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Food/exercise importance over the Circadian mechanism is no longer tenable

Discussion in 'Mitochondrial Rx' started by Jack Kruse, Mar 3, 2020.

  1. Jack Kruse

    Jack Kruse Administrator

    Anyone who does not understand that the circadian mechanism trumps food should be fired from your care team. The data is overwhelming now in 2020. The most recent studies have indicated that changes in mitochondrial morphology (i.e., fusion and fission), as well as generation of new mitochondria, are WHOLLY dependent on a viable circadian mechanism. In addition, fission and fusion processes display diurnal changes that are aligned to the light/darkness cycle. Besides morphological changes in the matrix, mitochondrial respiration also displays diurnal changes too. Disturbing the molecular clock in animal models leads to abrogated mitochondrial rhythmicity and altered oxidative respiration. Moreover, mitochondrial-dependent production of reactive oxygen species (ROS/RNS), which plays a role in cellular signaling, has also been linked to the circadian clock mechanism dysfunction. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854864/

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