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COVID, Obesity, High Latitude, Melatonin, and NIR

Discussion in 'Educating Doctors' started by Dr. Marcus Ettinger, Oct 17, 2022.

  1. Dr. Marcus Ettinger

    Dr. Marcus Ettinger Platinum Member

    A geographical approach to the development of hypotheses relating to Covid-19 death rates
    Geography of Covid-19 death rates, developing hypotheses

    10-3-22 - One of the most interesting and thought-stimulating papers in the current issue is the report published by Skutsch et al.; they noted that COVID-19 deaths per million were higher in South America than in either Europe and North America, while Asia, Africa, and Oceania had death rates which were only a fifth of those in South America. They found that the COVID-19 death rate was strongly associated with overweight and high latitudes but not with the vaccine coverage percentage in these countries. In an attempt to explain these differences, they hypothesized that: (1) In overweight people there is less penetration of near-infrared radiation (NIR) to the depth of important organs; stimulation of these organs by NIR would result in elevated production of subcellular melatonin, a strong antioxidizing factor. (2) In overweight people, fatty tissue holds much of the body´s 25(OH)D3 leaving less circulating in the blood making it less systemically protective. The hypothesis advanced by Skutsch et al. receives support from an article by Zimmerman and Reiter published also in this issue. They observed that large quantities of melatonin, greater than 5 pg/ml min ramp rates for plasma and sweat melatonin, have been detected during strenuous exercise in sunlight as compared to 0.15 pg/ml min ramp rates for plasma melatonin under dim light melatonin onset conditions. This difference is in excessive of 30-fold. Sunlight contains high levels of NIR which likely stimulate mitochondrial melatonin production. High latitude has less NIR irradiation and excessive weight restricts NIR penetration to the important organs such as the lungs and heart. Thus, both obesity and high latitude are factors that limit local melatonin production and compromise the protective effects of locally-produced melatonin in these important organs. These observations may not only apply to COVID-19 patients but to other disorders including diabetes, neurodegenerative diseases and seasonal depression.
    Last edited: Oct 17, 2022
    JanSz likes this.
  2. JanSz

    JanSz Gold

  3. JanSz

    JanSz Gold

  4. South Americans I have observed and spoke with are all in on avoiding the sun. Hats required in school, lotion, always long sleeved and pants, some wear gloves. Can't blame them for believing the narrative as most of the world does also. I asked a couple of vets if they had observed any melanomas or cancers in high altitude, equatorial animals such as cows, horses, or sheep. "Of course not" they said, "why would they?" There may be large populations of sun lovers in South America like maybe in Brazil, but ones I've seen are very modest and don't expose much skin.
    John Schumacher likes this.
  5. Thank you for the post @Dr. Marcus Ettinger

    For those following this thread, here's the reference
    More COVID post vaccine outcome data is still rolling in...

    Taiwan has one of the world’s highest vaccination rates according to Duke University. They maintain consistent 95%+ mask compliance for over 1.5 years.
    However, the outcome data is not favorable.

    Also, Taiwan’s total fertility rate, births per woman, will be estimated to be the lowest in the world for 2021 & 2022


  6. Jack Kruse

    Jack Kruse Administrator

    You avoid the sun you get the spear of disease. It is not difficult to understand.
    Brent Patrick, Jeff Conway and JanSz like this.
  7. JanSz

    JanSz Gold

    @Jack Kruse
    Please discuss the mitochondrial melatonin.

    So far lots of time pineal melatonin was discussed.
    But it seems like the mitochondrial melatonin need to have some attention.

    Last edited: Oct 20, 2022
    John Schumacher likes this.
  8. Last edited: Oct 31, 2022
  9. Sue-UK

    Sue-UK New Member

    JanSz likes this.
  10. JanSz

    JanSz Gold

  11. Sue-UK

    Sue-UK New Member

    I've read a bit about the vaccines potential links to vitiligo (e.g https://www.medicalnewstoday.com/articles/vitiligo-and-covid-vaccine#can-they-cause-vitiligo) but the focus seems to be on visible signs on the skin, when there's a lot of melanin internally (Herrera and human photosynthesis dot ....).
  12. The COVID vaccine is designed to edit the human genome. I've written on Dr. @Jack Kruse site multiple threads. Example:
  13. Sue-UK

    Sue-UK New Member

    I'm a visual learner and found this very interesting about what is happening at a mitochondrial level with the spike proteins .....
  14. Sue-UK

    Sue-UK New Member

    Makes me think of dehydration and low humidity , particularly n high population density areas at cold and dry latitudes.

  15. JanSz

    JanSz Gold

    @Jack Kruse

    Thank you for the blog. Please continue in that direction.


    Now, if you do not mind
    please discuss (possibly in the next November 2022 PowWow) where I posted that question.
    How it is that the energy in food we consume is almost immaterial comparing to energy from almost two kilograms of hydrogen that passes through us daily via hydrogen in ATP.

    We are using energy of 4 horse-power to continue on living.
    That kind of energy flux is not coming (in real time) from the sun to shine on the person (even at noon at Equator, way up above where the earth atmosphere starts).
    How does the eukaryotic life impact the rest of the life on the Earth?

    About mitochondria.
    If humans contain X amount of mitochondria per kilo of healthy body weight,
    how that compares to a kilo of other mitochondria possessing creatures?


    Last edited: Nov 4, 2022
  16. JanSz

    JanSz Gold

    Last edited: Nov 4, 2022
  17. 5G Canary

    5G Canary Gold

    JanSz likes this.
  18. JanSz

    JanSz Gold

  19. 5G Canary

    5G Canary Gold

    That image pretty much sums it up... Lol! Personally I would watch or listen to the whole video but I know a lot of people don’t like/understand the media stuff when they included it... most people will only watch the first few minutes.
    JanSz likes this.
  20. Sue-UK

    Sue-UK New Member

    Musings ...:)
    I've thought about it in terms of the centenarians in the blue zones, who in general are modestly covered. In terms of melatonin production from NIR, I don't think being modestly covered makes a lot of difference because NIR can still penetrate through clothing, so if an animal is in its natural environment an animal's skin will give a certain protection from excessive UV, whilst also allowing NIR through.(My DD has a dog that the vet told her that when she gets him groomed, not to take his fur too short in summer, and deffo don't get him shaved).

    I've learned about the polar extreme of a polar bear generating its own heat/NIR, which its skin and fur is adapted to reflect back into its body, which makes me think that mitochondrial uncoupling possibly provides a source of NIR that can make melatonin, and that in that extreme a polar bear is adapted to recycle what it emits. So in a low quantum yield environment (whether by latitude, season or by staying indoors), an uncoupled haplotype human may have a advantage in making melatonin endogenously. It could also be why certain dietary traditions developed in different parts of the world, for example the caffeine in coffee drinking, vinegars and polyphenols being signalling molecules to mitochondria to uncouple to repair and make more of themselves, (which in turn might provide more subcellular melatonin production?) Apart from fructose driving fat accumulation, it may be a factor in brown bears gorging on berries before going into hibernation. Also some plants being sources of melatonin. My feeling is that there has to be a back door (like the ancient pathway behind CT) that allows nocturnal and hibernating animals to be able to maintain tissue melatonin levels. :confused:

    The pineal producing < 5% of the body's melatonin and its relationship to darkness may be less about providing a source of melatonin to cells, but more about being enough for signalling the mitochondria to uncouple and repair themselves while we sleep. If at the right time and in the right dark conditions (and low NIR from sunlight) the pineal samples the serum and the level is low enough, that might be enough to trigger the signal, which might be critical for high mitochondria areas such as the brain and heart. I think that might be an important thing for not eating within 4 hours of bedtime, any melatonin in foods which might transiently increase serum levels, or high amounts of NIR from the setting sun would presumably have mostly gone into tissues, but not necessarily enough for the tissues of the energy hogs of the brain and heart. If the pineal signal pulse is a signal to all mitochondria, the tissues with the highest mitochondrial density would presumably get the most benefit from the signal, compared to say fat cells which have few mitochondria.
    JanSz likes this.

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