and continued until the end of experiment. Control homogenate was incubated in the dark. Depending on wavelength, illumination reactivates respiratory activity inhibited by NO.

    Conclusion - Visible light facilitates the recovery of mitochondria inhibited by NO at the levels generated under septic conditions in a wavelength dependent manner: short wavelengths are more efficient. This could be a simple new clinical approach in therapy of diseases accompanied by excessive NO production and mitochondrial dysfunction.

    The data presented in this study has direct relevance to sepsis and shock, dangerous clinical symdromes often causing multiple organ failure and death. Sepsis and shock induce overexpression of iNOS leading to an excessive formation of NO which was suggested to inactivate mitochondrial respiration contributing to the pathology of sepsis. One can expect that illumination therefore may be an appropriate means to reverse the effect of NO and improve mitochondrial function.
    So let's shine a "light" on blue-light therapy. ;)

    Optogenetic control of mitochondrial protonmotive force to impact cellular stress resistance

    Light-activated mitochondrial fission through optogenetic control of mitochondria-lysosome contacts

    Light-inducible Deformation of Mitochondria in Live Cells

    Illumination with blue light reactivates respiratory activity of mitochondria inhibited by nitric oxide

    The electro-conductivity of microtubules

    Last edited: Nov 16, 2022
    JanSz likes this.
  14. Centralized Medicine is so hopeful for new avenues for their drugs. Polina Anikeeva at the Massachusetts Institute of Technology said, "We’re dealing with something very small, injectable, more like a drug than a device. I think it’s really exciting. All of a sudden we can have subjects (human patients) that look entirely natural, no wires, no connectors no implants, and yet we will be able to control their symptoms using drug delivered nano-particles equipped with the ability to receive our stimulus."

    Electricity is the brain’s language, and now we can speak to it without wires or implants.

    Executive summary
    • The capability to externally control local electric fields due to the neural activity deep in the brain is hard to overestimate.
    • The potential applications range from deep brain stimulation for treating neurodegenerative diseases to nanotechnology tools to understand the brain.
    • In in vivo study on imprinting control region mice is conducted to show that magnetoelectric nanoparticles (MENs) may be able to address this subject. Due to the magnetoelectric effect, these ‘smart’ nanoparticles can directly couple intrinsic electric-field-driven processes with external magnetic fields for providing another dimension to control the neural activity.
    • Toxicity-free MENs, made of CoFe2 O4–BaTiO3 core-shell 30-nm nanostructures coated with a 2-nm glycerol mono-oleate, were pulled into the brain via magnetic field gradient of 3000 Oe/cm.
    • Scanning electron microscopy and magnetic force microscopy were used to detect nanoparticles in brain sections of imprinting control region mice.
    • A surgically attached electroencephalography headmount was used to confirm MEN-induced stimulation via application of an external magnetic field of 100 Oe in a frequency range from 0 to 30 Hz.
    Results & conclusions
    • The presence of MENs in the brain was confirmed via the above two imaging methods.
    • An external a.c. magnetic field modulated electroencephalography signal by a 1-mV a.c. signal.
    • The modulation signal depended on the external field frequency and amplitude, with a saturation field of 100 Oe
    In the first control measurement, EEG waveforms were recorded without introducing any nanoparticles in the brain. The typical EEG waveforms at five values of the a.c. frequency, 0, 5, 10, 15 and 20 Hz, respectively, are shown in Supplementary Figure 3 (left). The frequency spectrum (Fourier Transform) of the signal for each a.c. frequency response is shown in Supplementary Figure 3 (right). See figure 3 below.


    Figure 3 above. EEG Waveforms (left) and their frequency spectra (right) from the two EEG channels with MENs in the brain under exposure to an external 100-Oe a.c. magnetic field at frequencies of 0, 5, 10, 15 and 20 Hz. The vertical scale bar for the waveform signal is 5 mV.

    The authors are so excited -> "This study has demonstrated the feasibility of using magnetoelectric nanoparticles (MENs) as externally controlled ‘smart’ EMF stimulant that could potentially be used for navigation and selective control of specific functions deep in the brain. Even more far-reaching applications might be envisioned when biodegradable MENs will be developed in the future, which is definitely not out of reach due to the recent development in the emerging field of carbon based nanotechnology. The potential applications span from the prevention and treatment of neurodegenerative disorders to opening a pathway to significantly improving our fundamental understanding of the brain and reverse-engineering the brain."​

    Now let's put these statements into perspective -> These last two+ years have demonstrated AI big data mining capability, producing the power of COVID vaccine compliance. Once we have modeled through the reverse-engineering of human brain electrical firing variation, the word better Control - comes to mind...

    Magnetoelectric ‘spin’ on stimulating the brain

    20 billion nanoparticles talk to the brain using electricity

    Last edited: Nov 11, 2022
  15. JanSz

    JanSz Gold

    That could explain behavior of our leader and some others.

    Yes, to windmills, no to nuclear power.
    Oil is too precious, should not be wasted to produce power.

  16. Our Piezoelectric system is how voltage moves from our feet up our back side into our head and then down the front of our body into our feet. Building up a strong charge differential from one end of our cells to the other end is vital, making sure the polarity of the voltage has not flipped. There are devices to reorient these charges back to "correct" flow of electrical potential - https://tennantinstitute.com/ These devices are an important therapy; but the patient/client must do the work to build the correct charge (piezoelectric) voltage.

    Dr. @Jack Kruse understands human health is tied to light-water-magnetism; however, what we need to understand is magnetism is a by-product. Specifically, it is the "right-handed-rule" of piozoelectrical flow as the voltage moves. The "science" of magnetism is beginning to form out from "the dark ages" of Einstein thinking into a "better" understanding. The study of plasma physics is helpful.

    The question maybe: How does piezoelectric & photoelectric forces interact? I believe ->

    Light is a electromagnetic field-wave carrying the frequency height and intensity potential along a dielectric field wave vector. This information is stored in our melanin of our melanosomes which intermingle with other organelles (endoplasmic reticulum, peroxisomes) including our mitochondria, using our microtubules as the photoelectric highway. Once the capacity of stored light reaches a threshold, human photosynthesis potential is released across the melanin. The paramagnetic effect of an oxygen molecule is pushed out by the bipolar magnetic field-wave generated by the inductive electric discharge from this (human photosynthesis) process; and it (the oxygen) breaks its bond from the hydrogen within the crystalline (EZ) structured-water surrounding our organelles including our mitochondria.

    As the reader may know my focus is on three elements for increasing the human cellular "Energy" quotient
    • Photoelectric force
    • Biochemical-electrical force / signaling
    • Piezoelectric force
    When we look to "medical" or "scientific" journals, we must use our "critical thinking" to reverse engineer -> "What does human health look like?"
    Centralized medical science is stuck on how to inhibit human cellular function in order to substantiate their next drug sale.
    So if we are looking for "answers" to how to fix our sick human condition/elements, current science at best will show how to break it.
    Last edited: Jan 20, 2023
  17. Richard Watson

    Richard Watson New Member

    So true, this sentence would be ideal as a bumper sticker
    JanSz and John Schumacher like this.
  18. Sunlight as our Anti ->
    • microbial
    • fungal
    • parasitic
    • viral

    In this review, I will "highlight"
    • Light-based anti-infectives work against biofilms and localized infections.
    • Ultraviolet C light will kill all pathogens without killing host mammalian cells.
    • Photodynamic inactivation produces reactive oxygen species that kill pathogens.
    • Blue light can kill many pathogens due to accumulation of porphyrins.
    • Femtosecond infrared laser pulses can selectively kill pathogens.

    Light based anti-infectives: ultraviolet C irradiation, photodynamic therapy, blue light, and beyond

    As is well known, ultraviolet light, particularly UVC (200–280nm), is germicidal, but it has not been much developed as an anti-infective approach.

    Until recently, when it was realized that the possible adverse effects to host tissue were relatively minor compared to its high activity in killing pathogens.

    Photodynamic therapy is the combination of non-toxic photosensitizing dyes with harmless visible light that together produce abundant destructive reactive oxygen species (ROS).

    Certain cationic dyes or photosensitizers have good specificity for binding to microbial cells while sparing host mammalian cells and can be used for treating many localized infections, both superficial and even deep-seated by using fiber optic delivered light.

    Many microbial cells are highly sensitive to killing by blue light (400–470 nm) due to accumulation of naturally occurring photosensitizers such as porphyrins and flavins.

    Near infrared light has also been shown to have antimicrobial effects against certain species.​

    Tissue penetration of light is a limiting factor by the extremely short wavelength and difficulties in the delivery approach, UVC for anti-infective diseases is likely to be applied exclusively to superficial infections.

    One of the key questions about the use of UVC as an anti-infective is:
    Can UVC destroy microbial cells in tissue without causing irreversible and unacceptable severe damage to the host DNA and host cells?​

    Ultraviolet C irradiation: an alternative antimicrobial approach to localized infections?
    • With appropriate doses, UVC can selectively inactivate microorganisms while preserving viability of mammalian cells.
    • UVC is also found to be less damaging to tissue than UVB.
    • Even though UVC may produce DNA damage in mammalian cells, it can be rapidly repaired by DNA repair enzymes.
    Clinical applications:

    Comparison of ultrasound/ultraviolet-C and laser for treatment of pressure ulcers in patients with spinal cord injury

    All patients received standard wound care consisting of wound cleaning twice daily, application of moist dressings, and continuous relief of pressure until the wounds were healed.

    The laser protocol consisted of three treatments weekly using a cluster probe with an 820-nm laser diode and 30 superluminous diodes (10 each at 660, 880, and 950 nm), and energy density of 4J/cm2, and a pulse repetition rate of 5,000 pulses per second.

    The US/UVC regimen consisted of five treatments weekly, alternating the treatment modality daily.

    The pulsed US was applied at a frequency of 3 MHz and a spatial average-temporal average intensity of 0.2 W/cm2 (1:4 pulse ratio) for 5 minutes per 5 cm2 of wound area.

    The UVC dosage (95% emission at 250 nm) was calculated each session according to wound appearance. The dosage level was E1 for clean/granulating areas, E3 for purulent/slow-granulating areas, E4 for heavily infected areas, and 2E4 for wound debridement.

    Wounds were traced every 14 days, and surface areas were calculated using the Sigma-Scan Measurement System. Weekly percentage changes in wound area were compared.​

    Results: Results showed that US/UVC treatment had a greater effect on wound healing than did nursing care, either alone or combined with laser.​

    Conclusion and discussion: Ultrasound/ultraviolet-C may decrease healing time and may allow faster return to rehabilitation programs, work, and leisure activities for patients with spinal cord injury who have pressure ulcers.​


    Ultraviolet-C irradiation in the management of pressure ulcers in people with spinal cord injury: a randomized, placebo-controlled trial

    Conclusions: UVC is beneficial for stage 2 buttock ulcers. Further studies are warranted using a larger sample size, carefully considered exclusion criteria, and strategies to ensure homogeneity of the groups that are being compared.


    Bacterial cells can be divided into two groups called Gram-positive and Gram-negative bacteria, characterized by large differences in the cellular structure and organization (Figure 3A and B above).​

    Blue light (400-500nm) for infectious disease - Visible blue light, as given in the present study, does not cause deoxyribonucleic acid damage or early photo-ageing. The biological effects of blue light on normal skin are transient melanogenesis and inexplicable vacuolization without resulting apoptosis. In conclusion, the (short-term) use of visible blue light in dermatological practice is safe. https://pubmed.ncbi.nlm.nih.gov/20070834/

    Blue light for infectious diseases: Propionibacterium acnes, Helicobacter pylori, and beyond?

    In this review, we discussed the blue light sensing systems in microbial cells,
    • antimicrobial efficacy of blue light,
    • the mechanism of antimicrobial effect of blue light,
    • the effects of blue light on mammalian cells, and the effects of blue light on wound healing.
    It has been reported that blue light can regulate multi-cellular behavior involving cell-to-cell communication via blue light receptors in bacteria, and inhibit biofilm formation and subsequently potentiate light inactivation.

    At higher radiant exposures, blue light exhibits a broad-spectrum antimicrobial effect against both Gram-positive and Gram-negative bacteria.

    Blue light therapy is a clinically accepted approach for Propionibacterium acnes infections.

    Clinical trials have also been conducted to investigate the use of blue light for Helicobacter pylori stomach infections and have shown promising results.

    Studies on blue light inactivation of important wound pathogenic bacteria, including Staphylococcus aureus and Pseudomonas aeruginosa have also been reported.

    The mechanism of blue light inactivation of P. acnes, H. pylori, and some oral bacteria is proved to be the photo-excitation of intracellular porphyrins and the subsequent production of cytotoxic reactive oxygen species.

    Although it may be the case that the mechanism of blue light inactivation of wound pathogens (e.g., S. aureus, P. aeruginosa) is the same as that of P. acnes.


    Figure 1 above. Blue light (405-nm) inactivation of medically important bacteria.
    (A) Gram-positive bacteria;
    (B) Gram-negative bacteria. Irradiance: 10 mW/cm2.​

    Advances in the research on bactericidal effect of blue light and its mechanism

    As stated earlier on this post: Blue light is commonly used to kill Propionibacterium acnes in clinic.

    Blue light exhibits a good bactericidal effect against Helicobacter pylori, methicillin-resistant Staphylococcus aureus, Pseudomonas aeruginosa, and many oral bacteria in laboratory studies.

    The bactericidal mechanism of blue light as commonly accepted consists photo-excitation of intracellular porphyrins resulting in production of cytotoxic reactive oxygen species which can inactivate bacteria. Thus, Blue light can kill bacteria without additional exogenous photosensitizers. In addition, it produces little harm to mammalian cells.​

    Near-infrared (NIR) femtosecond laser via impulsive stimulated raman scattering (ISRS) to produce damage (e.g. to the protein coat of a virus) is a method for selectively inactivating microorganisms.

    Advantages of such a new laser technology over the presently prevailed disinfection methods have been proposed to be:
    1) it is a noninvasive disinfection technology, because no extraneous materials are needed in the disinfection process;
    2) it is a harmless environmental disinfection method since no chemicals are used in the pathogen inactivation process;
    3) it is a general method for selective disinfection of pathogens with potential minimal side effects.​
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  19. I believe each of us sees this beautiful jewel before us called life from different points of view through our own chosen rose colored glasses.

    As we put together our paradigm, I believe it is important to know that this developed understanding is at best our subjective perspective. This is why I am completely interdependent on others to help me see a different view of life.

    When we are connected with Nature, naked before her, knowing our vulnerabilities, I so appreciate her knowledge as she intuitively shares and reveals herself to us.

    I do not have the finances to fly to see Dr. @Jack Kruse, let alone the money to purchase the lodging once I get there. My wife and I go out to eat lunch once per year. Our idea of a vacation is a trip to the beach, sleep over night in the back of the car and cook discounted pork on a coleman burner.

    Dr. @Jack Kruse has stated multiple times, "If someone is not will to spend time with me, I don't have time for them."

    Dr. @Jack Kruse knows what it is to grow up financially humble; however, he was gifted with a magnificent mind & he put it to the task of learning neurosurgery.

    I too grew up financially humble; however, as I told Dr. @Jack Kruse during my 1-hour consult (which took me a year to save up for) that my mind was not so blessed.

    Each month, my wife and I contribute $49 towards Dr. @Jack Kruse 's online business. It is a sacrifice; however, it is the only way I know of to show Dr. @Jack Kruse that I care.

    My life time savings IRA went into GBTC when it was $44 dollars a share. Just to let you-all know, it was only 400K in US dollars at the time.

    I say these things only to let Dr. @Jack Kruse know that he is special and I respect his thinking - even though I may never get to tell him in person.

    I may be seeing life from a different paradigm.

    That is a perspective which sees life as an ever-expanding opportunity to connect. I see life itself within an organism of individuals who interact each other, cooperatively. As each “help” the other, a view (perspective) towards interdependency develops. Others may see things about ourselves we can not see. The old saying, “You can't read the label when you are inside the wine bottle.” When we attempt to objectively look outside of ourselves, we may try by using a mirror and look at what we recognize, but what do we see? Only others can help us see what we “can’t see”. Since not all individuals have developed a “caring” paradigm, it is important to find a circle of those you can trust. On these fibers of trust, we maybe able to accept messages we may perceive as “wrong” or as offensive; but the message may had been intended to be for our help. Our question maybe, do we react insulted, or do we ask, why had the message been sent from someone who seems to have been trustworthy to this point so far and do we pursue a dialog? The choice is ours to make as we develop our paradigm, our perspective towards life.


    Water instructs us best in understanding why Nature designed molecular collaboration. It shows us that water is preoccupited with extensive self-association. Water clathrates (pulls) its positive electrons in and stratifies (pushes out) its negative electrons. Nature reveals both a push toward surface tension and a cohesive pull, creating a beautiful spherical form. This gives water properties for hydration and solubility, yet it can repell “almost hold at bay” molecules like lipid hydrocarbons, fatty acids, without losing its innate characteristics.
    Last edited: Jan 20, 2023
  20. It's raining at the 38th latitude where I live; a nice 50 degrees fahrenheit.
    I love the rain at warm temperatures like these.

    I'm typically bare foot in shorts; however, when it really poses, I prefer to be nude.
    I love the negatively charged ion moister falling on all my exposed skin.

    With my head tipped back, feeling its gentle touch, splashing onto my closed eyes, falling off my face and down my body.

    I love to use this time to let go of my concerns, let go of my anxieties, let discouragement fall like the drops rolling off my very being.
    There maybe a tendency to hold on emotionally to the past, but I prefer Nature's active instruction to help train me in the practice of just letting go...

    Last edited: Dec 4, 2022
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