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Do viruses alter mitochondrial redox to set the stage for mutants?

Discussion in 'Educating Doctors' started by Jack Kruse, Mar 20, 2021.

  1. Jack Kruse

    Jack Kruse Administrator

    Growing evidence suggests that people with cancer and other conditions that challenge their immune systems may be incubators of mutant viruses.

    Did you know that damage to DNA in a cellular organelle called the mitochondrion triggers an immune response in the nucleus? Mechanistic insights into this process shed light on how organelles communicate.

    Writing in Nature, Tigano et al.uncover a mechanism by which cells sense toxic mtDNA damage to initiate an immune response in the nucleus.

    The study highlights an immunostimulatory role for mtRNA.

    This paper has huge implications for mRNA vaccines. Can you guess why we have variants now?

    1. Nature 591, 372-373 (2021)
    doi: https://doi.org/10.1038/d41586-021-00429-w
    John Schumacher and Sandy Dwan like this.
  2. Michael CULLEN

    Michael CULLEN New Member

    Dr Kaufman would not agree.

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