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Cannibinoid Curiosity

Discussion in 'Biohacking 101' started by cantweight, Nov 28, 2014.

  1. sjoshua

    sjoshua New Member

    I read this as saying, CB receptor activation assists the system in being metabolically flexible. Considering it is naturally a fall harvest plant, it would make sense to utilize seasonally at the transition into winter in order to assist with switching to a winter-like diet (i.e. 'eat like a shark' - when minimal carb availability is more typical, dependent on location).

    So, bearing in mind the current state of the surface of our planet (regarding nnEMF saturation in/around poulated areas and exponentially greater with increases in populus), and the manner in which society has shifted towards perceiving 'endless summer' (unlimited light exposure potential, blue light into the night hours sitting in front of TVs, phones, computers, etc.; moving between indoor, climate controlled environments in a A/C 60Hz field), it would make sense that 'the people'/voters are latching onto cannabis as an useful medical/recreational tool, since in a way it is delivering the 'seasonal change' signals most do not even receive anymore...

    And, it appears to have a regulating effect on leptin when 'eating like a shark'.
    Last edited: Feb 4, 2015
  2. cantweight

    cantweight Gold

    Perhaps this is what aided my transition into winter this year...was the easiest one I have had in ages!

    Took it out for a bit as it is expensive and I have been trying new things...now that they are fairly settled I plan to add it back in. Thanks so much for the input!
  3. rlee314

    rlee314 Silver

    Brother John likes this.
  4. rlee314

    rlee314 Silver

  5. cantweight

    cantweight Gold

    rlee314 and nicld like this.
  6. nicld

    nicld Gold

    ^^^^ Oh I so wish this was available in our state. I would try it for my daughter on it in a heart beat.
  7. cantweight

    cantweight Gold

    Nicole the CBD oil is available anywhere. It contains no thc and is not illegal. I get mine from Bluebird Botanical :)
    sjoshua, rlee314 and nicld like this.
  8. Do you notice any benefits from the Bluebird Botanical CBD oil? A lot of people on various cannabis-medicine groups state that all the legal non-medicinal (as in, from a dispensary) CBD oil is in fact not worthy of purchase as it either doesn't work at all or has vastly smaller amounts than claimed. In fact, there is a group on facebook that propped up solely to investigate all the companies selling CBD oil and to oust the ones that aren't truthful, lol. I tried one that seemed good, but the doses I was using were far too small to have any benefit. Many of the studies showing benefits, for instance, some showing that CBD protects mitochondria from calcium efflux, use doses in the gram range, daily. Some of the CBD gums have only about 10mg per piece. It'd be impossible to get the proper doses, then.

    Is anyone here located in a place with medical or legal access to marijuana? I'm frequently in the mid-west, and completely forgot that in 2014 medical marijuana is legal in Illinois. I'm planning on obtaining a medical marijuana card and first toying around with raw, non-psychoactive (almost dietary) cannabis, and then potent CBD extracts. I'm wondering what strains and cannabinoids are best for neurological issues..
  9. I've found these quite interesting:

  10. According to the research of Dr. William Courtney and a few others, cannabis when not heated is not psychoactive because many of the cannabinoids are in an entirely different form - the 'acid' form; there is THCA, CBDA, etc. Not only do these cannabinoids not have psychoactivity, this very fact allows one to consume thousands of times higher doses of cannabinoids, thus there is heightened medicinal value.
  11. "Far from equilibrium thermodynamics" - reminds me of what I posted in my journal about energy causing positive changes that facilitate increased coherence, complexity, and organization, in other words, evolution, which continues to this day (even in us):

  12. yewwei.tan

    yewwei.tan Gold

    His website is http://www.cannabisinternational.org , where you can find lots more information

    And here's part 2 of the video that you linked


    The recommended dose is 500-600mg of CBD acid. This is probably best by drinking a raw smoothies with a set portion raw cannabis leaves.

    However, the CBD to THC ratio also makes a difference in therapeutic outcomes. In general, cannabis contains anywhere from a 2:1 to 1:2 ratio of CBD:THC-acid. Personally, I have not done enough research on the ratio to comment. Perhaps I'll start reading now. :) (will need to understand cannibinoid receptors, the NMDA pathways, and possibly the nicotinic receptors)

    You're right that heating THC-acid turns it into the psychoactive THC. It takes just 10mg of THC to get really really high (which is most strains will only get you anywhere from 5-20mg of CBD). Hence the recommendation is to juice the cannabis raw, which does not cause any psychoactive effects, and is extremely therapeutic.

  13. yewwei.tan

    yewwei.tan Gold

    I also want to bring attention to this paper 'Phosphene phenomenon: A new concept' --http://citeseerx.ist.psu.edu/viewdoc/download?doi=

    I have made an excerpt summary here -- http://qhwiki.com/study:phosphene-phenomenon

    This talks about how Reactive Oxygen and Nitrogen Species can stimulate weak biophoton emissions at reaction sites :eek:

    It then talks briefly about how psychedelic compounds induce formation of these ROS and RNS. We can make an argument that one of the reasons "harmful psychedelics" are harmful is because they flood the body with too great a ROS/RNS signal.

    "Good psychedelics" provide for controlled ROS/RNS signalling, which gives rise to both the quantum-mechanical entanglement-signalling that Jack has talked about, but also provides for weak biophoton emission at the site of sick cells. I wouldn't be surprised if we found out that THC-induced ROS gives rise to emission of the "380nm healing wavelength" of light at precisely the right intensity :rolleyes:, though I have no proof as of yet.

    Tensegrity #14 tackles the 380nm wavelength -- http://jackkruse.com/tensegrity-8-communication-breakdown-gut/


    OPINION on use of CBD, THC, and other ROS-inducing compounds

    These compounds are likely stimulators of ROS, with cascades into the rest of circadian signalling.

    There is obvious seasonality to such compounds. eg: cannabis is traditionally a fall harvest herb -- precisely at the time when ROS signalling is most required due to seasonal changes (see this post -- http://forum.jackkruse.com/index.php?threads/reverse-electron-flow.12744/#post-154292)

    Use of such compounds DOES NOT add energy to the system. They help re-establish signalling between components. Energy-adding behaviours like eating a good epi-paleo diet, grounding, etc.. must be performed in conjunction with these compounds. Though when used in conjunction with optimal health strategies, they act as a great aid to re-establish communication between components of the body.

    ROS induction through non-dietary pathways is something that I view is useful in the treatment of almost any disease state whereby there is communication breakdown (almost all disease states).

    I think this is the most helpful with gut-mediated disorders like excessive leaky-gut-induced autoimmuny, or with something like a candida infection. This these cases, you do not want to introduce ROS-producing carbohydrates to the diet, which can hurt the disease state even more.

    While I did mention seasonality, I think such compounds are useful in all seasons when diseased (for the reasons above, and with the appropriate caveats). They are likely not needed in a healthy individual, whereby oxidative signalling is already under control.

    Overdosing on such compounds is basically an ROS overdose, with all the known side effects.

  14. One thing I'm still not understanding about seasonality is that we can re-create our environment rather easily. For instance, after I move, I'm going to get into perma-culturing, regular ol' gardening, aqua-culturing, growing mushrooms, perhaps spirulina, and more. So, I can eat those all year round in that respect, and thus seasonality for me would be drastically different than one who is in the same location as myself, but not growing their own foods. This would be further augmented if I had a chicken coop or something.

    I mostly agree with what you say, though. Great points made! :) Of course, I also agree that these things need to be used as an adjunct to things Dr. Kruse has outlined, such as CT, circadian rhythm entrainment, and an epi-paleo diet. I'll look for the post and researcher/physician, but someone from MAPS has actually been researching microdosed psychedelics, particularly LSD and psilocybin, Apparently, they don't cause hallucinations, but are mood improving and nootropic; in the case of LSD, it can be indirectly anti-cancerous to certain tissues due to mild anti-serotonergic effects. So, even the 'bad' psychedelics can probably be improved via this way of dosing. Perhaps if the initial research into psychedelics and the like used micro-doses, all of medical history in the U.S. would be different and those compounds would be similar to frequently prescribed medications...

    This all makes me want to go back and read Dr. Shulgin's work, at least after I understand chemistry a bit better.
    Brother John likes this.
  15. nicld

    nicld Gold

    When we were in Colorado in December we talked to a gift shop owner who gave us some insight into the two major types of marijuana and how each of them works differently depending on what the desired outcome is. I am hoping that states see the major medical benefits of this and stop letting big pharmaceutical companies control them.
  16. yewwei.tan

    yewwei.tan Gold

    An implication of that paper I shared even suggests that all the psychedelic effects are just a by-product of the huge burst of biophoton activity that you get when you take these compounds.

    Eventually, I'd think it's possible to be able to shoot bio-photons directly to the appropriate tissues using technologies like targeted low-intensity lasers. Whether or not these will have "psychedelic effects" likely depends on the technological implementation. ie: whether or not you can target say just the prefrontal cortex, without affecting any of the visual or auditory pathways that lead to hallucinations.

    The natural method of using such psychoactive substances will continue to be relevant of course, and are at your disposal today (not in Australia where they are illegal as fuck :mad:)

    "Seasonality" here broadly means any external factors that change over the natural course of a revolution of the earth around our current Sun and the rotation of the Earth on its axis, which end up affecting our circadian biology.

    So far, we lack practical manipulation over stuff like magnetic and electrostatic (gravitational) variations across the seasons. Both are stronger during the winter time, and affect our circadian biology massively as I laid out in the 'reverse electron flow' post -- http://forum.jackkruse.com/index.php?threads/reverse-electron-flow.12744/#post-154292

    We could possibly re-create those environmental factors eventually, even without understanding the direct impact on biology, so long as we can directly measure and mimic exactly the conditions that earth would provide. (This is a pre-requisite for safe space travel)

    We definitely have not even begun to study how exactly our body measures these forces using the various SQUIDs in the body (which work at different scales, at the mitochondrial level, at the extracellular level in AQP4 gates, etc ....)

    It's a decent assumption that evolution and natural forces have been yoked pretty tightly, which means that plants such as cannabis are ready for harvest under a particular set of conditions, brought about by natural seasonal changes. We cannot claim to understand why this occurs yet, though we can get one perspective from qualitative measures of ROS signalling (which we cannot quantify :rolleyes:)

  17. On a side note, literally JUST came across this:

    Anyhow, great points again, yewwei! In terms of seasonality, my particular comment was more so meant in terms of food and light, though I do know electromagnetism, lunar cycles, etc. all play a role. I just know that, for instance, a lot of Dr. Kruse's protocols are based around hebbian learning and "neuosurgery without a knife", in which we can yolk our body to other forms of entrainment, otherwise known as zeitgebers. So, although I may not know enough about my locations particular seasonal variance in cosmic radiation, magnetism, and so forth, I can take care of some of the legs of the stool by eating a daily BAB + time restricted feeding/IF, light exposure in the morning + darkness and/or red light, candles, fire, etc. at night, and then eat basically the same all year 'round, from home grown foods. I'd imagine my body, or actually, my brain and peripheral clocks, would yoke to the entrainment that I personally give it, as opposed to what's happening around me; this is, of course, under the very large assumption that my SCN, pineal gland overall, etc. aren't completely 'confused' due to nn-EMF and can't even accept what signals I'm giving it.

    Lastly, thanks for the phosphene paper. I've only read the abstract, but, it seems to be very applicable to me. Some of the symptoms I've outlined here: http://forum.jackkruse.com/index.ph...working-towards-a-recovery.12766/#post-154947 are kind of alluded to in the paper. I have visual snow, which are similar to phosphenes in a way: http://en.wikipedia.org/wiki/Visual_snow#mediaviewer/File:Red-blue-noise.gif this is a symptom present 24/7. So, perhaps my visual system is messed up, perhaps 'confused' and then randomly 'firing' bioluminescent photons that are then internally recognized and displayed in my visual field as visual snow....? I posted about intranasal LLLT recently, as well as LLLT into the ear to target the vestibulae; perhaps I can target my occipital lobes, too...
  18. yewwei.tan

    yewwei.tan Gold

    No excuse not to read the paper summary ;) -- http://qhwiki.com/study:phosphene-phenomenon


    We could make an argument over how having an environment-controlled growing system is a circadian mismatch in a way :oops:. Food is another important and powerful environmental signal, and manipulation of that variable independent of the rest of the variables must be understood in the context of those other variables.

    Last edited: Feb 8, 2015
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  19. nicld

    nicld Gold

    There is a dispensary on almost every corner in Denver, at least where my SIL lives. We have suggested that she try some for her health issues but she has not yet, that we know of.
  20. I'm sorry to hear that; hopefully some day she'll decide to give it a try. With the way cannabis science is now turning out, it is likely each individual can find strains and methods of administration that work particularly well for their personal problems. As I posted above about cannabinoid acids vs. psychoactive cannabinoids, the method of administration has also been noted to change the structure, amount, and ratio of different cannabinoids (smoking vs. vaporizing vs. edibles vs. hash vs. budder (not butter for edibles), etc). I hope to some day lend a hand in all the research and efforts to help people via cannabis medicine. When something can do so much - medicine, food, building material (think Hempcrete), etc - we must pay attention and thoroughly explore it, just as Dr. Kruse has laid out with things as seemingly simple as cold exposure.
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