1. Registering for the Forum

    We require a human profile pic upon registration on this forum.

    After registration is submitted, you will receive a confirmation email, which should contain a link to confirm your intent to register for the forum. At this point, you will not yet be registered on the forum.

    Our Support staff will manually approve your account within 24 hours, and you will get a notification. This is to prevent the many spam account signups which we receive on a daily basis.

    If you have any problems completing this registration, please email support@jackkruse.com and we will assist you.

Food/exercise importance over the Circadian mechanism is no longer tenable

Discussion in 'Mitochondrial Rx' started by Jack Kruse, Mar 3, 2020.

  1. Jack Kruse

    Jack Kruse Administrator

    Anyone who does not understand that the circadian mechanism trumps food should be fired from your care team. The data is overwhelming now in 2020. The most recent studies have indicated that changes in mitochondrial morphology (i.e., fusion and fission), as well as generation of new mitochondria, are WHOLLY dependent on a viable circadian mechanism. In addition, fission and fusion processes display diurnal changes that are aligned to the light/darkness cycle. Besides morphological changes in the matrix, mitochondrial respiration also displays diurnal changes too. Disturbing the molecular clock in animal models leads to abrogated mitochondrial rhythmicity and altered oxidative respiration. Moreover, mitochondrial-dependent production of reactive oxygen species (ROS/RNS), which plays a role in cellular signaling, has also been linked to the circadian clock mechanism dysfunction. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854864/
     

Share This Page