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Discussion in 'Redox Rx' started by Jack Kruse, Aug 9, 2021.

  1. Jack Kruse

    Jack Kruse Administrator

  2. upload_2021-8-9_20-15-57.png

    The problem with most of these studies, however, is the basic belief that glycation is fundamental. This creates presupposition that carbohydrates are the primary biological fuel for all living forms – (insects to humans). Let’s just start with this figure above, watch the arrows, it all begins with Glucose which makes its way up to NAD+ then to Pyruvate, which is used to make NAD+ again, which is used in the TSA Cycle beginning with Acetyl-CoA. The next great cycle of glucose is through the Glutamate & Citrate process to NAD+.

    Ok, so what? -> reactive oxygen species (ROS). It is reactive α,β-dicarbonyl species such as methylglyoxal and glyoxal, which are up to 50,000-fold more reactive than glucose. Glycation takes place in the extracellular environment, in our cells, in the cytosol, in organelles, starting from our mitochondria. As total available glucose availability increase this “little mitochondrial motor” will rev up, producing advanced glycation species (AGS) https://www.hindawi.com/journals/ijcb/2012/843505/

    Of course, cell damage occurs from advanced glycation species as it oxidizes everything in its path. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3556769/, https://www.nature.com/articles/s41598-017-04214-6 This proinflammatory chemistry takes its toll. There are no chronic diseases which do not have its roots in “inflammation”. C-Reactive Protein (CRP) is one of our liver’s responses to glycation.

    Note: This discussion is about the "Aerobic" mitochondrial pyruvate dehydrogenase of the "Citric Acid and Electron Transport Chain" process.

    We know blue light is the stimulus. It's balanced with IR sunrise light. It's with us all day (outside).
    But... man-made blue light... well that stimulus in our retina from our beloved devises -> how many hours accumulative over a 18 hour period?

    The blue light is the most energetic radiation reaching the macula; it photo-oxides lipofuscin, generating reactive photoproducts including N-retinylidene-N-retinylethanolamine (A2E), DNA oxidation, and cells apoptosis.​


    Other than avoidance, mitigation through filtration -> are these enough to over come the "burning" advanced glycation species, oxidizing our neurons' mitochondria?

    What is interesting to me is how little "we know" about how much blue to green light excites the pyruvate dehydrogenase and it's manifestation in its aerobic production of advanced glycation species.

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    Last edited: Aug 10, 2021
    Sean Waters and JanSz like this.
  3. Sean Waters

    Sean Waters New Member

    IMO I don't believe it is. I think you need Red Light to re-build those pathways... massive amounts of it. The Mitochondria give us Insulin Resistance and all kinds of diseases when there are too many Blue light photons incoming and the circuit is about to be shorted. Mitochondria do everything they can to avoid the Warburg shift.
    John Schumacher and ND Hauf like this.

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