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Coronavirus (2019-nCoV)

Discussion in 'The New Monster Thread' started by ElectricUniverse, Feb 1, 2020.

  1. nonchalant

    nonchalant Silver

    Sheddie and John Schumacher like this.
  2. Penny

    Penny New Member

  3. Penny

    Penny New Member

  4. Teddyjones

    Teddyjones New Member

    How many here think covid19 is fake?

    the human unleashed group of 4 think it’s not real

    does Jack think it’s real or fake?
  5. Jack Kruse

    Jack Kruse Administrator

    it is real but a non-issue for those who have a good immune system.

    Why do we need to scrub the idea of universal health care? C19 has shown us the real risk as physicians.
    All political parties become authoritarians under socialized medicine.
    The annual flu vax has < a 50% efficacy (CDC).
    An Ebola vax has just been released by Merck after 10 years of research and trials.
    An HIV Vax is nowhere in sight after nearly 40 years of research. Why is there a belief on the left that a C19 vax is right around the corner?

    CDC most recent data showing the death rates continue to drop.

    Kary Mullins who invented PCR thinks it should never be used for testing.
  6. Pablo

    Pablo New Member

    @Jack Kruse and what about people with good inmune system that live with people with not that good of an imune system??? Do we get it and transmit it similarly? Meaning... should we take extra care to protect our dads?

    More concretely... tomorrow I´m meeting a woman, shoul I proceed or pospone, since weekend I´ll be at parents house (60-65 yo, no meds or anything diagnosed but my father sneezes with 20 Celsius)

    Occasionally an aunt of mine 70yo in blood pressure meds and sleep pill comes around.

    Seeing and kissing the girl or not??? She has no symptoms. :)
  7. Inger

    Inger Silver

    Of course you can kiss her!!!
    Do not be afraid Pablo :love:

    If you have no symptoms of having flu, you will be fine and you will not kill your uncle. I promise you :)
    The sun will kill the viruses anyways :)
    Stop worrying. Live, laugh.. and dance... kiss and love :) :)
    Sandra, Pablo, caroline and 1 other person like this.
  8. Pablo

    Pablo New Member

    I will!!! :)

    By the way, masks got mandatory in my region and several areas of Spain. Almost in all situations, except during exercise and little more. Sunbathing in the city´s park too, at 10 fucking meters of anyone? I think so. If that´s the case I´m not aquiescing, holly fuck. I´ve been reading Jack´s articles about masks... I hope it goes to courts. Stay good guys :)
    John Schumacher likes this.
  9. Jack Kruse

    Jack Kruse Administrator

    Listen to this beginning at 41:00 mark. In a 2017 lecture at Lawrence Livermore National Laboratory's Center for Global Security Research, neuroweapons biologist Dr. James Giordano speaks of self-assembling nanoparticles being used as a "stroking" agent.
    They can be programmed to clump together/clot and restrict blood flow to organs.
    41:00 minutes - “Drugs and bugs, weapons of mass disruption”
    43:00 minutes - "using the media to 'spread' viruses through target populations…"
    This scenario he describes (3 years ago!) seems uncannily familiar to what is going on right now. The nasopharyngeal swab PCR “test” should be avoided at all costs.
    Anne V, Inger and John Schumacher like this.
  10. Casey55

    Casey55 New Member

    It actually looks really familiar.
  11. Last edited: Jul 22, 2020
  12. Jack Kruse

    Jack Kruse Administrator

    NEW BLOG OUT TODAY: Recently quantitative mass spectrometry-based phosphoproteomics survey of SARS-CoV-2 infection in Vero E6 cells has revealed that cells who get infected undergo dramatic rewiring of phosphorylation on the host and viral proteins. One of the key players here is a heme based enzyme in your blood plasma. No, it is not hemoglobin. It is another. Can you guess what it is? SARS-CoV-2 infection promoted casein kinase II (CK2) and p38 MAPK activation, production of diverse cytokines, and shutdown of mitotic KINASES, resulting in cell cycle arrest. In this way, it mimics circadian disruption. C19 Infection also stimulated a marked induction of CK2-containing filopodial protrusions possessing budding viral particles. Eighty-seven drugs and compounds were identified by mapping global phosphorylation profiles to dysregulated kinases and pathways. Researchers found pharmacologic inhibition of the p38, CK2, CDK, AXL, and PIKFYVE kinases to possess antiviral efficacy, representing potential COVID-19 therapies. Today you learn about a novel one, CATALASE
    Catalases are among the enzymes with the highest turnover rates known: under optimal conditions, each subunit can dismutate 2 × 105 mol of hydrogen peroxide per second.
    John Schumacher likes this.
  13. Mapping Regulated Kinases to Kinase Inhibitors Identifies SARS-CoV-2 Therapies
    Mapping Regulated Kinases to Kinase Inhibitors Identifies SARS-CoV-2 Therapies

    (A) Kinase inhibitors (left) mapped to kinases (right) whose activity was regulated by SARS-CoV-2 infection. Lines connecting them indicate known kinase targets for each drug/compound.

    (B) Vero E6 cells pre-treated with remdesivir at the indicated doses, followed by SARS-CoV-2 infection for 48 h. Percent viral titer compared with mock drug treatment (anti-NP antibody; red line, dots, and text) and cell viability (black) is depicted. Error bars represent SD.

    (C) As in (B). Vero E6 cells were treated with the CK2 inhibitor silmitasertib. Physical interactions between N protein and the CSNK2A2 and CSNK2B CK2 subunits were observed in a prior study (Gordon et al., 2020).

    (D) Predicted increased kinase activity for the p38 signaling pathway and drugs/compounds targeting pathway members (ralimetinib, MAPK13-IN-1, and ARRY-797) and upstream drivers (gilteritinib).

    (E–G) As in (B). Vero E6 cells treated with the AXL inhibitor gilteritinib (E), the MAPK11/14 inhibitor ralimetinib (F), or the MAPK13 inhibitor MAPK13-IN-1 (G) prior to SARS-CoV-2 infection.

    (H) A549-ACE2 lung epithelial cells were treated with the MAPK14 inhibitor ARRY-797 prior to SARS-CoV-2 infection.

    (I) Small interfering RNA (siRNA) knockdown of p38 pathway genes in A549-ACE2 leads to a significant decrease in SARS-CoV-2 viral replication (red), as assessed by qRT-PCR in the absence of effects on cell viability (black). ACE2 and non-targeting siRNAs are included as positive and negative controls, respectively.

    (J and K) Vero E6 or A549-ACE2 cells were treated with PIKFYVE inhibitor apilimod (J) or the CDK inhibitor dinaciclib (K) prior to SARS-CoV-2 infection.

    Last edited: Jul 22, 2020
  14. It is necessary that the wavelengths of external electromagnetic fields be equal or less than the size of a cell. For this reason, 5G technology waves have a main potential role in the emergence of COVID-19.
  15. Chitosan is a derived from the shells of crustaceans such as crabs, shrimp, and lobster.

    The use of chitosan in intranasal delivery of an influenza vaccine to healthy human volunteers produces systemic (IgG) protection.

    Chitosan alone elicits both Th1 and Th2 responses, whereas alum triggers strong Th2 and very weak Th1 responses. In general, the Th1 response plays a dominant 27 role in adaptive immunity (a.k.a. acquired immunity) to viral infections, and is responsible for cellular immunity and killing of infected cells by cytotoxic T lymphocytes (CTL), whereas Th2 is humoral and promotes antibody production. Ideally, both Th1 and Th2 processes are elicited by appropriate antigens and adjuvants, and which to target by vaccination are likely to be pathogen specific. Spike protein stimulation of peripheral blood mononuclear cells (PBMC) of SARS-CoV-2 patients results in secretion of high levels of primarily Th1 cytokines, and elevated but much lower levels of Th2 cytokines. This suggests that SARS-CoV-2 infection provokes a primarily Th1 T-cell response, and a protective vaccine should similarly produce a primarily Th1-based prophylactic response.

    Model of chitosan nanoparticle (CSP)-induced NLRP3 inflammasome activation and cross-presentation: Ag together with CSP (via adsorption or encapsulation) was internalized by APCs. The protonation of the amino groups (“proton sponge effect”) leads to an extensive inflow of ions and water into the lysosome, which causes the osmotic swelling and deconstruction of the lysosome. The entrapped components (CSP and Ag) are released and finally presented onto MHC I, by cytoplasm degradation (with proteasome and ER involved); After the rupture, lysosome enzymes, cathepsin B, was also leaked into the cytoplasm, which induced the assembly and activation of NLRP3 complex. The capacity of TLR4 stimulation of CSP also played an important role in the intracellular synthesis of pro IL-1β and triggered the secretion of IL-1β and inflammatory responses, together with NLRP3 activation. (Ag: antigen; CSP: chitosan particle.)
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185844/ .


  16. Stop the quarantine of the healthy

    People deserve the right to work
    Children deserve the right to an education

    According to a Journal of the American Medical Association Pediatrics study, “children are at far greater risk of critical illness from influenza than COVID-19.”

    California & New York failed with the highest rates of COVID.
    South Dakoda did best.

    Let’s follow the lead the Swiss provided.
    Germany, Switzerland, and Austria have all reopened their schools without seeing an impact on COVID-19 caseloads or hospitalizations.

    "Economic Lockdowns" and school closures during the pandemic have disproportionately harmed low-income communities.

    Last edited: Aug 13, 2020
    JanSz likes this.
  17. Our sun’s UV sterilizes

    UVC has been used for years, it's not new," Indermeet Kohli, a physicist who studies photomedicine in dermatology at Henry Ford Hospital in Detroit, told Live Science. UVC at a specific wavelength, 254 nanometers, has been successfully used to inactivate H1N1 influenza and other coronaviruses, such as severe acute respiratory virus (SARS-CoV) and Middle Eastern Respiratory Syndrome (MERS-CoV), she said. A study published June 26 to the preprint database medRxiv from Kohli's colleagues awaiting peer review now confirms that UVC also eliminates SARS-CoV-2.

    UVC-254 works because this wavelength causes lesions in DNA and RNA. Enough exposure to UVC-254 damages the DNA and RNA so that they can't replicate, effectively killing or inactivating a microorganism or virus.

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