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EMF 4 - Stumped ATP beta-ox questions

Discussion in 'The EMF Rx' started by dantothep, Feb 10, 2015.

  1. dantothep

    dantothep Follow life's little clues...

    Actually should I take creatine or d-ribose & carnitine ?
     
  2. Penny

    Penny New Member

    http://www.life-enhancement.com/magazine/article/2947-its-a-nad-nad-nad-nad-world

    If you're a slow methylator (not enough methyl groups) take creatine - because it is expensive (in terms of methyl groups) to synthesize - if you are a fast methylator (excess methyl groups lots of times due to COMT) then take niacinimide because it uses up methyl groups - I could have this totally backwards...

    You could just take nicotinimide d-riboside from lef.org and that would make NAD - don't know if it's more effective than just taking d-ribose chased with niacinimide -

    http://www.lef.org//Magazine/2012/10/Restoring-Cellular-Energy-Metabolism/Page-01

    glutamine and creatine are huge in the body building world... :)

    acetyl-l-carnitine transports fatty acids into the cell - so taking carnitine with coq10 + omega 3 fatty acids is synergistic -

    When I pop an acetyl-l-carnitine with a ubiquinol in the morning, I notice more energy - I also put d-ribose in my coffee and pop a niacinimide - when I remember to... I don't have a regular schedule for supplements - I try to get it from food - except for phospholipids which I take religiously before bed - I noticed memory improvements with phosphatidyl choline and serine (PS)- even more so when I added seafood and milk thistle -

    In fact, my latest love fest with smelts is causing me to remember stuff so much that I am actually noticing I am remembering stuff :)
     
  3. Penny

    Penny New Member

    Nicotinamide riboside, a trace nutrient in foods, is a vitamin B3 with effects on energy metabolism and neuroprotection.
    Chi Y1, Sauve AA.
    Author information

    Abstract
    PURPOSE OF REVIEW:
    This review focuses upon the biology and metabolism of a trace component in foods called nicotinamide riboside. Nicotinamide riboside is a precursor of nicotinamide adenine dinucleotide (NAD), and is a source of Vitamin B3. Evidence indicates that nicotinamide riboside has unique properties as a Vitamin B3. We review knowledge of the metabolism of this substance, as well as recent work suggesting novel health benefits that might be associated with nicotinamide riboside taken in larger quantities than is found naturally in foods.

    RECENT FINDINGS:
    Recent work investigating the effects of nicotinamide riboside in yeast and mammals established that it is metabolized by at least two types of metabolic pathways. The first of these is degradative and produces nicotinamide. The second pathway involves kinases called nicotinamide riboside kinases (Nrk1 and Nrk2, in humans). The likely involvement of the kinase pathway is implicated in the unique effects of nicotinamide riboside in raising tissue NAD concentrations in rodents and for potent effects in eliciting insulin sensitivity, mitochondrial biogenesis, and enhancement of sirtuin functions. Additional studies with nicotinamide riboside in models of Alzheimer's disease indicate bioavailability to brain and protective effects, likely by stimulation of brain NAD synthesis.

    SUMMARY:
    Initial studies have clarified the potential for a lesser-known Vitamin B3 called nicotinamide riboside that is available in selected foods, and possibly available to humans by supplements. It has properties that are insulin sensitizing, enhancing to exercise, resisting to negative effects of high-fat diet, and neuroprotecting.
     
    Josh (Paleo Osteo) likes this.
  4. JanSz

    JanSz Gold

    Niacinamide (Vitamin B-3)

    I take it daily, if not the flush gets bigger.
    I am doing it 5+ years, then yearly check with Spectracell to adjust dose.

    Does that allows me to estimate my PPP situation??

    .
     
  5. Penny

    Penny New Member

  6. Why not use niacin, a "ketone-mimetic", as opposed to niacinamide, which suppresses FFA oxidation and promotes glucose oxidation? Kind of the opposite of what is intended to access the PPP as far as I'm understanding.
     
  7. Penny

    Penny New Member

    I would guess most people take niacinamide or inositol hexacinimate (sp) because they loathe the niacin flush...
     
  8. dantothep

    dantothep Follow life's little clues...

    Wouldn't exogenous d-ribose ingestion make it harder to fully embrace the PPP?

    i.e. not encourage the body to make it's own....
     

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