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Do you need AM UVA sunlight in winter if you are coupled to cold and not light?

Discussion in 'The Cave' started by Curves, Oct 20, 2015.

  1. Curves

    Curves Guest

    I get that in winter, when you become cold adapted, your SCN becomes entrained to temperature and not light but I'm wondering about our need for am UVA.

    I'm thinking that it's a YES -- you need AM sunlight no matter what time of year for water chemistry to charge your battery etc but just confirming.

    Am I right?


    An excerpt from CT6: The Ancient Pathway

    Step 3. The suprachiasmatic nucleus (SCN) is the circadian pacemaker that monitors this dance between darkness and light and the seasonal cold and hot temperatures in our environment. Cold temperatures reverses all the normal biology that is used when the SCN is entrained to light. This metabolic trap door is huge for mammalian biochemistry. This is the only way to naturally way to enter this brain pathway now that we know of. When temperature becomes the dominant environmental trigger and not light cycles, the leptin receptor induces endothelial nitric oxide synthetase (eNOS) formation.
     
  2. JMO

    JMO Gold

    I'm guessing yes since we don't live in the cold...usually everyone is inside in their cozy warm house.
     
  3. Jack Kruse

    Jack Kruse Administrator

    eNOS is big........Why?
     
  4. Curves

    Curves Guest

    eNOS shuts down the photic effects of VIP on the SCN. eNOS by cold blocks the SCN from reacting to photic stimuli to entrain our circadian rhythms.
     
  5. Curves

    Curves Guest

    KEY POINT: In summer, we use eNOS with the photons of UVB and IR light to make sulfated proteins to deliver cholesterol and oxygen to tissues that need it. In winter, we use eNOS to deliver cholesterol and oxygen to tissues that need it using a plasma that is more loaded with electrons. Here you can see how our SCN goes from its light switch to its cold switch that I mentioned in CT 4 and CT 6. This is the metabolic trap door of the Ancient Pathway. Calcium efflux is the key metric to the change in the metabolic sensor in seasons. Today’s technology alters how that switch works
     
  6. Jack Kruse

    Jack Kruse Administrator

    [​IMG]

    Light penetration in the skin
    (attenuation down to 1% occurs for light wavelengths of 250-280 nm at around 40 μm depth; for 300 nm at 100 μm; for 360 nm at 190 μm; for 400 nm at 250 μm; for 700 nm at 400 μm; for 1.2 μm at 800 μm; for 2 μm at 400 μm; for 2.5 μm at 1μ; and for 400 μm at 30 μm)

    When you see how UVC only penetrates 55 microns, and UVC is universally toxic to all life it should make you realize how destruction of the surfaces of things trumps the biochemistry of things way below it. This picture says a million words no paleo biochemist could understand with their conventional wisdom ideas. I told you cancer is an epi-oncogenic phenomena in the Ubiquitination series. This also explains why 90% of cancers originate in the epithelial layer of our body and organs. It also shows you why most breast and prostate cancers are associated with low vitamin D levels. The problem is not at the nucleus in the genome. It is at the surface where the environment meets the cell. Light controls carbon flows.

    Also note how UVC and IRC both only affect the top layers and yet both are deadly...........anyone connecting dots yet?

    UVC is germicidal, no? Also kills skin cells ridiculously quick right? Yep...........but here is the thing.........paleo biochemists tell people it is cellular biochemistry that destroys you........yet UVC light only bothers the first 55 microns.........that means they are missing something quite big.................and they are. What is it?

    It is called light effect at surfaces: 1921 Noble Prize : the photoelectric effect by Einstein. This means light alone can change the atomic lattice of anything it hits. And if what it hits has a ton of fluorophores the effect is greater. Think the RPE, skin, and NAD+ as classic examples. The effect is always mediated when light hits electrons and not the nucleus.

    So do we glow when light hits us causing us to lose higher energy electrons? We glow and release nitric oxide from our surface cells to change the surface of the skin hit by light. Nitric oxide also happens to have an free electrons with its own spin because it is a free radical. When light hits it, the electron is liberated by scatter to form a triplet state.
    Full spectrum sunlight is fully capable of alters charge of NO by making that electron a higher energy electron filled with UV light to change other proteins in the skin that like UV light excited electrons. What might those proteins be?

    The thing is there is no way to satisfy the octet rule for both atoms in NO. The structure is a double bond with three non-bonding electrons on N and four on O but really one of the electrons on N is not localized to N but the entire molecule.
    Formal charge = electrons in ground state - (non-bonding electrons + 0.5 * bonding electrons)
    Formal charge for N = 5 - ( 3 + 4 * 0.5) = 0 (there are two bonds so four electrons are involved in bonding)
    Formal charge for O = 6 - (4+ 4 * 0.5) = 0
    Sunlight alters that balance of charge.
     
    Last edited: Dec 3, 2015
    Brent Patrick, rlee314 and Curves like this.
  7. Jack Kruse

    Jack Kruse Administrator

    Hemoglobin, porphyrins and nitric oxide.
     
  8. Jack Kruse

    Jack Kruse Administrator

    Exposing skin to sunlight may help to reduce blood pressure and thus cut the risk of heart attack and stroke, a study published in the Journal of Investigative Dermatology suggests

    Research carried out at the Universities of Southampton and Edinburgh shows that sunlight alters levels of the small quantum messenger molecule, nitric oxide (NO) in the skin and blood, reducing blood pressure.

    Martin Feelisch, Professor of Experimental Medicine and Integrative Biology at the University of Southampton, comments: "NO along with its breakdown products, known to be abundant in skin, is involved in the regulation of blood pressure. When exposed to sunlight, small amounts of NO are transferred from the skin to the circulation, lowering blood vessel tone; as blood pressure drops, so does the risk of heart attack and stroke."

    Dr Richard Weller of the University of Edinburgh, suggest that minimizing exposure may be disadvantageous by increasing the risk of prevalent conditions related to cardiovascular disease and likely will extend to the CNS because it gets 20% of the hearts output.

    Cardiovascular disease, often associated with high blood pressure, accounts for 30 per cent of deaths globally each year. Blood pressure and cardiovascular disease are known to vary according to season and latitude, with higher levels observed in winter and in countries further from the equator, where ultraviolet radiation from the sun is lower.

    During the study, the skin of 24 healthy individuals was exposed to ultraviolet (UVA alone was able to show this effect) and light from tanning lamps for two sessions of 20 minutes each. In one session, the volunteers were exposed to both the UVA rays and the heat of the lamps. In another, the UV rays were blocked so that only the heat of the lamps affected the skin.

    The results suggest that UVA exposure specifically dilates blood vessels, significantly lowers blood pressure, and alters NO metabolite levels in the circulation, without changing vitamin D levels. RNS triplet state free radical metabolites have powerful far reaching effects in humans beyond their skin surfaces. Further experiments indicate that pre-formed stores of NO in the upper skin layers are involved in mediating these effects. The data are consistent with the seasonal variation of blood pressure and cardiovascular risk at temperate latitudes.

    Professor Feelisch adds: "These results are significant to the ongoing debate about potential health benefits of sunlight and the role of Vitamin D in this process. It may be an opportune time to reassess the risks and benefits of sunlight for human health and to take a fresh look at current public health advice. Avoiding excess sunlight exposure is critical to prevent skin cancer, but not being exposed to it at all, out of fear or as a result of a certain lifestyle, could increase the risk of cardiovascular disease. Perhaps with the exception of bone health, the effects of oral vitamin D supplementation have been disappointing.

    "We believe that NO from the skin is an important, so far overlooked contributor to cardiovascular health. In future studies we intend to test whether the effects hold true in a more chronic setting and identify new nutritional strategies targeted at maximizing the skin's ability to store NO and deliver it to the circulation more efficiently."
     
  9. Jack Kruse

    Jack Kruse Administrator

    Pills don't give you triplet state. UVA light does. Still afraid of black lights indoors?
     
  10. Jack Kruse

    Jack Kruse Administrator

    You know that all sunlight contains UVA no matter the season right?
     
  11. Jack Kruse

    Jack Kruse Administrator

    Nitric oxide (nitrogen oxide,nitrogen monoxide) is a molecular, chemical compound with chemical formula of NO that is a colorless gas under standard conditions. Nitric oxide is a free radical—i.e., its bonding structure includes an unpaired electron with a specific electronic spin state. It is a practically important intermediate in the chemical industry. In addition, some is unavoidably produced during combustion of fossil fuels in power plants and automobile engines, with excess being created when there is present more air, or higher temperatures, than needed for efficient and complete combustion of the fuel. In skin thermal temps are raised by UV/IR light and oxygen is increased by UV light striking the skin alone. Not only does skin make it with powerful sun but so does the atmosphere in quantum fashion. It is also produced naturally by the extremely high air temperatures produced along the path of lightning in thunderstorms.

    It was found that NO acts through the stimulation of the soluble guanylate cyclase, which is a heterodimeric enzyme with subsequent formation of cyclic-GMP. Cyclic-GMP activates protein kinase G, which causes reuptake of Ca2+ and lowers the intra cellular calcium by the opening of calcium-activated potassium channels. This is protective in high nnEMF environments. The fall in concentration of Ca2+ ensures that the myosin light-chain kinase (MLCK) can no longer phosphorylate the myosin molecule, thereby stopping the crossbridge cycle and leading to relaxation of the smooth muscle cell allowing more RBC s loaded with porphyrin to continue absorbing UV light.
     
  12. Jack Kruse

    Jack Kruse Administrator

    Nitric oxide, is also known as the 'endothelium-derived relaxing factor', or 'EDRF', is biosynthesized endogenously from L-arginine, oxygen, and NADPH by various nitric oxide synthase (NOS) enzymes. Reduction of inorganic nitrate may also serve to make nitric oxide. The endothelium of blood vessels uses nitric oxide to signal the surrounding smooth muscle to relax, thus resulting in vasodilation and increasing blood flow so we can collect a lot of UV light. How does Hemoglobin fit in to this blood UV story?

    Two important biological reaction mechanisms of nitric oxide are S-nitrosation of thiols, and nitrosylation of transition metal ions. S-nitrosation involves the (reversible) conversion of thiol groups, including cysteine residues in proteins, to form S-nitrosothiols (RSNOs). S-Nitrosation is a mechanism for dynamic, post-translational regulation of most or all major classes of protein in all living things. This is why the ubiquitination series has so many blogs. Light controls protein turnover by this mechanism. The second mechanism, nitrosylation, involves the binding of NO to a transition metal ion like iron or copper. These are found in the mouth of every cytochrome protein. Did you also know that cytochrome C is also a heme protein? In this nitroslyation function, NO is referred to as a nitrosyl ligand. Typical cases involve the nitrosylation of heme proteins like cytochromes, thereby disabling the normal enzymatic activity of the enzyme when it becomes necessary in cold environments. Nitrosylated ferrous iron is particularly stable, as the binding of the nitrosyl ligand to ferrous iron (Fe(II)) is very strong. Hemoglobin is a prominent example of a heme protein that may be modified by NO by both pathways: NO may attach directly to the heme in the nitrosylation reaction, and independently form S-nitrosothiols by S-nitrosation of the thiol moieties. Hemoglobin absorbs light at 280 nm and 3 other IR frequencies. Maybe now you can see why they link to NO.
     
    Last edited: Oct 20, 2015
    Curves likes this.
  13. Jack Kruse

    Jack Kruse Administrator

    Brent Patrick and rlee314 like this.
  14. Curves

    Curves Guest

    So, sit naked under your black lights indoors if you can't get outside due to rain or snow, and experience triplet state optimal health no matter what the season. Got it Dr. K..
     
    nikita, rlee314, cantweight and 4 others like this.
  15. caroline

    caroline Moderator

    pictures please.....
     
    enyaw, nikita, Kristi Lambert and 3 others like this.
  16. nicld

    nicld Gold

    I love sitting under my black light at night before bed. Sleep has been improving. Now to just see if it stays that way during the second half of my cycle.
     
    Curves and thisbirdhaswings like this.
  17. Shijin13

    Shijin13 Guest

    Damn there's an epic amount of purple in this thread. pure gold.
     
    enyaw, Scompy and Curves like this.
  18. Shijin13

    Shijin13 Guest

    I contemplated this yesterday - and posted this on the FB Quantum Group.... it fits here....

    Thoughts on light as I drove to the office today and inspired by trees. As UV fluctuates as the N.Hemisphere transitions from fall to winter, the decrease in overall UV exposure, as well as exposure of all light diminishes, directly effects the surface chemistry of leaves of deciduous trees resulting in the brilliant explosion of color. Trees then begins their migration toward dormancy until the UV reaches the minimum to facilitate growth of new leaves. So In Animals drop of UV levels signal the last dash before hibernation or migration. So if you're a human you have two choices. Embrace the cold as your signaling for surface chemistry or follow the sun.
     
    cmegan, seanb4, Optimalbound and 5 others like this.
  19. Curves

    Curves Guest

    Gretchen, I loved your FB post yesterday. In fact, it was your post that -- I'll use the phrase "gave me the courage" -- to ask this question here as it's been spinning around in my head as we all contemplate the winter months.
     
    Shijin13 likes this.
  20. Curves

    Curves Guest

    You made me laugh - hard!
     
    Shijin13 likes this.

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