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Aging is Not a Disease, Damn It!

Discussion in 'The Cave' started by Dennis Clark, Sep 27, 2020.

  1. JanSz

    JanSz Gold

  2. jrobertson1984

    jrobertson1984 New Member

    haha great thread
     
  3. JanSz

    JanSz Gold

  4. DrEttinger

    DrEttinger Choice, the only thing we control

    JanSz, Pablo and John Schumacher like this.
  5. Melatonin Signaling Pathway in a Long-Term Memory https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017053/

    Long-term memory formation requires gene expression and protein synthesis-dependent stabilization processes that take place in the brain, particularly in the hippocampus.

    Our electromagnetic system flows through melanin rich melatonin and dopamine pathways. The question is: How do you best supplement these pathways? https://forum.jackkruse.com/index.php?posts/294488

    I believe the melatonin pathway stimulus is not the lack of light but the activation of darkness.

    upload_2021-1-10_7-57-13.png
    The CREB signaling pathway stimulated by melatonin in HT-22 cells. The effect of melatonin shows Raf-ERK-CREB cascades through the MT1 receptor.
     
  6. JanSz

    JanSz Gold

    JanSz said:
    I use 20mg/(24hrs) melatonin taken the moment I go to bed (usually 10:00PM), so far I am very happy with it.
    -----------------------------------------------------------------------
    Since I wrote above
    I have changed to 30mg/night.
    Slowly I am getting ready to test.
    Will post results when available.
    Off hand I do not see or feel much difference.
    ..
     
    John Schumacher likes this.
  7. Are you sleeping better?
     
  8. JanSz

    JanSz Gold

    About the same.
    The first day I was more sleepy.
    ----------------
    The situation was highly similar to my history with MT-II injections.
    My first injection was minimal in size; I reacted with immediate very high penis erection and needed to get off.
    Had high expectations for the follow-up injections that newer materialized.

    .............
     
    Last edited: Jan 10, 2021 at 7:28 PM
    John Schumacher likes this.
  9. Jack Kruse said, “Deep brain stimulation is exactly what it sounds like — a pacemaker-like implant delivers electricity to misfiring brain cells. Scientists are only beginning to tap into its potential for treating puzzling brain conditions.” https://www.discovermagazine.com/he...imulation-and-why-does-it-work-for-parkinsons Reference: https://forum.jackkruse.com/index.php?threads/raffael’s-journal.22980/page-3#post-294491

    However, I believe that we need to take into account the electromagnetism form, frequencies, intensities values as very important variables when evaluating clinical protocols.

    Magnetic field desensitizes 5-HT1B receptor in brain: pharmacological and functional studies https://www.sciencedirect.com/science/article/abs/pii/S0006899399024865?via=ihub

    Nativis Voyager® device in patients with recurrent glioblastoma: first cohort in US https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499016/

    https://emulatetx.com/our-science/scientific-platform/
     
    Last edited: Jan 11, 2021 at 6:37 PM
    JanSz likes this.
  10. Could 40Hz Gamma be the brain’s fountain of youth?
    upload_2021-1-11_16-1-55.png
    https://sens.ai/blog/40hz-gamma

    Physical exercise during exposure to 40-Hz light flicker improves cognitive functions https://alzres.biomedcentral.com/articles/10.1186/s13195-020-00631-4
    Alzheimer’s disease caused by hippocampal atrophy have impairments of the axonal organelles including the mitochondria. Cognitive function is improved through light-emitting diode (LED) therapy with a 40-Hz flicker rate.

    And we thought all flicker was bad. https://www.nature.com/articles/nature20587

    upload_2021-1-11_15-43-11.png

    https://www.scientificamerican.com/...and-sound-a-day-might-keep-alzheimers-at-bay/

    The increase was most prevalent in the occipital lobe and frontal lobe, and most concentrated in the occipital lobe as the flickering light was turned on.
    upload_2021-1-11_15-53-49.png
    https://skemman.is/bitstream/1946/30688/1/Bachelor Thesis-NoSupervisor.pdf
     
    Last edited: Jan 11, 2021 at 6:03 PM
    Dan2 and JanSz like this.
  11. Attached Files:

    Dan2 and JanSz like this.
  12. Keeping to the subject of melatonin...
    https://onlinelibrary.wiley.com/doi/full/10.1111/jpi.12370
    Melatonin suppresses tumor metastases via its regulation on cell adhesion, ECM remodeling, cytoskeleton reorganization, the EMT, and angiogenesis at the molecular, cellular, and organismic levels
    upload_2021-1-12_9-55-20.png

    I don't what to loose sight on why its supplication maybe a good thing.
     
    Last edited: Jan 12, 2021 at 3:21 PM
    JanSz likes this.
  13. Dan2

    Dan2 New Member

    How to get a computer monitor that can set the refresh rate to 40 hz...

    After a little reading basic stuff about computer monitors, it looks like it's popular for monitors designed for gaming to have adjustable refresh rates. This seems to be the most popular technology that does that:

    https://www.amd.com/en/technologies...FreeSync™-technology-and-where-can-I-buy-one?
    which monitors.png

    I clicked on "See the current list of FreeSync monitors":
    https://www.amd.com/en/products/freesync-monitors

    This is a computer parts store:
    https://www.newegg.com/p/pl?N=100898493 600284704&Order=1
    On the left, the results can be filtered by refresh rate.
    On the list of FreeSync monitors page (previous link), the ranges are often from 48 or 40 to 60 or 75 hz.
    So I filtered the Newegg results by 60 hz and 75 hz and sorted by lowest price, and searched the monitor model name on the AMD List of Freesync Monitors page to check the refresh rate hertz range for the cheapest gaming monitors on Newegg.

    This is the cheapest that goes down to 40 hz:
    https://www.newegg.com/p/N82E16824025889
    https://www.lg.com/levant_en/monitors/lg-27MK400H-B
    LG refresh range.png

    27MK400H-B user manual
    https://www.lg.com/us/support/product/lg-27MK400H-B.AUS
    LG manual.png

    https://www.amd.com/en/technologies...ch-products-support-AMD-FreeSync™-technology?
    which graphics cards.png

    https://en.wikipedia.org/wiki/Radeon_Rx_200_series#Radeon_R7_250

    Radeon R5 2x0 series graphics card costs ~$50
    https://www.google.com/search?q=rad...hXzOn0KHU9XDLMQ_AUoAXoECA8QAw&biw=939&bih=490


    So about $200 to get a 40 hz refresh rate monitor setup, I guess.
     

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