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Boric Acid intake in mice activates UPC-2

Discussion in 'Redox Rx' started by Valerie, Jan 20, 2019.

  1. Valerie

    Valerie New Member

    So if boric acid activates UPC-2 is this a way to deplete deuterium out of the mitrochondrial cells? Maybe this is a cheaper approach than DDW.


    Objective.The effect of oral boric acid intake on reducing body weight has been previously demonstrated although the mechanism has been unclear.This research study reveals the mechanism.

    Subjects. Twelve mice were used, in groups of six each in the control and study groups. For five days, control group mice drank standard tap water while during the same time period the study group mice drank tapwaterwhich contains 0.28mg/250mL boric acid.After a 5-day period, gene expression levels for uncoupling proteins (UCPs) in the white adipose tissue (WAT), brown adipose tissue (BAT), and skeletal muscle tissue (SMT) and total body weight changes were analyzed.

    Results. Real time PCR analysis revealed no significant change in UCP3 expressions, but UCP2 inWAT :) 0.0317), BAT :) 0.014), and SMT :) 0.0159) and UCP1 in BAT :) 0.026) were overexpressed in the boric acid group. In addition, mice in the boric acid group lost body weight (mean 28.1%) while mice in the control group experienced no weight loss but a slight weight gain (mean 0.09%, < 0.001).

    Conclusion. Oral boric acid intake causes overexpression of thermogenic proteins in the
    adipose and skeletalmuscle tissues. Increasing thermogenesis through UCP protein pathway results in the accelerated lipolysis and body weight loss.
    https://www.ncbi.nlm.nih.gov/pubmed/23861682
     
    Corey Nelson and recoen like this.

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