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GHB

Discussion in 'Ask Jack' started by Jim Laird, Jun 30, 2019.

  1. Jim Laird

    Jim Laird Gold

    Most sleep drugs of course are an absolute failure, because they don't address the root cause, light.

    Why was GHB such a great sleep aid? Does it have something to do with circadian cycles? Maybe a reset of the system? Or was it just an band aid for being disconnected from nature like everything else.

    Thanks
     
    Scompy likes this.
  2. Jack Kruse

    Jack Kruse Administrator

    GHB (gamma-hydroxybutyrate) is a natural product of human metabolism. It is a carbohydrate, found extensively throughout the human diet (all animal-flesh foods contain GHB). GHB is biologically synthesized from the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), a structurally similar amino acid that is also widespread in human metabolism and diet. GHB is also biologically converted back into GABA.

    Since it is a GABA analog it works on their receptors in the sleep pathways in the brain stem.
    GABA enables the body and mind to relax and fall asleep, and sleep soundly throughout the night. Low GABA activity is linked to insomnia and disrupted sleep. In one study, GABA levels in people with insomnia were almost 30 percent lower than in people without the sleep disorder.

    GABA synthesized from the excitatory neurotransmitter glutamate in a process that requires vitamin B6 as a cofactor. The delicate balance in the brain between GABA and glutamate is orchestrated by shuttle systems from the Krebs Cycle (TCA), the presence of NMDA and GABA receptor modulators, enzyme cofactors, and reuptake mediators. This makes poor sleep a big clue due to deuterium effects in the matrix due to its high KIE. Brain GABA has to be made in the brain to work because it does not cross the BBB. So taking GABA usually does not help sleep. GHB gets across the BBB so this is why it helps sleep in the brainstem.

    In the rest of the body, GABA plays a myriad of important protective roles. It modulates the adrenal response to stress by acting as the gate-keeper of norepinephrine and epinephrine release. These are catecholamines who also rely on Vitamin C cycling for their creation as I laid out in the November 2018 webinar. In the gut, GABA regulates the activity and regeneration of β-islet cells in the pancreas which are responsible for insulin secretion and blood sugar regulation. Diabetics often have a bad gut and brain GABA cycles and poor sleep and gut function due to melanopsin damage of their mitochondrial cytochromes. GABA made and stored in the nerves of the enteric nervous system (GALT) acts to mediate the upper gastrointestinal tract’s secretion and emptying mechanisms and modulate the sensation of visceral pain there. This is why diabetics have altered gut motility. The guts are absolutely covered in GABA receptors of all types.


    In low doses (<1 gm), GHB is a mild relaxant. It causes a subtle drop in muscle tone and a mild relaxation of inhibitions (making people more sociable), very much like drinking a beer or a glass of wine. This effect lasts for 1 or 2 hours. In moderate doses (1-2 gm), GHB causes strong relaxation (mental and physical). This effect happens in 5 to 10 minutes on an empty stomach and 15 to 30 minutes on a full stomach. GHB slows and deepens respiration (causing no net effect on blood gasses) and it slows the heart rate. There may be noticeable interference with articulation, motor coordination, and balance. At this dose, the effects can last 2 to 3 hours. In larger doses (2-4 gm), interference with motor control and speech is more pronounced and the relaxation effect is quite strong, often causing sleepiness or sleep.

    The sleep induced by GHB is very deep, making it more difficult than usual to wake somebody. This deep sleep has allowed lemming to criticize its use.

    During GHB-induced sleep, all the normal physiological sleep functions of the brain (stages 1, 2, 3 and 4, and REM) take place in a normal sequence.

    GHB selectively deepens stage 3 and 4 sleep, which are most frequently impaired in the elderly. This is probably the mechanism by which GHB treats narcolepsy. Deepening stage 3 and 4 sleep may also be the mechanism by which GHB increases growth hormone output (which normally takes place during the deepest stages of sleep). At the 2-4 gm dose range, GHB's effects last about 3 to 4 hours. At high doses (4-8 gm) and on an empty stomach, extremely deep sleep is usually induced within 5 to 15 minutes. The effect will sometimes last up to 4 hours. At extremely high doses (10-30 gm), the deep-sleep lasts for much longer periods. The highest reported GHB dose (termed a "poisoning" by the authors) involved a man who took an estimated 15 tablespoons (50-75 grams) of GHB! He woke up 24 hours later feeling groggy with a mild headache. He had no long term lasting effects based upon case reports.

    CITES:
    https://www.ncbi.nlm.nih.gov/pubmed/11983310
     
    Richelle Jones, Scompy, Arne and 6 others like this.
  3. Jim Laird

    Jim Laird Gold


    Thanks for the amazing reply. I used to use GHB back in my early powerlifting days after really hard training sessions, when you could buy it over the counter at GNC. I was always curious why It made my sleep so amazing... Funny thing is now that I take my light seriously it's pretty close to using GHB. It's sad some dip shits used it at a date rape "drug" and it got banned. It was a nice tool with little to no side effects.
     
    Last edited: Jul 1, 2019
    Alex97232 likes this.

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