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Ca channel blockers

Discussion in 'The EMF Rx' started by NeilBB, Oct 11, 2013.

  1. NeilBB

    NeilBB New Member

    Titanium dioxide, which is used in toothpaste as a whitener, can function as a photo-voltaic cell and capture solar energy... Photoelectric effect...
     
  2. Josh

    Josh Gold

    Toothpaste is Calcium carbonate CaCO3 based vs Tofu which has Gypsum/Calcium Sulfate CaSO4 as a coagulant for the soy proteins. Tofu undergoes a phase change with the proteins being crosslinked into a structure with tertiary and maybe quaternary structure from liquid to a gel with cross links as in collagen. Toothpaste typically does not. I am guessing that tofu is a hydrated gel and toothpaste is just a suspension. This ultimately is related to the same factors that maintain collagen in our own system. Thus, electromagnetic effects that destroy the crosslinkages would change tofu to toothpaste. Similar things happen in the brain under similar circumstances. Since we are in the Calcium channel world, the concentration or perhaps the form that the calcium is in, carbonate versus sulfate is probably the point. Also, the electromagnetic effect on the channel itslef causing it to open would change the intracellular pH and destroy the collagen cytoskeleton resulting in the loss of volume control, energy efficiency, etc.. This is probably the bigger point as the brain would then become soft and mushy like toothpaste that lacks the tertiary and quaternary protein structure of tofu.

    http://pubs.acs.org/doi/pdf/10.1021/jf0342021
     
    Last edited: Apr 16, 2014
    rlee314, Clayton and NeilBB like this.
  3. NeilBB

    NeilBB New Member

    Haven't put it all together yet, but here are some random thoughts...

    So, I was cogitating on hypertonic saline and cerebral edema, and I usually think of this as an osmotic effect of water being drawn out of the brain as classically described. (Which relies on an intact BBB and would be expected to only last about 4 hours due to eventual Na equilibration). But it just doesn't seem to me that just "dehydrating" a "non-acutely swollen" brain would facilitate any kind of photoelectric effect of red or infrared light to do anything like charge separating water though. That doesn't really compute much, so I doubt that has a lot to do with what you are thinking. There must be another mechanism.

    So I did literature search and found this meta-analysis that mentions several alternative mechanisms for the decreased ICP effect of hypertonic saline that are potentially more sustained, including effects on blood viscocity (zeta potential?) leading to cerebral oxygenation and also endothelial cell shrinkage, among other potential mechanisms.

    http://thejns.org/doi/pdf/10.3171/2011.7.JNS102142

    The other funny thing is I didn't realize it til after I read it, but that article is actually from UAB and the two lead authors were residents that I personally trained. Martin and I actually used to go out to lunch together before he left here. He is a character, for sure, but we never actually discussed these alternative mechanisms of hypertonic saline when he was here... Sometimes, your students teach you something, even if its through the literature...
     
    SCRN2007 and Shijin13 like this.
  4. Josh

    Josh Gold

    Wouldn't the hypertonic saline create a net dehydration that would decrease the size of the cells and allow them to become more energy efficient and be more effectively energized with electrons from the red light?
     
    Shijin13 likes this.
  5. Jack Kruse

    Jack Kruse Administrator

    and...................keep going
     
  6. Josh

    Josh Gold

    Something along the lines of:

    1. Decrease cell volume with hypertonic solution. This increases energy efficiency, but decreases magnesium and available ATP so this energy production needs to be replaced.
    2. Increase extracellular water available for superconduction with added energy from intranasal infrared to replace lost ATP potential from magnesium loss inside the cell.
    3. The Calcium channel blockers prevent calcium from rushing into the cell to balance the osmotic gradient which would make the cell less efficient and reduce the potential for energizing the collagen through superconduction of the electrons from the light via water. And, protons from water instead of the inefficient mitochondria.
    Quotes from GutCollagen 1

    http://jackkruse.com/organizational-structural-failure-1-gutcollagen-link/
     
    Last edited: Apr 16, 2014
    Shijin13 likes this.
  7. Josh

    Josh Gold

    More DC current in CSF=collagen reassembly and volume regulation....
     
    Shijin13 likes this.
  8. Jack Kruse

    Jack Kruse Administrator

    and................
     
  9. ssj3

    ssj3 Silver

    higher vesicle concentration?
     
  10. Shijin13

    Shijin13 Guest

    Ok this thread has totally blown me away! every single drop... especially Neil and Josh's ability to pick apart Jack's breadcrumbs. but for me a Key component to figuring out what's going was this comment by SeaHorse

    Particularly

    My E went off the charts high this winter..... and that got me googling. BOOM! PCOS is offering me a way to mitigate non-Native EMF NATURALLY by increasing E-dominance. While E-Dominance is driving my aversion to cold, increasing SHBG; its also protecting me as a form of energy conservation by limiting Ca+ flooding my mitochondria. so If I understand this process correctly, this is why Bio-Identical Estrogen (Tri-Est) is protective for the heart in women who've transitioned into menopause! Its also why I'm able to leverage a better redox potential that what people would think I'd be able to leverage. HOLY SCHNIKES!

    This might be one of the best threads every dropped that NO ONE picked up until now! TOTAL AWESOMENESS!

    http://www.pnas.org/content/105/39/15148.full.pdf
    http://www.plosone.org/article/info:doi/10.1371/journal.pone.0011791
    http://www.baliadvertiser.biz/articles/anti_aging/2011/estrogen.html
    http://www.ncbi.nlm.nih.gov/pubmed/12148697
    http://eurheartj.oxfordjournals.org/content/17/suppl_D/27.full.pdf
     
  11. nonchalant

    nonchalant Silver

    Gretchen, you and Sarah are awesome.
     
    Shijin13 likes this.
  12. nonchalant

    nonchalant Silver

    http://www.ncbi.nlm.nih.gov/pubmed/9236206
     
  13. BJK77

    BJK77 Gold

    Gretchen,

    You rock! And I have absolutely no estrogen in my body this winter, so my poor mitochondria are getting flooded and completely trashed!
     
    Josh (Paleo Osteo), Josh and Shijin13 like this.
  14. BJK77

    BJK77 Gold

    Shijin13 likes this.
  15. Jack Kruse

    Jack Kruse Administrator

    Gretch thought you knew that about E2. Why? What did I tell you about puberty? It is a phase transition by e2. What does it do......it increase cell volumes in the stroma of the breast area......what happens when electrons are removed? The tissues get larger........this is why breast grow in puberty. Ovulation works the same ways......Egg swells and pops fallopian tube.
     
    rlee314 likes this.
  16. Jack Kruse

    Jack Kruse Administrator

    no
     
  17. cantweight

    cantweight Gold

    If someone with E dominance/PCOS adds a calcium channel blocker are we going to do more harm than good? That E has to be doing something....mine favors increasing volume in thigh/ass area!
     
  18. Jack Kruse

    Jack Kruse Administrator

    Calcium mechanisms connecting endoplasmic reticulum (ER) stress and autophagy in mitochondria are big. Different ER stresses lead to autophagy activation. Ca2+ release from the ER can stimulate different kinases that regulate autophagy.
     
  19. cantweight

    cantweight Gold

    Can someone dumb that down for me? I am barely getting a C in microbiology right now....obviously not my strong suit :confused:
    Big time cognitive decline in the last 6 months or so not helping either.
     
  20. Josh

    Josh Gold

    http://en.wikipedia.org/wiki/Endoplasmic_reticulum

    I am guessing that we are talking about a smooth ER function where Ca2+ release activates enzymes (kinases) that signal the mitochondria to regenrate/increase capacity in some fashion. As Dr. K suggests that the Ca2+ release is a "stress" signal which would require more energy, it would make sense. I envision that EMF "stress" =too much energy to maintain order in the cell and surrounding environment, would require more metabolism to do damage control by trying too for example unfold proteins to maintain or increase the amount of coherent energy available from water to mitigate the damage from the increased entropy. So see the Ca2+ as a carrier pigeon carrying a message to the mitochondria to step it up handle more work...
     
    Last edited: Apr 17, 2014
    Stella likes this.

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