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Another relatively easy article on prions...

Discussion in 'The Cave' started by Penny, May 14, 2021.

  1. Dan2

    Dan2 Pedantic schlub

    Gotu kola (centella asiatica)' and brahmi (bacopa monnieri) are each called a medhya rasayana -- translates to ~ brain/nerves restorative. Medhya rasayanas are often cooked with fat so the fat carries the herb to the nervous system better. Ghee (clarified butter) cooked with an herb to infuse the herb into the ghee is called ghrita, medicated ghee. For example, simmering brahmi in ghee and a little water until the water reduces and straining out the herb makes brahmi ghrita, and if the moisture content is little it preserves well. Or adding gotu kola or brahmi to the fat when cooking makes a quick infusion of the fat-soluble chemicals, like a dose of ghrita made fresh each time, and gotu kola and brahmi are generally safe to eat like a food, amounts between a seasoning herb and a vegetable. A good neuroprotective blend to cook with easily is a quick sauce of simmered fat, spices (garam masala or you're a schlub), black cumin, gotu kola, brahmi, and tea.
     
    Last edited: Sep 12, 2021
    Penny likes this.
  2. Dan2

    Dan2 Pedantic schlub

    @Jeremy Fox
    This might be what the Twitter mention of methylene blue to you was about. I saw this somewhere in comments on @veryvirology's (Adam Gaertner) Twitter.

    Binding of methylene blue to a surface cleft inhibits the oligomerization and fibrillization of prion protein
    Paola Cavaliere et al.
    https://pubmed.ncbi.nlm.nih.gov/23022479/


    Adam Gaertner's prion treatment studies links:

    https://prions.rip/potential-treatments/

    From that page...

    Related to cinchona bark...
    ( https://forum.jackkruse.com/index.p...sy-article-on-prions.25857/page-2#post-300105
    https://forum.jackkruse.com/index.p...sy-article-on-prions.25857/page-2#post-302631 )

    The curious antiprion activity of antimalarial quinolines
    By Eric Vallabh Minikel
    https://www.cureffi.org/2015/06/19/the-curious-antiprion-activity-of-antimalarial-quinolines/


    Jack has said a lot about NAD+...

    Neuronal death induced by misfolded prion protein is due to NAD+ depletion and can be relieved in vitro and in vivo by NAD+ replenishment
    Minghai Zhou et al.
    https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4840455/


    Gaertner UVB prions.png

    @Jack Kruse
    Able to increase endogenous UVB in the brain?

    ____________


    https://prions.rip/making-rt-quic-tests-available/


    Gaertner prion nasal swab test.png
     
    Last edited: Sep 14, 2021
  3. Dan2

    Dan2 Pedantic schlub

    Spoke protein monocytes nicotine.jpg


    "...When you get infected with COVID, the spike proteins go around infecting certain cells and injecting viral RNA (set of temporary instructions) and duplicating the virus. It takes about 1 week for your body to recognize the virus is bad and evoke a immune response. When your body does this, it sends a bunch of monocytes to kill the infected cells. The spike proteins are eaten by the Classical Monocytes and SHOULD be destroyed inside of them, and then the monocyte wil undergo apoptosis (die). This is working for the S2 protein, but not the S1. The S1 protein is being eaten by Classical Monocytes, but it is making the Monocytes change into Intermediate, and Non-Classical monocytes, and the S1 protein is NOT BEING DESTROYED in them, so they are refusing to undergo apoptosis. A monocyte should only live for 1 day to 1 week, but the Non-Classical Monocytes with the S1 protein in them are not dying for up to 15 months or more. Dr. Bruce Patterson is leading the research on this:

    So even after your body has killed off COVID-19 inside of you, you have a bunch of monocytes presenting the S1 protein. These monocytes with the S1 protein can pass through the blood brain barrier, and go anywhere in your body. They are causing vasodilation (increased size of blood vessels) throughout people's bodies, inflammation of blood vessels, and nano-clotting, especially in the capillaries. These nano-clots and inflammation can cause heart attacks, fatigue, and all sorts of other problems. This is what is called Long Haul COVID.

    The vaccine... causes your cells to begin producing spike proteins via mRNA... This causes your body to have an immediate immune response and begin producing antibodies against the spike proteins. This does make your body effectively immune to COVID if it worked properly. But it doesn't for 1 reason. The S1 spike proteins being eaten by your Classical Monocytes are being turned into Non-Classical monocytes (which should die in 1 week or less normally) that are not undergoing apoptosis, and therefore never dying. These S1 presenting monocytes are going throughout the body and causing serious damage, and hurting your immune system. https://www.biorxiv.org/content/10.1101/2021.06.25.449905v1.full

    IF YOU COULD FORCE YOUR NON-CLASSICAL MONOCYTES TO UNDERGO APOPTOSIS, the vaccine would work properly. Bruce Patterson suggests using several drugs in his protocol to achieve the goals. Ivermectin kills the virus. Statins prevent the S1 protein presenting Monocytes from attaching to your cells, and several drugs (including nicotine) can induce monocyte apoptosis. When the S1 presenting Non-Classical monocytes undergo apoptosis, the S1 protein is destroyed, and the nano clotting, inflammation, etc go away. This is also why smokers have been shown to test positive for COVID symptoms 80% less than the general population: the nicotine effectively renders them immune to the effects of the S1 protein, and thus most of COVID's symptoms. https://www.webmd.com/lung/news/20200430/smokers-hospitalized-less-often-for-covid-19

    So, now, does the vaccine work and why is COVID and its variants killing people still? Simply put, as your body is introduced to more and more COVID virus (or vaccines), your body begins building a larger and larger resevoir of very harmful S1 presenting Non-Classical Monocytes, that will eventually killy you. So, if you had COVID, you have a resevoir already; if you get the vax, now you have even more. If you get a second vax, or encounter people with COVID, you get even more and more, until you die unless you do something to induce apoptosis in your Non-Classical Monocytes.

    So, yes, the vaccine is not useless; it does immunize people against COVID, but it destroys their immune system by creating a resevoir of S1 protein presenting Non-Classical Monocytes that reduce the body's ability to produce antibodies to fight off future COVID infection. If you induce apoptosis in your monocytes, then the vaccine works, and is not overly dangerous. As it is right now, the vaccine is immunizing people against COVID, but then putting their body in a state that it can't fight off COVID, as well as many other pathogens. In addition, the vaccine can kill you, either immediately (via blood clotting), or long-term via your resevoir of S1 presenting Monocytes. But COVID can do the latter if you are exposed to enough viral load, even over months or years..."



    I found that picture in the second post of these:

    https://raypeatforum.com/community/...r-7-months-need-help.42632/page-3#post-701939

    "Have you tried nicotine? It's like penicillin for non-classical monocytes, enabling them to go through apoptosis (cell death), a function which the spike protein disables upon being absorbed into the monocyte. Much of the long-covid could be the result of spike proteined monocytes hanging around indefinitely and causing havoc."

    https://raypeatforum.com/community/...r-7-months-need-help.42632/page-3#post-702010
     
  4. Dan2

    Dan2 Pedantic schlub

  5. Dan2

    Dan2 Pedantic schlub

    Rose hips and amla (Indian gooseberry), vitamin C and bioflavonoids

    _______

    Fatty Acid, Sugar and Vitamin Contents in Rose Hip Species
    I. Hakki Yoruk et al.

    https://www.researchgate.net/profil...-and-vitamin-contents-in-rose-hip-species.pdf


    Rose hips vitamin C levels table.png

    Rosa canina is common rose hip species.
    2855 ug / g =
    2.85 mg / g
    So ~285 mg vit. C / 100 g rose hips.

    _______


    INFLUENCE OF PROCESSING ON VITAMIN C CONTENT OF ROSEHIP FRUITS
    Sorina Ropciuc, Ana Leahu

    http://spasb.ro/index.php/spasb/article/view/1812

    "Ascorbic acid values of rosehip fruits dried tea and syrup were determined as 0.72 and 2.18 mg/100g, respectively. In addition, ascorbic acid contents of the rosehip fruits and jam were established as 415.86 and 37 mg /100g, respectively."

    Rose hips vitamin C table 2.png

    Rosa canina, L ascorbic acid = 754 mg / 100 g

    _______


    Polyphenols, vitamin C and antioxidant activity in wines from Rosa canina L. and Rosa rugosa Thunb.
    Author links open overlay panel
    A. Czyzowska, A. Nowak

    https://www.sciencedirect.com/science/article/abs/pii/S0889157514002099

    "The purpose of this study was to determine the concentration of biologically active compounds (polyphenols and l-ascorbic acid) in Rosa canina L. and Rosa rugosa Thunb. wines... The final concentrations of ascorbic acid were 1200 for Rosa rugosa Thunb. and 600 mg/L for Rosa canina L."

    ______


    Comparative bioavailability to humans of ascorbic acid alone or in a citrus extract
    J A Vinson, P Bose

    https://academic.oup.com/ajcn/article-abstract/48/3/601/4716518

    "This study was performed to determine whether synthetic ascorbic acid (AA) alone or in a natural citrus extract containing bioflavonoids, proteins, and carbohydrates was more bioavailable to human subjects... The citrus extract was 35% more absorbed than AA [ascorbic acid] (p less than 0.001) and was more slowly absorbed than AA (p less than 0.001)... Citrus extract ascorbate was less excreted than AA (p less than 0.05) in 12 nonsaturated subjects. Ascorbate in the citrus extract was found to be more bioavailable than AA alone in human subjects."

    _______


    Amla

    A REVIEW ON REJUVENATING HERBS
    S. Balamurugan et al.

    https://wjpr.s3.ap-south-1.amazonaws.com/article_issue/1540983164.pdf

    Page 5:
    "The citrus bioflavonoids that comprise hesperidine, quercetin, rutin (a glycoside of quercetin) and tangeritin, in addition to possess antioxidant activity and an ability to surge intracellular levels of ascorbic acid, rutin and hesperidin exert beneficial effects on capillary permeability and blood flow. [9] They also exhibit some of the anti-allergic and anti inflammatory benefits of quercetin.[11]"

    Page 7:
    "The flavonoid content of the [amla] extract was 15.80±0.20 mg of quercetin equivalent/gm dry weight. The tannin content of P. emblica [amla] was found to be 11.50±0.25 mg rutin equivalent/gm dry weight. [14]"


    ...

    (Amla also has vitamin C, and rose hips also have bioflavonoids.)

    ________


    What herbs I'm using for COVID prophylaxis

    Hot water infusion of rose hips, amla, maybe elderberries (more expensive than rose hips), green tea, maybe ginkgo -- for vitamin C and bioflavonoids (quercetin, EGCG, and others) for zinc ionophore effect (with a meal of meat or eggs or shellfish), maybe ginkgo for cardio complement. Hawthorn berries would fit good with these too -- has some amount of vitamin C and bioflavonoids and good for the heart. Or schisandra berries, bilberries, sea buckthorn berries. The berries get expensive; I think rose hips and amla have the most vitamin C for the money (with the complementary blends of bioflavonoids too).

    Hot water infusion of or simmered black cumin seeds, milk thistle seeds, licorice, and spices (ginger, turmeric, fenugreek, maybe cinnamon or cardamom) -- blood cleanser, liver support, antiviral, general prophylactic

    Gotu kola, brahmi, ashwagandha, black cumin seeds; simmered in milk or cooked with in fat to help carry the fat-soluble chemicals to the nervous system -- neuroprotective

    Hot water infusion of cinchona bark -- has quinine; substitute for hydroxychloroquine

    I also make propolis extract with vodka and add that to tea.

    I drink a cup or two each day of each of the three other than cinchona, cinchona less often.

    Also, a blend of oils I put on my hands and in my nose -- black cumin seed oil base, maybe some neem oil too, with .125-2% concentration each of essential oils: frankincense, myrrh, spruce needle, lavender, tulsi, rosemary, clove
     
    Last edited: Nov 5, 2021
    Jude, John Schumacher and Penny like this.
  6. Penny

    Penny New Member

    ginko also detoxes glyphosates - add glycine to sweeten and replace glycine lost due to glyphosates... this is really how grains kill your gut...

    NICE POST:) thanks!
     
    Dan2 likes this.
  7. Dan2

    Dan2 Pedantic schlub

    @Penny
    "ginko also detoxes glyphosates"
    Who'd you hear that from?
     
  8. Penny

    Penny New Member

    I would guess Stephanie Seneff - she is always blathering on about that but I honestly don't remember - I read/listen to so much stuff - it is getting jumblesd into mush in my brain...- it might have been the Herbal Antibiotics book by Steven Harrod Buhner - it might have been Perlmutter in the book Grain Brain - I was as surprised as you are:) I knew it made you more clear headed, but no clue why - if I run into it again, I will ping you:)
     
    Dan2 likes this.
  9. Penny

    Penny New Member

    Dan2 likes this.
  10. Dan2

    Dan2 Pedantic schlub

    Related to excess of manganese associated with prion growth...

    ( earlier posts about that
    https://forum.jackkruse.com/index.p...sy-article-on-prions.25857/page-2#post-302756

    https://forum.jackkruse.com/index.p...sy-article-on-prions.25857/page-3#post-304148 )


    Excess of vitamin B1 can deplete manganese (animal studies from 1939) (?)

    https://raypeatforum.com/community/...r-7-months-need-help.42632/page-6#post-707026


    and manganese binds to free B1

    https://raypeatforum.com/community/...itamin-b1-and-the-level-of-pyruvic-acid.8700/


    @Sue-UK You know some about high dose B1, right? Have you seen much recently about it related to covid? Or high dose B1 people talking about it affecting TDP-43 or FUS proteins?

    https://childrenshealthdefense.org/...ccines-parkinson-neurodegenerative-disorders/

    "Immunologist J. Bart Classen, one-time National Institutes of Health (NIH) contract scientist and proprietor of Classen Immunotherapies, a Maryland biotechnology firm, published a paper in February outlining the potential for messenger RNA (mRNA) COVID vaccines to trigger development of prion diseases as well as other chronic diseases.
    ...

    Classen offers several explanations which are not necessarily mutually exclusive. First, he suggests COVID vaccines could be accelerating disease progression in individuals who either already have subclinical prion disease or have mild prion disease that has not been properly diagnosed.

    In addition, there is evidence indicating the vaccine spike protein can prompt misfolding of essential RNA/DNA binding proteins called TDP-43 and FUS and catalyze a toxic “chain reaction.”

    The vaccine spike protein may also cause proteins “including [normal] prions already in cells” to form abnormal clumps (called Lewy bodies) that can result in “relatively rapid cell death.” Research has shown development of Lewy bodies in monkeys exposed to SARS-CoV-2. Notably, Lewy bodies “cause some or all of the motor symptoms of Parkinson’s disease.”"
     
    Last edited: Oct 10, 2021
  11. Sue-UK

    Sue-UK New Member

    Only general stuff such as

    https://ccforum.biomedcentral.com/articles/10.1186/s13054-021-03648-9
    Evaluation of thiamine as adjunctive therapy in COVID-19 critically ill patients: a two-center propensity score matched study

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7428453/
    Be well A potential role for vitamin B in covid 19.

    Vitamin B2 and UV is interesting .....
     
    Last edited: Oct 10, 2021
  12. Sue-UK

    Sue-UK New Member

    https://www.bmj.com/content/370/bmj.m3489/rapid-responses
    Long covid: How to define it and how to manage it

    28th Sept 2020 and 26 Nov 2020 posts link to thiamin and long covid.
     
  13. Dan2

    Dan2 Pedantic schlub

    Licorice tea...

    Glycyrrhizin effectively neutralizes SARS-CoV-2 in vitro by inhibiting the viral main protease

    L. van de Sand, M. Bormann, M. Alt, L. Schipper, C.S. Heilingloh, D. Todt, U. Dittmer, C. Elsner, O. Witzke, A. Krawczyk

    https://www.biorxiv.org/content/10.1101/2020.12.18.423104v1.full

    "We demonstrated that glycyrrhizin, the primary active ingredient of the licorice root, potently neutralizes SARS-CoV-2 by inhibiting the viral main protease...

    In the present study, we investigated aqueous licorice root extract for its neutralizing activity against SARS-CoV-2 in vitro... The neutralization capacity of licorice root extract was determined in cell culture by endpoint dilution.... The aqueous licorice root extract showed neutralizing effects even at a subtoxic concentration of 2 mg/ml, (Figure 1A and B). This concentration is lower than the normal consuming dilution e.g. in tea (12.5 mg/ml).

    Based on our results with the aqueous licorice root extract, we investigated the antiviral activity of glycyrrhizin acid against a clinical SARS-CoV-2 isolate and subsequently examined the underlying mechanism of viral neutralization.

    The neutralizing activity of glycyrrhizin against a clinical SARS-CoV-2 isolate was investigated in cell culture... The neutralization capacity of glycyrrhizin was determined by endpoint dilution. The antiviral activity against SARS-CoV-2 was analysed under pre- and post-entry conditions... Complete virus neutralization was achieved at subtoxic concentrations of 0.5 mg/ml under pre- and 1 mg/ml under post-entry conditions...

    The initial finding was supported by quantifying the SARS-CoV-2 RNA from the supernatants of SARS-CoV-2 infected cells treated with glycyrrhizin... Glycyrrhizin treatment significantly reduced the genomic SARS-CoV-2 RNA levels...

    Next, we investigated the underlying mechanism how glycyrrhizin may interfere with the virus replication... We focused on the SARS-CoV-2 main protease (Mpro) as a potential target for glycyrrhizin. Mpro is essential for processing the viral polyproteins that are translated from the viral RNA and thus, for virus replication. Glycyrrhizin was suggested as a possible inhibitor of Mpro by in silico analysis, but this hypothesis has never been experimentally proven... Here we provide evidence that glycyrrhizin potently inhibits Mpro activity in vitro... Glycyrrhizin completely inhibited Mpro activity at a concentration of 2000 µM (1.6 mg/ml) and reduced its activity by 70.3% at a concentration of 30 µM (0.024 mg/ml)."

    _____


    Licorice dosage, safety guidelines

    https://forum.jackkruse.com/index.p...t-a-disease-damn-it.25242/page-16#post-303554
     
    Last edited: Oct 11, 2021
  14. Dan2

    Dan2 Pedantic schlub

    Related to post # 43 about nicotine causing apoptosis of spike protein S1 subunit-infected lingering monocytes

    ( https://forum.jackkruse.com/index.p...sy-article-on-prions.25857/page-3#post-304023 )


    https://www.sott.net/article/234667-Pestilence-the-Great-Plague-and-the-Tobacco-Cure

    Pestilence, the Great Plague and the Tobacco Cure

    "...[Londoners during the plague] believed that tobacco offered some protection from the plague. According to one website which summarizes the history of the Great Plague:

    Those who stayed in London did all they could to protect themselves from the plague. As no one knew what caused the plague, most of these were based around superstition. In 1665 the College of Physicians issued a directive that brimstone 'burnt plentiful' was recommended for a cure for the bad air that caused the plague. Those employed in the collection of bodies frequently smoked tobacco to avoid catching the plague.

    "For personal disinfections nothing enjoyed such favour as tobacco; the belief in it was widespread, and even children were made to light up a reaf in pipes. Thomas Hearnes remembers one Tom Rogers telling him that when he was a scholar at Eton in the year that the great plague raged, all the boys smoked in school by order, and that he was never whipped so much in his life as he was one morning for not smoking.
    It was long afterwards a tradition that none who kept a tobacconist shop in London had the plague." - A J Bell writing in about 1700.

    There seemed to be a widespread belief that tobacco protected people from whatever this plague was that was going around; enough of a belief anyways for people to force their children to smoke! It seems reasonable, given the environmental pressures at the time, that the belief in tobacco as a protective remedy against the plague was more than just a trite superstition."

    Healthy tobacco?
    https://raypeatforum.com/community/threads/guilt-free-smoking-room.25186/page-2#post-371875
    https://raypeatforum.com/community/threads/tobacco.43033/
     
    Last edited: Nov 20, 2021
  15. Dan2

    Dan2 Pedantic schlub

    I asked Tyler LeBaron, with the Molecular Hydrogen Institute ( http://www.molecularhydrogeninstitute.com ), about if molecular hydrogen therapy can increase heat shock proteins, because of Stephanie Seneff's recommendation to increase heat shock proteins to help prevent or revert misfolding of prion proteins. This is an excerpt of the conversation:


    "Do you know of any studies or anecdotes about molecular hydrogen treating prion diseases?"

    "I have not seen any studies or heard any anecdotes about that. Maybe it can help reduce some of the symptoms, but I don't know.

    Best,
    Tyler L."

    "Okay. I read some about heat shock proteins, popularized by sauna therapy, being something that can prevent or revert back to normal the misfolded prions. And heat shock proteins are also called stress proteins sometimes, because of their involvement in hormetic stress response pathways. And when I inhale molecular hydrogen before or during exercise, my exercise endurance improves, which I think suggests that the hormetic stress response pathways are functioning more efficiently. So I think it's a reasonable guess that maybe inhaling molecular hydrogen would activate heat shock proteins somehow too. And so that heat shock protein activation and/or other hormetic stress reponses stengthened by molecular hydrogen might help prevent or revert prion misfolding. But that's all just my guesswork, which is why I was curious if someone (you, or other people in your organization) who knows more about the scientific literature about molecular hydrogen might have more specific leads about it."

    "Yes, we do have data that H2 increase heat shock proteins.
    https://www.tandfonline.com/doi/abs/10.1080/10715762.2018.1439166.
    nice thinking!
    -Tyler L."

    "Cool! Thanks!"
    (Don't laugh at me for being a cheeseball.)

    https://www.tandfonline.com/doi/abs/10.1080/10715762.2018.1439166

    Molecular hydrogen upregulates heat shock response and collagen biosynthesis, and downregulates cell cycles: meta-analyses of gene expression profiles

    Hiroshi Nishiwaki, Mikako Ito, Shuto Negishi, Sayaka Sobue, Masatoshi Ichihara & Kinji Ohno
    Free Radical Research
    Volume 52, 2018 - Issue 4
     
    Last edited: Nov 24, 2021
  16. Dan2

    Dan2 Pedantic schlub

    Adding a zinc supplement to herbal teas (with vitamin C and bioflavonoids) for zinc ionophore effect

    Related to post # 45 in this thread:

    https://forum.jackkruse.com/index.p...sy-article-on-prions.25857/page-3#post-304550

    _______


    A zinc supplement without fillers in the capsules:

    https://store.emeraldlabs.com/products/zinc-25mg?_pos=1&_sid=fb0243ca6&_ss=r

    Emerald brand Pure Albion® Zinc 25 mg
    "Therapeutic amount of 100% Pure Albion® Zinc as Glycinate Chelate.
    Serving Size: 1 Capsule
    Servings Per Container: 90
    Amount Per Serving / %DV*
    Zinc (TRAACS® Bisglycinate Chelate) 25mg / 227%
    Tocotriene Complex 217mg
    Other ingredients: Vegetable Capsule"

    I found that at a health food store for about $10.


    The manufacturer of the zinc chelate:

    https://balchem.com/human-nutrition-health/hnh-products/albion-minerals/zinc/

    "This chelate binds zinc to two organic glycine ligands, resulting in a low pH, highly stable structure that is easily absorbed."

    https://balchem.com/human-nutrition-health/products/z-life/

    __________


    Why use a zinc supplement that has no filler ingredients?

    Second to last paragraph:
    https://forum.jackkruse.com/index.php?threads/correcting-high-omega-6-3-ratio.24801/#post-287920

    "A dose of 120 gm of Atlantic oysters contained 108 mg of elemental zinc and produced a mean elevation in plasma zinc of 142 ± 22 μg/dl (mean ± S.E.M.) at 3 hr after ingestion. Both black beans and corn tortillas, at intakes of 120 gm, decreased the bioavailability of zinc from oysters, and inhibition was significantly greater by tortillas than by beans. In the presence of black beans, equivalent doses of elemental zinc as ZnSO4.7H2O and as oysters produced indistinguishable plasmal zinc patterns. In the presence of tortillas, absorption was slightly greater from inorganic zinc than from oysters, but the biological importance of this difference is unclear... When 70 gm of tortillas were ingested with the herring, plasma zinc concentration declined significantly."

    Lots of zinc supplements have mixed in with the zinc inside the capsule rice flour and/or vegetable cellulose. The tiny amount of that in the capsule probably doesn't inhibit zinc absorption as much as eating tortillas. But if I'm mixing the zinc supplement into a cup of tea, I'd rather there not be those fillers that might inhibit zinc bioavailability to some extent, or react with things in the herbs and limit bioavailability of those.

    If you don't have time to make a meal of food that has lots of zinc to eat with the tea but want to use the zinc ionophore effect to prevent spike protein infection, adding a bioavailable zinc supplement to rose hips or other herbal teas with vitamin C and bioflavonoids is convenient.
     
    Last edited: Nov 24, 2021
  17. Dan2

    Dan2 Pedantic schlub

    Related to post # 43 about nicotine causing apoptosis of spike protein S1 subunit-infected lingering monocytes

    https://forum.jackkruse.com/index.p...sy-article-on-prions.25857/page-3#post-304023


    More ways to fix S1 subunit-infected non-classical monocytes

    ______


    https://live.childrenshealthdefense.org/shows/the-defender-show/j1Ys0Y-zFv

    Interview of Dr. Ryan Cole by RFK Jr.
    August 30, 2021


    10:44 --

    RFK Jr.: "A lot of our audience has asked me, 'What are doctors doing for long-haul COVID and vaccine injuries... that last for months?'"

    Dr. Ryan Cole: "Kudos to Dr. Bruce Patterson, and he has a website, www.covidlonghaulers.com; they're doing research. Mechanistically, there's a certain type of white blood cell -- a non-classical monocyte -- that is still holding fragments of virus and/or spike protein inside of it. It's kind of the same mechanism in the long-hauler and/or the post-COVID patient. Fascinatingly, ivermectin is fantastic for that. For those who have neurologic injury post-vaccine or post-long-haul, fluvoxamine has had great effect in a good percentage of those patients; some patients don't tolerate it, but it's a low dose for a short period of time. I've treated a handful of these individuals -- maybe 16. I would say about 75% of them -- I got this beautiful letter from a gal in New York saying she could barely move, she couldn't function, she couldn't go back to work; after three weeks on treatment she was ecstatic, saying, "I'm 80, 90% better; I'm functional again."

    The fluvoxamine is turning off a certain type of white blood cell [infected non-classical monocyte]. Not only those drugs are able to do that. I would encourage people to look at www.flccc.net and look at their I-RECOVER protocols [ https://covid19criticalcare.com/covid-19-protocols/i-recover-protocol/ "I-RECOVER Management Protocol for Long Haul COVID-19 Syndrome (LHCS)"]... Vitamin D in good dose will help repolarize and inactivate those non-classical monocytes. One of the statins, atorvastatin, is effective [for infected non-classical monocytes?]. Melatonin, interestingly, because it affects your hormones [is effective for other long-hauler COVID symptoms, I think he means, maybe not for infected non-classical monocytes].

    And then there's another line of cells -- your kind of itchy, inflammatory cells -- your mast cells. Some of these patients are hyperactivated in that line of cells, so they can use some antihistamines: famotidine, which is Pepcid, or Claritin allegra, the non-drowsy type."

    ______


    youtube.com/watch?v=JwjJs5ZHKJI

    Interview of Dr. Bruce Patterson by Dr. Mobeen Syed
    June 24, 2021

    6:20 --
    Dr. Bruce Patterson: "...non-classical monocytes carry spike protein S1 subunit up to 15 months after diagnosis. These cells bind to blood vessel walls and endothelial cells through fractalkine and the fractalkine receptor that's expressed on non-classical monocytes and cause inflammation, and these cells can cross the blood brain barrier and cause vascular inflammation in the brain. The most exciting thing that we found in the literature... is that these non-classical monocytes are mobilized by exercise and activity. And so here you have a cell carrying spike protein, and no RNA by the way -- we just had a round of sorting experiments and next-gen sequencing... to show that there really isn't any protein in these cells, yet they express the S1 subunit protein. But they are mobilized by exercise, and so of course to a person who's a long-hauler, they get worse after activity, after exercise. We've had individuals who've gotten back to pre-COVID levels, and some individuals who were absolutely bedridden, who felt well enough to work in the yard and take their kids to sporting events and overdid it and had a relapse. The fact is, these cells still contain S1 subunit protein, are still circulating, and a little bit of exercise -- you know, more than just a mile or two walk -- and they're gonna get a flare-up of their symptoms, and that's why you see this waxing and waning. And when we talk about our therapeutic approach, we'll talk about how that can mitigate these flares and eliminate these cells from the circulation."

    18:55 --
    "We can also interrupt this fractalkine, fractalkine receptor pathway with statins. So the hallmark of our treatment regimen we recommend now is a CCR5 antagonist and statins. And of course, ivermectin, we've found to be very useful in our combinations. We tend not to use it alone because now that we understand the mechanism behind long COVID, we want to interrupt the pathway; we want to treat the cause and not the symptoms. But by no stretch of the imagination do we think ivermectin isn't important in its immunomodulatory effects that complement the CCR5 antagonists and fractalkine...

    This has been an important question from our patients: the post-vaccination long-haulers, or the people who've never had [symptomatic] COVID and three or four months after vaccination they have long-hauler symptoms... We found four individuals who had an inflammatory profile that looked a lot like COVID and severe, active COVID, although it wasn't; and the rest look exactly like long-haulers from the long-hauler index... Immunologically, they resemble very much like long-haulers, we've treated them as such, and we've been very successful treating them. As much as it's a side effect of vaccines, I think it's not something to be too concerned about; it's treatable and it's not something that'll stick forever."

    22:56 --
    "The key point about our discovery is that it's in a highly mobile cell that's in the blood. They're true monocytes -- non-classical monocytes but monocytes nevertheless -- and they have the capacity to go all over your body and cause inflammation..."

    25:28 -- "These cells have a definitive lifespan, and if you look at classical monocytes, intermediate monocytes, and non-classical monocytes in normal human beings, you're talking about lifespans of days and weeks. But what happens in pathologic conditions, a whole set of mechanisms that prevent cell death come into play, that make them more long-lived than in normal individuals. That said, using a combination of CCR5 antagonists, statins, and ivermectin, we've seen, by doing serial monitoring of these cells, the levels go down... We've already shown patients in our program who we've got their immune systems back to normal, absolute normal; every one of the cytokines in our panel is normal... Sometimes there's a lag in the symptoms... Usually their symptoms improve right along with their immune profile improving..."

    36:15 -- "These non-classical monocytes are expressing CCR5, and much like bees are attracted to honey, these immune cells are attracted to RANTES. And we already showed in our first paper, RANTES are statistically signficantly elevated in long-haulers compared to severe, mild, or moderate, and normal individuals. So, again, RANTES is playing a role in long COVID. It's made by activated platelets, which are probably responding on the inflamed endothelium..."

    41:06 --
    Dr. Mobeen Syed: "Post-vaccines -- we established that this is happening post-vaccine as well - how is the vaccine ending up causing this?"

    Dr. Bruce Patterson: "There's one thing we see that's different from long COVID, and that's the elevations of vascular inflammation markers. The long-hauler index [immune profile]... we don't see the elevations in VEGF, which is great because that causes peripheral neuropathy, and I think it's responsible for the brain fog because those cells cross the blood brain barrier and cause VEGF expression there and vasodilation which is probably the cause of headaches and migraines, but we don't see that [VEGF elevation] in [non-vaccinated?] long-haulers. The most common pattern we see in post-vaccination long-hauler symptoms is RANTES, [also known as] CCL5, plus soluble CD40 ligand in addition to elevations in the long-hauler index... We're going to look in these monocytic subsets, to see in the post-vaccination individuals, if they're still harboring fragments of COVID protein three and four months after vaccination."

    Dr. Mobeen Syed: "...Dr. Patterson's team has input on the I-RECOVER protocol on www.flccc.net [ https://covid19criticalcare.com/covid-19-protocols/i-recover-protocol/ ]."

    50:22 --
    Dr. Mobeen Syed: "...What is the relationship of tinnitus with this mechanism?"

    Dr. Bruce Patterson: "We very often see tinnitus with brain fog, and what's really miraculous is that I'd say within 3-5 days tinnitus is gone with a CCR5 antagonist... I'm thinking that preventing the migration of cells, at least in long-haulers, into the brain, and preventing vasodilation, which I think is part and parcel with tinnitus and increased pressure in certain parts of the brain -- we see tinnitus a lot, we treat it a lot, and I think we're very good at eliminating it.

    My worry is that with the long-haulers, when there is a continuous inflammation going on, and now thanks to your work we know that it is at the boundaries of the blood vessels and vasculitis is occurring, there could be damage if this continues on for a long time because there could be scarring on top of the damage and that can become a permanent issue. And so that means that managing this as fast as possible becomes an important issue... to prevent scarring."
     
    Last edited: Nov 24, 2021
  18. Jack Kruse

    Jack Kruse Administrator

  19. Jack Kruse

    Jack Kruse Administrator

    https://pubmed.ncbi.nlm.nih.gov/18628989/

    UVB light creates Vitamin D which activates a proper immune response. It seems like it also lowers the probability of prion related diseases in the future. That info might come in handy in human future.
     
  20. ND Hauf

    ND Hauf Pleb

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