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Corneal Neuropsin and Eye surgery

Discussion in 'Educating Doctors' started by Jay Montgomery, May 23, 2019.

  1. Jay Montgomery

    Jay Montgomery New Member

    From what I understand Neuropsin has currently been found in the mammalian cornea, Retina and skin. From this article 2015, https://www.pnas.org/content/112/42/13093.long it has been identified in the ipRGC’s and the “cornea”. My question is do we have any further clarifications on the cells in the cornea that harbor Neuropsin. I think this is a critical question as it relates to corneal procedures like LASIK, PRK, PKP’s (full thickness corneal transplants), and EK’s (endothelial or lamellar keratoplasites). While it would seem nature designed us to have redundancy in these photoreceptors for photoentraimment, how would disruption in this system from corneal surgery, or retinal injury/surgery for that matter, disrupt this photoentrainment in those individuals. Is there enough redundancy to allow the individual to function and photoentrainment to occur normally, would these individuals require a drastic change in environment after said procedures (of course depending on their personal context), and does a simple Refractive procedure like myopic Lasik which removes a small amount of corneal stroma (ie: collagen and keratocytes) be enough to disrupt this system? To me the answer to that last question depends on the cellular layer in the cornea that harbors the Neuropsin (epithelium-ectoderm derived, keratocytes-mesenchyme derived, corneal nerves (branches of the Trigeminal) - neuroectoderm derived, or the endothelium-neural crest derived. Anyway, just some thoughts I’ve had as it relates to my field.
    Last edited: May 23, 2019
    lev0phedMD and Ed Pomicter like this.
  2. lev0phedMD

    lev0phedMD New Member

    Did you ever find the answer? I briefly searched the references on the paper you linked and didn't find anything.
  3. Jay Montgomery

    Jay Montgomery New Member

    I have not found it. I was hoping someone may have come across the answer. It may have not been determined yet.
  4. DockMD

    DockMD That’s the reason why

  5. DockMD

    DockMD That’s the reason why

    Q&A Jan 2016 1hr18min Lasik discussion, mentions at 1:23 that sometimes Lasik can actually improve the eye clock, but doesn’t elaborate.

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