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FOOD GURU PROBLEMS: Many blame glucose. Is it wise?

Discussion in 'The Epi-Paleo Diet' started by Jack Kruse, Feb 16, 2019.

  1. Jack Kruse

    Jack Kruse Administrator

    Lactate--not glucose--is the primary energy substrate in ALL mammals. You might want to read that again FOLKS. https://www.nature.com/articles/nature24057

    Glucose is the monosaccharide utilized by most eukaryotes to generate metabolic energy, and in the majority of eukaryotic systems, glycolysis is the first biochemical pathway where glucose breaks down via a series of enzymatic reactions to produce relatively small amounts of adenosine triphosphate (ATP). In 1940, the sequence of these glycolytic reactions was elucidated, a breakthrough that was recognized as the very first such elucidation of a biochemical pathway in history. Accordingly, the glycolytic breakdown of glucose ends up either with pyruvate as the final product under aerobic conditions or with lactate, to which pyruvate is being reduced, under anaerobic conditions. Consequently, pyruvate has been designated and is held to be the substrate of the mitochondrial tricarboxylic acid cycle, where it is completely oxidized into CO2 and H2O, while lactate has been defined and being held to as a useless dead-end product, poisonous at times, of which cells must discard off quickly.

    More than four decades after the glycolytic pathway has been elucidated, studies of both muscle and brain tissues have suggested that lactate is not necessarily a useless end product of anaerobic glycolysis and may actually play a role in bioenergetics. These studies have shown that muscle and brain tissues can oxidize and utilize lactate as a mitochondrial energy substrate. These results have been met with great skepticism, but a large number of publications over the past quarter of a century have strengthened the idea that lactate does play an important and, possibly, a crucial role in energy metabolism. These findings have shed light on a major drawback of the originally proposed aerobic version of the glycolytic pathway, that is, its inability to regenerate nicotinamide adenine dinucleotide (oxidized form) (NAD+), as opposed to anaerobic glycolysis that features the cyclical ability of the glycolytic lactate dehydrogenase (LDH) system to regenerate NAD+ upon pyruvate reduction to lactate. An examination of scientific investigations on carbohydrate metabolism of brain tissue in the 1920s and 1930s has already revealed that lactate can be readily oxidized. However, due to the prevailing dogma, according to which lactate is a waste product, its oxidation was assumed to be a possible mechanism of elimination. This chapter examines both old and new research data on glucose glycolysis both in muscle and in brain tissues. This chapter consolidates the available data in an attempt to form a more accurate and clear description of this universal and very important bioenergetic chain of reactions.
  2. Jack Kruse

    Jack Kruse Administrator

    A low carb zealot said on Twitter: "90 days beef & salt only carnivore, then went on a 1-week cruise to Mexico and Belize. Did not use sunscreen at all, experienced no burning. I am very light-toned, used to burn often, even with a screen."

    My answer was simple: Here is why it worked: https://www.patreon.com/posts/13077291

    #BlackSwanWisdom #MitochondriacWisdom #sunrise

    Alex97232 and caroline like this.
  3. Jack Kruse

    Jack Kruse Administrator

    Is losing weight just simply breathing out carbon at a faster rate than you absorb it from your food, over time? ANSWER: No it is not because the process is quantized in mitochondria by light. Seems like people needs to understand photosynthesis a bit better that made that food from CO2 and water and sunlight. The light the food is consumed under controls the enzymatic flux of carbon motions in mitochondria……this is precisely why food gurus are impotent to understand why blue light exposure fattens humans. This paper is a GEM. Dr. Kruse strikes again with uncommon wisdom around light. Hebbian learning controls the mitochondria in neurons that drive mitochondrial change programs, autophagy and apoptosis. Blue light shrinks the brain and retina using this mechanism buried within Hebbian modeling and everyone seems to forget that mitochondrial biology change programs are altered by blue light exposure via the geometry of the respiratory proteins and the effect of blue light sans UV/IR at CCO where water is created from the oxidative metabolism of foods. Carbohydrates make 50% less water at CCO compared to fats and it makes way less CO2 than fats do too. Yet carbohydrates fatten humans the most under blue light exposure. Not one food guru can solve for X. This is why food gurus fail the public. They forget all the key details and only focus on what they understand. Food gurus deride what escapes their ability to comprehend. MITOCHONDRIAC WISDOM IS ON DISPLAY HERE. How many will study it carefully to understand it well? How many will complain it is too hard to understand? https://www.cell.com/cell/fulltext/S0092-8674(19)30166-7
    Alex97232 and recoen like this.
  4. Emma C

    Emma C Titanium

    Ugh.....challenge accepted. I REALLY wanted to say it's too hard, but I'm not wired to be a "complainer" so now I have to study it. It will be my PDC beach study this weekend ;)

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