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DEEP IMPLICATIONS OF VERMONT 2018 are................

Discussion in 'Mitochondrial Rx' started by Jack Kruse, Jun 3, 2018.

  1. Jack Kruse

    Jack Kruse Administrator

    Deep Implications of Vermont 2018 talk: If electric topology makes water more susceptible to UV spectrum interactions what does this mean for water chemistry in the UVC range @270nm? Might our endogenous production of shortwave UVC separate water in the blood plasma into ortho and para-water clusters? I think so. Every water molecule in the universe is either a para-water
    molecule or an ortho-water molecule. Para-H2O does not interact with an external magnetic field, but ortho-H2O does. Conversion between these isomers is symmetry-forbidden for isolated water molecules and they act as different molecular species. Could the attobiology of shortwave UV allow for proton tunneling in these two forms of water in your blood plasma? If so can these water clusters work during day and night because of their different electrical properties? I think so based upon one of the new papers I unleashed in Vermont 2018.

    Based upon the physical differences in the properties of these two forms of water in our blood plasma, I'd expect them to show a greater reactivity to manifest in a varying electric field. That is what a day night cycle really is. Daytime has a much higher electric field potential than night time so I'd expect para-water to be the form of water that operates with deuterium and UV light in our skin. This version of water would be more highly reactive with proteins and lipids in our cells if my instincts are correct.

    These effects on the spin state of water may be imposed externally, from surfaces or from water clustering itself. Many materials preferentially adsorb para-H2O due to its non-rotation ground state can CHANGE spin state on interaction with another particle, electron, proton, photon including other water molecules. This is likely how sunlight information is transferred to lipids and proteins in cells. Our DNA is the hardware, but water and sunlight are the software that runs the hardware in us. The equilibrium ratio of these nuclear spin states in H2O is all para at zero Kelvin. In this temperature environment, the molecules have no rotational spin in their ground state. This temperature shift allows the spin state of water to shift to the most stable ratio that the environment allows. https://www.sciencealert.com/quantu...r-water-greater-reactivity-than-ortho-isomer?

    [​IMG]
     
  2. So, UVC increases the ratio of ortho/para - right? My guess is that, as UV builds redox during the day, ortho is the fraction that builds redox the most? If so, that would be a good reason to have UVC as part of an IV blood irradiation protocol. But, of course as I said, only a guess.
     
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  3. JanSz

    JanSz Gold

  4. Jack Kruse

    Jack Kruse Administrator

  5. Jack Kruse

    Jack Kruse Administrator

    You'll get the implications when you see the talk on Patreon.
     
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  6. Jack Kruse

    Jack Kruse Administrator

  7. Jack Kruse

    Jack Kruse Administrator

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  8. Jack Kruse

    Jack Kruse Administrator

  9. Jack Kruse

    Jack Kruse Administrator

    This slide came from my Vermont 2018 talk. People who heard the talk might not make the following connections but that is the implication in the slide. Prolactin inhibits sex hormones, and melatonin stimulates prolactin (supportive data by Gill-Sharma 2009 & Campino et al., 2008). Thus, high levels of blue light in the summer in sunlight create less melatonin in our system in the summer which implies less activation and activation of prolactin = more production of sex & fertility. What is the off switch to control the sex steroid hormones? The strong UV rays hit your skin when you have skin in the game and this limits the power of the increased production of hormones. That is how nature controls herself with excessive blue light and more plentiful UV light.

    [​IMG]
     
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  10. Jack Kruse

    Jack Kruse Administrator

  11. Jack Kruse

    Jack Kruse Administrator

  12. Jack Kruse

    Jack Kruse Administrator

    In the days before electric lights and technology screens, humans spent summers, sleeping less in summer and as autumn came they would eat more heavily in preparation for winter because the changing solar light cycles triggered an increasing hunger for foods like late season carbohydrates. Today, blue light is present 24 hours a day, and modern humans live in it over 90% of the time. Now that research is clear that melanopsin is present in our skin and that opsin is loosely covalently bound to melanopsin, we have created the perfect storm to cause all modern disease epidemics. Bad lighting choices, heating and air-conditioning climate control our mitochondria to lead to hormonal responses to consume carbohydrates now available year round. The reason is simple. Melatonin controls mtDNA and autophagy. The lowered Vitamin A levels in the plasma destroy melatonin levels while also putting a cap on the ability to make Vitamin D3 from LDL cholesterol at the skin. This is the scenario for every disease we see today.

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  13. Jack Kruse

    Jack Kruse Administrator

    Now more collateral effects about how seasonal sunlight really operates in tissue compartments based upon my talk in Vermont 2018: Dopamine production is strongly created by summer sun because tyrosine is aromatic amino acids that build dopamine and its absorption spectra are deep in the UVC range as the slides showed. What are the implications? Dopamine is created in strong UV environments and this inhibits prolactin, whereas Thyroid releasing hormone (Vermont 2017 talk) and melatonin creation stimulate it. Melatonin is also made from an aromatic amino acid with a 240-300nm UVC/UVB light. That amino acid is TUNABLE by sunlight as the talk showed.

    How tryptophan really works with the sun is the key to the mystery of what deuterium is really up to in the vessels and its absence in Kreb's bicycle. Recall that POMC is stimulated by AM sunlight and ACTH is one of the 6 proteins cleaved from POMC in the eye and skin. Melatonin also blunts ACTH induced cortisol secretion we see early in the AM that wakes us up. Cortisol allows for more water flows to alter the tensegrity stretch in the brain. This idea is supported by data from Torres-Farfan 2003 and Campino 2008. It has been reproduced many times since then too. This implies the winter season with cooler temperatures is still capable of leading to higher melatonin, prolactin, and low cortisol and dopamine. How does this occur? Temperature and pH control the information in electrons and protons flowing from the water made by mitochondria to the hydrogen bonding network in the 7 places in the brain with no blood-brain barrier where these chemicals transmit the sun's knowledge to our proteins.

    The effect is seen in how H+, deuterium, and electrons are programmed differently as light changes and eNOS takes over. This is why CT 4 and CT 6 now should fully make sense to any member on this site. Biochemistry is thermoplastic and that change leads to changes in where deuterium and hydrogen flow in a cell. This implies that the summer season should be associated with a high dopamine and cortisol cycle, and low melatonin and prolactin. Prolactin is supposed to be high in winter, to support a pregnancy and live birth and proof of concept is a low dopamine cycle at this time would support this driven by weaker sunlight. It is also true. This is why blue light causes so much SAD in the winter. The finding of melanopsin and Vitamin A in the largest organ in the body helps close a confusing circle for many who do not see how the pieces fit...........because they have not seen them fall apart in thousands of patients as a physician has who is paying attention to nature.

    1.https://www.ncbi.nlm.nih.gov/pubmed/12519889
    2.https://www.ncbi.nlm.nih.gov/pubmed/19301769
    3.https://www.ncbi.nlm.nih.gov/pubmed/16399687

    There are many papers that confound the above findings because none of these researchers can figure out why some parts of the human brain have different levels of dopamine and melatonin in brain nuclei........why does brain location cause a variation in production of these chemicals? IT occurs because they vary as the solar calendar of the environment of the animal varies. This implies there will be LESS variation in humans who live inside the tropics and have an uncoupled haplotype. These people will always have systems built around strong summer signals and they will have no need to uncouple protons from ECT to make heat to control biochemistry in deeper levels because UV light also creates heat and pile driving effect at the skin surface to keep deuterium in the blood and out of tissues to create the light aromatic amino acids need to operate in us. These amino acids are our sundials or gears of the circadian mechanism.
     
  14. Jack Kruse

    Jack Kruse Administrator

    [​IMG]The more malignant the tumor, the higher its fermentation rate.
    [​IMG]Why? An oxygen-deprived environment is primed for glycolysis.
    [​IMG]️Baking soda not only buffers against acidification but starts repair of damaged circadian rhythms.
    The destruction of the rhythms is 100% to the effect of blue light on melanopsin in the eye and skin and what Vitamin A does to melatonin.

    This fact was in the Vermont 2018 talk in a big way.

    What helps the situation further? Sunlight because of it the VDR/D3 and NO from UVA at the skin all lower ECT and improve apoptosis and one cannot get cancer unless apoptosis and autophagy are destroyed.https://www.genengnews.com/gen-news...da-may-clean-cancers-circadian-clock/81255864
     
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  15. Jack Kruse

    Jack Kruse Administrator

    Artificial light exposure at night blunts melatonin secretion. This is worse for young children or people who live in cities with a big nightlife and with lots of people who use technology devices for their brain and their gut. It is devastating because now melanopsin is not just in the eye it is in the skin and the skin is by far our largest organ and it controls all the peripheral clock genes in the human body. This has massive implications for many organ diseases.
    Jeff Leach’s research team findings on the Hazda at the equator, recently published in SCIENCE have broken the false narrative of the microbiome gurus. In Vermont 2018 he reported to the audience that the Hazda were given processed food, coke, Fanta, and wheat and ANTIBIOTICS and their microbiome was exactly the same as it was 24-48 hours after exposure with direct fecal testing in the field. He told the audience that this data broke their hypothesis that food really was the main driver of mitochondrial diversity. When I mentioned to him that night did he know why the microbiome remained constant he had no answer? He said his research team was going to study it. I told I had the answer and that I would give it on stage on Saturday, June 2, 2018, and blow him away and ruin the thesis of Zach Bush in one sentence.

    The microbiome remains the same because solar light also has NO VARIATION at the equator and as such the skin controls all the peripheral clocks in the gut because of the melanopsin mechanism in the skin and subcutaneous fat and eye. Since melanopsin is loosely bound to Vitamin any blue light exposure of the skin causes circadian disruption. Since Vitamin A cycles are tightly yoked to Vitamin D production in the skin as Vitamin A drops in the plasma from skin irradiation with the blue light it DIRECTLY limits how much Vitamin D3 can be made. This affects the VDR receptors in the enterocytes. Without the VDR and D3 complex present in the gut ECT of the enterocytes could not be slowed. Moreover, the blue light exposure on the skin caused alterations in the peripheral clock genes of the enterocytes. This means we'd lose control of replacing them as the body normally does. I also reminded him that when the circadian mechanism is intact, the body normally repairs all enterocytes in 24-48 hours no matter the cause of the gut surface insult, proving that the strong solar stimulates strengthened the enterocyte damage by FULL REPLACEMENT from all etiologies. Nature expects environmental insults to these cells hence why they are replaced so fast normally. It also explains why humans are the only primate with zonulin that makes the gut more leaky by design to viruses that drive genomic change in us using solar light as well. This is why Barry Marshall had to drink infect himself with H pylori because none of the chimps he was using had zonulin to see the effect himsself.

    I also told the audience that people like Zach Bush, who study the microbiome of people in the USA, would never be capable of seeing, studying, much less understanding this effect because his clinic is in Virginia and his patients do not have tightly coupled mtDNA haplotypes and they are not wild humans who live close to the equator who expose their skin to the sun with strong UV light.

    Moreover, this is where the other skin opsin comes to play, neuropsin. It is the key opsin in the creation of endogenous light activation of the shortwave UV light mechanism I mentioned in the Vermont talk. UVA light sensation is the key stimulus to the creation of the UV spectrum cells need to operate optically. They do this by pressurizing deuterium in the blood plasma after having a sustained pile driving pinch by the suns rays from outside in, and the upward rise of blood and subcutaneous fat because of the effect of UVA light on nitric oxide production.

    Jeff and his team have proved one of my predictions again that food cannot alter the microbiome if the sun is strong and builds the circadian mechanism into a fortress. With this new knowledge, no one should buy any probiotics or RESTORE probiotics from anyone including Dr. Bush. Never mind there is not one in vivo study showing RESTORE works, now with the news melanopsin is on the skin/fat it blows all the bullshit memes about food changing the microbiome out of the water. This is why for years I have told my patients to avoid the meme of probiotics. The shortwave UV light we make is how the blood is kept free of pathogens because prokaryotes and parasites cannot tolerate UV light at all!!!! The same is true for mycotoxins and fungi. The mechanism of shortwave UV production helps you now understand why immunity is wholly related to solar exposure, proper T cell activation in the skin and proper optical signaling in the skin controls the entire immune system body wide including the GUT!!!! That is where the GALT lies. The functional medicine community try hard to sell the meme it is the gut where most immune diseases begin because they have NO IDEA what they missed in the skin. Effectively they have ZERO SKIN in any game but their own profit lines.

    The light on the skin does it and Jeff Leach proved in the Hazda. Instead, they should book trips to the Yucatan peninsula and follow Jeff’s findings in the field on how the sun sculpts the microbiome by controlling the immune system and circadian mechanisms built into the UV spectrum of sunlight. That is how real science is performed. Well done Jeff Leach!!! This was my top moment from Nourish Vermont 2018.

    Jeff launched the Human Food Project (non-profit, 501(c)(3)) to blur the line between the science and the general public. He also co-founded American Gut, the world’s largest open-source/crowd-funded microbiome project in the world (also includes British Gut, Asian Gut, and Australian Gut). Jeff is a Visiting Research Fellow within the Department of Twin Research & Genetic Epidemiology at King’s College London.
    Aashish R. Jha, Emily R. Davenport, Yoshina Gautam, Dinesh Bhandari, Sarmila Tandukar4, Katharine Ng, Jeff Leach, Susan Holmes, Guru Prasad Gautam, Jeevan Bahadur Sherchand, Carlos D. Bustamante, Justin L. Sonnenburg. Gut microbiome transition across a lifestyle gradient in Himalaya (In Press PLOS Biology, 2018)

    Gabriela K. Fragiadakis, Samuel A. Smits, Erica D. Sonnenburg, William Van Treuren, Gregor Reid, Rob Knight, Alphaxard Manjurano, John Changalucha, Maria Gloria Dominguez-Bello, Jeff Leach, Justin L. Sonnenburg. Links between environment, diet, and the hunter-gatherer microbiome (In Press Gut Microbes, 2018)

    Daniel McDonald, Embriette Hyde, Justine W. Debelius, James T. Morton, Antonio Gonzalez, Gail Ackerman, Alexander A. Aksenov, Bahar Behsaz, Caitriona Brennan, Yingfeng Chen, Lindsay DeRight Goldasich, Pieter C. Dorrestein, Rober R. Dunn, Ashkaan K. Fahimipour, James Gaffney, Jack A. Gilbert, Grant Gogul, Jessica L. Green, Philip Hugenholtz, Greg Humphrey, Curtis Huttenhower, Matthew A. Jackson, Stefan Janssen, Dilip V. Jeste, Lingjing Jiang, Scott T. Kelley, Dan Knights, Tomasz Kosiolek, Joshua Ladau, Jeff Leach, Clarisse Marotz, Dmitry Meleshko, Alexy V. Melnik, Jessica L. Metcalf, Hosein Mohimani, Emmanuel, Jose Navas-Molina, Tanya T. Nguyen, Shyamal Peddada, Pavel Pevzner, Katherine S. Pollard, Gholamali Rahnavard, Adam Robbins Pianka, Naseer Sangwan, Joshua Shorenstein, Larry Smarr, Se Jin Song, Timothy Spector, Austin D. Swafford, Varykina G. Thackray, Luke R. Thompson, Anupriya Tripathi, Yoshiki Vazquez Baeza, Alison Vrbanac, Paul Wischmeyer, Elaine Wolfe, Qiyun Zhu, The American Gut Consortium, Rob Knight. American Gut: an Open Platform for Citizen Science Microbiome Research mSystems May 2018, 3 (3) e00031-18; DOI: 10.1128/mSystems.00031-18

    Samuel A. Smits, Jeff Leach, Erica D. Sonnenburg, Carlos G. Gonzalez, Joshua S. Lichtman, Gregor Reid, Rob Knight, Alphaxard Manjurano, John Changalucha, Joshua Elias, Maria Gloria Dominguez-Bello, and Justin L. Sonnenburg. Science Seasonal cycling in the gut microbiome of the Hadza hunter-gatherers of Tanzania, Vol 357, Issue 6353, Aug 2017, pp 802-806.
     
  16. Jack Kruse

    Jack Kruse Administrator

  17. Jack Kruse

    Jack Kruse Administrator

    Vermont 2018 WISDOM: Truths are all approximations. All of them because they are relative to the physics of the present moment. Most think of sunlight as energy and as something that we can see. Sunlight is energy but is MOSTLY information (and it speaks in the language that our body completely understands Artificial light = foreign language Artificial frequencies = foreign language .............. Photon --- travels at the speed of light and information collected by the cell tells photons where to go ----- faster than light via Fermat's law and they use entanglement to embrace femtochemistry and attobiology.

    You may have heard the saying that biology is just applied chemistry, chemistry is just applied physics, and physics is just applied math. In this case, femtobiology is femtochemistry applied to biological reactions. Most (if not all) biological functions are initiated or conducted through chemical transfers, including the movement of electrons, protons, and energy. So, understanding these chemical and physical reactions will lead to a better understanding of biological interactions at both femtometer magnitudes as well as more easily observable macroscopic scales.

    Femtobiology: Ultrashort Intervals in Quantum Time
    The other way of approaching biology through femtoscience bears even more fruit. Using ultrashort pulse laser technology, biologists can peer into known biological reactions at shorter time intervals than ever before. There are multitudes of chemical processes vital to biology that happen at the nanosecond, picosecond, femtosecond, and attosecond range. In fact, the shortest time interval ever measured presently is 12 attoseconds. This is how fast UV light operates in your skin and blood.
     
  18. @Jack Kruse When is the best time for a baby to be born? I thought it would have been Spring (more chance of survival evolutionarily). I've heard you mention that strong UV turns off sex hormones and lowers sex drive but given the 9 month pregnancy, I always thought late summer would be the best time to conceive?

    Is this the case and the more blue vs strong UV is still a net benefit? Or is there a better time to conceive?
     
  19. Jack Kruse

    Jack Kruse Administrator

    What were some other implications of Skin in the game from Vermont 2018?

    Why are makeup and facial tattoo's a crazy thing to do now that attendees learned about this slide below? Just putting makeup on ones face can alter many things that would astound you.
    [​IMG]

    We already know that heat release links to deuterium content and TCA spin rate. In all cases, raising the temperature invokes thermal vibrational and entropic effects. This tends to preferentially stabilize H+ over deuterium bonds in cells.

    It was found that the effect is most pronounced above the sinuses around the nose, and those facial temperatures were reduced as participants carried out tasks of increasing difficulty. Reduced temperatures mean blood was being shunted from the external carotid system to the internal carotid system to feed the harder working neo-cortex with their mitochondrial density and spinning ATPases in the grey matter of the brain that allows for the cognitive work to be done. I want all the ladies to remember that the skin is linked to the brains function because the skin and brain come from the same cell line in the embryo called neuroectoderm. This is why your facial skin must be in the game to win!.
     
  20. Jack Kruse

    Jack Kruse Administrator

    Depends on the animals retina and circadian construction.
     

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