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Cipro ruins the topology in mtDNA causing a lowered redox = disease

Discussion in 'Mitochondrial Rx' started by Jack Kruse, Sep 21, 2022.

  1. Jack Kruse

    Jack Kruse Administrator

    How do topologic insulators like DNA and drugs which contain Fluoride ruin one another? Fluoride as a dielectric blocker cause topologic breakdown of the enzymes in humans to cause Floxin damage. This paper totally explains why certain antibiotics need to be avoided in people with poor redox and high heteroplasmy rate. It also means if you are a "floxxie" by definition your mitochondrial DNA is trashed and you better become a Black Swan to learn how to deal with it. Topoisomerases are enzymes in humans that participate in the overwinding or underwinding of DNA. Hydrogen bonding between water and the phosphate backbone is how the process is programmed epigenetically.

    Humans have more supercoils in their DNA than any other species on Earth and this is why we have the most complex epigenetic programs to run them smoothly. All are tightly controlled by the electromagnetic spectrum of the environment our mitochondrial colony senses.

    DNA topology was built for the Alkali metals and their reactivity. If you look at a periodic table you'll be shocked to see hydrogen, a gas, sitting atop this group of metals. Hydrogen is a nonmetal and is placed above this group in the periodic table because it has one s1 electron configuration like the alkali metals. When hydrogen loses its electron it becomes a super alkali metal and forms hydrogen bonds. The formation of hydrogen bonds creates a decentralized network that acts like the internet to transmit data. The variability of the hydrogen bond network controls the bandwidth. The light absorbed by the water is what creates the message to be transferred over the collar internet internally. That network changes the charge density around proteins and bases in DNA. It also can change the behavior of hydrogen adjacent to DNA/RNA. Moreover, this is why DNA and RNA topology uses it to control our epigenetic toolbox on phosphate, sugar, and base moieties in our nucleic acids. Modern biology still has not woken up to this reality.

    The winding problem of DNA/RNA arises due to the intertwined nature of its double-helical structure. This makes it the ideal antenna for electromagnetic radiations but it causes topology problems for the epigenetic toolbox to read them. During DNA replication and transcription, DNA becomes overwound ahead of a replication fork. If left unabated, this torsion would eventually stop the ability of DNA or RNA polymerases involved in these processes to continue down the DNA strand. This is essentially what fluoride does to DNA and RNA in humans. It blocks the electric and magnetic reading of these chemicals by changing the binary code buried in the hydrogen bonds of water. This ruins the fidelity of the signals by creating noise in the network channel.

    In order to prevent and correct these types of topological problems caused by the double helix, topoisomerases bind to DNA and cut the phosphate backbone of either one or both the DNA strands. This intermediate break allows the DNA to be untangled or unwound, and, at the end of these processes, the DNA backbone is resealed again. Since the overall chemical composition and connectivity of the DNA do not change, the DNA substrate and product are chemical isomers, differing only in their global topology, resulting in the name of these enzymes. I have taught my Black Swans about topology now for 10 years and I made sure they knew that the Nobel Prize was given several October ago in physics for topology. Topoisomerases are isomerase enzymes that act on the topology of RNA/DNA. This is also how mRNA \/causes redox loss.


    https://academic.oup.com/nar/article/46/18/9625/5088042?login=false
     
  2. Jack Kruse

    Jack Kruse Administrator

    [​IMG]
    A scanning tunneling micro image of helical Dirac fermions on the surface of a topological insulator
     
    ND Hauf likes this.
  3. Jack Kruse

    Jack Kruse Administrator

    The Nobel Prize for physics in 2016 was given for the discovery of topologic insulators (TI’s).
    Topological insulators conduct electricity on their surfaces but do not conduct the current deep inside their cores. This helps explain why DNA’s surface is highly coiled and coated with histones, chromatin, and methyl groups in its “quiet state” and how it can receive photo-electric instructions through the hydrogen bonding network that surrounds nucleic acids to run the epigenetic programming it contains deep within. What happens on its surface can awaken the code of life buried deep below its double helix which is capable of change because of how Dirac fermions operate.

    Claude Shannon taught the world that information flows via entropy. Wheeler taught physics that information and energy are one and the same thing. Shannon’s mathematics from his 1948 paper advanced the linkage of entropy and information. Shannon's paper also told us anything can be a message.
    Light's information is messaged on water's hydrogen bonds adjacent to proteins in a cell.

    Water makes up 99% of molecules in every cell. Water is a very small molecule that has more hydrogen bonds in it than any other compound. Liquid water contains the densest hydrogen bonding of any solvent, with almost as many hydrogen bonds as there are covalent bonds and hydrogen bonds in its structure found anywhere on Earth. These two bonding networks are the binary code in water. Just as a computer can use a 1 and 0 to create digital information on the internet, hydrogen bonds create the internet in your cells. Shannon taught us
    the information content of any kind of message could be measured in binary digits, or just bits-

    Water's hydrogen bond network changes at a pico and femtosecond level in any environment. Inside a cell, its atomic arrangement is controlled by electrostatic forces in a cell created by the redox power of the mitochondria in that cell. These hydrogen bonds can rapidly rearrange in response to, light frequencies, charge density, and changing conditions and environments (for example, solutes like K+ in a cell).

    Shannon demonstrated, contrary to what was commonly believed in the 1940s, that engineers could beat their worst enemy ever: transmission errors-or in their technical jargon, "noise." Noise is anything that disturbs communication. It can be an electric signal in a telephone wire that causes crosstalk in an adjacent wire, a thunderstorm static that perturbs TV signals distorting the image on the screen, or a failure in network noise was to increase the energy of the transmission signals or send the same message repeatedly-much as when, in a crowded pub, you have to shout for a beer several times. Shannon showed a better way to avoid errors without wasting so much energy and time: coding. Nature does the same thing.

    She takes the message in the hydrogen bonding network and encodes it in mRNA, mtDNA, RNA, tRNA, and DNA

    Coding is at the heart of information theory. All communication processes need some sort of coding to limit the noise and create a high fidelity signal that doesn't degrade. Water preserves the information and transfers it to nucleic acids via hydrogen bonds. Just as the telephone system transforms the spoken voice into electrical signals. In Morse code, letters are transmitted with combinations of dots and dashes. The DNA molecule specifies a protein's structure with four types of genetic bases. Digital communication systems use bits to represent-or encode- information. Each letter of the alphabet, for example, can be represented with a group of bits, a sequence of zeroes and ones. You can assign any number of bits to each letter and arrange the bits in any way you want. In other words, you can create as many codes as desired. Cells have done this to run life's program.

    The interactions of electrons in a solid or liquid crystal change space in abstract ways. If you look at the picture below you can see odd shape and size changes and this leads to the different thermodynamics of what is possible on the surface. Many TI’s develop “holes” where electrons are absent and this allows them to act as P-type semiconductors and then there are adjacent regions that are extremely electron rich that can act as an N-type semiconductor. Those positive and negative regions can act like “charges” and can lead to striking effects. For example, an insulating material (phosphorus) can become conductive at its surface when sunlight hits it. Phosphorus has ten atoms that stick directly out from the surface of DNA when you look at it from an axial view. See figure C below. Those ten atoms are surrounded by 447 water molecules to form part of the TI in DNA. The addition of phosphorus and iodine in the liquid crystalline water networks create a “playground of charges and spins” to control DNA from the surface.

    [​IMG]
    Note the ten phosphorus groups sticking out to bind with EZ water as DNA unwinds above

    Within the heavily condensed and coiled state DNA structure tightly holds atoms, electrons and photons in one “spin state”. When DNA is uncoiled by electromagnetic signals from our mitochondria on its surface, light is liberated from the double helix and the surface template of hydrogen bonds radically changes its “topology” by altering spin states. This can turn on and off DNA replications
    The spins of electrons/protons (H+) are not only manipulated by magnetic fields (mitochondria) but also by electrical fields (proteins side chains) and can be used to collect and store information from electrons or the photons they carry. All magnetic drives use spintronics today to magnetically store data on hard drives.

    We already know a leaf can do it via photosynthesis and so can a European Robin using a light inclination magnetic compass in its eye. In my humble opinion, this process works in all animals tissues to create the many species of animals we all observe in the classical world we inhabit.

    Topology is a branch of mathematics focused on the fundamental shapes of things as they change. In cells, proteins can vary their size and shape based upon the light energy that is added or subtracted to their bonds. In this way, life can be considered a quantum computer that is working in parallel with a quantum universe that also runs on light. The messages are information buried in light waves frequencies in the sun that can be magnetically stored in a thin film of water surrounding nucleic acids.using non-linear aspects of light. DNA is the ultimate topologic insulator or superconductor suspended in a superfluid of coherent and non coherent water that imprints information, conducts electrons, protons, and photons in different ways. This Nobel Prize may soon get biology away from its “solution based ideas” in biochemistry books and push them toward quantum biology which uses a solid-state foundation. That is what this Nobel Prize means to me in 2016. The state of fluctuation of the hydrogen bonding network creates probabilities in a cell.

    PHYSICS IS THE SCIENCE OF PROBABILITIES. BIOLOGY IS THE STORY OF THE IMPROBABLE AND BIOLOGY CAN ONLY MAKE SENSE FROM THE PERSPECTIVE THAT THE LIVING STATE IS ONLY PROBABLE ON EARTH USING REACTIONS UNDER SUNLIGHT WHICH ARE STATISTICALLY IMPROBABLE anywhere but on Earth.

    Knowing is just not enough. Understanding connections is critical. Stop being your own worse enemy. Stop looking outside for solutions when the wisdom you seek is buried within.
     
    JanSz likes this.

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