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Dan2's Journal

Discussion in 'My Optimal Journal' started by Dan2, Oct 13, 2020.

  1. JanSz

    JanSz Gold

    Green parts of plants are low in deuterium (per dr Boros).
    Some plant sugars are low in deuterium (cacti types)(per dr Boros).

    We are not discarding all carbohydrates from consumption.
    We are discarding only carbohydrates that convert to high deuterium sugars.
    A cow has low deuterium meat because she eats green grass (that is low in deuterium).

    One way to lower deuterium intake is to drink green juices and call them DDW.
    A number of vegetables contain desirable micronutrients that will remain in juices.
    Green juice made of wheatgrass is known among juice drinkers as highly desirable.

    We have to breathe. Tropical air is humid and high in deuterium.
    When in the tropics, we daily breathe 2 liters of high deuterium water.
    It would make sense to breathe low deuterium air (especially from places known for low cancer rates).

    The solar energy that a naked person on the equator is exposed to (is minuscule) when comparing it to energy released synthesizing 7500 liters daily of brand new water (2H + 1O)(to make blood) (when at rest)(and up to 3x that when running from a lion).
    Solar energy is mainly information (but not a source of (immediate) energy).

    .................
    Wonder if someone tested the deuterium content of watermelons?

    ...................
     
    Last edited: Nov 24, 2020
  2. @Marko Pollo - Your sealed greenhouse <- That's brilliant !
     
    Marko Pollo likes this.
  3. Dan2

    Dan2 New Member

    This is a conversation between Sue_UK and I about silica, aluminum, hydrogen, and production of hydrogen in the body from colon bacteria.

    ___

    Dan:
    Do you know if OSA removes nanoparticle aluminum too?

    [OSA is orthosolicic acid. From "Silica Water" by Dennis Crouse: "This book is about orthosilicic acid (OSA). When OSA is dissolved in water the mixture is called silica water. OSA is soluble in water at low concentrations (i.e. at or below 2 millimolar = mM, or 200 parts per million = ppm... Silica water is generally regarded as safe (GRAS) by the U.S. FDA in in drinking water at or below 160 ppm of OSA or 100 ppm of silica as SiO2."

    The Silica Thread:
    https://forum.jackkruse.com/index.php?threads/the-silica-thread.25231/]

    ___

    Sue:
    I think so, because OSA water has been used for nanoparticle aluminum vaccine damage ...

    From a general thing on nanoparticles there's also that nanoparticles can be transported from the nose to the brain via the upper lining of the nose. (so from traffic fumes for example, or from aluminium based aerosols such as antiperspirant). I think detox can work in reverse - certainly a high level of silica in the water caused me a snots response. Although its not about aluminium directly, this page is quite interesting when you think of aluminum's properties .... particularly section 4.2

    https://ec.europa.eu/health/scientific_committees/opinions_layman/nanomaterials/en/l-2/4.htm#0

    Sue :)

    ___

    Dan:
    Oh, right. I should've thought of that. Thanks for reminding me.

    The snot detox idea is interesting to me because I recently started trying inhalation of Brown's Gas (hydrogen, oxygen, and plasma water gases), the hydrogen is a selective antioxidant that neutralizes hydroxyl and peroxynitrite radicals and that frees up glutathione to do other things (if I'm understanding it right), like maybe increase removal of metals, and I've had a little bit of a runny nose often while and after inhaling it. Of course it could also be something directly happening in my nostrils; I'm not sure.

    ___

    Sue:
    Interesting, and there may be a link to aluminium/silicon/OSA and hydrogen gas..... but through the microbiome.....?

    https://journals.plos.org/plosone/a... six fecal bacterial,to produce hydrogen [18].
    Quantification of hydrogen production by intestinal bacteria that are specifically dysregulated in Parkinson's disease

    I've not gone into it much yet, but its possible that aluminum poisons certain beneficial bacteria, or "feeds" pathogenic bacteria, but I'm interested in what foods stimulate the hydrogen producing bacteria ...:)

    ___

    Dan:
    http://www.molecularhydrogeninstitute.com/h2-from-bacteria

    Here's what I've posted about hydrogen and Brown's Gas:

    https://forum.jackkruse.com/index.php?threads/raffael’s-journal.22980/page-2#post-292158 and the next post

    https://forum.jackkruse.com/index.php?threads/low-cortisol-levels.14194/page-138#post-292165

    https://forum.jackkruse.com/index.p...-water-makers-worth-buying.25327/#post-293223

    https://forum.jackkruse.com/index.php?threads/dan2s-journal.25288/#post-292846

    ___

    Sue:
    Thanks for the links, particularly the molecular hydrogen institute one. From that https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716677/
    Breath Hydrogen Produced by Ingestion of Commercial Hydrogen Water and Milk

    "however, it should be remembered that hydrogen concentration in the body strongly depends on colonic fermentation and the food consumed everyday. "

    It seems milk can stimulate hydrogen by the microbiome. (lactose intolerance not necessarily pathologic?). Figure 3 of the linked paper is pretty mindblowing ......

    ___

    Dan:
    Hm. But since that's in people with lactose intolerance, that makes me wonder if making hydrogen in the colon is one of the body's (most important? most fundamental? (because of the simplicity and permeability of the hydrogen)) ways of reacting to digestive problems, and so if the research about increasing hydrogen production from the colon are thinking the thing that makes more hydrogen is good to eat overall, net beneficial, because of the extra hydrogen, when really if the hydrogen is a reaction to it being harmful then production of hydrogen in the colon is healthy when it's a medium (maybe minimal?) amount and hydrogen in other organs/contexts is the net beneficial way.
    Like this about the liver (from that same study):

    "However, breath hydrogen release was almost finished 60 min after ingestion of hydrogen water, possibly because it was unable to reach colon. Therefore, it was considered that at least 20% of ingested hydrogen was consumed in the body and that the main hydrogen consumption occurred in the liver rather than by the colonic bacteria or other organs such as the brain."

    ___

    Sue:
    I think the colon is a hydrogen factory. If I think of its role in extracting water from stool, it will be essentially a form of hydrogen enriched water because a healthy gut will provide additional hydrogen each time the hydrogen making bacteria are "fed".

    I think whether it comes from milk or some other foodstuff that feeds the colon microbiome just shows our omnivorous evolution. The extra hydrogen in the enriched drinking water not reaching the colon would be expected, and it going out via the breath rather than returning to the colon for consumption would also be expected. The factory making it shouldn't need it delivered .....?

    Speculations only ...:confused:

    ___

    Dan:
    I heard there was a study in Japan of families who usually live into, I don't know, maybe 80s, and families who usually live into their 60s, and the longer-lived ones consistently had more hydrogen being produced in their colons. So yeah I think you're right that optimally the supplemented hydrogen wouldn't do much.

    Did you see something similar to the milk vs hydrogen water graph for other foods?

    I wonder what the graph would be for people who don't have lactose intolerance, and also with fermented milk with very little lactose.

    Also, I've seen testimonials of people having good results with long-term digestive problems, so dysbiosis, from eating fermented raw animal foods. Do you know of "high meat"? Fermented fish is a delicacy traditionally in some cultures. Sushi was originally fermented. And I've even seen people say a raw egg can be fermented safely without salt, but that's.. nhmnuhnm

    ___

    Sue:
    I think a lot of cultures have their own foods, from fermented meat to saurkraut, kimchi etc ... Even sourdough bread ... it doesn't seem to matter that the bread is cooked and the bacteria are dead, the bacterial fragments are enough to prompt a beneficial response. In the blue zones book, the elderly aren't all sunbathing on the beach all day, and will often be conservatively dressed ....I would suspect that although they might have different diets, apart from the silica angle, they are probably also feeding their microbiomes, either directly or prebiotically .... I'm reading Eat to Beat Disease by William Li, after watching him on youtube. He is not vegan or even vegetarian oriented , he includes things like oysters and fish .... There's a section on the microbiome and the effects of certain fruits, vegs, cheeses, sourdough breads, pumpernickel bread, mushrooms, fermented foods ... and its relationship to diseases, and it mentions Parkinson's.

    The damage to the substantia nigra (i.e less melanin) in Parkinsons would mean less hydrogen produced from water splitting via human photosynthesis (Herrera). But there's now growing evidence of microbiome dysfunction in PD. For example

    https://www.cell.com/action/showPdf?pii=S0092-8674(16)31590-2
    Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease

    So whether its not enough of a particular microbe, too much of another (perhaps using up hydrogen meant for circulation), or aluminium contributing to dysbiosis, the overall effect could be that the colon hydrogen factory is at best inefficient, at worst stuffed. This ties in with food being more important the further away from the equator we are.

    If you look at the Hazda, they may have good access to human photosynthesis from the sun, and they have a very diverse microbiome, but they are at risk of dying of intestinal infection, they have high infant mortality rate etc ...

    I think Inger has done the high meat thing, and possibly Caroline. It seems to be a pretty controlled process, whereas for the Hazda their microbial intake is riskier, and they also have times in semi starvation, affecting sleep
     
  4. @Sue-UK & @Dan2 - may I add to the thread?

    The following bacteria were tested for their hydrogen gas output:

    upload_2020-11-25_14-37-0.png

    https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208313
    We found that Blautia coccoides JCM 1395 (Note below on Blautia Coccoides) in Blautia coccoides group and Clostridium leptum ATCC 29065 in Clostridium leptum subgroup produced larger amounts of hydrogen gas than the other species. In addition, Bacteroides fragilis ATCC 25285 in Bacteroides fragilis group constituted the second group of hydrogen production. Thus, the three bacterial strains in three bacterial groups/genera/species that were decreased in Parkinson’s disease (PD), produced large amounts of hydrogen.
    upload_2020-11-25_14-38-42.png

    Note: However, Blautia Coccoides - We identified 200 high-resolution taxonomic units within Blautia using oligotyping. https://www.nature.com/articles/ismej201497

    Clostridium Species as a probiotics https://jasbsci.biomedcentral.com/articles/10.1186/s40104-019-0402-1 In the intestine of human and animals, Clostridium species, as one of the richest bacterial cluster. In a study conducted in 2008, F. prausnitzii was reported to protect from inflammation in vitro and in vivo through blocking NFB activation and IL8 production. In humans, Clostridium species mostly utilize indigestible polysaccharide. Clostridium generate short-chain fatty acids (SCFAs) from carbohydrate fermentation and particularly butyrate. Generally, Clostridium prefers dietary carbohydrate, especially non-starch polysaccharides. For instance, the diets enriched in different fibers, such as inulin, oligofructose, arabinoxylan, guar gum and resistant starch, all of which induced the enrichment of Clostridium cluster IV and XIVa representatives along with changed mucosal energy metabolism.

    Non-starch Polysaccharides - Jerusalem Artichoke https://www.sciencedirect.com/science/article/pii/S2211601X11002434

    Pharmacological potential of naturally occurring non-starch polysaccharides (NSP) http://www.phytopharmajournal.com/Vol4_Issue6_07.pdf

    upload_2020-11-25_15-55-51.png
    Naturally occurring polysaccharides are also referred to as “biological response modifiers" (BRMs)

    https://thethirty.whowhatwear.com/prebiotic-foods/slide9

    Edible mushrooms extracts displayed highly efficient prebiotic properties compared with FOS and inulin. https://www.sciencedirect.com/science/article/pii/S2452316X18301376

    Polish wild mushroom polysaccharides https://link.springer.com/article/10.1007/s00394-017-1436-9

    https://www.cancer.gov/publications/dictionaries/cancer-drug/def/clostridium-butyricum-cbm-588-probiotic-strain <- Clostridium butyricum MIYAIRI (CBM) 588 is the 588th MIYAIRI strain, isolated from a soil sample in Japan in 1963.

    https://selfhacked.com/blog/c-butyricum/ <- What is Clostridium butyricum?

    https://acnfp.food.gov.uk/sites/default/files/miya_pro.pdf <- MIYARISAN PHARMACEUTICAL CO

    https://www.fixyourgut.com/why-i-do-not-recommend-aor-probiotic-3-a-review/ C. butyricum MIYAIRI 588 has been tested and does not appear to contain any toxin genes and showed antibiotic sensitivity.

    https://www.bulletproof.com/supplements/dietary-supplements/lions-mane-mushroom-benefits/

    https://shop.realmushrooms.com/coll.../products/organic-lions-mane-extract-capsules

    I use it in my cooking https://hostdefense.com/products/lions-mane-powder

    You know @Jack Kruse has always recommended sea weed -> "Non-starch polysacchrides extracted from seaweed" https://pubmed.ncbi.nlm.nih.gov/10737549/

    https://www.sciencedirect.com/topics/food-science/seaweed-polysaccharide - Several seaweed polysaccharides show antiviral activity against enveloped viruses, including important human patogens as Herpex simplex virus (HSV), human immunodeficiency virus (HIV), dengue virus and others. Seaweed biomass can absorb a large quantity of heavy metal ions. In particular, alginic acid has a strong binding to lead ions and is known to be able to absorb radioactive elements. Sodium alginate was approved for use as a food additive for lead removal in 1997 by the Chinese Health Ministry.

    https://www.americanscientist.org/article/the-science-of-seaweeds

    https://jackkruse.com/brain-gut-6-epi-paleo-rx
    https://jackkruse.com/brain-gut-5-paradigm-drifts-paradigm-shifts-epi-paleo/
     
    Last edited: Nov 25, 2020
    Dan2 likes this.
  5. JanSz

    JanSz Gold

    In discussions about intestinal microbiome produced hydrogen or production of hydrogen water
    is there any effort to figure out the amount and role of deuterium?
    ----
    I think of H hydrogen as a fuel, source of energy, and D deuterium as a controller of the process of producing energy.

    ....
    Hydrogen water seems to be expensive and having a short life, difficult to carry around, expensive specialized containers, comparing to DDW.
    Time wise, what came first, hydrogen water or DDW?
    ....
    Possibly those are just discussions that eventually may end up in better care and supplementation of intestinal microbiomes.
    Similarly to discussions on DDW ending with watching one's vassopressin and eating better fat.

    .....
     
    Last edited: Nov 26, 2020
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  6. It is my understanding hydrogen water made through the electrolysis method is how deuterium rich water is manufactured - https://forum.jackkruse.com/index.php?posts/293460

    The research is playing out positively for deuterium depleted water. https://forum.jackkruse.com/index.php?posts/293300

    Yes - hydrogen is the electron transduction molecule for human life. Deuterium is not.

    <- The reason why has yet to be determined. I have my hypothesis.

    Molecular hydrogen is the energy carrier https://www.oatext.com/The-unsuspec...otations-in-cancer-biochemistry.php#gsc.tab=0

    2H2O(liquid) ↔ 2H2(gas) + O2(gas) + 4e-​

    Supplement your gut bacteria with low-starch polysaccharides. @Jack Kruse recommends, sea vegetables. I eat them daily.

    The question for me is -> Since hydrogen is our "energy" molecule and "evidence" indicates an increase of its "lighter" version shows positive results, than what methods of hydrogen "supplementation" are clean and provide the best therapeutic intervention?
     
    Last edited: Nov 26, 2020
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  7. JanSz

    JanSz Gold

    So far I have heard that deuterium is a vital part of life, we just happen to have too much of it.

    Consuming correct fats is "supplementation" of hydrogen (into a place where it is able to be used to create matrix water).
    Drinking DDW or (hydrogenated water)
    (even if it happens to be overall low in deuterium)
    places hydrogen outside cells (where it cannot be used in water synthesis).

    ...
     
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  8. Dan2

    Dan2 New Member

    "Drinking DDW or (hydrogenated water)
    (even if it happens to be overall low in deuterium)
    places hydrogen outside cells (where it cannot be used in water synthesis)."

    People talking about molecular hydrogen therapy commonly say that because of hydrogen's size (smallest atom) it can permeate anywhere in the body easily that it's useful.

    This is about saturation of different kinds of body tissues from inhaling hydrogen, the implication being (I think) that if it can saturate all these kinds of tissues then it could also be used for water synthesis from breathing it, right?
    From "Hydrogen Molecular Biology and Medicine" edited by Xuejun Sun, Shigeo Ohta and Atsunori Nakao, 2015. Chapter 2 excerpt attached.
    Pages 8 and 9 of that that excerpt:
    (the pages before this in the chapter explain what "half-saturation time" is more)

    one.png


    two.png
     
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  9. Dan2

    Dan2 New Member

    I agree it might be inconvenient or pricey to inhale from a hydrogen or Brown's Gas-producing machine compared to if the same effects can be from hydrogen production in the body.

    But there are some testimonial examples of inhaled hydrogen/Brown's Gas doing things that are uncommon even if that person were to be eating healthy, drinking good water, getting sun, etc consistently.

    https://eagle-research.life/online-video-testimonials/
    Scroll down to "Healing Zinsen Chan’s Parkinson’s".
    On Facebook:



    Parkinson's hydrogen Facebook comments.png

    (I originally posted that here; there are more related things here:
    https://forum.jackkruse.com/index.php?threads/raffael’s-journal.22980/page-2#post-292158)

    ___

    Maybe using of these machines is a shortcut that will cause long-term problems; like how supplementing testosterone can make the body make less, maybe supplementing hydrogen will make the body stop doing something that then would become much more inconvenient because of needing to use one of these machines regularly to not have problems there wouldn't have been if not for starting using it..?
     
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  10. Sue-UK

    Sue-UK Gold

    If for example aluminium was a causal factor, or substantia nigra melanin destruction, or something else ....then those factors could continue on ....

    I couldn't help thinking when it mentioned he'd had treatment sessions morning, noon and evening for 2 hours each time ... with a correctly functioning colon microbiome producing hydrogen from 3 meals a day he might have got a 24 hour a day steady input ....

    It would also likely be a deuterium depleted source of hydrogen too, for the hydrogen to quantum tunnel through the colon wall ....?
     
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  11. JanSz

    JanSz Gold

    upload_2020-11-27_7-30-21.png

    DDW---->Deuterium Depleted Water
    DEW----->Deuterium Enriched Water
    Both types of waters are water
    The separate cases that should have its own experiments is when Hydrogen gas (of varying Deuterium content) is dissolved in waters (made of variety water molecules H2O, HDO, D2O).

    ...
     
    Last edited: Nov 27, 2020
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  12. Sue-UK

    Sue-UK Gold

    As well as the possibility of a reduced number of hydrogen producing bacteria of the microbiome, there's also Hydrogenotrophs ....

    "Hydrogenotrophs are organisms that consume hydrogen as part of their metabolism and are integral for maintaining the normal functioning of the gut microbiota."

    https://microbewiki.kenyon.edu/index.php/Gut_hydrogenotrophs
     
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  13. Sue-UK

    Sue-UK Gold

    I watched one about doing the hydrogen gas hack during sleeping. Lower levels over a longer time frame. If the colon was generating hydrogen overnight, as during sleep the breath rate slows, theoretically hydrogen would be in circulation longer.

    "Upwards of 13 L·day−1 of H2 can be produced in the human colon"

    https://febs.onlinelibrary.wiley.com/doi/epdf/10.1002/1873-3468.13064
    Metabolism of hydrogen gases and bile acids in the gut microbiome

    Reading that, my thought is that, although you could top up aging losses of the 13L of hydrogen by breathing it in or via water, its not the only role of the microbiome, not only for the body as a whole but also for maintaining the colon specifically. For example the cells of the colon would presumably have first dibs on the hydrogen produced by the colon microbiome? Its interesting that the microbiome is described as a "virtual organ" and I'd like to know if there's a risk that enhanced hydrogen in the circulation from a not usual source could give a false signal as to the health of the microbiome? In the long run its whether there's a colon cancer risk. As a therapy if the shit has already hit the fan its one thing, but for longevity generally the blue zones aren't mucking about with tubes up their noses as a lifestyle choice, and I suspect their traditional diets, and their environment as a whole, helps maintain their microbiomes, and their hydrogen producing capacity. :)
     
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  14. Dan2

    Dan2 New Member

    @Sue-UK
    "Its interesting that the microbiome is described as a "virtual organ" and I'd like to know if there's a risk that enhanced hydrogen in the circulation from a not usual source could give a false signal as to the health of the microbiome? In the long run its whether there's a colon cancer risk."

    Do you have a more specific idea of what else would be involved in the false signal, and how the hydrogen being from an unusual source might fit in context with the signaling? Just wondering; I don't have a guess about that.

    I'm a little suspicious about the long-term effects. (Why isn't there a side-eye squinty suspicious smiley..)

    The research about hydrogen's use as a diving gas -- how it's been tested for safety the longest -- must not've considered small disruptions leading to chronic disease effects because of there being so many other variables in the long-term health of divers who've inhaled it.

    There's been research about its health uses in Japan for about 20 years. And people there have been using water "ionizer" machines since I think the '60s or '70s, and there were tests with ionized water with and without hydrogen gas in it and the hydrogen gas turned out to be the thing that made the ionized water machines beneficial, so people there have been drinking hydrogen-rich water longer than there's been research intentionally about hydrogen gas for health; some research about water ionizers was like accidental hydrogen research before hydrogen research became popular in the last 20 years. But I don't know what the Japanese's thoughts are about long-term unwanted effects of that. There might be animal studies that could be used to infer long-term effects in people but I don't know enough about which ones are how relevant.

    I'll try emailing the Molecular Hydrogen Institute and see if they have something to say about Japanese thoughts about long-term unwanted effects in people.

    And even if the Japanese think there are no long-term unwanted effects from drinking hydrogen-rich water, inhaling it enough that the body's saturated with it could be different. (There's more about saturation times of different body tissues in post #28 of mine above.)
     
    Last edited: Dec 1, 2020
  15. Sue-UK

    Sue-UK Gold

    The tissue saturation times are interesting in that it may show why the overnight hack works better. But a properly working microbiome producing hydrogen in line with diurnal rhythms of specific bacteria would presumably do the same thing. Also if someone was outside in the sun for a couple of hours, I would suspect that theoretically human photosynthesis would increase the saturation levels of the compartments.

    What would be an interesting statistic is how many centenarians in the world are using hydrogen gas breathing or water technologies, versus those who aren't. If I think of human photosynthesis as a source of hydrogen, and the hydrogen production from the microbiome, I can relate that to the centenarians in the blue zones. Depending on haplotypes etc, but I think that theoretically the melanin part of human photosynthesis and an optimal microbiome could place humans at optimal hydrogen production at any latitude. Context is important, but what concerns me about the tube up the nose or water lifestyle is that it may lull someone into a false sense of security that their context doesn't allow for, for example if their human photosynthetic pathways continue to be destroyed or atrophy further, or their gut microbiome becomes even more oversimplified over time, what happens acutely if they are suddenly not able to access the enriched air or the water .... For example if someone has an accident and ends up in hospital ... or the machine breaks and they can't afford a new one immediately ... If hydrogen saturation is itself a signal that all is well, at what point would signal collapse be fatal? If someone was using a tube to breathe whilst carrying around an oxygen tank or using a CPAP machine at night, they wouldn't be considered healthy. The impression I get is that it is essentially a medical treatment. If it buys me time to improve more natural hydrogen production its one thing, apart from that, I can see potential uses for space travel, or on earth for times we acutely go beyond what is our natural environment (such as diving). But relying on it as a lifestyle choice long term seems to have risks. :)
     
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  16. Sue-UK

    Sue-UK Gold

    John Schumacher likes this.
  17. Wow - beautifully written!

    We know the hydrogen (that is light hydrogen) molecule is used in our human photosynthesis by our melanosome for supplying over a third of all the "energy" to our cells and organells, and it is the melanin's capacity to absorb and transduce these photons into usable potential. Supplementing hydrogen's negative ions seems to up regulate this basic process, raising the net negative charge for our cells and thus therapeutic. The repair & recreation of new cells requires charge potential. In order to heal and repair, your cells’ voltage needs to be greater (negatively speaking) than -50mV. Some doctors say, -125mV.

    When a cell begins its downward spiral, the voltage will move from negative to positive. Once this value passes zero, the polarity flips. We move from health to disease. So, when our cell's clocking in at or above +50mV, it's in cancer territory. Cell membrane potential (Vm), the voltage across the plasma membrane is the mechanism of action that functionally plays out in cancer cell migration.

    [​IMG]
    Decreased intracellular K+ concentration occurred during oncogenesis
    .

    Since we know our health is dependent on our cell's capacity to thrive, then raising our net negative potential could provide positive results.
     
    Dan2 likes this.
  18. What I like about this article, is it recognizes the need to understand both phospholipids and sphingolipids.
    What concerns me is thier apparent jump to -> inflammation is "bad" and anti-inflammatory is "good".
    We have basic functions like Prostaglandin-endoperoxide synthase, which is a non-mitochondrial mechanism for generating ATP through the COX pathway.

    I believe there are three elements for increasing our cellular "Energy" quotient
    When evaluating our Biochemical-electric potential, we can look at what signal each lipid type expresses. Some turn on, some turn off - just look at the two hormones (which have lipid structures) melatonin and dopamine. These not only play their roles at night and during the day, respectively; but they cancel each other out. Yet both are required to cognitive function.
     
  19. Sue-UK

    Sue-UK Gold

    This is still a musing in progress but I don't think the night and day roles are quite so clear cut .... I doubt its an all or nothing scenario with melatonin, when its abundant in many foods. There's also an association with melanin, which links it to Herrera's human photosynthesis book and his work using melanin or its precursors as a treatment for AD, and its relevance to the substantia nigra in PD.

    "Melatonin controls pigmentation changes by aggregation of melanin into the melanocytes within the skin, causing the skin to change color. This interaction is also responsible for the paler skin color of elderly people and those with insomnia."
    https://www.news-medical.net/health...ion changes by,people and those with insomnia.

    Herrera says that we begin to lose our capacity to split and reform the water molecule (i.e. melanin) at around 26, losing function at an approx rate of 10 per cent with each decade after mid twenties, and it goes into free fall when we reach our 50s. (Reminds me of mitochondrial heteroplasmy). The dietary angle (whether precursors or direct) may be the evolutionary back door for nocturnal or underground mammals, or for mammals that are dependent on high melanin in the skin under fur for recycling light (such as polar bears). That's an evolutionary back door that has hack potential, and may be what the blue zone centenarians are doing naturally, to maintain levels as they age. That and avoiding things that damage or deplete melanin stores in the body, could make a big difference.

    Then there's the potential for melanin itself (in this case from cuttlefish) to influence the microbiome.
    https://bmcmicrobiol.biomedcentral.com/articles/10.1186/s12866-017-1058-7#Fig4

    Effects of melanin from Sepiella Maindroni ink (MSMI) on the intestinal Microbiome of mice

    Culinary use of squid inks .... Herrera mentions squid ink here https://www.linkedin.com/pulse/melanin-energy-future-arturo-solis-herrera
    Elsewhere there could be melanin from chaga ... or something else ....

    In the cognitive frailty article, Akkermansia muciniphila is mentioned in relation to fish oil, so that ticks the seafood eating epi paleo box. Eating the melanin containing parts of fish adds the melanin dimension. But not all blue zones eat much seafood. There are probably more examples, but another way to increase akkermansia is through mushrooms, certain fruits, (and wines ) and bamboo shoots. Certain mushrooms promote an increase in akkermansia, and some of them are a source of melanin......

     
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  20. JanSz

    JanSz Gold

    You said many good things about melanin. (I try to keep my skin as dark as possible via using MT-2)
    Currently on the Earth mammals with higher melanin content are concentrated near the equator (black people) and near the North Pole (Inuit's, white polar bears that have black skin).
    Between those two extremes are people with much lighter skin.
    How would you explain that?
    Add vit D to the equation and (how northern black-skinned mammals acquire ample amounts of it).

    I am thinking of above, having in mind the way Earth rotates like a top, exposing to Sun different parts more than others.
    25000 years ago Siberia had a tropical climate and the Sahara desert was green.
    That must have induced migration of all living things.

    .................
     
    Last edited: Dec 2, 2020

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