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"CCO isn't the primary acceptor for NIR--mitochondrial bound water is"

Discussion in 'The New Monster Thread' started by Corey Nelson, Jul 30, 2019.

  1. Corey Nelson

    Corey Nelson CoreyNelson.io

    Interesting work by one Andrei P. Sommer.

    From Mitochondrial cytochrome c oxidase is not the primary acceptor for near infrared light—it is mitochondrial bound water: the principles of low-level light therapy:

    "There is observational evidence that R-NIR photons and presumably other wavelengths (in model experiments we worked with 670 nm—a wavelength for which bulk water is practically transparent) interact with the bound water, i.e., nanoscopic interfacial water layers (IWL) attached to surfaces, especially to hydrophilic ones. IWL consist of 2–3 monolayers of water molecules. The interaction has at least two biologically important impacts: change in IWL density (volume expansion) and reduction in IWL viscosity"

    Another: Light Effect on Water Viscosity: Implication for ATP Biosynthesis

    Might be the case that he's missing some key points about production of matrix water, structuring of water, and negative charge of EZ water, but I think the title of the first paper is at least a promising conceptual step :).

    To whoever's reading this though, is the friction/lubrication thesis suggesting reductions in viscosity totally backwards, in your opinion?
  2. Jack Kruse

    Jack Kruse Administrator

    This is why 600-3100 nm light make energy and increase ATP.

    No shocker.

    It is also why UVA light and blue do the opposite.

    That is why NO was innovated.
    Corey Nelson likes this.
  3. Jack Kruse

    Jack Kruse Administrator

    CCO does have 4 red light chromophores so the paper is not 100% spot on.
    Corey Nelson likes this.
  4. drezy

    drezy New Member

    Have to admit.... I love me some systems level thinking.
  5. JanSz

    JanSz Gold

    The energy that you are talking about
    is that the energy that came from (ATP---->>NADH--->>water synthesis)
    created during (2H+ + 1/2O2) water synthesis
    or the two are additive?

  6. Jack Kruse

    Jack Kruse Administrator

    The first law of photobiology states that: a photon must be absorbed by some molecule within the tissue to have any biological effect. The identity of these chromophores has been the subject of much scientific investigation and speculation. Largely due to the efforts of Tiina Karu in Russia, the enzyme cytochrome c oxidase (CCO) has been identified as a major chromophore of red/NIR light (Karu, 1999; Karu & Kolyakov, 2005; Karu, Pyatibrat, & Afanasyeva, 2004a; Karu, Pyatibrat, & Kalendo, 2004b). CCO is unit IV in the mitochondrial respiratory chain and has absorption peaks reaching well into the NIR spectral region (up to 900 nm) as well as in the red and blue regions. The most discussed hypothesis to explain exactly how photon absorption can stimulate the activity of CCO involves the photodissociation of inhibitory nitric oxide (NO) that can bind to the copper and heme centers in the enzyme and prevent oxygen from gaining access to the active sites (Lane, 2006). In experimental models (such as isolated mitochondria) oxygen consumption and ATP production are increased and the mitochondrial membrane potential is raised (Passarella et al., 1984).

    A less appreciated mechanism involves light and heat‐gated ion channels. These cation ion channels are thought to be members of the transient receptor potential (TRP) superfamily, consisting of over 28 distinct members, organized into six subfamilies, based on their primary amino acid structures (Caterina & Pang, 2016). TRPV (vanilloid sub‐family) members, including TRPV1 (capsaicin receptor), have shown to be activated by various wavelengths of light, including green, red, and NIR

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