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Another paper destroying CICO.

Discussion in 'Educating Doctors' started by Jack Kruse, Jun 23, 2018.

  1. Jack Kruse

    Jack Kruse Administrator

    When you eat the steak tells you more about things than the macro's in a steak.

    For GNG enthusiasts:

    "After fasting overnight, they ingested a steak (120 g).

    (...) fractional gluconeogenesis increased from 68.2 {plus minus} 7.2% before the meal to 75.5 {plus minus} 5.8% 8 h after the meal, the latter corresponding to 22 h without a glucose supply."

    https://www.physiology.org/doi/abs/10.1152/ajpendo.00157.2018
     
    Brent Patrick, Antonis and JanSz like this.
  2. Jason Coates

    Jason Coates Losing the Shade.

    In the postprandial state, glucose homeostasis is challenged by macronutrient intake, including proteins that trigger insulin secretion and provide glucose precursors. However, little is known about the postprandial response of gluconeogenesis to a protein meal. We aimed to quantify the evolution of fractional gluconeogenesis after a meat meal. Thirteen healthy subjects received oral doses of D2O. After fasting overnight, they ingested a steak (120 g). Glycemia, insulinemia and 2H enrichments in glucose and plasma water were measured for 8 h after the meal. Fractional gluconeogenesis was assessed using the average method. Glucose was stable for 5 h and then decreased. There was a slight increase of insulin 1 h after the meal. 2H enrichment in C5 increased after 2 h, whereas it decreased in plasma water. Consequently, fractional gluconeogenesis increased from 68.2 {plus minus} 7.2% before the meal to 75.5 {plus minus} 5.8% 8 h after the meal, the latter corresponding to 22 h without a glucose supply. These values are consistent with the exhaustion of glycogen stores after 24 h, but represents the highest among values in the literature. The impact of methodological conditions is discussed.
     
  3. Jack Kruse

    Jack Kruse Administrator

    If CICO was true.........no way this result is possible: Did you know fast food restaurant meal servings on average have about 30% less calories than meals at full service restaurants - across the globe????

    https://www.bmj.com/content/363/bmj.k4864
     

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