Hi everyone! Per Jacks rec for nicotine gum - have most people here purchased it? How are you using it? Prophylactically? Or waiting for symptoms? My husband is one of the essential professions and has to continue working. He has asked if this gum will cause an addiction? (He is a non-smoker) thoughts?

also - how’s everyone holding up? We are in Chicago on lockdown mandated by governor.

 

I'm a non smoker and I bought some gum yesterday. Took one 4 mg gum and it definitely gave me a jolt, not in the best way. Not sure how often I will take it but maybe twice a day, if I can tolerate it.

 

can you cut it into smaller pieces?

 

So your plan is to chew this daily prophylactically?

 

You can cut the gum in smaller pieces. I got me 4 mg gums too but I am not going to use it except if I get sick.. I think. Not sure if prophylactic is good? You get used to nicotine. I got addicted to the gums so I stopped completely a year ago. Have not chewed any after that. But if it helps with corona, I will chew them again, sure!

If taking prophylactic, I would use very small amounts, like 1 mg/day or so...maybe divided into 2 times. and then if getting sick, taking more. That is how I would do. I have no idea if this is the right way though.

 

Nicotine gum is meant to be taken once symptomatic. It is not a prophylactic. Your husband's best defense right now is appropriate PPE.

All the best to you and your family.

 

Nicotine gum/spray/lozenge by itself is not addictive like cigarettes are and even less so for non-smokers or people who have never smoked.
But indeed it shouldn't be taken as a prophylactic. And as a biohack it works best with strong UV exposure.

 

Thank you!

 

Are there any study links to nicotines effects in this situation?

 

I have become confused on the subject in the recent past. Could someone enlighten me preferentially @Jack Kruse ,please ? Highly confusing subject.



https://www.researchgate.net/public...pe_2_Receptor_of_the_Renin-Angiotensin_System
"In cardiac fibroblasts, nicotine exposure resulted in near complete suppression of angiotensin-converting enzyme 2 and AT2R. In the brain, nicotine vapor inhalation inhibited angiotensin-converting enzyme 2 expression in the hypothalamus, a region involved in central regulation of cardiopulmonary function"

https://febs.onlinelibrary.wiley.com/doi/pdf/10.1111/febs.15303 Is nicotine exposure linked to cardiopulmonary vulnerability to COVID-19 in the general population? " In this case, however, smoking appears to participate in a direct cellular process that effects COVID-19 infection and possible outcome, in a mechanism involving the ability of the nicotinic receptor to regulate ACE2 protein expression in cells"

https://www.preprints.org/manuscript/202003.0191/v1
Individual Variation of the SARS-CoV2 Receptor ACE2 Gene Expression and Regulation
"Together with the shockingly common enrichment of viral infection pathways among ACE2 anti-expressed genes, binding of virus infection-related transcription factors at ACE2 regulatory regions, the repression of ACE2 expression by inflammatory cytokines and by type 2 diabetes, and the induction by estrogen and androgen (both decrease with age) established a negative correlation between ACE2 expression and CovID19 fatality at both population and molecular levels."