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Cannibinoid Curiosity

Discussion in 'Biohacking 101' started by cantweight, Nov 28, 2014.

  1. Inger

    Inger Silver

    bio-fractal-soul-self,
    how are you going to cultivate your veggies etc.? I think as long as you do not use a green house it will always be somehow seasonal. In Finland many uses greenhouses in their garden to be able to grow more stuff and longer.... but I would never use that. I think it is stupid. The plants need real sunlight to be real healthy. That way they will be more seasonal too. I have read it makes quite a difference if a plant gets real light or filtered through glass/fake light.....

    I am a fan of wild foods... I think it is way more practical to pick and eat wild plants, berries and mushrooms and eat, than have to do lots of work with gardening ;)
    Somehow the wild stuff makes me feel amazing too. I love the whole procedure of searching for it... eating it... being in the wild..... I prefer that over gardening anytime... I sometimes think, why do people pick away the weeds from their gardens.... all those healthy wild edibles.... full of nutrients... that are maybe way healthier than the carrot they grow? So much work. I never understood this. Then comes a deer.. and eats the veggies.. all the hard work was for nothing. or other issues..... too dry.. too wet.. you cant control the weather. But the wild stuff is so hard core it always survives. Here are wild greens that survive under the snow! Amazing! Must be full of life force :)

    That said... I do love to munch on some home grown cucumbers or dirty carrots.... ;) I just would always grow them naturally to get natural lights and temps, no greenhouses
     
    Kristi Lambert likes this.
  2. Well, I will firstly have a garden, as I have some minor experience gardening and feel like picking up a few new skills as it is; it would be great for CT, grounding, light, active meditation, etc. as well. I know things are different in different parts of the world, but in the Midwest people often plant carrots in the winter, often in sand, and they continue to grow quite easily. There are also berries, edible acorns, grasses and shrubs, and much more, in the dead of winter, just under the fresh snow. If I chose to eat these foods alone as sources of carbs, it'd be easy to get around 70 grams of carbs each day, even in the coldest days of winter. The coastal inuit tribes did very similar - they never ate under 50 grams of carbs, and often ate 70+ in addition to hundreds of grams of protein everyday - not even close to a ketogenic diet. Technically speaking, dairy isn't so hard to find in winter, either (I'm speaking of local, grass-fed/raw dairy). If I ate a more 'Optimal Diet' like Peter at HyperLipid, who prefers saturated fats especially from dairy, well, I'd easily be able to get 70-100+ carbs a day in the winter if consuming full fat raw milk, fermented cream and yogurt, matsoni, etc. There is strong evidence that plant foods were readily available during the ice ages in winter as well, such as tiger nuts, and various shrubs and fatty plants. So, I'm not necessarily worried about eating certain foods that someone does or doesn't think is appropriate for winter, so much as I'm concerned with optimal beta oxidation, mitophagy, and so on, especially during winter. CT and a high fat diet alone can accomplish this; DHA, AA, and tons of saturated fat, iodine, selenium, and sulfur from eggs, sardines, etc. alongside some PQQ and resistance training can enhance these adaptations via transcription factors such as PGC-1a and increased activity of some PPAR's.

    Further, it's very easy to grow herbs, spices, and other plants indoors. Oregano, ginger, avocados, and more, can be easily nurtured inside even in the winter. Spirulina and mushrooms seem rather easy to grow, too, all year round. This isn't even including things such as aqua-culturing and utilizing the work of Viktor Schauberger and others to drastically increase plant growth sans additional food (using water and minerals alone), which can completely alter what is "normal" in any given environment. There is a show called Bizarre Foods with Andrew Zimmern, where he travels the world eating, well, "bizarre" foods. Interestingly, they're often just traditional/indigenous dishes. Recently I saw his episode of the Farroe Islands in Europe where things like fermented sheeps head, blood pancakes and blood pudding are frequent dishes. What else did they eat? Massive amounts of raw parsnips, potatoes, and winter fruits, in the dead of winter; and these weren't imported foods... they were naturally occurring for people in small towns in the hills with almost no access to the main cities nearby. So, seasonal foods = relative to what you are looking at, and also, what you aren't looking at.

    This isn't to decline the validity of your approach or ideas - someone as youthful as yourself, well, I can't argue with those results, and I definitely think fat burning pretty much all year round is optimal, and in Winter, I see no reason to not be in pretty deep ketosis (30 or less carbs, 100 or less grams of protein, maybe 50-70 if dealing with neurological/psychiatric issues); but in the event that my various experiments work out (with food production), there is no way I'd decline some fresh berries, shrooms, home grown avocados, etc. just because there is some trace evidence that in some remote location some time in history those foods weren't available. Oh, also, I plan to mineralize all my soil with sea veggies and the shells of shellfish :)
     
    Brother John likes this.
  3. Inger

    Inger Silver

    Cool :)
    Let us know how you do along the road :)

    I might be just too lazy :rolleyes: i get the crisis if i think i have to care for so much gardening...lol cause i am kinda stuck in it then. In the wild, it is always there for you to take, when you have time :)
    I do like the idea of permaculture, where everything grows together.. it is way less work too i guess?
    I have so many people in my life that needs me i need to think about ways how to lessen my work load...lol there is a huge need for help and i am no way enough :confused:

    My brain very much like the ketosis and high fat. Maybe because it is so broken? Yep... i definitely need it! Makes me feel so calm and happy and crazy good :)
    Ketosis with seafood it is for me..... and as wild as it gets..lol

    That is cool you plan to mineralize your soil like that :)
    I still would just eat the sea veggies ;) that way you have the goods stuff inside you immediately without much work at all :) but it might be it is my laziness that pops its ugly head :eek:
     
  4. cantweight

    cantweight Gold

    I just started back on the CBD oil. And I notice a difference immediately. Its so odd to me because other members of my family as well as friends have tried higher dosages and gotten no reaction (noticeable anyway).

    Immediately I experience decreased appetite, energetic almost caffeinated feeling, increased thirst. Sorry if this is tmi but also a diuretic effect frequent urination and extremely loose bowels....this happened before as well and rights itself after day one.


    So a massive water/electron shift? I can only tolerate about 12 drops of the cbd I have....thats a very small amount as I believe the dose to be up to 15 drops 3 times daily.

    At 15 drops I was so revved up I was uncomfortable and extremely irritable....
     
    Martin and Brother John like this.
  5. Shijin13

    Shijin13 Guest

    @yewwei.tan & @cantweight So, as a result of the Geomagnetic storm earlier this week, I ended up with a migraine yesterday. I could feel it starting, so I worked from home, and kept my computer/screen time to under 1 hour, I ate nothing but seafood (salmon, shrimp and oysters, took additional hormones. threw on the CFB on my neck/head...

    So I decided to see what would happen if I tried CBD oil. ughh.. lets just say I'm not doing that again. 15 drops of CBD oil sublingual ramped up my migraine beyond the point where I was functioning, yet as a mom, I don't have a choice, and must function anyway.

    So... wondering how CBD oil makes migraines worse for me? I'm guessing it degrades my ECT? or maybe it needs to be taken at onset.

    Any thoughts?
     
  6. cantweight

    cantweight Gold

    It sounds like a good idea....that over caffeinated feeling I get seems like it could lend itself to the same action caffeine has on a migraine. I have found it leaving me feeling a bit of testosterone type rage so I have shelved mine for the time being. Not a good match at this moment.

    Perhaps you are similar to me in that it was too much? I found a sweet spot at 4 drops 3 times a day. 15 drops at once I could not tolerate.....15 drops in day was too much for me.
     
  7. Shijin13

    Shijin13 Guest


    yeah I don't know @cantweight I just happened to be re-reading this thread, looking for how THC, CBD could be used to help PTSD patients.

    I know when I was exposed to mj in highschool - I didn't have a good trip, and it was only a contact high from a concert.

    *goody two shoes* here, as I regularly got "popped" for drug testing swimming at the national level through out my teen years, beginning at 12yo and on.
     
  8. Shijin13

    Shijin13 Guest

    One more question for those thinking outside the box on this

    @Josh @Josh (Paleo Osteo) @yewwei.tan

    How would COMT, MTRR and other dopamine/serotonin snps impact the THC/CBD response, as well as Pregnenolone levels?
     
    Josh likes this.
  9. fitness@home

    fitness@home Silver

    Interesting question. I am curious too.
     
  10. Shijin13

    Shijin13 Guest

    Another follow up. how does cycloset, when coupled with DHA and Sunlight upon rising, bind to the same receptor sites? or is it just the stimulation of Dompamine that affects the SCN.
     
  11. yewwei.tan

    yewwei.tan Gold


    As usual, I am not 100% certain on the mechanisms of CBD oil :rolleyes:

    Regarding migraines, I personally subscribe to this mechanism -- http://forum.jackkruse.com/index.ph...-csf-semiconductors-in-brain.7564/#post-89605

    So basically, I think migraines are an upset in the water balance within the brain, and depending on which part is upset, you'll get more water into some parts of the brain more so than the others. Malfunction of the water balance system (AQP4 gates) is likely the root cause, so the next question is why do AQP4 gates fail?

    A quick review is recommended of some of the notes I made on the May 2014 Webinar -- http://tanyewwei.com/notes/jk-webinar-may-2014

    Some extra technical notes on AQP4 function -- http://tanyewwei.com/notes/grotthuss-aquaporin-4-conductance . Note really needed for this discussion though​

    When it comes to CBD oil and migraines, we've got to look at the CB1 receptor and its effects on the Central Nervous System (http://en.wikipedia.org/wiki/Cannabinoid_receptor_type_1). Activating this receptor does a lot of downstream ACTIVATION of the neurotransmitters in the brain. Both CBD and THC will activate this receptor pretty strongly.

    Where I think the COMT SNPs come into play, is that COMT is needed for DE-ACTIVATION of several neuronal pathways. So having a COMT defect basically means that you cannot de-activate overly-excited pathways very well. This is purely based of theoretical speculation, but if that holds true, then CBD/THC dosing in people with such defects will have to be much lower; You'll still get the benefits of CBD/THC, but the required dose will be lower than in people with these defects.


    With migraines, I still the best treatment is going to be to restore AQP4 function, aka: re-zip collagen. Red light to the brain seems like the best solution. Intra-nasal red light therapy, or possibly red-light LLLT is probably the best bet. (In the operating room, doctors would pump saline solution into the brain to get the same effect :eek:)


    IMO yeah, it's just the stimulation of the D2 receptor, which happens to mimic a lot of the downstream effects of Leptin. Both the D1 and D2 receptors will have good downstream effects on NPY and CRH (this guy is mentioned heavily in CT4 and CT6 -- "bypass the thyroid and make CRH directly").

    Leptin affects both the D1 and D2 receptors, while Cycloset will only affect D2, and actually reduce activation of D1 slightly (though not enough to reduce the overall effect).

    So I basically view it as a boost to the Leptin Reset protocol.

    ....
     
    Martin likes this.
  12. Josh

    Josh Gold

    The relative health of the methylation pathways/reliable proton tunneling due to mass equivalence, water quality, etc. will affect the pharmacokinetics and persistence in the systems/half-life. There may be persistent intermediate effects along the detoxification/biotransformation pathways that have their own effects as well, otherwise known as a "hangover". etc...

    Consider some of the factors involved in reliable H+ tunneling that effect enzyme function/pharmacokintics by factors of up to 10 to the 25th power.
    Pages from HydrogenandProtonTunnelingKlinman2013.jpg

    http://www.annualreviews.org/doi/abs/10.1146/annurev-biochem-051710-133623
     
  13. Josh

    Josh Gold

    I would hypothesize that if conditions were suboptimal, one might require additional methyaltion pathway support to handle significant dosages of CBD/THC products. Reviewing the biotransformation pathways would illuminate the possible bottlenecks.
     
  14. BTA

    BTA New Member

    I just took 5000 mg of CBD THC under my tongue - that's enough to cause a coma in the average person. It did NOTHING for me! I can take 50 mg of morphine by IV and nothing - no effect. All medicine is like that for me. I can take 9 Grams of Magnesium by IV - that's enough to kill the average person - but for me it does nothing. No clue why. Same thing for CT - I can get into water that's below freezing & I dont shiver. No effect on me at all.

    Dazed & confused :confused:
    .
    .
    .
     
  15. As I alluded to before, one also has to be careful with what "CBD oil" they're getting. The 'legal' stuff made from hemp is crap and doesn't work, and there is in fact a large group on facebook that has been calling out differen companies selling "CBD oil" for quite some time. Not only is there often barely any CBD in the oil, it is typically filled with potentially allergenic impurities. That alone can cause migraines, body aches, etc.

    It seems interesting that most people on various forums get NO beneficial effects - and sometimes adverse effects - from CBD oil, yet, when people go and see a MD who then prescribes them medical marijuana and they get medical grade CBD made from cannabis, not hemp, they respond positively.
    '
     
    Martin likes this.
  16. BTA

    BTA New Member

    This was medical grade - prescribed by an MD. The dispensery has three different labs run independent tests on the % of active ingredients. Very closely monitored. Yet no effect.
     
  17. Shijin13

    Shijin13 Guest

    @yewwei.tan

    I think one of the key things to addressing the AQP4 is the proper Pg:E2 ratio. You can be rocking everything perfectly, etc but if at any point in the hormonal cycle across both the 24-hour, monthly, and seasonal that ratio is off, the gates don't work.

    Usually for me that's two points in my cycle - day 5/6 or day 26. these are the days I usually have issues with migraines (thought not every time)

    This cycle - I got hit with a killer migraine on cd3. not normal. I think the geomagnetic storm induced the migraine.

    I also think that based upon what Jack has commented about women having a more sensitive epigenetic antenna - that its possible that if we lived in a world with just native EMF, the balance issue at AQP4 is required to inform egg release as well as influence fertilization and pregnancy. If the balance is off, AQP4 might actually result in the inability to sustain a pregnancy given environmental factors.

    Yet when you live in a world flooded with nnEMF and you have balance issues at AQP4 - that epigenetic antenna sets you up for failure as system faster. the only signals might actually be the migraine, or the inability to get pregnant or carry a child to term w/o medical intervention.

    As for the COMT I've never thought about its inability to turn off the neural pathways. but that would make total sense. Especially given someone who has PTSD. I've always looked at COMT from my perspective recently of not generating enough Dopamine and supporting the Liver detox pathways of P450. but it makes sense. Especially given my COMT status as +/- . I should be able to make enough dopamine, and turn off the hyper-activation of the neural pathways, but I get stuck. courtesy of the good old bipolar issues. when the switch flips, its hard for me to turn it off... when the switch is off its hard for me to turn it on... I would assume that something similar is happening in individuals with PTSD/TBI as well. @Josh & @QuantumRadical alert.

    much more to ponder here.... I really need to get signed up for my anatomy and Physiology and biochem class.
     
  18. yewwei.tan

    yewwei.tan Gold

    Posting here some of the stuff that I posted in this QH Facebook Group thread: https://www.facebook.com/groups/872967099382852/permalink/978212452191649/

    ----
    (excerpts commence)
    ----

    Rubin linked to this paper: http://www.ncbi.nlm.nih.gov/pubmed/9472423

    Important to note that the study involved psychoactive THC, introduced into the body after it has been heated. Non-heated THC is non-psychoactive, which probably means it doesn't excite particular neuronal pathways.

    ----

    Whether or not CBD or TCH this is useful for something like PTSD will IMO depend heavily on the mechanism being used when taking something like medical marijuana.

    My opinion is to do it raw (never heated above 40C)

    PTSD is basically over-excitation of the brain's emotional centres. I personally don't think exciting it further with psychoactive THC is helpful

    Non-psychoactive CBD in combination with Non-psychoactive (non-heated) THC, could potentially be a good way to re-establish cellular signalling. Binding to the cannabinoid receptors also help with the downstream dopamine pathways, which ultimately feedback to Leptin function (improving it).

    ----

    IMO cannabis works by producing Reactive Oxygen Species (ROS) in the appropriate cells to re-establish cellular signalling, while decreasing ROS production in other cells (see papers below). This would normalise the ROS response to "tune the system to work together".

    Chemical reduction of ROS induces biophoton emission at the site of reaction, which transmits information both at this site of reaction, and at the original ROS generation site (due to quantum entanglement)

    - Control over Macrophage ROS production -- http://cardiovascres.oxfordjournals.org/content/early/2009/07/31/cvr.cvp240.short

    - Reduction of Oxidative Load on rat PC12 neural cells -- http://onlinelibrary.wiley.com/doi/10.1111/j.1471-4159.2003.02327.x/full

    - Killing malfunctioning cells with ROS over-production -- http://molpharm.aspetjournals.org/content/70/3/897.short


    IMO cannabis was designed by Nature as a plant to aid with this ROS signalling during the Autumn transition period, when light levels are decreasing, and it isn't cold enough for matter to be condensed.

    The body will need to find more ways of generating signalling molecules, and cannabis is one of those ways.

    Overview -- http://forum.jackkruse.com/index.php?threads/reverse-electron-flow.12744/#post-154292

    ----

    ^^ Implication of the previous section is that I do not think cannabis is useful for people who already have good cellular signalling, other than to have a good time :p (which I fully support)

    It is designed as a stress mitigation strategy, and can be useful acutely for that purpose (again, I believe raw is best), or chronically in sick populations until health is restored.

    Don't forget that the stressor still needs to be removed :cool::confused::D Using cannabis as a band-aid is a losing strategy.

    ....
     
    brandie likes this.
  19. @yewwei.tan @Jack Kruse Do you know what mechanisms could trigger spasmophily/tetany seizure when someone smoke or eat weed? (very cold hands and anxiety/hypertension/tachycardia/palpitations)?
     
  20. yewwei.tan

    yewwei.tan Gold

    Arborescence likes this.

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