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Aging is Not a Disease, Damn It!

Discussion in 'The Cave' started by Dennis Clark, Sep 27, 2020.

  1. JanSz

    JanSz Gold

  2. jrobertson1984

    jrobertson1984 New Member

    haha great thread
  3. JanSz

    JanSz Gold

  4. DrEttinger

    DrEttinger Choice, the only thing we control

    JanSz, Pablo and John Schumacher like this.
  5. Melatonin Signaling Pathway in a Long-Term Memory https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017053/

    Long-term memory formation requires gene expression and protein synthesis-dependent stabilization processes that take place in the brain, particularly in the hippocampus.

    Our electromagnetic system flows through melanin rich melatonin and dopamine pathways. The question is: How do you best supplement these pathways? https://forum.jackkruse.com/index.php?posts/294488

    I believe the melatonin pathway stimulus is not the lack of light but the activation of darkness.

    The CREB signaling pathway stimulated by melatonin in HT-22 cells. The effect of melatonin shows Raf-ERK-CREB cascades through the MT1 receptor.
  6. JanSz

    JanSz Gold

    JanSz said:
    I use 20mg/(24hrs) melatonin taken the moment I go to bed (usually 10:00PM), so far I am very happy with it.
    Since I wrote above
    I have changed to 30mg/night.
    Slowly I am getting ready to test.
    Will post results when available.
    Off hand I do not see or feel much difference.
    John Schumacher likes this.
  7. Are you sleeping better?
  8. JanSz

    JanSz Gold

    About the same.
    The first day I was more sleepy.
    The situation was highly similar to my history with MT-II injections.
    My first injection was minimal in size; I reacted with immediate very high penis erection and needed to get off.
    Had high expectations for the follow-up injections that newer materialized.

    Last edited: Jan 10, 2021
    John Schumacher likes this.
  9. Jack Kruse said, “Deep brain stimulation is exactly what it sounds like — a pacemaker-like implant delivers electricity to misfiring brain cells. Scientists are only beginning to tap into its potential for treating puzzling brain conditions.” https://www.discovermagazine.com/he...imulation-and-why-does-it-work-for-parkinsons Reference: https://forum.jackkruse.com/index.php?threads/raffael’s-journal.22980/page-3#post-294491

    However, I believe that we need to take into account the electromagnetism form, frequencies, intensities values as very important variables when evaluating clinical protocols.

    Magnetic field desensitizes 5-HT1B receptor in brain: pharmacological and functional studies https://www.sciencedirect.com/science/article/abs/pii/S0006899399024865?via=ihub

    Nativis Voyager® device in patients with recurrent glioblastoma: first cohort in US https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499016/

    Last edited: Jan 11, 2021
    JanSz likes this.
  10. Could 40Hz Gamma be the brain’s fountain of youth?

    Physical exercise during exposure to 40-Hz light flicker improves cognitive functions https://alzres.biomedcentral.com/articles/10.1186/s13195-020-00631-4
    Alzheimer’s disease caused by hippocampal atrophy have impairments of the axonal organelles including the mitochondria. Cognitive function is improved through light-emitting diode (LED) therapy with a 40-Hz flicker rate.

    And we thought all flicker was bad. https://www.nature.com/articles/nature20587



    The increase was most prevalent in the occipital lobe and frontal lobe, and most concentrated in the occipital lobe as the flickering light was turned on.
    https://skemman.is/bitstream/1946/30688/1/Bachelor Thesis-NoSupervisor.pdf
    Last edited: Jan 11, 2021
    Dan2 and JanSz like this.
  11. Attached Files:

    Dan2 and JanSz like this.
  12. Keeping to the subject of melatonin...
    Melatonin suppresses tumor metastases via its regulation on cell adhesion, ECM remodeling, cytoskeleton reorganization, the EMT, and angiogenesis at the molecular, cellular, and organismic levels

    I don't what to loose sight on why its supplication maybe a good thing.
    Last edited: Jan 12, 2021
    JanSz likes this.
  13. Dan2

    Dan2 Pedantic schlub

    How to get a computer monitor that can set the refresh rate to 40 hz...

    After a little reading basic stuff about computer monitors, it looks like it's popular for monitors designed for gaming to have adjustable refresh rates. This seems to be the most popular technology that does that:

    which monitors.png

    I clicked on "See the current list of FreeSync monitors":

    This is a computer parts store:
    https://www.newegg.com/p/pl?N=100898493 600284704&Order=1
    On the left, the results can be filtered by refresh rate.
    On the list of FreeSync monitors page (previous link), the ranges are often from 48 or 40 to 60 or 75 hz.
    So I filtered the Newegg results by 60 hz and 75 hz and sorted by lowest price, and searched the monitor model name on the AMD List of Freesync Monitors page to check the refresh rate hertz range for the cheapest gaming monitors on Newegg.

    This is the cheapest that goes down to 40 hz:
    LG refresh range.png

    27MK400H-B user manual
    LG manual.png

    which graphics cards.png


    Radeon R5 2x0 series graphics card costs ~$50

    So about $200 to get a 40 hz refresh rate monitor setup, I guess.
    Richard Watson likes this.
  14. When we study medicine, we see hardcore beliefs in evolutionary biology. So, when we turn to medicine for an answer, we may do well to understand the paradigm. Making evolutionary biology a basic science for medicine is the foundation of thought for: Human Genetics, the scientific method, biochemistry, cell biology and physiology.

    The belief in Natural Selection arises from chaos

    • which separates competing life forms
    • for a limited set of resources
    • as the means for modification
    thus, evolution’s selection always improves.

    Medicine is the study of the progression of disease. Understand that the evolutionary model of natural selection towards a slow progression of improvement does not mean the body knows what it is doing nor does it make “good” decisions for itself. That’s where medicine comes to the rescue -> 1) Disease identification and diagnosis 2) Prescription of medical intervention with the primary objective -> symptom reduction. Examples:

    Neutrophils in Cancer
    What is the medical intervention? -> shutdown the biological system with autoimmune drugs, chemo-cell-killing-drugs, etc.

    Prostaglandins in Cancer Cell Adhesion, Migration, and Invasion
    What is the medical intervention? -> shutdown the biological system with anti-inflammatory drugs, radiation, etc.

    Dermatology & Skin Cancer
    Yet most melanoma occurs in parts of the body which never see the light of day.

    I could write hundreds of the pages on this subject -> How the hell could medical science be so wrong?
    But this write up is not a work of apologetics in medicine; but a request for the reader to investigate the mechanisms of action rather than believing that Nature is so dam stupid, that it requires “smart doctor’s” evolutionary drug interventions.

    Is health a supplementation of multiple interventions or is it wrapped in the "epigenetics" of human group biological, human mental thought processes and emotional interactions in an optimal physical environment?

    • How we think maybe influence by our perception of the data.
    I am not convinced by current dogma that most people believe they are evolved. Examples of previous civilizations are depicted in inferior light. Whether its historians’ stories of politics, economy or technical advantage, we modern humans think we are better than others before us. "Data" observed through this lens is very limiting.

    Join me at looking to evidence when forming our beliefs; we need better perspectives when evaluating the data.
    Last edited: Jan 29, 2021
    JanSz likes this.
  15. Let’s take a moment down Jack Kruse memory lane: https://optimalklubs.com/qt24-non-linear-light-effects-in-a-5g-world/

    “When human skin is exposed to sunlight it can only convert approximately 15% of 7-dehydrocholesterol to previtamin D3. Any further exposure will result in a photoequilibrium whereby previtamin D3 is converted into lumisterol and tachysterol as well as revert back to 7-dehydrocholesterol.”

    Drum-row please: Dermatoendocrinol. January 1st 2013 “D3 is photodegraded into products that have no calcemic activity” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897598/

    So what is the mechanism of action? Cellular Signaling Transduces

    Cells can transduce mechanical stimuli to electrical signals which can be conveyed along their surface for rapid spatial relay of the signal. At the end of the cell, the electrical signal is transduced to a chemical signal to convey the signal across the gap between the cells. The postsynaptic cell transduces this chemical signal back to an electrical signal. https://www.sciencedirect.com/science/article/pii/B9780128008836000197

    Specifically with “vitamin” D3 metabolism is the Cholecalciferol Induces Prostaglandin E2 Biosynthesis and Transglutaminase Activity https://www.sciencedirect.com/science/article/pii/S0022202X15402374

    They found that cholecalciferol induces COX-2 mRNA and protein expression under regulation of PKC, resulting in enhanced PGE2 production, and that cholecalciferol may affect keratinocyte differentiation.

    So why are prostaglandins important in this pathway?

    Prostaglandins are generated from arachidonate by the action of cyclooxygenase (COX) isoenzymes.

    https://www.yourhormones.info/hormones/prostaglandins/ - Unlike most hormones, which are produced by glands and transported in the bloodstream to act on distant areas of the body, the prostaglandins are produced at the site where they are needed. Prostaglandins are produced in nearly all cells and are part of the body’s way of dealing with injury and illness.

    Prostaglandins act as signals to control several different processes depending on the part of the body in which they are made. Prostaglandins are made at sites of tissue damage or infection, where they cause inflammation, pain and fever as part of the healing process. When a blood vessel is injured, a prostaglandin called thromboxane stimulates the formation of a blood clot to try to heal the damage; it also causes the muscle in the blood vessel wall to contract (causing the blood vessel to narrow) to try to prevent blood loss. Another prostaglandin called prostacyclin has the opposite effect to thromboxane, reducing blood clotting and removing any clots that are no longer needed; it also causes the muscle in the blood vessel wall to relax, so that the vessel dilates. The opposing effects that thromboxane and prostacyclin have on the width of blood vessels can control the amount of blood flow and regulate response to injury and inflammation.

    Evolutionary medicine shuts down this process with hundreds of drugs - from controlling pain, shutting down the immune system, to anti-cancer drugs -> Brilliant

    Do you think these medical interventions have anything to do with improving the health of the human?
    Is it possible that the great “vitamin” D deficiency in the general population maybe a “side-effect” of the common use of NSAID drugs?

    Perhaps we should take @Jack Kruse advice, and fully expose ourselves as much as possible to our sun from morning to set.
    Last edited: Jan 29, 2021
    JanSz likes this.
  16. JanSz

    JanSz Gold


    Going back to our early Dec 2020 discussions,
    I have just started the third gallon of 12% hydrogen peroxide while humidifying my house using water containing 0.01% H2O2.
    Three times during the day, I immerse my head in humidifier-produced vapors and take few deep breaths at that time.
    All is well.
    Last edited: Jan 29, 2021
    John Schumacher likes this.
  17. Keeping our Melatonin thread alive.
    Just placing @DrEttinger's thread here -> https://forum.jackkruse.com/index.p...revents-infection-by-novel-coronavirus.25514/
    JanSz likes this.
  18. JanSz

    JanSz Gold

    How much,

    how many milligrams,
    how many cm^3,
    70kg person would have to ingest potassium bicarbonate
    to ingest 454 mEq/d.

    Since 454 mEq/d is 17706 mg potassium per day
    and it is about 15x larger than the 1200mg/day dose that you are recommending,
    would you like to make any additional comment (other than it looks like most of us are horrendously lacking in potassium?

    The anion gap test tells you how much acid is in your blood.
    Anion gap = Na⁺ + K⁺ – (Cl⁻ + HCO₃⁻)

    Conversion Calculator: mEq to Milligrams (mg) (nafwa.org)

    doi:10.1016/j.semnephrol.2006.10.003 (advancedhealing.com)
    Last edited: Aug 3, 2022
  19. DrEttinger

    DrEttinger Choice, the only thing we control

    I just went downstairs to weigh out a tsp of PB, but my scale is broken - bummer. Do not do what I do. On the days I run I take 2 tsp of PB in water before bed. The other days I take 1 tsp. I take 3-4 Now Foods Magnesium Transporters and Baja Gold Sea Salt Liberally.
    JanSz and John Schumacher like this.

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