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Bio-Hacking Altitude: Ubiquination one is live

Discussion in 'The EMF Rx' started by Jack Kruse, Feb 19, 2015.

  1. Jack Kruse

    Jack Kruse Administrator

    Do set trends? How is your style? Are you unique? Your best style is your authentic self. Use your talents to the fullest. In order to be irreplaceable one must always be unique. Personal style is the answer to most everything that troubles us. It's a fresh way to approach a dull or dangerous thing. Style is knowing who you are, what you want to say, and not giving a damn what critics think. Style is the innovator's difference, it's a new way of doing an old thing from a new perspective, a new way of being done for the world to see. Embrace your style today.

    How much do you know about altitude and where you live? You might want to bio hack that............http://jackkruse.com/ubiquination-1-bio-hacking-altitude-suicide-loss-muscle-mass/
     
  2. bionaut

    bionaut New Member

    Since moving from Va to Fl I have noticed a few things. I used to have a lot of dry dead skin on my feet around a fungal infection. The skin is totally fine and nails are slowly clearing up. My muscle mass is slowly creeping up with very little exercise. I also had a fungus right on top of my femoral artery on my thigh. That is now gone at this point. I am still doing CT down here but I am seeing change faster. My wife has recently started with me and she has had a chronic rib and hip injury that is no longer painful. This was in a span of about 19 days of 20 min of CT either in the day or at night coupled with 20-30 min of sunlight between 10-12. I need to put a pulse oximeter on my wish list:D.

    This blog shines a light on the "why", thanks for the details. I will be re reading it again soon.;)
     
    fitness@home likes this.
  3. Josh

    Josh Gold

    Yup.....might have to move one of these days.....o_O

    [​IMG]
     
    Marie likes this.
  4. Josh

    Josh Gold

    [QUOTE
    Cell signaling and ubitiquin
    The post-translational modification ubiquitination involves the covalent linkage of ubiquitin moieties on a lysine residue of a target protein. Ubiquitination exists under different forms, ranging from the addition of one ubiquitin (monoubiquitination) to the formation of polyubiquitin chains. Several types of polyubiquitin chains are found, depending on the residue from ubiquitin engaged in the chain formation. The topologies displayed by the different polyubiquitin chains are associated with various biological outputs, including degradation by the proteasome, ER-associated degradation, endocytosis, DNA repair, transcription activation, etc (Figure 1). As such, ubiquitination is involved in a wide array of cellular processes and signaling pathways. Our group is mostly focused on proteasome-independent functions of ubiquitin, particularly in the context of monoubiquitin and polyubiquitin chains involving the lysine residue K63 from ubiquitin (Figure 1). The role of these sub-types of ubiquitination events on plasma membrane protein dynamics and signaling pathways are studied using Arabidopsis thaliana as a multicellular organism.
    ][/QUOTE]

    [​IMG]

    http://www.isv.cnrs-gif.fr/veranglais/research/gva/gva.html
     
    Last edited: Feb 19, 2015
  5. Josh

    Josh Gold

    [​IMG]

    http://embor.embopress.org/content/15/1/28
     
  6. Josh

    Josh Gold

    [​IMG]

    http://embor.embopress.org/content/15/1/28
     
  7. Josh

    Josh Gold

    http://embor.embopress.org/content/15/1/28
     
  8. Josh

    Josh Gold

    [​IMG]

    http://circres.ahajournals.org/content/100/9/1276.full.pdf+html
     
  9. Josh

    Josh Gold

    [​IMG]
     
  10. Josh

    Josh Gold

    I just like the colors, the people who make these get my kudo's.....:p...it reminds me of looking at the maps from National Geographic when I was a kid....
     
    Marie likes this.
  11. Andrea

    Andrea What is NOT on the menu?

    In my twenties, I liked high altitude hiking.
    Everyone in the group got more and more tired the higher we got, sleep got worse, appetite gone, decreased brain function, shortness of breath, increased heart rate, head aches, etc.
    Oddly enough, each and every time I felt better and better the higher we got. My body reacted in exactly the opposite way of everyone else. The days before starting my hike up on Mt. Kilimanjaro, I had a 42°C (107.6F) fever. Not very smart, but back then I thought I had EVERLAST written across my chest... I was pretty tired in the lower slopes, but ended up jogging the last part from Stella Point to the summit. It was so easy to breathe and move!
    I've always wanted to move to a high altitude place...
     
    nicld likes this.
  12. Josh

    Josh Gold

    I have had the same experiences at higher altitudes 7500+ throughout my life. However living at 6650ft for 4 years in CO, my health did not thrive. I feel better at 4300ft in AZ. There are a number of other major variables that make comparisons limited from one part of my life to another.

    On all of my higher altitude treks and climbs; I was always sleeping on the ground, had good circadian rhythm and other things that supported optimal function.
     
  13. Josh

    Josh Gold

  14. Josh

    Josh Gold

    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227407/
     
  15. I'm not understanding how this pairs up with all the studies on the protective effects of altitude and CO2 inhaled as a gas, bathed in as a dry gas, etc. I'm about to read the article Dr. Kruse wrote now, though, but here are some things to chew on:


    [​IMG]
    Combined
    [​IMG]

    Although there are some... confounding factors

    [​IMG]
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057635/Cancer Mortality in Six Lowest Versus Six Highest Elevation Jurisdictions in the U.S.
     
  16. By the way, once again, I'm about to read Dr. Kruse's article, and also, I'm not posting the above as a 'dispute' or something or to question Dr. Kruse or what Josh posted above.... just to give some more information!
     
  17. Jack Kruse

    Jack Kruse Administrator

    Talking CO2 is not the same as pseudohypoxia.......They are mutually exclusive at elevation. And thy do some more interesting things in deep water. The article talks about suicide and muscle mass.........specifically.

    The missing link is a lack of purple light
     
    Last edited: Dec 1, 2015
  18. I agree. You make some great points in that article. I'm in fact about to re-read it and also print out all the citations. That being said, as I posted above, there is a large body of evidence showing that at altitude:

    - There is less cancer and less mortality from cancer
    - Less heart disease and less mortality from heart disease
    - There is often increased longevity
    - People are often thinner
    - T3, testosterone, DHEA, and more are all increased at altitude
    - Mitochondrial density increases at altitude, as does the activity of enzymes, synthases, etc. that are involved in energy production
    - The higher you go, the more pronounced these benefits are
    - CO2 in blood, plasma, and tissues is increased, and oxygen is decreased, which to many would indicate bad news, yet somehow this achieves what I outlined above.

    There are examples of extremely long lived clams in low 02, high CO2 environments:
    http://www.karger.com/Article/Pdf/221004 Masters of Longevity: Lessons from Long-Lived Bivalves – A Mini-Review

    http://epic.awi.de/22151/1/Abe2010b.pdf Mantle cavity water oxygen partial pressure (PO2) in marine molluscs aligns with lifestyle

    http://jeb.biologists.org/content/214/24/4223.full.pdf Physiological responses to self-induced burrowing and metabolic rate depression in the ocean quahog Arctica islandica

    http://www.biomed.cas.cz/physiolres/pdf/51/51_335.pdf The Role of Carbon Dioxide in Free Radical Reactions of the Organism

    http://www.ncbi.nlm.nih.gov/pubmed/9190222 [Carbon dioxide--a universal inhibitor of the generation of active oxygen forms by cells (deciphering one enigma of evolution)].

    So, from an epi-paleo-optimal perspective, what is the explanation for these very frequent occurrences?
     

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