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Exercise and ammonia metabolism

Discussion in 'Optimal Fitness' started by chocolate, May 7, 2012.

  1. chocolate

    chocolate Silver

    Ammonia metabolism, the brain and fatigue; revisiting the link. http://www.ncbi.nlm.nih.gov/pubmed/20138956

    Wilkinson DJ, Smeeton NJ, Watt PW.


    Department of Sport and Exercise Science, Chelsea School, University of Brighton, 30 Carlisle Road, Eastbourne, UK. D.Wilkinson@brighton.ac.uk


    This review addresses the ammonia fatigue theory in light of new evidence from exercise and disease studies and aims to provide a view of the role of ammonia during exercise. Hyperammonemia is a condition common to pathological liver disorders and intense or exhausting exercise. In pathology, hyperammonemia is linked to impairment of normal brain function and the onset of the neurological condition, hepatic encephalopathy. Elevated blood ammonia concentrations arise due to a diminished capacity for removal via the liver and lead to increased exposure of organs, such as the brain, to the toxic effects of ammonia. High levels of brain ammonia can lead to deleterious alterations in astrocyte morphology, cerebral energy metabolism and neurotransmission, which may in turn impact on the functioning of important signalling pathways within the neuron. Such changes are believed to contribute to the disturbances in neuropsychological function, in particular the learning, memory, and motor control deficits observed in animal models of liver disease and also patients with cirrhosis. Hyperammonemia in exercise occurs as a result of an increased production by contracting muscle, through adenosine monophosphate (AMP) deamination (the purine nucleotide cycle) and branched chain amino acid (BCAA) deamination prior to oxidation. Plasma concentrations of ammonia during exercise often achieve or exceed those measured in liver disease patients, resulting in increased cerebral uptake. In this article we propose that exercise-induced hyperammonemia may lead to concomitant disturbances in brain function, potentially through similar mechanisms underpinning pathology, which may impact on performance as fatigue or reduced function, especially during extreme exercise.
  2. chocolate

    chocolate Silver

    So now I'm seeing that a yeast infection likes to make its own ammonia if necessary to morph.


    Everything I tried to search regarding exercise and yeast infections said to change out of clothes immediately, shower immediately, blah, blah, blah.... Ammonia is ammonia.... I was reading on the horse racing website about horses with sore livers and to give them the aminos and less protein... but enough to get them well and some sort of citrus... What I'm wondering is, if during that alkalization phase when the yeast is doing its weirdo stuff, if it might be more vulnerable to the iodide? Like maybe, instead of eating meat and having no control, just exercise enough to stir the cooties up with ammonia and take the iodide and drink lots of water. I wonder if salty lemon water would help?
  3. chocolate

    chocolate Silver


    I'm thinking my fasting plan of exercise and iodide is ok, the iodine, not so much. I guess this is why iodine has to be converted to iodide anyway.
  4. chocolate

    chocolate Silver


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