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Diabetes and Fuel switching: low carb flu = poor mitochondrial ineffieciency

Discussion in 'The Leptin Rx' started by Jack Kruse, Jan 4, 2013.

  1. Jack Kruse

    Jack Kruse Administrator

    Sujoe123 likes this.
  2. Dali Dula

    Dali Dula Moderator

    Do you agree with is and what do we take away? Is cortisol reduction the most important factor in improving insulin resistance? Can you comment on the final statement of this article:

    Support for diabetics should entail, based on the discussion above, foremost, body fat loss, rational dietary changes, calcium and magnesium, suppression of NEFA (e.g., with sugar, glycine, niacinamide, and red light), and restoration of glucose oxidation (e.g., with fructose and T3).
  3. Jack Kruse

    Jack Kruse Administrator

    Bob read this again please: http://www.jackkruse.com/hormone-cascade-101/

    Read the summary carefully and the first two paragraphs.
  4. Jack Kruse

    Jack Kruse Administrator

    We can all have good ideas in parts of our theories........but it does not make the big Idea correct.

    And Yes I am constantly aware of that with respect to myself.

    I look to adapt my knowledge base instead of defending things I now know are fallacies.......

    I dont see that in paleo land.
  5. Jack Kruse

    Jack Kruse Administrator

    fructose has zero role .............but the rest of it is not bad at all........if leptin Resistance Part deux is perfect.......(yes another blog I wrote) that means gluconeogenesis is perfect and you make your own 6 carbon sugars to make enough D ribose from the Hexose Monophosphate shunt to replenish ATP.

    Fructose ingestion actually depletes ATP faster than any sugar.

    Andrew and Ray Peat dont get that part.....they believe it increases it. RQ in patients who eat it clinically say otherwise

    We are all about ATP production.

    Without it, they call us cadavers.
    labellavita and David Limacher like this.
  6. Destiny

    Destiny New Member

    I just want to mention my own experience. My FBG was in 100's until I absolutely avoided any fructose.
    This also led to a quick fat loss from 142 lbs to 128 lbs (over 3 months). Now, my FBG is in 70's.
  7. Jack Kruse

    Jack Kruse Administrator

    Darleen likes this.
  8. Dali Dula

    Dali Dula Moderator

    Thanks for the pointer. I think I got it.
  9. Shijin13

    Shijin13 Guest

    ok... I've finally had the time to dig into this thread...

    so, I have a question. what does it mean when your IL-6 is low, but your TNF is high, yet you're converting T4 --> T3, but your T4 is low and your TSH is high? obviously continued inflammation - but the question is where? is it at the brain, liver - or is it specifically at the mitochondrial level as the result of leakiness at level 1 b/c you're not yet a fat burner? I'm still showing the "Dawn Phenomena" when I wake before the sun on work days. but when I sleep in or CT its in the low 80s, which I see as yet another indicator of inefficient mitochondria....

    next set of labs should be interesting...
    cantweight and David Limacher like this.
  10. Jack Kruse

    Jack Kruse Administrator

    the testing we have today can not answer that.....but do i believe soon will will have new tools to help us decipher this? yes
    Josh (Paleo Osteo) likes this.
  11. Charlotte

    Charlotte New Member

    I am planning to attend. Look forward to find out, what is new.
  12. Jack Kruse

    Jack Kruse Administrator

    Jan Webinar is on the Mitochondrial Rx. Bring your A game because we going to talk some biochemistry before the clinical stuff.
    cantweight likes this.
  13. Shijin13

    Shijin13 Guest

    Ill be ready!

  14. http://www.andrewkimblog.com/2013/02/response-to-dr-paul-jaminets-rebuttal.html

    Kim seems to acknowledge this point in point 5:

    "Fructose does, in fact, deplete ATP more than glucose does simply because of the nature of its metabolism, but the effect is subtle and not necessarily undesirable. By rapidly depleting the high-energy phosphate bonds of ATP, fructose (1) forces glucose to be used at a higher rate and (2) depletes the reducing cofactor called NADH, which is a good thing (and a topic for a whole other post).
    So, through these dynamic processes the excessive accumulation of ADP, AMP, and adenosine (which irreversibly diffuses out of the cell and is ultimately degraded to uric acid) is effectively kept in check, and ATP levels inside cells don’t decrease too much."

    i am not sold yet.
    David Limacher likes this.
  15. Jack Kruse

    Jack Kruse Administrator

    not one mention about light......ATP levels are tied to red light. Modern light has none.
    QuantumRadical and Danco3636 like this.
  16. enyaw

    enyaw New Member

    What is the 'Dawn Phenomena'?
  17. Jack Kruse

    Jack Kruse Administrator

    Not one mention of altered mitochondrial oscillations. Not one. Kim misses the target for me.
  18. Jack Kruse

    Jack Kruse Administrator

    Low quantum yield exacerbates the Dawning phenomena. Why? You need AM sunlight to yoke the melatonin, dopamine and cortisol cycles. So the 4 AM spike of cortisol ends the melatonin surge from midnight. This raises AM blood glucose because fat burning is not optimized when AM sunlight is out. During darkness it is optimized. So when the sun hits the retina you initially need that small burst of glucose to help jump start AM metabolism with a photopic eye. An environment with low quantum yield exacerbates the Dawning phenomena and the spike grows larger than one would expect. This is why most diabetics show a large respond because their AM light environment sucks.
    Coldsnow, Danco3636 and lohd2015 like this.
  19. Jack Kruse

    Jack Kruse Administrator

    The same key can open the doors to heaven or hell. The environment it occurs in or the redox time stamp of the gut when it occurs decides which outcome you experience is the take home. Stop blaming food for what you environment is causing. Lesson is here. https://www.nature.com/articles/s41586-022-04408-7

    Here you can see protein fuels can do two things based upon redox power from the environment.
  20. Jack Kruse

    Jack Kruse Administrator

    Diabetes acute onset is always linked to seasons with suboptimal sunlight. No shocker to any Black Swan. Adams, S. F. (1926). The seasonal variation in the onset of acute diabetes: The age and sex factors in 1,000 diabetic patients. Archives of Internal Medicine, 37(6), 861-864. https://doi.org/10.1001/archinte.1926.00120240133010

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